Gene description for HIST3H2BB
Gene name histone cluster 3, H2bb
Gene symbol HIST3H2BB
Other names/aliases H2Bb
Species Homo sapiens
 Database cross references - HIST3H2BB
ExoCarta ExoCarta_128312
Vesiclepedia VP_128312
Entrez Gene 128312
HGNC 20514
MIM 615046
UniProt Q8N257  
 HIST3H2BB identified in sEVs derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Neuroblastoma cells 25944692    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
Prostate cancer cells 22723089    
 Gene ontology annotations for HIST3H2BB
Molecular Function
    DNA binding GO:0003677 IEA
    structural constituent of chromatin GO:0030527 IEA
    protein heterodimerization activity GO:0046982 IEA
Subcellular Localization
    nucleosome GO:0000786 IEA
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
 Experiment description of studies that identified HIST3H2BB in sEVs
1
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
6
Experiment ID 138
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
7
Experiment ID 139
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name DU145 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
8
Experiment ID 140
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
9
Experiment ID 141
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name VCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
10
Experiment ID 142
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
11
Experiment ID 143
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|LAMP2|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name LNCaP - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
12
Experiment ID 145
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|RAB5|CD10
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name C4-2 - Rep 3
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
13
Experiment ID 146
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|CD9
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors "Hosseini-Beheshti E, Guns ES."
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for HIST3H2BB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
2 XPC  
Affinity Capture-MS Homo sapiens
3 H2AFJ 55766
Cross-Linking-MS (XL-MS) Homo sapiens
4 ZNHIT1  
Affinity Capture-MS Homo sapiens
5 MBTD1  
Affinity Capture-MS Homo sapiens
6 HDAC2 3066
Affinity Capture-MS Homo sapiens
7 UBE2O 63893
Affinity Capture-MS Homo sapiens
8 ARID5B 84159
Affinity Capture-MS Homo sapiens
9 TRRAP 8295
Affinity Capture-MS Homo sapiens
10 TEX35  
Cross-Linking-MS (XL-MS) Homo sapiens
11 BAHD1  
Affinity Capture-MS Homo sapiens
12 ARL6IP4  
Cross-Linking-MS (XL-MS) Homo sapiens
13 KIF20A 10112
Affinity Capture-MS Homo sapiens
14 HIST1H2BB 3018
Cross-Linking-MS (XL-MS) Homo sapiens
15 TONSL  
Affinity Capture-MS Homo sapiens
16 UBC 7316
Cross-Linking-MS (XL-MS) Homo sapiens
17 MIER3 166968
Affinity Capture-MS Homo sapiens
18 CENPA  
Affinity Capture-MS Homo sapiens
19 HIST2H2AA3 8337
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
20 LZTS3  
Affinity Capture-MS Homo sapiens
21 DMAP1 55929
Affinity Capture-MS Homo sapiens
22 EPC1  
Affinity Capture-MS Homo sapiens
23 RUVBL1 8607
Affinity Capture-MS Homo sapiens
24 SRCAP  
Affinity Capture-MS Homo sapiens
25 MEAF6  
Affinity Capture-MS Homo sapiens
26 VPS72  
Affinity Capture-MS Homo sapiens
27 HIST1H2BM 8342
Cross-Linking-MS (XL-MS) Homo sapiens
28 MCM2 4171
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 RRP12 23223
Affinity Capture-MS Homo sapiens
30 ING3  
Affinity Capture-MS Homo sapiens
31 PRC1 9055
Affinity Capture-MS Homo sapiens
32 MED27  
Affinity Capture-MS Homo sapiens
33 KRI1  
Affinity Capture-MS Homo sapiens
34 HMGA1 3159
Cross-Linking-MS (XL-MS) Homo sapiens
35 HAUS6  
Affinity Capture-MS Homo sapiens
36 HIST2H2AC 8338
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
37 HIST1H2AA 221613
Cross-Linking-MS (XL-MS) Homo sapiens
38 NAP1L4 4676
Affinity Capture-MS Homo sapiens
39 H2AFY2 55506
Affinity Capture-MS Homo sapiens
40 USP7 7874
Biochemical Activity Homo sapiens
41 NCK1 4690
Affinity Capture-MS Homo sapiens
42 HAUS4  
Affinity Capture-MS Homo sapiens
43 KIF14 9928
Affinity Capture-MS Homo sapiens
44 CCDC86  
Affinity Capture-MS Homo sapiens
45 CHMP4C 92421
Affinity Capture-MS Homo sapiens
46 H2AFZ 3015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 TRIM41 90933
Affinity Capture-MS Homo sapiens
48 HAUS2  
Affinity Capture-MS Homo sapiens
49 HIST2H2AB 317772
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
50 HIST1H4A 8359
Cross-Linking-MS (XL-MS) Homo sapiens
51 RBM19 9904
Affinity Capture-MS Homo sapiens
52 HMGN2 3151
Cross-Linking-MS (XL-MS) Homo sapiens
53 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
54 TIPIN  
Affinity Capture-MS Homo sapiens
55 DPPA2  
Cross-Linking-MS (XL-MS) Homo sapiens
56 VRK1 7443
Affinity Capture-MS Homo sapiens
57 RPL5 6125
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
58 CFDP1  
Affinity Capture-MS Homo sapiens
59 TIMELESS  
Affinity Capture-MS Homo sapiens
60 HAUS8  
Affinity Capture-MS Homo sapiens
61 ACTL6A 86
Affinity Capture-MS Homo sapiens
62 CBX5 23468
Reconstituted Complex Homo sapiens
63 RAD18  
Affinity Capture-MS Homo sapiens
64 RPL27A 6157
Cross-Linking-MS (XL-MS) Homo sapiens
65 HECTD1 25831
Affinity Capture-MS Homo sapiens
66 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
67 NECAP1 25977
Affinity Capture-MS Homo sapiens
68 ZNF474  
Cross-Linking-MS (XL-MS) Homo sapiens
69 PPM1G 5496
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 HIST1H2AB 8335
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
71 HCLS1 3059
Cross-Linking-MS (XL-MS) Homo sapiens
72 IPO9 55705
Affinity Capture-MS Homo sapiens
73 HIST1H2AI 8329
Cross-Linking-MS (XL-MS) Homo sapiens
74 HMGN3  
Cross-Linking-MS (XL-MS) Homo sapiens
75 YEATS4  
Affinity Capture-MS Homo sapiens
76 NUMA1 4926
Affinity Capture-MS Homo sapiens
77 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
78 MIER1  
Affinity Capture-MS Homo sapiens
79 BMS1  
Affinity Capture-MS Homo sapiens
80 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
81 FANCD2  
Affinity Capture-MS Homo sapiens
82 RPS2 6187
Affinity Capture-MS Homo sapiens
83 BRD8 10902
Affinity Capture-MS Homo sapiens
84 MAP4K4 9448
Affinity Capture-MS Homo sapiens
85 CDK5R2 8941
Cross-Linking-MS (XL-MS) Homo sapiens
86 H1F0 3005
Affinity Capture-MS Homo sapiens
87 EP400  
Affinity Capture-MS Homo sapiens
88 ANP32E 81611
Affinity Capture-MS Homo sapiens
89 ACTR6  
Affinity Capture-MS Homo sapiens
90 HIST1H3B 8358
Affinity Capture-MS Homo sapiens
91 HAUS5 23354
Affinity Capture-MS Homo sapiens
92 CDYL 9425
Affinity Capture-MS Homo sapiens
93 HIST1H2AH 85235
Cross-Linking-MS (XL-MS) Homo sapiens
94 SS18L2  
Affinity Capture-MS Homo sapiens
95 CEBPZ  
Affinity Capture-MS Homo sapiens
96 NAP1L1 4673
Affinity Capture-MS Homo sapiens
97 EHMT2 10919
Affinity Capture-MS Homo sapiens
98 KAT5  
Affinity Capture-MS Homo sapiens
99 CRAMP1L 57585
Affinity Capture-MS Homo sapiens
100 MMS22L  
Affinity Capture-MS Homo sapiens
101 ACTL6B  
Affinity Capture-MS Homo sapiens
102 DDRGK1 65992
Affinity Capture-MS Homo sapiens
103 RNF2  
Affinity Capture-MS Homo sapiens
104 RBP1 5947
Affinity Capture-MS Homo sapiens
105 MPRIP 23164
Affinity Capture-MS Homo sapiens
106 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
107 HIST1H2AJ 8331
Cross-Linking-MS (XL-MS) Homo sapiens
108 SUPT16H 11198
Affinity Capture-MS Homo sapiens
109 MDM2  
Affinity Capture-MS Homo sapiens
110 HAUS3  
Affinity Capture-MS Homo sapiens
111 HUWE1 10075
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
112 H2AFX 3014
Cross-Linking-MS (XL-MS) Homo sapiens
113 RPS27A 6233
Cross-Linking-MS (XL-MS) Homo sapiens
114 SPOP  
Affinity Capture-MS Homo sapiens
115 PARP1 142
Affinity Capture-MS Homo sapiens
116 HMGN4  
Cross-Linking-MS (XL-MS) Homo sapiens
117 LIG3 3980
Affinity Capture-MS Homo sapiens
118 HIST1H2AC 8334
Cross-Linking-MS (XL-MS) Homo sapiens
119 HAUS1  
Affinity Capture-MS Homo sapiens
120 MCM5 4174
Affinity Capture-MS Homo sapiens
121 SRSF12  
Affinity Capture-MS Homo sapiens
122 UBA52 7311
Cross-Linking-MS (XL-MS) Homo sapiens
123 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
124 NPAT  
Affinity Capture-MS Homo sapiens
125 SECISBP2L  
Cross-Linking-MS (XL-MS) Homo sapiens
126 GON4L  
Affinity Capture-MS Homo sapiens
127 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
128 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
129 H2AFY 9555
Affinity Capture-MS Homo sapiens
130 PARP2  
Affinity Capture-MS Homo sapiens
131 HAUS7  
Affinity Capture-MS Homo sapiens
132 UFL1 23376
Affinity Capture-MS Homo sapiens
133 UBB 7314
Cross-Linking-MS (XL-MS) Homo sapiens
134 EIF4B 1975
Cross-Linking-MS (XL-MS) Homo sapiens
135 DUOX2 50506
Cross-Linking-MS (XL-MS) Homo sapiens
136 PINK1  
Affinity Capture-MS Homo sapiens
137 TNN 63923
Cross-Linking-MS (XL-MS) Homo sapiens
138 SERBP1 26135
Affinity Capture-MS Homo sapiens
139 SSRP1 6749
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 TEX10 54881
Affinity Capture-MS Homo sapiens
141 C16orf87 388272
Affinity Capture-MS Homo sapiens
142 CDKN2A 1029
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
143 EPC2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HIST3H2BB is involved
PathwayEvidenceSource
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 TAS Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis IEA Reactome
Activation of HOX genes during differentiation IEA Reactome
Amyloid fiber formation TAS Reactome
Assembly of the ORC complex at the origin of replication TAS Reactome
Assembly of the pre-replicative complex TAS Reactome
B-WICH complex positively regulates rRNA expression TAS Reactome
Base Excision Repair TAS Reactome
Base Excision Repair IEA Reactome
Base-Excision Repair, AP Site Formation TAS Reactome
Base-Excision Repair, AP Site Formation IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle Checkpoints TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Chromatin modifications during the maternal to zygotic transition (MZT) IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin modifying enzymes IEA Reactome
Chromatin organization TAS Reactome
Chromatin organization IEA Reactome
Chromosome Maintenance TAS Reactome
Cleavage of the damaged purine TAS Reactome
Cleavage of the damaged purine IEA Reactome
Cleavage of the damaged pyrimidine IEA Reactome
Condensation of Prophase Chromosomes TAS Reactome
Defective pyroptosis TAS Reactome
Deposition of new CENPA-containing nucleosomes at the centromere TAS Reactome
Depurination TAS Reactome
Depurination IEA Reactome
Depyrimidination IEA Reactome
Deubiquitination TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of programmed cell death TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
DNA Double Strand Break Response TAS Reactome
DNA Double-Strand Break Repair TAS Reactome
DNA methylation IEA Reactome
DNA Repair TAS Reactome
DNA Repair IEA Reactome
DNA Replication TAS Reactome
DNA Replication Pre-Initiation TAS Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes IEA Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Formation of the beta-catenin:TCF transactivating complex IEA Reactome
Formation of the beta-catenin:TCF transactivating complex TAS Reactome
G2/M Checkpoints TAS Reactome
G2/M DNA damage checkpoint TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
HATs acetylate histones TAS Reactome
HATs acetylate histones IEA Reactome
HCMV Early Events TAS Reactome
HCMV Infection TAS Reactome
HCMV Late Events TAS Reactome
HDACs deacetylate histones TAS Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) TAS Reactome
Homology Directed Repair TAS Reactome
Infectious disease TAS Reactome
Inhibition of DNA recombination at telomere TAS Reactome
M Phase TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
Meiosis IEA Reactome
Meiotic recombination IEA Reactome
Meiotic synapsis IEA Reactome
Metabolism of proteins TAS Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis IEA Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Negative epigenetic regulation of rRNA expression TAS Reactome
Negative epigenetic regulation of rRNA expression IEA Reactome
Nonhomologous End-Joining (NHEJ) TAS Reactome
NoRC negatively regulates rRNA expression TAS Reactome
NoRC negatively regulates rRNA expression IEA Reactome
Nucleosome assembly TAS Reactome
Oxidative Stress Induced Senescence TAS Reactome
Packaging Of Telomere Ends TAS Reactome
Positive epigenetic regulation of rRNA expression TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Post-translational protein modification TAS Reactome
PRC2 methylates histones and DNA TAS Reactome
Pre-NOTCH Expression and Processing IEA Reactome
Pre-NOTCH Transcription and Translation IEA Reactome
Processing of DNA double-strand break ends TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine TAS Reactome
Recognition and association of DNA glycosylase with site containing an affected purine IEA Reactome
Recognition and association of DNA glycosylase with site containing an affected pyrimidine IEA Reactome
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TAS Reactome
Regulation of endogenous retroelements TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins TAS Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex TAS Reactome
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex IEA Reactome
Replacement of protamines by nucleosomes in the male pronucleus IEA Reactome
Reproduction IEA Reactome
RHO GTPase Effectors TAS Reactome
RHO GTPases activate PKNs TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Promoter Escape TAS Reactome
RNA Polymerase I Promoter Opening TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function TAS Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs IEA Reactome
Senescence-Associated Secretory Phenotype (SASP) TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by NOTCH IEA Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by Rho GTPases TAS Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 TAS Reactome
Signaling by WNT IEA Reactome
Signaling by WNT TAS Reactome
SIRT1 negatively regulates rRNA expression TAS Reactome
TCF dependent signaling in response to WNT IEA Reactome
TCF dependent signaling in response to WNT TAS Reactome
Telomere Maintenance TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by RUNX1 IEA Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional regulation of granulopoiesis IEA Reactome
Ub-specific processing proteases TAS Reactome
Viral Infection Pathways TAS Reactome





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