Gene description for HNRNPA2B1
Gene name heterogeneous nuclear ribonucleoprotein A2/B1
Gene symbol HNRNPA2B1
Other names/aliases HNRNPA2
HNRNPB1
HNRPA2
HNRPA2B1
HNRPB1
IBMPFD2
RNPA2
SNRPB1
Species Homo sapiens
 Database cross references - HNRNPA2B1
ExoCarta ExoCarta_3181
Vesiclepedia VP_3181
Entrez Gene 3181
HGNC 5033
MIM 600124
UniProt P22626  
 HNRNPA2B1 identified in sEVs derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 19415654    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 17956143    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for HNRNPA2B1
Molecular Function
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IDA
    mRNA 3'-UTR binding GO:0003730 IBA
    mRNA 3'-UTR binding GO:0003730 IDA
    protein binding GO:0005515 IPI
    miRNA binding GO:0035198 IDA
    identical protein binding GO:0042802 IPI
    single-stranded telomeric DNA binding GO:0043047 IBA
    single-stranded telomeric DNA binding GO:0043047 IDA
    G-rich strand telomeric DNA binding GO:0098505 ISS
    molecular condensate scaffold activity GO:0140693 IDA
    N6-methyladenosine-containing RNA reader activity GO:1990247 IDA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 IBA
    mRNA splicing, via spliceosome GO:0000398 IC
    mRNA splicing, via spliceosome GO:0000398 IMP
    mRNA processing GO:0006397 IDA
    mRNA export from nucleus GO:0006406 IDA
    primary miRNA processing GO:0031053 IDA
    G-quadruplex DNA unwinding GO:0044806 ISS
    RNA transport GO:0050658 IDA
    mRNA transport GO:0051028 IBA
    positive regulation of telomere maintenance via telomere lengthening GO:1904358 ISS
    miRNA transport GO:1990428 IDA
Subcellular Localization
    chromosome, telomeric region GO:0000781 ISS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 IDA
    cytoplasm GO:0005737 IDA
    Cajal body GO:0015030 ISS
    membrane GO:0016020 HDA
    nuclear matrix GO:0016363 ISS
    extracellular exosome GO:0070062 IDA
    extracellular exosome GO:0070062 TAS
    catalytic step 2 spliceosome GO:0071013 IBA
    catalytic step 2 spliceosome GO:0071013 IDA
    ribonucleoprotein complex GO:1990904 IDA
 Experiment description of studies that identified HNRNPA2B1 in sEVs
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 65
MISEV standards
✘ Biophysical techniques
✔
HSP60|HSP27|GAPDH|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19415654    
Organism Homo sapiens
Experiment description Proteomics of MUC1-containing lipid rafts from plasma membranes and exosomes of human breast carcinoma cells MCF-7.
Authors "Staubach S, Razawi H, Hanisch FG."
Journal name PROTEOMICS
Publication year 2009
Sample Breast cancer cells
Sample name MCF-7
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
9
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
14
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
15
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
16
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
20
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
24
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
27
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
29
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
30
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 254
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
33
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
35
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
36
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 219
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
38
Experiment ID 220
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 221
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
40
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
41
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
42
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
43
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
44
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
45
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
46
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
47
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
48
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
49
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
50
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
51
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
52
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
53
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
54
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HNRNPA2B1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ISG15 9636
Affinity Capture-MS Homo sapiens
2 BTBD6  
Affinity Capture-MS Homo sapiens
3 PPP1CB 5500
Affinity Capture-MS Homo sapiens
4 UBL4A 8266
Affinity Capture-MS Homo sapiens
5 SHC1 6464
Affinity Capture-MS Homo sapiens
6 STAT5B 6777
Two-hybrid Homo sapiens
7 LDHB 3945
Co-fractionation Homo sapiens
8 PKM 5315
Co-fractionation Homo sapiens
9 PSMA4 5685
Co-fractionation Homo sapiens
10 EIF2B2 8892
Co-fractionation Homo sapiens
11 EBNA-LP  
Affinity Capture-Western
Affinity Capture-MS
12 UBA1 7317
Co-fractionation Homo sapiens
13 BRCA1 672
Affinity Capture-RNA Homo sapiens
14 KIF20A 10112
Affinity Capture-MS Homo sapiens
15 SLIRP 81892
Co-fractionation Homo sapiens
16 UBC 7316
Affinity Capture-MS Homo sapiens
17 CSNK2A1 1457
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
18 VHL  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-RNA Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-RNA Homo sapiens
19 DNAH8 1769
Cross-Linking-MS (XL-MS) Homo sapiens
20 SOX2  
Affinity Capture-MS Homo sapiens
21 SBDS 51119
Affinity Capture-MS Homo sapiens
22 CKB 1152
Affinity Capture-MS Homo sapiens
23 SRA1 10011
Co-fractionation Homo sapiens
24 IGF2BP3 10643
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 SNRNP70 6625
Co-fractionation Homo sapiens
26 CRNKL1 51340
Co-fractionation Homo sapiens
27 KIF23 9493
Affinity Capture-MS Homo sapiens
28 DNAJC3 5611
Cross-Linking-MS (XL-MS) Homo sapiens
29 TRIM35 23087
Two-hybrid Homo sapiens
30 AP2A1 160
Affinity Capture-MS Homo sapiens
31 CPSF7 79869
Affinity Capture-MS Homo sapiens
32 HSPH1 10808
Co-fractionation Homo sapiens
33 TFIP11  
Co-fractionation Homo sapiens
34 SMC2 10592
Cross-Linking-MS (XL-MS) Homo sapiens
35 CLINT1 9685
Affinity Capture-MS Homo sapiens
36 DNAJC8 22826
Affinity Capture-MS Homo sapiens
37 MECP2 4204
Affinity Capture-MS Homo sapiens
38 ARIH2 10425
Affinity Capture-MS Homo sapiens
39 BUD31 8896
Cross-Linking-MS (XL-MS) Homo sapiens
40 SLU7  
Co-fractionation Homo sapiens
41 SREK1 140890
Affinity Capture-MS Homo sapiens
42 FAM120A 23196
Affinity Capture-MS Homo sapiens
43 RBM14 10432
Affinity Capture-MS Homo sapiens
44 NEIL3  
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
45 KIF14 9928
Affinity Capture-MS Homo sapiens
46 RBMX 27316
Affinity Capture-MS Homo sapiens
47 UNC45A 55898
Cross-Linking-MS (XL-MS) Homo sapiens
48 AURKA 6790
Affinity Capture-MS Homo sapiens
49 MTCH2 23788
Affinity Capture-MS Homo sapiens
50 SPTA1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
51 RNF4 6047
Affinity Capture-MS Homo sapiens
52 MRE11A 4361
Co-fractionation Homo sapiens
53 MEPCE 56257
Affinity Capture-MS Homo sapiens
54 SAE1 10055
Cross-Linking-MS (XL-MS) Homo sapiens
55 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
56 BRE 9577
Co-fractionation Homo sapiens
57 RANBP3L  
Cross-Linking-MS (XL-MS) Homo sapiens
58 UBASH3B 84959
Affinity Capture-MS Homo sapiens
59 PABPC1 26986
Co-fractionation Homo sapiens
60 EEF1E1 9521
Co-fractionation Homo sapiens
61 YWHAE 7531
Affinity Capture-MS Homo sapiens
62 TRIM21 6737
Affinity Capture-MS Homo sapiens
63 CKAP5 9793
Cross-Linking-MS (XL-MS) Homo sapiens
64 SYNCRIP 10492
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
65 MAEL  
Affinity Capture-MS Homo sapiens
66 YWHAQ 10971
Affinity Capture-MS Homo sapiens
67 HECTD1 25831
Affinity Capture-MS Homo sapiens
68 CUL2 8453
Affinity Capture-MS Homo sapiens
69 DDX39B 7919
Co-fractionation Homo sapiens
70 PICALM 8301
Affinity Capture-MS Homo sapiens
71 GAK 2580
Affinity Capture-MS Homo sapiens
72 PAPSS2 9060
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
73 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
74 ERO1L 30001
Co-fractionation Homo sapiens
75 MGMT 4255
Affinity Capture-MS Homo sapiens
76 ZNF326 284695
Affinity Capture-MS Homo sapiens
77 BCLAF1 9774
Cross-Linking-MS (XL-MS) Homo sapiens
78 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
79 HSPA5 3309
Affinity Capture-MS Homo sapiens
80 RBM39 9584
Affinity Capture-MS Homo sapiens
81 EPS15 2060
Affinity Capture-MS Homo sapiens
82 DCP1B  
Affinity Capture-MS Homo sapiens
83 IQCB1  
Affinity Capture-MS Homo sapiens
84 ACAD11 84129
Affinity Capture-MS Homo sapiens
85 CD274 29126
Affinity Capture-MS Homo sapiens
86 TNFRSF1A 7132
Negative Genetic Homo sapiens
87 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 EPRS 2058
Co-fractionation Homo sapiens
89 FN1 2335
Affinity Capture-MS Homo sapiens
90 IST1 9798
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
91 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
92 Hnrnpa3 229279
Affinity Capture-MS Mus musculus
93 AP2A2 161
Affinity Capture-MS Homo sapiens
94 HSPA1A 3303
Co-fractionation Homo sapiens
95 KIAA1109 84162
Cross-Linking-MS (XL-MS) Homo sapiens
96 Rpl35 66489
Affinity Capture-MS Mus musculus
97 CSDE1 7812
Affinity Capture-MS Homo sapiens
98 SUPT16H 11198
Cross-Linking-MS (XL-MS) Homo sapiens
99 Fbxw11  
Affinity Capture-MS Mus musculus
100 YBX1 4904
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
101 DNAH6 1768
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
102 RPS27A 6233
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
103 FAM175B 23172
Co-fractionation Homo sapiens
104 GRB2 2885
Affinity Capture-MS Homo sapiens
105 IARS 3376
Co-fractionation Homo sapiens
106 NAA20  
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
107 SRSF9 8683
Co-fractionation Homo sapiens
108 HIST1H2BN 8341
Cross-Linking-MS (XL-MS) Homo sapiens
109 CAPZB 832
Affinity Capture-MS Homo sapiens
110 TRA2B 6434
Co-fractionation Homo sapiens
111 SSBP1 6742
Proximity Label-MS Homo sapiens
112 LARP7 51574
Affinity Capture-MS Homo sapiens
113 NCL 4691
Co-fractionation Homo sapiens
114 HNRNPL 3191
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
115 EIF4B 1975
Co-fractionation Homo sapiens
116 ITPA 3704
Co-fractionation Homo sapiens
117 CLTA 1211
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 SNW1 22938
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
119 ANXA2 302
Co-fractionation Homo sapiens
120 SNRPA1 6627
Co-fractionation Homo sapiens
121 HSPA1B 3304
Affinity Capture-MS Homo sapiens
122 IFIT2 3433
Affinity Capture-MS Homo sapiens
123 ACAA2 10449
Co-fractionation Homo sapiens
124 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-RNA Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
125 PSMA6 5687
Co-fractionation Homo sapiens
126 DENR 8562
Co-fractionation Homo sapiens
127 LIG4 3981
Two-hybrid Homo sapiens
128 HOMER3 9454
Negative Genetic Homo sapiens
129 NCBP1 4686
Co-fractionation Homo sapiens
130 SPRTN  
Affinity Capture-MS Homo sapiens
131 GART 2618
Co-fractionation Homo sapiens
132 TARDBP 23435
Affinity Capture-MS Homo sapiens
133 BTF3 689
Affinity Capture-MS Homo sapiens
134 ADRB2  
Affinity Capture-MS Homo sapiens
135 CHMP5 51510
Affinity Capture-MS Homo sapiens
136 ZFR 51663
Affinity Capture-MS Homo sapiens
137 CAND1 55832
Affinity Capture-MS Homo sapiens
138 EIF4EBP2 1979
Co-fractionation Homo sapiens
139 SRSF2 6427
Co-fractionation Homo sapiens
140 CLTB 1212
Affinity Capture-MS Homo sapiens
141 RPS3 6188
Co-fractionation Homo sapiens
142 PGK1 5230
Co-fractionation Homo sapiens
143 ELAVL3  
Affinity Capture-MS Homo sapiens
144 B3GNT2 10678
Affinity Capture-MS Homo sapiens
145 H1FX 8971
Cross-Linking-MS (XL-MS) Homo sapiens
146 COPS6 10980
Affinity Capture-MS Homo sapiens
147 PHLDA2 7262
Cross-Linking-MS (XL-MS) Homo sapiens
148 HIST2H3A 333932
Cross-Linking-MS (XL-MS) Homo sapiens
149 PRC1 9055
Affinity Capture-MS Homo sapiens
150 AP1G1 164
Affinity Capture-MS Homo sapiens
151 NPM1 4869
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
152 SRRM2 23524
Affinity Capture-MS Homo sapiens
153 OBSL1 23363
Affinity Capture-MS Homo sapiens
154 GGCT 79017
Co-fractionation Homo sapiens
155 MRRF  
Proximity Label-MS Homo sapiens
156 NR4A1  
Two-hybrid Homo sapiens
157 ZNF35  
Cross-Linking-MS (XL-MS) Homo sapiens
158 VCAM1 7412
Affinity Capture-MS Homo sapiens
159 MRPS7 51081
Affinity Capture-MS Homo sapiens
160 CUL1 8454
Affinity Capture-MS Homo sapiens
161 RBM42  
Affinity Capture-MS Homo sapiens
162 DNAH2 146754
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
163 PRNP 5621
Affinity Capture-MS Homo sapiens
164 LSM2 57819
Affinity Capture-MS Homo sapiens
165 ZMAT3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
166 VRK3 51231
Affinity Capture-MS Homo sapiens
167 HNRNPA0 10949
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
168 TPR 7175
Co-fractionation Homo sapiens
169 DDX21 9188
Affinity Capture-MS Homo sapiens
170 CDKN1A  
Affinity Capture-MS Homo sapiens
171 CCDC88C 440193
Cross-Linking-MS (XL-MS) Homo sapiens
172 EFHD2 79180
Cross-Linking-MS (XL-MS) Homo sapiens
173 SNRNP200 23020
Co-fractionation Homo sapiens
174 VRK1 7443
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
175 CFDP1  
Cross-Linking-MS (XL-MS) Homo sapiens
176 SNRPD1 6632
Co-fractionation Homo sapiens
177 GAPDH 2597
Co-fractionation Homo sapiens
178 PATL1 219988
Affinity Capture-MS Homo sapiens
179 RIN3  
Affinity Capture-MS Homo sapiens
180 PSMA5 5686
Co-fractionation Homo sapiens
181 RPLP0 6175
Co-fractionation Homo sapiens
182 NFX1  
Affinity Capture-MS Homo sapiens
183 SNRPB2 6629
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
184 HNRNPD 3184
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
185 PER2  
Proximity Label-MS Homo sapiens
186 PSMA3 5684
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
187 ACLY 47
Co-fractionation Homo sapiens
188 AIFM1 9131
Co-fractionation Homo sapiens
189 RC3H2  
Affinity Capture-MS Homo sapiens
190 SEC13 6396
Affinity Capture-MS Homo sapiens
191 IKZF3  
Affinity Capture-MS Homo sapiens
192 SRSF5 6430
Co-fractionation Homo sapiens
193 HSD17B10 3028
Co-fractionation Homo sapiens
194 FUS 2521
Affinity Capture-MS Homo sapiens
195 IKZF1  
Affinity Capture-MS Homo sapiens
196 HIST3H3 8290
Protein-peptide Homo sapiens
197 MYC  
Affinity Capture-MS Homo sapiens
198 BAG1 573
Affinity Capture-MS Homo sapiens
199 LINC00963  
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
200 LSM7  
Affinity Capture-MS Homo sapiens
201 HNRNPAB 3182
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
202 HIP1 3092
Affinity Capture-MS Homo sapiens
203 CUL7 9820
Affinity Capture-MS Homo sapiens
204 Junb  
Affinity Capture-MS Mus musculus
205 AHNAK2 113146
Cross-Linking-MS (XL-MS) Homo sapiens
206 XRCC3  
Affinity Capture-MS Homo sapiens
207 FAIM3  
Cross-Linking-MS (XL-MS) Homo sapiens
208 PSMB1 5689
Co-fractionation Homo sapiens
209 HUWE1 10075
Affinity Capture-MS Homo sapiens
210 DSP 1832
Co-fractionation Homo sapiens
211 LSM1 27257
Affinity Capture-MS Homo sapiens
212 PA2G4 5036
Affinity Capture-MS Homo sapiens
213 RNF43  
Proximity Label-MS Homo sapiens
214 HNRNPH2 3188
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
215 GDI2 2665
Co-fractionation Homo sapiens
216 ILF3 3609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
217 TP53 7157
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
218 FOLR1 2348
Affinity Capture-MS Homo sapiens
219 HSPA8 3312
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
220 CDKN2A 1029
Reconstituted Complex Homo sapiens
221 SF3B4 10262
Co-fractionation Homo sapiens
222 ADAMTS14  
Cross-Linking-MS (XL-MS) Homo sapiens
223 ATXN2 6311
Co-fractionation Homo sapiens
224 PTBP1 5725
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
225 SQSTM1 8878
Co-fractionation Homo sapiens
226 AGO2 27161
Co-fractionation Homo sapiens
227 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
228 HNRNPK 3190
Affinity Capture-MS Homo sapiens
229 MMGT1 93380
Affinity Capture-MS Homo sapiens
230 ESR1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
231 KHDRBS2  
Affinity Capture-MS Homo sapiens
232 Srsf1 110809
Affinity Capture-MS Mus musculus
233 STXBP2 6813
Co-fractionation Homo sapiens
234 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
235 KRAS 3845
Affinity Capture-MS Homo sapiens
236 NEFM 4741
Cross-Linking-MS (XL-MS) Homo sapiens
237 EPC2  
Affinity Capture-MS Homo sapiens
238 Prmt1 60421
Biochemical Activity Rattus norvegicus
239 TIMM13 26517
Co-fractionation Homo sapiens
240 CUL4A 8451
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
241 AP2S1 1175
Affinity Capture-MS Homo sapiens
242 UBE2H 7328
Affinity Capture-MS Homo sapiens
243 HNRNPC 3183
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
244 Fus  
Affinity Capture-MS Mus musculus
245 PTMA 5757
Affinity Capture-MS Homo sapiens
246 MAP4K2  
Two-hybrid Homo sapiens
247 CD4 920
Affinity Capture-MS Homo sapiens
248 ABCF1 23
Co-fractionation Homo sapiens
249 RPS19 6223
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
250 MANF 7873
Affinity Capture-MS Homo sapiens
251 HNRNPR 10236
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
252 RPS6KB2  
Affinity Capture-MS Homo sapiens
253 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
254 ATG13 9776
Affinity Capture-MS Homo sapiens
255 DIMT1 27292
Co-fractionation Homo sapiens
256 RDX 5962
Co-fractionation Homo sapiens
257 DYNC1LI2 1783
Co-fractionation Homo sapiens
258 MCM2 4171
Affinity Capture-MS Homo sapiens
259 COPB2 9276
Affinity Capture-MS Homo sapiens
260 FKBP3 2287
Co-fractionation Homo sapiens
261 DDRGK1 65992
Affinity Capture-MS Homo sapiens
262 SF3A2 8175
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
263 SRSF3 6428
Co-fractionation Homo sapiens
264 XRN1 54464
Affinity Capture-MS Homo sapiens
265 ITGA4 3676
Affinity Capture-MS Homo sapiens
266 ATG16L1 55054
Affinity Capture-MS Homo sapiens
267 SERBP1 26135
Affinity Capture-MS Homo sapiens
268 CSNK2B 1460
Reconstituted Complex Homo sapiens
269 PABPC4 8761
Co-fractionation Homo sapiens
270 MTERF3  
Proximity Label-MS Homo sapiens
271 RBM8A 9939
Affinity Capture-MS Homo sapiens
272 EEA1 8411
Cross-Linking-MS (XL-MS) Homo sapiens
273 DUS2 54920
Cross-Linking-MS (XL-MS) Homo sapiens
274 INSIG2  
Affinity Capture-MS Homo sapiens
275 DLD 1738
Co-fractionation Homo sapiens
276 CHMP1A 5119
Affinity Capture-MS Homo sapiens
277 PSMB4 5692
Co-fractionation Homo sapiens
278 EPX 8288
Cross-Linking-MS (XL-MS) Homo sapiens
279 CUL4B 8450
Affinity Capture-MS Homo sapiens
280 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
281 Taf15  
Affinity Capture-MS Mus musculus
282 CAST 831
Co-fractionation Homo sapiens
283 EPS8L2 64787
Co-fractionation Homo sapiens
284 ACACA 31
Negative Genetic Homo sapiens
285 ABCF2 10061
Co-fractionation Homo sapiens
286 CHMP4B 128866
Affinity Capture-MS Homo sapiens
287 RPA2 6118
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
288 MSN 4478
Co-fractionation Homo sapiens
289 NTRK1 4914
Affinity Capture-MS Homo sapiens
290 U2AF2 11338
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
291 DCP1A 55802
Affinity Capture-MS Homo sapiens
292 Srp72  
Affinity Capture-MS Mus musculus
293 RPL36 25873
Affinity Capture-MS Homo sapiens
294 RPA4  
Proximity Label-MS Homo sapiens
295 ACTB 60
Co-fractionation Homo sapiens
296 DHX9 1660
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
297 ENY2 56943
Two-hybrid Homo sapiens
298 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
299 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
300 HNRNPA3 220988
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
301 HDAC5 10014
Affinity Capture-MS Homo sapiens
302 F8 2157
Cross-Linking-MS (XL-MS) Homo sapiens
303 SF3A3 10946
Co-fractionation Homo sapiens
304 RAN 5901
Co-fractionation Homo sapiens
305 ACTN4 81
Co-fractionation Homo sapiens
306 HNRNPDL 9987
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
307 OGT 8473
Reconstituted Complex Homo sapiens
308 EFNA4  
Affinity Capture-MS Homo sapiens
309 YAE1D1  
Two-hybrid Homo sapiens
310 MYCBP2 23077
Affinity Capture-MS Homo sapiens
311 METTL14  
Affinity Capture-MS Homo sapiens
312 BAZ1B 9031
Cross-Linking-MS (XL-MS) Homo sapiens
313 BAG2 9532
Affinity Capture-MS Homo sapiens
314 ECT2 1894
Affinity Capture-MS Homo sapiens
315 S100A16 140576
Co-fractionation Homo sapiens
316 EEF2 1938
Co-fractionation Homo sapiens
317 SF1 7536
Co-fractionation Homo sapiens
318 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
319 KIAA0430  
Affinity Capture-MS Homo sapiens
320 AP2M1 1173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
321 TROVE2 6738
Co-fractionation Homo sapiens
322 SPAG17  
Cross-Linking-MS (XL-MS) Homo sapiens
323 CUL9  
Affinity Capture-MS Homo sapiens
324 NSRP1  
Co-fractionation Homo sapiens
325 PSPC1 55269
Affinity Capture-MS Homo sapiens
326 EMC2 9694
Affinity Capture-MS Homo sapiens
327 PHF6  
Affinity Capture-MS Homo sapiens
328 SEC16A 9919
Affinity Capture-MS Homo sapiens
329 TXNDC16 57544
Affinity Capture-MS Homo sapiens
330 TOP1 7150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
331 PPA2 27068
Co-fractionation Homo sapiens
332 MATR3 9782
Affinity Capture-MS Homo sapiens
333 HSPD1 3329
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
334 CSF2 1437
Affinity Capture-RNA Homo sapiens
335 ZFP36  
Affinity Capture-RNA Homo sapiens
336 AHSA1 10598
Affinity Capture-MS Homo sapiens
337 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
338 FBXW11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
339 SMN1 6606
Affinity Capture-MS Homo sapiens
340 MAP1S 55201
Co-fractionation Homo sapiens
341 MCM5 4174
Affinity Capture-MS Homo sapiens
342 RPA1 6117
Affinity Capture-MS Homo sapiens
343 HIPK3 10114
Protein-RNA Homo sapiens
344 SNRPA 6626
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
345 HNRNPM 4670
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
346 C17orf89  
Affinity Capture-MS Homo sapiens
347 HSPB1 3315
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
348 PLOD1 5351
Co-fractionation Homo sapiens
349 EDC3 80153
Affinity Capture-MS Homo sapiens
350 MTHFD1 4522
Co-fractionation Homo sapiens
351 UFL1 23376
Affinity Capture-MS Homo sapiens
352 MBNL1 4154
Affinity Capture-Western Homo sapiens
353 HDGFRP2 84717
Cross-Linking-MS (XL-MS) Homo sapiens
354 API5 8539
Affinity Capture-MS Homo sapiens
355 HNRNPH3 3189
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
356 NEDD1 121441
Affinity Capture-MS Homo sapiens
357 RPS7 6201
Co-fractionation Homo sapiens
358 HNRNPF 3185
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
359 ERG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
360 RC3H1 149041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
361 ATXN3 4287
Affinity Capture-MS Homo sapiens
362 SSRP1 6749
Affinity Capture-MS Homo sapiens
363 SLC25A5 292
Cross-Linking-MS (XL-MS) Homo sapiens
364 IGF2BP2 10644
Affinity Capture-MS Homo sapiens
365 ASB2  
Affinity Capture-MS Homo sapiens
366 CUL5 8065
Affinity Capture-MS Homo sapiens
367 SIAH1  
Affinity Capture-RNA Homo sapiens
368 CRBN  
Affinity Capture-MS Homo sapiens
369 INSIG1  
Affinity Capture-MS Homo sapiens
370 SLFN11 91607
Affinity Capture-MS Homo sapiens
371 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
372 AP2B1 163
Affinity Capture-MS Homo sapiens
373 QARS 5859
Co-fractionation Homo sapiens
374 RPS3A 6189
Co-fractionation Homo sapiens
375 ANLN 54443
Affinity Capture-MS Homo sapiens
376 PPIE 10450
Affinity Capture-MS Homo sapiens
377 TNPO1 3842
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
378 HIST1H1D 3007
Cross-Linking-MS (XL-MS) Homo sapiens
379 TRUB2  
Proximity Label-MS Homo sapiens
380 CTNNBL1 56259
Co-fractionation Homo sapiens
381 CD2AP 23607
Affinity Capture-MS Homo sapiens
382 HSPA1L 3305
Affinity Capture-MS Homo sapiens
383 CCT4 10575
Co-fractionation Homo sapiens
384 COG2 22796
Cross-Linking-MS (XL-MS) Homo sapiens
385 SNRPD2 6633
Cross-Linking-MS (XL-MS) Homo sapiens
386 SF3B2 10992
Co-fractionation Homo sapiens
387 ILF2 3608
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
388 PPP1CC 5501
Affinity Capture-MS Homo sapiens
389 KIAA1429 25962
Affinity Capture-MS Homo sapiens
390 TSC22D4 81628
Cross-Linking-MS (XL-MS) Homo sapiens
391 ATXN2L 11273
Co-fractionation Homo sapiens
392 TTN 7273
Cross-Linking-MS (XL-MS) Homo sapiens
393 COPS5 10987
Affinity Capture-MS Homo sapiens
394 FBXW7  
Affinity Capture-MS Homo sapiens
395 C8orf82  
Proximity Label-MS Homo sapiens
396 SNRPC 6631
Affinity Capture-MS Homo sapiens
397 IFIT3 3437
Affinity Capture-MS Homo sapiens
398 MRPS26 64949
Proximity Label-MS Homo sapiens
399 RAD51  
Co-fractionation Homo sapiens
400 SERPINH1 871
Co-fractionation Homo sapiens
401 EED  
Affinity Capture-MS Homo sapiens
402 CEP57  
Affinity Capture-MS Homo sapiens
403 NAP1L4 4676
Cross-Linking-MS (XL-MS) Homo sapiens
404 MYCN  
Affinity Capture-MS Homo sapiens
405 NEDD4 4734
Affinity Capture-MS Homo sapiens
406 CCDC178  
Cross-Linking-MS (XL-MS) Homo sapiens
407 SETD8  
Affinity Capture-MS Homo sapiens
408 RN7SK 125050
Affinity Capture-RNA Homo sapiens
409 RPS28 6234
Co-fractionation Homo sapiens
410 ERBB3 2065
Affinity Capture-MS Homo sapiens
411 STAU1 6780
Affinity Capture-MS Homo sapiens
412 SYCP2 10388
Cross-Linking-MS (XL-MS) Homo sapiens
413 CTSA 5476
Co-fractionation Homo sapiens
414 VCP 7415
Affinity Capture-MS Homo sapiens
415 DDX5 1655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
416 PON2 5445
Cross-Linking-MS (XL-MS) Homo sapiens
417 AP1B1 162
Affinity Capture-MS Homo sapiens
418 BMP2K 55589
Affinity Capture-MS Homo sapiens
419 RPL27A 6157
Co-fractionation Homo sapiens
420 DDX1 1653
Co-fractionation Homo sapiens
421 PABPN1 8106
Co-fractionation Homo sapiens
422 UPF1 5976
Affinity Capture-MS Homo sapiens
423 H2AFY 9555
Cross-Linking-MS (XL-MS) Homo sapiens
424 CEBPA  
Protein-peptide Homo sapiens
425 ATP5B 506
Co-fractionation Homo sapiens
426 HIST1H2AB 8335
Co-fractionation Homo sapiens
427 NUMA1 4926
Cross-Linking-MS (XL-MS) Homo sapiens
428 SFPQ 6421
Co-fractionation Homo sapiens
429 HSF1  
Co-fractionation Homo sapiens
430 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
431 FANCD2  
Affinity Capture-MS Homo sapiens
432 CDK9 1025
Affinity Capture-MS Homo sapiens
433 PSMD13 5719
Co-fractionation Homo sapiens
434 SNRPB 6628
Affinity Capture-MS Homo sapiens
435 CTNNB1 1499
Affinity Capture-MS Homo sapiens
436 RNF150  
Cross-Linking-MS (XL-MS) Homo sapiens
437 AP1M1 8907
Affinity Capture-MS Homo sapiens
438 PDIA3 2923
Co-fractionation Homo sapiens
439 NXF1 10482
Affinity Capture-RNA Homo sapiens
440 SF3A1 10291
Co-fractionation Homo sapiens
441 AURKB 9212
Affinity Capture-MS Homo sapiens
442 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
443 FBXO6 26270
Affinity Capture-MS Homo sapiens
444 MTA3 57504
Co-fractionation Homo sapiens
445 TRAPPC12 51112
Two-hybrid Homo sapiens
446 ATP1B1 481
Co-fractionation Homo sapiens
447 CLTC 1213
Affinity Capture-MS Homo sapiens
448 ZMYM2  
Affinity Capture-MS Homo sapiens
449 H2AFX 3014
Affinity Capture-MS Homo sapiens
450 ARRB2 409
Affinity Capture-MS Homo sapiens
451 RRBP1 6238
Co-fractionation Homo sapiens
452 HAUS1  
Affinity Capture-MS Homo sapiens
453 CPSF6 11052
Affinity Capture-MS Homo sapiens
454 ERH 2079
Cross-Linking-MS (XL-MS) Homo sapiens
455 PAFAH1B2 5049
Co-fractionation Homo sapiens
456 ADSL 158
Co-fractionation Homo sapiens
457 DPY30 84661
Affinity Capture-MS Homo sapiens
458 UBA52 7311
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
459 SMURF1 57154
Affinity Capture-MS Homo sapiens
460 PRMT1 3276
Affinity Capture-MS Homo sapiens
461 ELAVL1 1994
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
462 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
463 HDGF 3068
Affinity Capture-MS Homo sapiens
464 CWC15  
Co-fractionation Homo sapiens
465 IDE 3416
Cross-Linking-MS (XL-MS) Homo sapiens
466 RPL39 6170
Co-fractionation Homo sapiens
467 EDC4 23644
Affinity Capture-MS Homo sapiens
468 PYGB 5834
Co-fractionation Homo sapiens
469 TRIM31  
Affinity Capture-MS Homo sapiens
470 PINK1  
Affinity Capture-MS Homo sapiens
471 GRSF1 2926
Proximity Label-MS Homo sapiens
472 HNRNPU 3192
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
473 C9orf72  
Affinity Capture-MS Homo sapiens
474 DCP2  
Affinity Capture-MS Homo sapiens
475 NME1 4830
Co-fractionation Homo sapiens
476 NEDD8 4738
Affinity Capture-MS Homo sapiens
477 CDC5L 988
Affinity Capture-MS Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here