Gene description for WDR6
Gene name WD repeat domain 6
Gene symbol WDR6
Other names/aliases -
Species Homo sapiens
 Database cross references - WDR6
ExoCarta ExoCarta_11180
Vesiclepedia VP_11180
Entrez Gene 11180
HGNC 12758
MIM 606031
UniProt Q9NNW5  
 WDR6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for WDR6
Molecular Function
    tRNA binding GO:0000049 IDA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    enzyme regulator activity GO:0030234 IDA
Biological Process
    wobble position ribose methylation GO:0002130 IDA
    negative regulation of cell population proliferation GO:0008285 IDA
    negative regulation of autophagy GO:0010507 IMP
    tRNA methylation GO:0030488 IBA
    G1 to G0 transition GO:0070314 IPI
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    COP9 signalosome GO:0008180 IDA
 Experiment description of studies that identified WDR6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for WDR6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 EDEM1  
Affinity Capture-MS Homo sapiens
3 UBE2H 7328
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 Pik3r2  
Affinity Capture-MS Mus musculus
6 UTRN 7402
Co-fractionation Homo sapiens
7 OCLN 100506658
Proximity Label-MS Homo sapiens
8 HSPA6 3310
Co-fractionation Homo sapiens
9 ARHGAP39  
Affinity Capture-MS Homo sapiens
10 MARCKS 4082
Proximity Label-MS Homo sapiens
11 LAMP3  
Proximity Label-MS Homo sapiens
12 GJA1 2697
Proximity Label-MS Homo sapiens
13 SSB 6741
Affinity Capture-MS Homo sapiens
14 PARD3 56288
Proximity Label-MS Homo sapiens
15 TRIM66  
Affinity Capture-MS Homo sapiens
16 MARCH2  
Affinity Capture-MS Homo sapiens
17 BRCA1 672
Two-hybrid Homo sapiens
18 IGHA2 3494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 RPL10 6134
Affinity Capture-MS Homo sapiens
20 KIF20A 10112
Affinity Capture-MS Homo sapiens
21 CDC25B 994
Affinity Capture-MS Homo sapiens
22 HSP90AB1 3326
Co-fractionation Homo sapiens
23 LAMP2 3920
Proximity Label-MS Homo sapiens
24 LOXL4 84171
Affinity Capture-MS Homo sapiens
25 ARHGAP18 93663
Affinity Capture-MS Homo sapiens
26 STX4 6810
Proximity Label-MS Homo sapiens
27 USP36  
Affinity Capture-MS Homo sapiens
28 C9orf78 51759
Affinity Capture-MS Homo sapiens
29 LAMTOR1 55004
Proximity Label-MS Homo sapiens
30 TSC22D4 81628
Affinity Capture-MS Homo sapiens
31 MLLT4 4301
Proximity Label-MS Homo sapiens
32 FAM212A  
Affinity Capture-MS Homo sapiens
33 PSMD12 5718
Co-fractionation Homo sapiens
34 PLCG1 5335
Co-fractionation Homo sapiens
35 FOXD4L6  
Affinity Capture-MS Homo sapiens
36 ATG7 10533
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
37 ABT1 29777
Affinity Capture-MS Homo sapiens
38 DNAJC7 7266
Proximity Label-MS Homo sapiens
39 JCHAIN 3512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 SPATA5L1 79029
Affinity Capture-MS Homo sapiens
41 RAB35 11021
Proximity Label-MS Homo sapiens
42 TFCP2 7024
Affinity Capture-MS Homo sapiens
43 FTSJ1 24140
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 EBAG9 9166
Proximity Label-MS Homo sapiens
45 Tmed10 68581
Affinity Capture-MS Mus musculus
46 DYRK1B  
Affinity Capture-MS Homo sapiens
47 LMAN1 3998
Proximity Label-MS Homo sapiens
48 PTPN3  
Two-hybrid Homo sapiens
49 C1orf106  
Affinity Capture-MS Homo sapiens
50 KRT8 3856
Proximity Label-MS Homo sapiens
51 MYH9 4627
Co-fractionation Homo sapiens
52 FAM96A  
Affinity Capture-MS Homo sapiens
53 IRS4 8471
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
54 C2orf27B  
Affinity Capture-MS Homo sapiens
55 MTCH2 23788
Proximity Label-MS Homo sapiens
56 MIB1 57534
Proximity Label-MS Homo sapiens
57 SAMM50 25813
Proximity Label-MS Homo sapiens
58 EMD 2010
Affinity Capture-MS Homo sapiens
59 USP11 8237
Affinity Capture-MS Homo sapiens
60 CXADR 1525
Proximity Label-MS Homo sapiens
61 B4GALT2  
Affinity Capture-MS Homo sapiens
62 CLNS1A 1207
Affinity Capture-MS Homo sapiens
63 MEX3C 51320
Affinity Capture-MS Homo sapiens
64 LYN 4067
Proximity Label-MS Homo sapiens
65 STK35  
Affinity Capture-MS Homo sapiens
66 PPIP5K2 23262
Co-fractionation Homo sapiens
67 Arrb2  
Affinity Capture-MS Mus musculus
68 DNAJC5 80331
Proximity Label-MS Homo sapiens
69 DHRS4L2  
Affinity Capture-MS Homo sapiens
70 YAP1 10413
Affinity Capture-MS Homo sapiens
71 DIRAS3  
Proximity Label-MS Homo sapiens
72 ARRDC2  
Affinity Capture-MS Homo sapiens
73 NTRK1 4914
Affinity Capture-MS Homo sapiens
74 KMT2E  
Affinity Capture-MS Homo sapiens
75 ALDH3B1 221
Affinity Capture-MS Homo sapiens
76 CBX6  
Affinity Capture-MS Homo sapiens
77 ARRDC3 57561
Affinity Capture-MS Homo sapiens
78 DHFRL1  
Proximity Label-MS Homo sapiens
79 PIK3R1 5295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 DNAJB5  
Proximity Label-MS Homo sapiens
81 Ksr1  
Affinity Capture-MS Mus musculus
82 ARHGAP20  
Affinity Capture-MS Homo sapiens
83 PAPSS2 9060
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 G2E3  
Two-hybrid Homo sapiens
85 KLHL14 57565
Affinity Capture-MS Homo sapiens
86 MAP2K7 5609
Affinity Capture-Western Homo sapiens
87 HSPA5 3309
Co-fractionation Homo sapiens
88 PPM1M  
Affinity Capture-MS Homo sapiens
89 PANK2 80025
Affinity Capture-MS Homo sapiens
90 RAB5A 5868
Proximity Label-MS Homo sapiens
91 RC3H2  
Affinity Capture-MS Homo sapiens
92 ECT2 1894
Affinity Capture-MS Homo sapiens
93 SIRT7  
Affinity Capture-MS Homo sapiens
94 RNF128  
Affinity Capture-MS Homo sapiens
95 EPB41L4A 64097
Proximity Label-MS Homo sapiens
96 LAMP1 3916
Proximity Label-MS Homo sapiens
97 MARCH8  
Affinity Capture-MS Homo sapiens
98 MEX3A  
Affinity Capture-RNA Homo sapiens
99 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 EGFR 1956
Affinity Capture-MS Homo sapiens
101 ARF6 382
Proximity Label-MS Homo sapiens
102 RIPK4  
Affinity Capture-MS Homo sapiens
103 CDC42EP4  
Two-hybrid Homo sapiens
104 AMY1C 278
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 FKBP5 2289
Affinity Capture-MS Homo sapiens
106 MAPK6  
Affinity Capture-MS Homo sapiens
107 EPHA2 1969
Proximity Label-MS Homo sapiens
108 MEX3B 84206
Affinity Capture-MS Homo sapiens
109 PSPC1 55269
Affinity Capture-MS Homo sapiens
110 RPA3 6119
Proximity Label-MS Homo sapiens
111 SOHLH1  
Affinity Capture-MS Homo sapiens
112 RAB9A 9367
Proximity Label-MS Homo sapiens
113 CDK20  
Affinity Capture-MS Homo sapiens
114 Bag2  
Affinity Capture-MS Mus musculus
115 DDRGK1 65992
Affinity Capture-MS Homo sapiens
116 RNF2  
Affinity Capture-MS Homo sapiens
117 RHOB 388
Proximity Label-MS Homo sapiens
118 ILK 3611
Affinity Capture-MS Homo sapiens
119 Rpl35 66489
Affinity Capture-MS Mus musculus
120 HAX1  
Proximity Label-MS Homo sapiens
121 GRIP1  
Two-hybrid Homo sapiens
122 JMJD6 23210
Affinity Capture-MS Homo sapiens
123 FLOT1 10211
Proximity Label-MS Homo sapiens
124 FARP1 10160
Affinity Capture-MS Homo sapiens
125 RPS16 6217
Affinity Capture-MS Homo sapiens
126 ZNF574  
Affinity Capture-MS Homo sapiens
127 HIPK4  
Affinity Capture-MS Homo sapiens
128 MAP2K2 5605
Affinity Capture-MS Homo sapiens
129 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
130 NSUN5P1  
Affinity Capture-MS Homo sapiens
131 SIRT6  
Affinity Capture-MS Homo sapiens
132 TIA1 7072
Co-localization Homo sapiens
133 GRB2 2885
Affinity Capture-MS Homo sapiens
134 FBXL6  
Affinity Capture-MS Homo sapiens
135 DNAJA2 10294
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 TPTE  
Affinity Capture-MS Homo sapiens
137 CDC37 11140
Affinity Capture-MS Homo sapiens
138 KDF1  
Affinity Capture-MS Homo sapiens
139 LCK 3932
Proximity Label-MS Homo sapiens
140 SMURF1 57154
Affinity Capture-MS Homo sapiens
141 DMWD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 NSUN5P2  
Affinity Capture-MS Homo sapiens
143 EPB41L2 2037
Co-fractionation Homo sapiens
144 ERGIC1 57222
Proximity Label-MS Homo sapiens
145 C11orf52 91894
Proximity Label-MS Homo sapiens
146 UFL1 23376
Affinity Capture-MS Homo sapiens
147 SF3B3 23450
Affinity Capture-MS Homo sapiens
148 RAB2A 5862
Proximity Label-MS Homo sapiens
149 DNAJC5B  
Proximity Label-MS Homo sapiens
150 Cdc37 12539
Affinity Capture-MS Mus musculus
151 RAB7A 7879
Proximity Label-MS Homo sapiens
152 KIF14 9928
Affinity Capture-MS Homo sapiens
153 RAB11A 8766
Proximity Label-MS Homo sapiens
154 STK11 6794
Affinity Capture-Western Homo sapiens
155 POLA1  
Co-fractionation Homo sapiens
156 WDR5B  
Affinity Capture-MS Homo sapiens
157 PIK3R2 5296
Affinity Capture-MS Homo sapiens
158 KRAS 3845
Proximity Label-MS Homo sapiens
159 RAB5C 5878
Proximity Label-MS Homo sapiens
160 C9orf72  
Affinity Capture-MS Homo sapiens
161 CAV1 857
Proximity Label-MS Homo sapiens
162 NOTCH1 4851
Affinity Capture-MS Homo sapiens
163 ATP5A1 498
Co-fractionation Homo sapiens
View the network image/svg+xml



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