Gene description for UFL1
Gene name	UFM1-specific ligase 1
Gene symbol	UFL1
Other names/aliases	KIAA0776 Maxer NLBP RCAD
Species	Homo sapiens
Database cross references - UFL1
ExoCarta	ExoCarta_23376
Vesiclepedia	VP_23376
Entrez Gene	23376
HGNC	23039
MIM	613372
UniProt	O94874
UFL1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Mesenchymal stem cells	36408942
Retinal pigment epithelial cells	35333565
Retinal pigment epithelial cells	35333565
Thymus	23844026

Gene ontology annotations for UFL1

Molecular Function     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IPI     UFM1 ligase activity GO:0061666 IDA     UFM1 ligase activity GO:0061666 IMP     UFM1 transferase activity GO:0071568 IBA Biological Process     DNA damage checkpoint signaling GO:0000077 IDA     osteoblast differentiation GO:0001649 HDA     negative regulation of T cell mediated immune response to tumor cell GO:0002841 IDA     DNA repair GO:0006281 IEA     DNA damage response GO:0006974 IDA     positive regulation of cell population proliferation GO:0008284 IMP     positive regulation of autophagy GO:0010508 ISS     erythrocyte differentiation GO:0030218 ISS     negative regulation of protein ubiquitination GO:0031397 IDA     negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP     regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032434 IMP     ribosome disassembly GO:0032790 IDA     regulation of protein localization GO:0032880 IMP     regulation of intracellular estrogen receptor signaling pathway GO:0033146 IDA     response to endoplasmic reticulum stress GO:0034976 IBA     response to endoplasmic reticulum stress GO:0034976 IDA     response to endoplasmic reticulum stress GO:0034976 IDA     negative regulation of apoptotic process GO:0043066 IEA     regulation of canonical NF-kappaB signal transduction GO:0043122 ISS     regulation of inflammatory response GO:0050727 ISS     protein stabilization GO:0050821 IDA     negative regulation of T cell activation GO:0050868 IDA     hematopoietic stem cell differentiation GO:0060218 ISS     positive regulation of glial cell proliferation GO:0060252 IEA     reticulophagy GO:0061709 IBA     reticulophagy GO:0061709 IDA     protein ufmylation GO:0071569 IDA     protein ufmylation GO:0071569 IMP     protein ufmylation GO:0071569 IMP     rescue of stalled ribosome GO:0072344 IDA     rescue of stalled ribosome GO:0072344 IMP     positive regulation of reticulophagy GO:0140501 IDA     response to L-glutamate GO:1902065 IEA     positive regulation of proteolysis involved in protein catabolic process GO:1903052 IDA     negative regulation of IRE1-mediated unfolded protein response GO:1903895 IDA     protein K69-linked ufmylation GO:1990592 IDA Subcellular Localization     nucleus GO:0005634 IDA     cytoplasm GO:0005737 IDA     mitochondrial outer membrane GO:0005741 IDA     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum GO:0005783 IDA     endoplasmic reticulum membrane GO:0005789 IBA     endoplasmic reticulum membrane GO:0005789 IDA     endoplasmic reticulum membrane GO:0005789 IDA     cytosol GO:0005829 IEA     membrane GO:0016020 HDA     protein-containing complex GO:0032991 IDA     site of double-strand break GO:0035861 IDA     neuron projection GO:0043005 IEA