Gene description for PHB2
Gene name prohibitin 2
Gene symbol PHB2
Other names/aliases BAP
BCAP37
Bap37
PNAS-141
REA
p22
Species Homo sapiens
 Database cross references - PHB2
ExoCarta ExoCarta_11331
Vesiclepedia VP_11331
Entrez Gene 11331
HGNC 30306
MIM 610704
UniProt Q99623  
 PHB2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 17956143    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for PHB2
Molecular Function
    protein binding GO:0005515 IPI
    nuclear estrogen receptor binding GO:0030331 NAS
    amide binding GO:0033218 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    sphingolipid binding GO:0046625 IDA
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    mitophagy GO:0000423 IDA
    positive regulation of immunoglobulin production GO:0002639 ISS
    protein import into nucleus GO:0006606 IDA
    mitochondrion organization GO:0007005 IBA
    mitochondrion organization GO:0007005 IMP
    mitochondrion organization GO:0007005 NAS
    sister chromatid cohesion GO:0007062 IDA
    cell migration GO:0016477 IDA
    regulation of complement activation GO:0030449 IDA
    estrogen receptor signaling pathway GO:0030520 IEA
    positive regulation of exit from mitosis GO:0031536 IMP
    negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 IEA
    mammary gland epithelial cell proliferation GO:0033598 IEA
    negative regulation of mammary gland epithelial cell proliferation GO:0033600 IEA
    RIG-I signaling pathway GO:0039529 IDA
    B cell activation GO:0042113 ISS
    negative regulation of apoptotic process GO:0043066 IMP
    positive regulation of MAPK cascade GO:0043410 IDA
    negative regulation of DNA-binding transcription factor activity GO:0043433 IMP
    negative regulation of DNA-templated transcription GO:0045892 IDA
    protein stabilization GO:0050821 IDA
    protein stabilization GO:0050821 IMP
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    mammary gland branching involved in thelarche GO:0060744 IEA
    mammary gland alveolus development GO:0060749 IEA
    regulation of branching involved in mammary gland duct morphogenesis GO:0060762 IEA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IMP
    cellular response to retinoic acid GO:0071300 IEA
    cellular response to hypoxia GO:0071456 IEA
    antiviral innate immune response GO:0140374 IDA
    regulation of cardiolipin metabolic process GO:1900208 ISS
    positive regulation of non-canonical NF-kappaB signal transduction GO:1901224 ISS
    positive regulation of cell cycle G1/S phase transition GO:1902808 IMP
    regulation of cytochrome-c oxidase activity GO:1904959 IMP
Subcellular Localization
    nucleus GO:0005634 HDA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 ISS
    mitochondrial inner membrane GO:0005743 TAS
    plasma membrane GO:0005886 IDA
    cell surface GO:0009986 IDA
    postsynaptic density GO:0014069 IEA
    nuclear matrix GO:0016363 IDA
    axon GO:0030424 IEA
    protein-containing complex GO:0032991 IDA
    mitochondrial prohibitin complex GO:0035632 IDA
    mitochondrial prohibitin complex GO:0035632 IPI
    presynaptic active zone GO:0048786 IEA
    cell periphery GO:0071944 IDA
    glutamatergic synapse GO:0098978 IEA
    GABA-ergic synapse GO:0098982 IEA
 Experiment description of studies that identified PHB2 in sEVs
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX|ACTB
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 20
MISEV standards
EM
Biophysical techniques
HSP90|CD63|CD81|LAMP1
Enriched markers
GOLGA2|cytochrome c
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
10
Experiment ID 407
MISEV standards
EM
Biophysical techniques
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 419
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 419
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 420
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 420
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 405
MISEV standards
EM
Biophysical techniques
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
16
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
17
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
18
Experiment ID 236
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
19
Experiment ID 417
MISEV standards
EM
Biophysical techniques
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX|ACTB
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 411
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 258
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1|CD81
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
23
Experiment ID 418
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
25
Experiment ID 413
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
27
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
28
Experiment ID 406
MISEV standards
EM
Biophysical techniques
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 415
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 434
MISEV standards
Biophysical techniques
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
31
Experiment ID 435
MISEV standards
Biophysical techniques
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
CANX
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
32
Experiment ID 408
MISEV standards
EM
Biophysical techniques
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX|ACTB
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 409
MISEV standards
EM
Biophysical techniques
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 416
MISEV standards
EM
Biophysical techniques
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
35
Experiment ID 410
MISEV standards
EM
Biophysical techniques
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PHB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SLC25A13 10165
Proximity Label-MS Homo sapiens
2 ISG15 9636
Affinity Capture-MS Homo sapiens
3 DNAJC11 55735
Proximity Label-MS Homo sapiens
4 HDAC2 3066
Reconstituted Complex Homo sapiens
5 UBL4A 8266
Affinity Capture-MS Homo sapiens
6 KPNA1 3836
Affinity Capture-Western Homo sapiens
7 LDHB 3945
Co-fractionation Homo sapiens
8 RIN3  
Affinity Capture-MS Homo sapiens
9 Calml3  
Affinity Capture-MS Mus musculus
10 EBNA-LP  
Affinity Capture-MS
11 BRCA1 672
Affinity Capture-MS Homo sapiens
12 APOE 348
Co-fractionation Homo sapiens
13 CDC25B 994
Affinity Capture-MS Homo sapiens
14 NMRAL1 57407
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 KPNA2 3838
Affinity Capture-Western Homo sapiens
16 Tmem109  
Affinity Capture-MS Mus musculus
17 CCDC90B  
Proximity Label-MS Homo sapiens
18 ARMC7  
Affinity Capture-MS Homo sapiens
19 HDAC3 8841
Reconstituted Complex Homo sapiens
20 MCU 90550
Proximity Label-MS Homo sapiens
21 TIMM8A 1678
Proximity Label-MS Homo sapiens
22 KIF23 9493
Affinity Capture-MS Homo sapiens
23 COX7A2L 9167
Co-fractionation Homo sapiens
24 ACTR3 10096
Cross-Linking-MS (XL-MS) Homo sapiens
25 AI837181  
Affinity Capture-MS Mus musculus
26 ETFA 2108
Proximity Label-MS Homo sapiens
27 INSIG2  
Affinity Capture-MS Homo sapiens
28 VPS13D 55187
Cross-Linking-MS (XL-MS) Homo sapiens
29 ACOT2 10965
Proximity Label-MS Homo sapiens
30 CLPB 81570
Proximity Label-MS Homo sapiens
31 RIPK2  
Affinity Capture-MS Homo sapiens
32 SLC30A9 10463
Proximity Label-MS Homo sapiens
33 MECP2 4204
Affinity Capture-MS Homo sapiens
34 SLC25A3 5250
Co-fractionation Homo sapiens
35 KIF14 9928
Affinity Capture-MS Homo sapiens
36 Vim 22352
Affinity Capture-MS Mus musculus
37 KLF16  
Affinity Capture-MS Homo sapiens
38 MTCH2 23788
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
39 PGAM5 192111
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
40 MTFR1L 56181
Proximity Label-MS Homo sapiens
41 MICU2 221154
Proximity Label-MS Homo sapiens
42 TUFM 7284
Co-fractionation Homo sapiens
43 PDXDC1 23042
Affinity Capture-MS Homo sapiens
44 DDX20 11218
Affinity Capture-MS Homo sapiens
45 ESRRB  
Affinity Capture-MS Homo sapiens
46 YAP1 10413
Affinity Capture-MS Homo sapiens
47 TRIM21 6737
Affinity Capture-MS Homo sapiens
48 SLX4  
Affinity Capture-MS Homo sapiens
49 CCDC109B 55013
Proximity Label-MS Homo sapiens
50 SCCPDH 51097
Co-fractionation Homo sapiens
51 CYC1 1537
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
52 ACTC1 70
Affinity Capture-MS Homo sapiens
53 MICU1 10367
Proximity Label-MS Homo sapiens
54 VDAC2 7417
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
55 PTAR1 375743
Proximity Label-MS Homo sapiens
56 HSPA5 3309
Co-fractionation Homo sapiens
57 RBM39 9584
Proximity Label-MS Homo sapiens
58 HADHB 3032
Co-fractionation Homo sapiens
59 HADHA 3030
Co-fractionation Homo sapiens
60 KIF20A 10112
Affinity Capture-MS Homo sapiens
61 LMNB1 4001
Affinity Capture-MS Homo sapiens
62 EPAS1  
Affinity Capture-MS Homo sapiens
63 ANXA1 301
Protein-peptide Homo sapiens
64 CD274 29126
Affinity Capture-MS Homo sapiens
65 BCAP31 10134
Co-fractionation Homo sapiens
66 CUL3 8452
Affinity Capture-MS Homo sapiens
67 FKBP8 23770
Proximity Label-MS Homo sapiens
68 VHL  
Two-hybrid Homo sapiens
69 FN1 2335
Affinity Capture-MS Homo sapiens
70 BLK 640
Affinity Capture-MS Homo sapiens
71 ZNF782  
Co-fractionation Homo sapiens
72 Rab11a 53869
Affinity Capture-MS Mus musculus
73 RPA3 6119
Proximity Label-MS Homo sapiens
74 TIMM8B 26521
Proximity Label-MS Homo sapiens
75 SERINC3 10955
Affinity Capture-MS Homo sapiens
76 COX2 4513
Co-fractionation Homo sapiens
77 AKT1 207
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
78 UPF2 26019
Two-hybrid Homo sapiens
79 MALL  
Affinity Capture-MS Homo sapiens
80 GBAS 2631
Co-fractionation Homo sapiens
81 DNAJC28  
Proximity Label-MS Homo sapiens
82 CCDC58 131076
Proximity Label-MS Homo sapiens
83 LRPPRC 10128
Proximity Label-MS Homo sapiens
84 COX5A 9377
Co-fractionation Homo sapiens
85 FKBP9 11328
Co-fractionation Homo sapiens
86 NUDT19 390916
Proximity Label-MS Homo sapiens
87 ATAD3A 55210
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
88 MAP1LC3A 84557
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
89 LONP1 9361
Proximity Label-MS Homo sapiens
90 RAB2A 5862
Affinity Capture-MS Homo sapiens
91 SLC25A51  
Proximity Label-MS Homo sapiens
92 RAB11A 8766
Affinity Capture-MS Homo sapiens
93 PCCB 5096
Co-fractionation Homo sapiens
94 RAB5C 5878
Affinity Capture-MS Homo sapiens
95 PLD6  
Affinity Capture-MS Homo sapiens
96 ASB14  
Affinity Capture-MS Homo sapiens
97 SNAP29 9342
Proximity Label-MS Homo sapiens
98 EMC4 51234
Co-fractionation Homo sapiens
99 AFG3L2 10939
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
100 Tmed2 56334
Affinity Capture-MS Mus musculus
101 PMPCA 23203
Proximity Label-MS Homo sapiens
102 ADRB2  
Affinity Capture-MS Homo sapiens
103 ALDH2 217
Synthetic Lethality Homo sapiens
104 Atp2a2 11938
Affinity Capture-MS Mus musculus
105 LGALS1 3956
Co-fractionation Homo sapiens
106 NDUFS2 4720
Co-fractionation Homo sapiens
107 ATP5L 10632
Co-fractionation Homo sapiens
108 HCCS 3052
Proximity Label-MS Homo sapiens
109 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
110 POTEE 445582
Proximity Label-MS Homo sapiens
111 NCOR1  
Co-localization Homo sapiens
112 OGDH 4967
Co-fractionation Homo sapiens
113 TUBB 203068
Co-fractionation Homo sapiens
114 NR2F2  
Reconstituted Complex Homo sapiens
115 TIMM17B  
Proximity Label-MS Homo sapiens
116 PRC1 9055
Affinity Capture-MS Homo sapiens
117 NUP93 9688
Affinity Capture-MS Homo sapiens
118 C1qbp 12261
Affinity Capture-MS Mus musculus
119 C12orf73  
Proximity Label-MS Homo sapiens
120 LACTB 114294
Proximity Label-MS Homo sapiens
121 PHB 5245
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
122 TOMM40 10452
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
123 NDUFV3 4731
Proximity Label-MS Homo sapiens
124 MYL12A 10627
Co-fractionation Homo sapiens
125 TIMM50 92609
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
126 ANKRD34C  
Co-fractionation Homo sapiens
127 SOX5 6660
Affinity Capture-MS Homo sapiens
128 TDRKH  
Proximity Label-MS Homo sapiens
129 LMAN1 3998
Co-fractionation Homo sapiens
130 ATG2A  
Affinity Capture-MS Homo sapiens
131 C6orf203  
Proximity Label-MS Homo sapiens
132 STOM 2040
Affinity Capture-MS Homo sapiens
133 COPG1 22820
Affinity Capture-MS Homo sapiens
134 NDUFA8 4702
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
135 TEAD3  
Two-hybrid Homo sapiens
136 LETM1 3954
Proximity Label-MS Homo sapiens
137 Hdac1 433759
Two-hybrid Mus musculus
138 TBRG4 9238
Proximity Label-MS Homo sapiens
139 UQCRC1 7384
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
140 BCL6  
Affinity Capture-MS Homo sapiens
141 AGPS 8540
Co-fractionation Homo sapiens
142 CYLD  
Affinity Capture-MS Homo sapiens
143 PSMA3 5684
Affinity Capture-MS Homo sapiens
144 AIFM1 9131
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
145 CANX 821
Co-fractionation Homo sapiens
146 ATL3 25923
Co-fractionation Homo sapiens
147 ICAM1 3383
Co-fractionation Homo sapiens
148 EMC8 10328
Co-fractionation Homo sapiens
149 USP15 9958
Affinity Capture-MS Homo sapiens
150 RC3H2  
Affinity Capture-MS Homo sapiens
151 MTX2 10651
Affinity Capture-MS Homo sapiens
152 PPARG 5468
Protein-peptide Homo sapiens
153 Rmdn3  
Affinity Capture-MS Mus musculus
154 CIT 11113
Affinity Capture-MS Homo sapiens
155 TUBB4B 10383
Co-fractionation Homo sapiens
156 PTPLA  
Affinity Capture-MS Homo sapiens
157 MTFR1  
Proximity Label-MS Homo sapiens
158 MTFR2  
Proximity Label-MS Homo sapiens
159 TOMM70A 9868
Proximity Label-MS Homo sapiens
160 CDK2 1017
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 BIRC6 57448
Proximity Label-MS Homo sapiens
162 MYC  
Proximity Label-MS Homo sapiens
163 ACAD9 28976
Proximity Label-MS Homo sapiens
164 DDRGK1 65992
Affinity Capture-MS Homo sapiens
165 XRCC3  
Affinity Capture-MS Homo sapiens
166 FHL2 2274
Two-hybrid Homo sapiens
167 MCUR1 63933
Proximity Label-MS Homo sapiens
168 HUWE1 10075
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 PHGDH 26227
Affinity Capture-MS Homo sapiens
170 TRIM5 85363
Affinity Capture-Western Homo sapiens
171 CS 1431
Proximity Label-MS Homo sapiens
172 C17orf80 55028
Proximity Label-MS Homo sapiens
173 AFP 174
Two-hybrid Homo sapiens
174 SPOP  
Affinity Capture-MS Homo sapiens
175 VDAC3 7419
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
176 ILF3 3609
Co-fractionation Homo sapiens
Affinity Capture-RNA Homo sapiens
Co-fractionation Homo sapiens
177 FOLR1 2348
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
178 KPNA6 23633
Affinity Capture-Western Homo sapiens
179 GOSR1 9527
Co-fractionation Homo sapiens
180 PDCL 5082
Proximity Label-MS Homo sapiens
181 HDAC6 10013
Affinity Capture-MS Homo sapiens
182 BCKDHA 593
Co-fractionation Homo sapiens
183 PTBP1 5725
Co-fractionation Homo sapiens
184 Htt  
Affinity Capture-MS Mus musculus
185 COX8A  
Proximity Label-MS Homo sapiens
186 UNK  
Affinity Capture-RNA Homo sapiens
187 Myh10 77579
Affinity Capture-MS Mus musculus
188 MMGT1 93380
Affinity Capture-MS Homo sapiens
189 ESR1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
190 TFE3  
Affinity Capture-MS Homo sapiens
191 MMS19 64210
Affinity Capture-MS Homo sapiens
192 YKT6 10652
Proximity Label-MS Homo sapiens
193 C1QBP 708
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
194 KRAS 3845
Negative Genetic Homo sapiens
195 TOMM5  
Co-fractionation Homo sapiens
196 HACD3 51495
Co-fractionation Homo sapiens
197 IDH1 3417
Co-fractionation Homo sapiens
198 RAB1A 5861
Co-fractionation Homo sapiens
199 NDUFS1 4719
Co-fractionation Homo sapiens
200 PTMA 5757
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
201 MRPL17  
Co-fractionation Homo sapiens
202 MTX1 4580
Proximity Label-MS Homo sapiens
203 Chmp4b 75608
Affinity Capture-MS Mus musculus
204 PTPN1 5770
Affinity Capture-MS Homo sapiens
205 MYOD1  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
206 ATG13 9776
Affinity Capture-Western Homo sapiens
207 POR 5447
Co-fractionation Homo sapiens
208 NDUFB9 4715
Co-fractionation Homo sapiens
209 MGST1 4257
Co-fractionation Homo sapiens
210 NDUFS3 4722
Co-fractionation Homo sapiens
211 NDUFB8 4714
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
212 MCM2 4171
Affinity Capture-MS Homo sapiens
213 TIMMDC1  
Proximity Label-MS Homo sapiens
214 MEF2A  
Affinity Capture-Western Homo sapiens
215 HINT2 84681
Proximity Label-MS Homo sapiens
216 MDC1  
Affinity Capture-MS Homo sapiens
217 SSR1 6745
Co-fractionation Homo sapiens
218 FAM136A 84908
Proximity Label-MS Homo sapiens
219 C20orf24  
Co-fractionation Homo sapiens
220 ITGA4 3676
Affinity Capture-MS Homo sapiens
221 CCDC47 57003
Co-fractionation Homo sapiens
222 Kif23 71819
Affinity Capture-MS Mus musculus
223 NDUFV1 4723
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
224 ATG16L1 55054
Affinity Capture-MS Homo sapiens
225 CLTC 1213
Co-fractionation Homo sapiens
226 MAVS 57506
Proximity Label-MS Homo sapiens
227 TFCP2 7024
Affinity Capture-MS Homo sapiens
228 CPOX 1371
Proximity Label-MS Homo sapiens
229 UQCRQ 27089
Co-fractionation Homo sapiens
230 NDUFS5 4725
Co-fractionation Homo sapiens
231 MDH2 4191
Proximity Label-MS Homo sapiens
232 ATAD3B 83858
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
233 ATP5A1 498
Co-fractionation Homo sapiens
234 CDC23 8697
Proximity Label-MS Homo sapiens
235 NDUFB7 4713
Co-fractionation Homo sapiens
236 PARK2  
Affinity Capture-MS Homo sapiens
237 IGF1R 3480
Affinity Capture-Western Homo sapiens
238 CHCHD3 54927
Proximity Label-MS Homo sapiens
239 TUBA1A 7846
Synthetic Lethality Homo sapiens
240 DIABLO 56616
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
241 CHMP4B 128866
Affinity Capture-MS Homo sapiens
242 TTC19  
Proximity Label-MS Homo sapiens
243 NTRK1 4914
Affinity Capture-MS Homo sapiens
244 U2AF2 11338
Affinity Capture-MS Homo sapiens
245 ACTB 60
Co-fractionation Homo sapiens
246 COA7  
Proximity Label-MS Homo sapiens
247 MRPL11 65003
Proximity Label-MS Homo sapiens
248 UQCRH 7388
Co-fractionation Homo sapiens
249 KPNA5 3841
Affinity Capture-Western Homo sapiens
250 HNRNPA3 220988
Co-fractionation Homo sapiens
251 HDAC5 10014
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
252 TMEM70  
Proximity Label-MS Homo sapiens
253 MRPL2 51069
Co-fractionation Homo sapiens
254 ENDOG  
Proximity Label-MS Homo sapiens
255 Rab5c 19345
Affinity Capture-MS Mus musculus
256 ZBTB2 57621
Affinity Capture-MS Homo sapiens
257 MRPL40 64976
Co-fractionation Homo sapiens
258 TNFAIP8L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
259 SLC25A12 8604
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
260 METTL14  
Affinity Capture-MS Homo sapiens
261 KIAA1244  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
262 ECT2 1894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
263 EEF2 1938
Co-fractionation Homo sapiens
264 EPPK1 83481
Affinity Capture-MS Homo sapiens
265 GLI1  
Affinity Capture-MS Homo sapiens
266 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
267 COX6B1 1340
Proximity Label-MS Homo sapiens
268 YIPF5 81555
Affinity Capture-MS Homo sapiens
269 CORO1C 23603
Co-fractionation Homo sapiens
270 OCIAD1 54940
Proximity Label-MS Homo sapiens
271 EMC2 9694
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
272 RAB11B 9230
Co-fractionation Homo sapiens
273 RNF2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
274 Kctd5  
Affinity Capture-MS Mus musculus
275 HAX1  
Proximity Label-MS Homo sapiens
276 RNF185  
Affinity Capture-MS Homo sapiens
277 HSPA9 3313
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
278 SNX6 58533
Proximity Label-MS Homo sapiens
279 AKAP1 8165
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
280 CPT1A 1374
Co-fractionation Homo sapiens
281 IMMT 10989
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
282 SMCR8 140775
Proximity Label-MS Homo sapiens
283 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
284 TSFM 10102
Proximity Label-MS Homo sapiens
285 NUP205 23165
Affinity Capture-MS Homo sapiens
286 PDE2A  
Affinity Capture-MS Homo sapiens
287 JUP 3728
Affinity Capture-MS Homo sapiens
288 ICT1 3396
Affinity Capture-MS Homo sapiens
289 MCM5 4174
Affinity Capture-MS Homo sapiens
290 PDHA1 5160
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
291 DDX58 23586
Affinity Capture-RNA Homo sapiens
292 GNG5 2787
Co-fractionation Homo sapiens
293 UFL1 23376
Affinity Capture-MS Homo sapiens
294 SMIM12  
Proximity Label-MS Homo sapiens
295 NDUFS8 4728
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
296 MRPS18B 28973
Reconstituted Complex Homo sapiens
297 NDUFA2 4695
Co-fractionation Homo sapiens
298 AARS2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
299 FGFR1OP2  
Affinity Capture-MS Homo sapiens
300 RAB7A 7879
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
301 RPUSD3  
Proximity Label-MS Homo sapiens
302 SERBP1 26135
Affinity Capture-MS Homo sapiens
303 COX7C 1350
Co-fractionation Homo sapiens
304 AR 367
Affinity Capture-MS Homo sapiens
305 RC3H1 149041
Affinity Capture-MS Homo sapiens
306 ATXN3 4287
Affinity Capture-MS Homo sapiens
307 IARS2 55699
Proximity Label-MS Homo sapiens
308 EP300 2033
Affinity Capture-MS Homo sapiens
309 UBE2H 7328
Affinity Capture-MS Homo sapiens
310 RIT1 6016
Negative Genetic Homo sapiens
311 FMNL1 752
Affinity Capture-MS Homo sapiens
312 XIAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
313 PAXIP1  
Affinity Capture-MS Homo sapiens
314 Mtx2  
Affinity Capture-MS Mus musculus
315 VAPA 9218
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
316 WWP1 11059
Affinity Capture-MS Homo sapiens
317 ATP6V1C1 528
Co-fractionation Homo sapiens
318 TRUB2  
Proximity Label-MS Homo sapiens
319 CKMT1A 548596
Proximity Label-MS Homo sapiens
320 DNAJC15  
Proximity Label-MS Homo sapiens
321 TMPO 7112
Affinity Capture-MS Homo sapiens
322 TOMM22 56993
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
323 ASB17  
Affinity Capture-MS Homo sapiens
324 CHCHD4  
Proximity Label-MS Homo sapiens
325 MARK2 2011
Affinity Capture-MS Homo sapiens
326 Eef1a1 13627
Affinity Capture-MS Mus musculus
327 DYRK1A 1859
Affinity Capture-MS Homo sapiens
328 KLF8  
Affinity Capture-MS Homo sapiens
329 CYB5R1 51706
Co-fractionation Homo sapiens
330 AGO3  
Affinity Capture-MS Homo sapiens
331 COA3 28958
Co-fractionation Homo sapiens
332 SURF1  
Proximity Label-MS Homo sapiens
333 ATP5O 539
Co-fractionation Homo sapiens
334 ATP5C1 509
Co-fractionation Homo sapiens
335 EXD2  
Proximity Label-MS Homo sapiens
336 EED  
Affinity Capture-MS Homo sapiens
337 ATP5H 10476
Co-fractionation Homo sapiens
338 RIC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
339 PSMC3 5702
Co-fractionation Homo sapiens
340 Lima1  
Affinity Capture-MS Mus musculus
341 TMEM63B 55362
Affinity Capture-MS Homo sapiens
342 LZTFL1 54585
Affinity Capture-MS Homo sapiens
343 STOML2 30968
Co-fractionation Homo sapiens
344 APOO 79135
Proximity Label-MS Homo sapiens
345 LRRC59 55379
Co-fractionation Homo sapiens
346 PPP1CA 5499
Biochemical Activity Homo sapiens
347 COX15 1355
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
348 NAA50 80218
Proximity Label-MS Homo sapiens
349 C3orf62  
Proximity Label-MS Homo sapiens
350 USP30  
Proximity Label-MS Homo sapiens
351 HSP90B1 7184
Co-fractionation Homo sapiens
352 STAU1 6780
Affinity Capture-MS Homo sapiens
353 LRIF1  
Affinity Capture-MS Homo sapiens
354 ATF2  
Affinity Capture-MS Homo sapiens
355 CYB5A 1528
Co-fractionation Homo sapiens
356 VCP 7415
Affinity Capture-MS Homo sapiens
357 OPA1 4976
Proximity Label-MS Homo sapiens
358 CHCHD6 84303
Proximity Label-MS Homo sapiens
359 RHOT2 89941
Proximity Label-MS Homo sapiens
360 NIPSNAP1 8508
Co-fractionation Homo sapiens
361 ATP5B 506
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
362 GOLT1B 51026
Affinity Capture-MS Homo sapiens
363 COX4I1 1327
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
364 VCAM1 7412
Affinity Capture-MS Homo sapiens
365 SLC25A24 29957
Co-fractionation Homo sapiens
366 CYB5B 80777
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
367 COX5B 1329
Co-fractionation Homo sapiens
368 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
369 FANCD2  
Affinity Capture-MS Homo sapiens
370 APOOL 139322
Proximity Label-MS Homo sapiens
371 NDUFB10 4716
Co-fractionation Homo sapiens
372 NDUFA9 4704
Co-fractionation Homo sapiens
373 NELFCD 51497
Affinity Capture-MS Homo sapiens
374 UQCRC2 7385
Co-fractionation Homo sapiens
375 HMOX2 3163
Co-fractionation Homo sapiens
376 CTNNB1 1499
Affinity Capture-MS Homo sapiens
377 ATG12  
Proximity Label-MS Homo sapiens
378 CYB5R3 1727
Co-fractionation Homo sapiens
379 ARF6 382
Proximity Label-MS Homo sapiens
380 SUZ12  
Affinity Capture-MS Homo sapiens
381 HSD17B4 3295
Co-fractionation Homo sapiens
382 YME1L1 10730
Proximity Label-MS Homo sapiens
383 B3GNT7  
Affinity Capture-MS Homo sapiens
384 ATP6V1A 523
Co-fractionation Homo sapiens
385 SIRT2 22933
Affinity Capture-MS Homo sapiens
386 HK1 3098
Proximity Label-MS Homo sapiens
387 VDAC1 7416
Co-fractionation Homo sapiens
388 NR2F1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
389 MDM2  
Affinity Capture-Western Homo sapiens
390 RUNX3  
Affinity Capture-MS Homo sapiens
391 FAP 2191
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
392 DNAJC19 131118
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
393 ZNF746  
Affinity Capture-MS Homo sapiens
394 Aifm1  
Affinity Capture-MS Mus musculus
395 TPTE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
396 MRPS31  
Proximity Label-MS Homo sapiens
397 DNAJA3 9093
Proximity Label-MS Homo sapiens
398 NDUFS7 374291
Co-fractionation Homo sapiens
399 PDHB 5162
Co-fractionation Homo sapiens
400 HDAC1 3065
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
401 C21orf33  
Proximity Label-MS Homo sapiens
402 SFXN1 94081
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
403 KIAA1429 25962
Affinity Capture-MS Homo sapiens
404 EZH2  
Reconstituted Complex Homo sapiens
405 TIMM13 26517
Proximity Label-MS Homo sapiens
406 TRIM31  
Affinity Capture-MS Homo sapiens
407 PINK1  
Affinity Capture-MS Homo sapiens
408 COX7A2 1347
Co-fractionation Homo sapiens
409 XRCC6 2547
Proximity Label-MS Homo sapiens
410 NDUFAF4 29078
Proximity Label-MS Homo sapiens
411 Ufl1  
Affinity Capture-MS Mus musculus
412 C9orf72  
Affinity Capture-MS Homo sapiens
413 METTL17  
Proximity Label-MS Homo sapiens
414 TRIM29 23650
Affinity Capture-MS Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here