Gene description for RPLP1
Gene name ribosomal protein, large, P1
Gene symbol RPLP1
Other names/aliases LP1
P1
RPP1
Species Homo sapiens
 Database cross references - RPLP1
ExoCarta ExoCarta_6176
Vesiclepedia VP_6176
Entrez Gene 6176
HGNC 10372
MIM 180520
UniProt P05386  
 RPLP1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 17956143    
Colorectal cancer cells 34887515    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
Prostate cancer cells 25844599    
Prostate cancer cells 25844599    
Thymus 23844026    
 Gene ontology annotations for RPLP1
Molecular Function
    structural constituent of ribosome GO:0003735 IBA
    structural constituent of ribosome GO:0003735 IDA
    structural constituent of ribosome GO:0003735 NAS
    protein binding GO:0005515 IPI
    protein kinase activator activity GO:0030295 IBA
    ribonucleoprotein complex binding GO:0043021 IBA
Biological Process
    cytoplasmic translation GO:0002181 IBA
    cytoplasmic translation GO:0002181 IC
    cytoplasmic translation GO:0002181 NAS
    translation GO:0006412 NAS
    translational elongation GO:0006414 IEA
Subcellular Localization
    cytoplasm GO:0005737 NAS
    cytosol GO:0005829 TAS
    focal adhesion GO:0005925 HDA
    cytosolic large ribosomal subunit GO:0022625 HDA
    cytosolic large ribosomal subunit GO:0022625 IBA
    cytosolic large ribosomal subunit GO:0022625 IDA
    cytosolic large ribosomal subunit GO:0022625 IPI
    cytosolic ribosome GO:0022626 IDA
 Experiment description of studies that identified RPLP1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 20
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
Enriched markers
✔
GOLGA2|cytochrome c
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
8
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
9
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
13
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
14
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
15
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
16
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
17
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
18
Experiment ID 274
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
19
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RPLP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPL11 6135
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
2 EIF3A 8661
Co-fractionation Homo sapiens
3 EMC4 51234
Affinity Capture-MS Homo sapiens
4 ZNF668  
Affinity Capture-MS Homo sapiens
5 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
6 IGF2BP1 10642
Affinity Capture-MS Homo sapiens
7 UBL4A 8266
Affinity Capture-MS Homo sapiens
8 ZNF346  
Affinity Capture-MS Homo sapiens
9 EIF2S3 1968
Affinity Capture-MS Homo sapiens
10 RPL30 6156
Co-fractionation Homo sapiens
11 RIN3  
Affinity Capture-MS Homo sapiens
12 SSB 6741
Affinity Capture-MS Homo sapiens
13 RPA2 6118
Two-hybrid Homo sapiens
14 CD4 920
Affinity Capture-MS Homo sapiens
15 RPL13A 23521
Affinity Capture-MS Homo sapiens
16 ADRB2  
Affinity Capture-MS Homo sapiens
17 G3BP1 10146
Affinity Capture-MS Homo sapiens
18 ACTC1 70
Affinity Capture-MS Homo sapiens
19 RPL37A 6168
Co-fractionation Homo sapiens
20 RPS19 6223
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
21 RPL10 6134
Co-fractionation Homo sapiens
22 RPL15 6138
Co-fractionation Homo sapiens
23 TAB1 10454
Two-hybrid Homo sapiens
24 RPL14 9045
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
25 CSNK2A1 1457
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
26 CAND1 55832
Affinity Capture-MS Homo sapiens
27 RPS17 6218
Co-fractionation Homo sapiens
28 RPS3 6188
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
29 RB1CC1 9821
Affinity Capture-MS Homo sapiens
30 ATG13 9776
Affinity Capture-MS Homo sapiens
31 MAP1LC3B 81631
Two-hybrid Homo sapiens
32 MRPS35 60488
Co-fractionation Homo sapiens
33 CAPZB 832
Affinity Capture-MS Homo sapiens
34 PARK2  
Affinity Capture-MS Homo sapiens
35 RPS20 6224
Co-fractionation Homo sapiens
36 METAP2 10988
Affinity Capture-MS Homo sapiens
37 IGBP1 3476
Co-fractionation Homo sapiens
38 PRC1 9055
Affinity Capture-MS Homo sapiens
39 KIF23 9493
Affinity Capture-MS Homo sapiens
40 UBE2O 63893
Affinity Capture-MS Homo sapiens
41 COPS6 10980
Affinity Capture-MS Homo sapiens
42 COPS5 10987
Affinity Capture-MS Homo sapiens
43 FBXW7  
Affinity Capture-MS Homo sapiens
44 RPL24 6152
Co-fractionation Homo sapiens
45 NUDT3 11165
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 CALD1 800
Affinity Capture-MS Homo sapiens
47 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 KATNAL2 83473
Co-fractionation Homo sapiens
49 RRS1 23212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 RPS8 6202
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
51 SRP19 6728
Affinity Capture-MS Homo sapiens
52 DDX58 23586
Affinity Capture-RNA Homo sapiens
53 GSPT1 2935
Affinity Capture-MS Homo sapiens
54 ADARB1 104
Affinity Capture-MS Homo sapiens
55 PRKRA 8575
Affinity Capture-MS Homo sapiens
56 SRP68 6730
Affinity Capture-MS Homo sapiens
57 RPL29 6159
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
58 ATG16L1 55054
Affinity Capture-MS Homo sapiens
59 DDX6 1656
Affinity Capture-MS Homo sapiens
60 RPS3A 6189
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
61 MPC2 25874
Two-hybrid Homo sapiens
62 CUL1 8454
Affinity Capture-MS Homo sapiens
63 KDM4D  
Affinity Capture-MS Homo sapiens
64 ARIH2 10425
Affinity Capture-MS Homo sapiens
65 RBM42  
Affinity Capture-MS Homo sapiens
66 RPS11 6205
Co-fractionation Homo sapiens
67 RPL19 6143
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
68 GSK3B 2932
Two-hybrid Homo sapiens
69 KIF14 9928
Affinity Capture-MS Homo sapiens
70 TPT1 7178
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
71 EMC9  
Affinity Capture-MS Homo sapiens
72 TRIM31  
Affinity Capture-MS Homo sapiens
73 PDZD8 118987
Affinity Capture-MS Homo sapiens
74 CHMP4C 92421
Affinity Capture-MS Homo sapiens
75 RPS23 6228
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
76 RPL27 6155
Co-fractionation Homo sapiens
77 VRK3 51231
Affinity Capture-MS Homo sapiens
78 JMJD6 23210
Affinity Capture-MS Homo sapiens
79 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
80 RPL9 6133
Co-fractionation Homo sapiens
81 SRP14 6727
Affinity Capture-MS Homo sapiens
82 CUL4B 8450
Affinity Capture-MS Homo sapiens
83 RPL4 6124
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
84 RPS10 6204
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
85 TMEM165 55858
Co-fractionation Homo sapiens
86 DNAJC2 27000
Affinity Capture-MS Homo sapiens
87 MAPRE1 22919
Affinity Capture-MS Homo sapiens
88 LRIF1  
Two-hybrid Homo sapiens
89 SRSF6 6431
Affinity Capture-MS Homo sapiens
90 RPL5 6125
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
91 RPL18A 6142
Co-fractionation Homo sapiens
92 CHMP4B 128866
Affinity Capture-MS Homo sapiens
93 FOXL2  
Affinity Capture-Western Homo sapiens
94 BTF3 689
Affinity Capture-MS Homo sapiens
95 TRIM21 6737
Affinity Capture-MS Homo sapiens
96 RPL31 6160
Co-fractionation Homo sapiens
97 RPS7 6201
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
98 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
99 MOV10 4343
Co-fractionation Homo sapiens
100 RPL36 25873
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
101 ASCC2 84164
Two-hybrid Homo sapiens
102 ANKRD13B  
Two-hybrid Homo sapiens
103 RPL27A 6157
Co-fractionation Homo sapiens
104 RPLP1 6176
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
105 ANKHD1 54882
Co-fractionation Homo sapiens
106 PML 5371
Affinity Capture-MS Homo sapiens
107 UBE2D3 7323
Two-hybrid Homo sapiens
108 GEMIN7  
Two-hybrid Homo sapiens
109 RPLP0 6175
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
110 RPLP0P6 220717
Co-fractionation Homo sapiens
111 MAGEB2 4113
Affinity Capture-MS Homo sapiens
112 DDX39B 7919
Affinity Capture-MS Homo sapiens
113 SAT1  
Two-hybrid Homo sapiens
114 RPS15A 6210
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
115 SEC61B 10952
Affinity Capture-MS Homo sapiens
116 CYLD  
Affinity Capture-MS Homo sapiens
117 LOC101929876 101929876
Co-fractionation Homo sapiens
118 HMGB2 3148
Affinity Capture-MS Homo sapiens
119 RPS6KA6 27330
Two-hybrid Homo sapiens
120 MGMT 4255
Affinity Capture-MS Homo sapiens
121 CDIPT 10423
Two-hybrid Homo sapiens
122 CNBP 7555
Affinity Capture-MS Homo sapiens
123 ANLN 54443
Affinity Capture-MS Homo sapiens
124 PTN  
Two-hybrid Homo sapiens
125 BRD7  
Two-hybrid Homo sapiens
126 CACHD1  
Cross-Linking-MS (XL-MS) Homo sapiens
127 HSPA5 3309
Co-fractionation Homo sapiens
128 RBM39 9584
Affinity Capture-MS Homo sapiens
129 RPL10A 4736
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
130 RPLP2 6181
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
131 UBE2H 7328
Affinity Capture-MS Homo sapiens
132 RPL7A 6130
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
133 RPS2 6187
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
134 KIF20A 10112
Affinity Capture-MS Homo sapiens
135 RC3H2  
Affinity Capture-MS Homo sapiens
136 ECT2 1894
Affinity Capture-MS Homo sapiens
137 SIRT7  
Affinity Capture-MS Homo sapiens
138 SURF6  
Affinity Capture-MS Homo sapiens
139 PRKCZ 5590
Affinity Capture-MS Homo sapiens
140 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 RPS6 6194
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
142 RPL21 6144
Co-fractionation Homo sapiens
143 RPL3 6122
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
144 EGFR 1956
Negative Genetic Homo sapiens
145 RPS27A 6233
Co-fractionation Homo sapiens
146 FUS 2521
Co-fractionation Homo sapiens
147 MYC  
Affinity Capture-MS Homo sapiens
148 RPL7 6129
Co-fractionation Homo sapiens
149 RIPK4  
Affinity Capture-MS Homo sapiens
150 AURKB 9212
Affinity Capture-MS Homo sapiens
151 MYCN  
Affinity Capture-MS Homo sapiens
152 FARSB 10056
Co-fractionation Homo sapiens
153 ATP5J2 9551
Two-hybrid Homo sapiens
154 DICER1  
Co-fractionation Homo sapiens
155 RPL17 6139
Co-fractionation Homo sapiens
156 IFIT1 3434
Affinity Capture-MS Homo sapiens
157 BAG1 573
Affinity Capture-MS Homo sapiens
158 RPS13 6207
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
159 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
160 RPS14 6208
Co-fractionation Homo sapiens
161 RPL12 6136
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
162 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
163 RPL18 6141
Co-fractionation Homo sapiens
164 DDRGK1 65992
Affinity Capture-MS Homo sapiens
165 RNF2  
Affinity Capture-MS Homo sapiens
166 BMI1  
Affinity Capture-MS Homo sapiens
167 RPS18 6222
Co-fractionation Homo sapiens
168 CPSF3L 54973
Affinity Capture-MS Homo sapiens
169 PSPC1 55269
Affinity Capture-MS Homo sapiens
170 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
171 PPP2CB 5516
Two-hybrid Homo sapiens
172 RPS16 6217
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
173 EEF1A1 1915
Two-hybrid Homo sapiens
174 TUBB2A 7280
Two-hybrid Homo sapiens
175 RPL13 6137
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 NUDT21 11051
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
177 ENY2 56943
Affinity Capture-MS Homo sapiens
178 ARRB2 409
Affinity Capture-MS Homo sapiens
179 CTCF  
Affinity Capture-MS Homo sapiens
180 CLIC1 1192
Two-hybrid Homo sapiens
181 RPS25 6230
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
182 ILF3 3609
Affinity Capture-MS Homo sapiens
183 CUL2 8453
Affinity Capture-MS Homo sapiens
184 NSF 4905
Two-hybrid Homo sapiens
185 C11orf58  
Two-hybrid Homo sapiens
186 RPL6 6128
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
187 RPS21 6227
Co-fractionation Homo sapiens
188 PDCD6IP 10015
Cross-Linking-MS (XL-MS) Homo sapiens
189 ZEB1  
Affinity Capture-MS Homo sapiens
190 NT5C2 22978
Co-fractionation Homo sapiens
191 USP36  
Affinity Capture-MS Homo sapiens
192 CDK2AP2  
Two-hybrid Homo sapiens
193 CUL5 8065
Affinity Capture-MS Homo sapiens
194 KIAA1429 25962
Affinity Capture-MS Homo sapiens
195 PFDN1 5201
Two-hybrid Homo sapiens
196 RPS4X 6191
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
197 ABL1 25
Affinity Capture-MS Homo sapiens
198 SRP72 6731
Affinity Capture-MS Homo sapiens
199 SEPSECS  
Co-fractionation Homo sapiens
200 RCHY1  
Two-hybrid Homo sapiens
201 G3BP2 9908
Affinity Capture-MS Homo sapiens
202 XRCC6 2547
Two-hybrid Homo sapiens
203 RPS5 6193
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
204 RPL34 6164
Co-fractionation Homo sapiens
205 TOP2A 7153
Affinity Capture-MS Homo sapiens
206 RPS26 6231
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
207 DRG1 4733
Affinity Capture-MS Homo sapiens
208 UFL1 23376
Affinity Capture-MS Homo sapiens
209 NCAPH 23397
Affinity Capture-MS Homo sapiens
210 RPL38 6169
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
211 RPS24 6229
Co-fractionation Homo sapiens
212 NCL 4691
Affinity Capture-MS Homo sapiens
213 RPSA 3921
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
214 RTCB 51493
Affinity Capture-MS Homo sapiens
215 IBTK 25998
Affinity Capture-MS Homo sapiens
216 RPL23 9349
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
217 COPRS  
Affinity Capture-MS Homo sapiens
218 RBM8A 9939
Affinity Capture-MS Homo sapiens
219 CUL4A 8451
Affinity Capture-MS Homo sapiens
220 RPS15 6209
Co-fractionation Homo sapiens
221 RPL28 6158
Co-fractionation Homo sapiens
222 LDLR 3949
Positive Genetic Homo sapiens
223 RPL23A 6147
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
224 KRAS 3845
Negative Genetic Homo sapiens
225 HNRNPU 3192
Co-fractionation Homo sapiens
226 GNB2L1 10399
Affinity Capture-MS Homo sapiens
227 SRP9 6726
Affinity Capture-MS Homo sapiens
228 RC3H1 149041
Affinity Capture-MS Homo sapiens
229 IFIT2 3433
Affinity Capture-MS Homo sapiens
230 NEDD8 4738
Affinity Capture-MS Homo sapiens
231 SUOX  
Two-hybrid Homo sapiens
232 EIF5 1983
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RPLP1 is involved
PathwayEvidenceSource
Axon guidance IEA Reactome
Cap-dependent Translation Initiation TAS Reactome
Cellular response to starvation IEA Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress IEA Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Eukaryotic Translation Elongation IEA Reactome
Eukaryotic Translation Initiation TAS Reactome
Eukaryotic Translation Termination IEA Reactome
Formation of a pool of free 40S subunits TAS Reactome
GTP hydrolysis and joining of the 60S ribosomal subunit TAS Reactome
Infectious disease TAS Reactome
Influenza Infection TAS Reactome
Influenza Viral RNA Transcription and Replication TAS Reactome
L13a-mediated translational silencing of Ceruloplasmin expression TAS Reactome
Major pathway of rRNA processing in the nucleolus and cytosol TAS Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Metabolism of RNA TAS Reactome
Nervous system development IEA Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) TAS Reactome
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) TAS Reactome
Nonsense-Mediated Decay (NMD) TAS Reactome
Peptide chain elongation IEA Reactome
Regulation of expression of SLITs and ROBOs IEA Reactome
Response of EIF2AK4 (GCN2) to amino acid deficiency IEA Reactome
rRNA processing TAS Reactome
rRNA processing in the nucleus and cytosol TAS Reactome
Selenoamino acid metabolism IEA Reactome
Selenocysteine synthesis IEA Reactome
Signaling by ROBO receptors IEA Reactome
SRP-dependent cotranslational protein targeting to membrane IEA Reactome
SRP-dependent cotranslational protein targeting to membrane TAS Reactome
Translation TAS Reactome
Translation IEA Reactome
Viral Infection Pathways TAS Reactome
Viral mRNA Translation TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here