Gene description for AIMP2
Gene name
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
Gene symbol
AIMP2
Other names/aliases
JTV-1 JTV1 P38 PRO0992
Species
Homo sapiens
Database cross references - AIMP2
ExoCarta
ExoCarta_7965
Entrez Gene
7965
HGNC
20609
MIM
600859
UniProt
Q13155
AIMP2 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells
25890246
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Thymus
23844026
Gene ontology annotations for AIMP2
Experiment description of studies that identified AIMP2 in exosomes
1
Experiment ID
283
ISEV standards
✔
CEM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81|EpCAM
EV Membrane markers
✘
EV Negative markers
✔
DLS
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25890246
Organism
Homo sapiens
Experiment description
Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors
Xu R, Greening DW, Rai A, Ji H, Simpson RJ.
Journal name
Methods
Publication year
2015
Sample
Colorectal cancer cells
Sample name
LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation Centrifugal concentration
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry Western blotting
2
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
4
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for AIMP2
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
FHL3
Two-hybrid
Homo sapiens
2
LNX
Two-hybrid
Homo sapiens
3
KARS
3735
Two-hybrid
Homo sapiens
4
EPS8
2059
Two-hybrid
Homo sapiens
5
DARS
1615
Two-hybrid
Homo sapiens
6
CEP170L
Two-hybrid
Homo sapiens
7
MGC11271
Two-hybrid
Homo sapiens
Affinity Capture-Western
Homo sapiens
8
PARK2
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
Two-hybrid
Homo sapiens
9
LMO3
Two-hybrid
Homo sapiens
10
AIMP2
7965
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
Invitro
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
11
EPRS
2058
Invivo
Homo sapiens
12
AIMP1
9255
Invitro
Homo sapiens
View the network
image/svg+xml
Pathways in which AIMP2 is involved