Gene description for TRIM21
Gene name tripartite motif containing 21
Gene symbol TRIM21
Other names/aliases RNF81
RO52
Ro/SSA
SSA
SSA1
Species Homo sapiens
 Database cross references - TRIM21
ExoCarta ExoCarta_6737
Vesiclepedia VP_6737
Entrez Gene 6737
HGNC 11312
MIM 109092
UniProt P19474  
 TRIM21 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for TRIM21
Molecular Function
    DNA binding GO:0003677 IEA
    transcription coactivator activity GO:0003713 IDA
    RNA binding GO:0003723 IEA
    ubiquitin-protein transferase activity GO:0004842 IDA
    ubiquitin-protein transferase activity GO:0004842 TAS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    identical protein binding GO:0042802 IPI
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
    ubiquitin protein ligase activity GO:0061630 TAS
Biological Process
    protein polyubiquitination GO:0000209 IDA
    protein monoubiquitination GO:0006513 IDA
    regulation of gene expression GO:0010468 IBA
    proteasomal protein catabolic process GO:0010498 IDA
    positive regulation of autophagy GO:0010508 IBA
    positive regulation of autophagy GO:0010508 IMP
    protein ubiquitination GO:0016567 IDA
    protein destabilization GO:0031648 IMP
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    positive regulation of protein binding GO:0032092 IMP
    regulation of type I interferon production GO:0032479 TAS
    negative regulation of viral transcription GO:0032897 IDA
    response to type II interferon GO:0034341 IDA
    stress granule disassembly GO:0035617 IDA
    protein K27-linked ubiquitination GO:0044314 IDA
    suppression of viral release by host GO:0044790 IDA
    innate immune response GO:0045087 IBA
    innate immune response GO:0045087 IDA
    positive regulation of cell cycle GO:0045787 IMP
    negative regulation of innate immune response GO:0045824 IDA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    regulation of viral entry into host cell GO:0046596 IBA
    positive regulation of viral entry into host cell GO:0046598 IEA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    protein autoubiquitination GO:0051865 IDA
    cellular response to chemical stress GO:0062197 TAS
    pyroptotic inflammatory response GO:0070269 IDA
    protein K63-linked ubiquitination GO:0070534 IDA
    protein K63-linked ubiquitination GO:0070534 IMP
    protein K48-linked ubiquitination GO:0070936 IDA
    protein K6-linked ubiquitination GO:0085020 IDA
    negative regulation of protein deubiquitination GO:0090086 IMP
Subcellular Localization
    P-body GO:0000932 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IC
    cytoplasm GO:0005737 IDA
    autophagosome GO:0005776 IEA
    cytosol GO:0005829 TAS
    cytoplasmic stress granule GO:0010494 IDA
    SCF ubiquitin ligase complex GO:0019005 IDA
    cytoplasmic vesicle GO:0031410 IEA
    ribonucleoprotein complex GO:1990904 IEA
 Experiment description of studies that identified TRIM21 in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
EM
Biophysical techniques
TSG101|CD81|CD9|CD63
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRIM21
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Mdm2  
Affinity Capture-MS Mus musculus
2 MMRN2 79812
Affinity Capture-MS Homo sapiens
3 SNX24  
Affinity Capture-MS Homo sapiens
4 ALDH16A1 126133
Affinity Capture-MS Homo sapiens
5 PKM 5315
Affinity Capture-MS Homo sapiens
6 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
7 SLC2A1 6513
Affinity Capture-Western Homo sapiens
8 UBC 7316
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
9 IGKV3OR2-268  
Affinity Capture-MS Homo sapiens
10 UGT2B15  
Affinity Capture-MS Homo sapiens
11 FHOD1 29109
Two-hybrid Homo sapiens
12 RIPK1 8737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
13 MAP1LC3B 81631
Reconstituted Complex Homo sapiens
14 DPPA4  
Affinity Capture-MS Homo sapiens
15 IGF2BP3 10643
Affinity Capture-Western Homo sapiens
16 DTX3  
Affinity Capture-MS Homo sapiens
17 DARS 1615
Affinity Capture-MS Homo sapiens
18 HDLBP 3069
Affinity Capture-MS Homo sapiens
19 RPLP1 6176
Affinity Capture-MS Homo sapiens
20 RHPN2 85415
Affinity Capture-MS Homo sapiens
21 SCN8A  
Affinity Capture-MS Homo sapiens
22 PIP4K2B 8396
Affinity Capture-MS Homo sapiens
23 NCOA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 RPS9 6203
Affinity Capture-MS Homo sapiens
25 DNAJB1 3337
Affinity Capture-MS Homo sapiens
26 FLG 2312
Affinity Capture-MS Homo sapiens
27 SCARB1 949
Affinity Capture-MS Homo sapiens
28 ERVK-21  
Affinity Capture-MS Homo sapiens
29 CD14 929
Affinity Capture-Western Homo sapiens
30 UBE2W  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
31 ARIH2 10425
Affinity Capture-MS Homo sapiens
32 NMT1 4836
Affinity Capture-MS Homo sapiens
33 RPS11 6205
Affinity Capture-MS Homo sapiens
34 RPL19 6143
Affinity Capture-MS Homo sapiens
35 KIF14 9928
Affinity Capture-MS Homo sapiens
36 BAG6 7917
Affinity Capture-MS Homo sapiens
37 FARSA 2193
Affinity Capture-MS Homo sapiens
38 MAP3K2 10746
Affinity Capture-MS Homo sapiens
39 SHMT1 6470
Affinity Capture-MS Homo sapiens
40 VRK1 7443
Affinity Capture-MS Homo sapiens
41 ILVBL 10994
Affinity Capture-MS Homo sapiens
42 TUFM 7284
Affinity Capture-MS Homo sapiens
43 IRF7  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
44 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
45 ARG1 383
Affinity Capture-MS Homo sapiens
46 PGGT1B 5229
Affinity Capture-MS Homo sapiens
47 RPL18A 6142
Affinity Capture-MS Homo sapiens
48 PABPC1 26986
Affinity Capture-MS Homo sapiens
49 EEF1E1 9521
Affinity Capture-MS Homo sapiens
50 MNAT1  
Two-hybrid Homo sapiens
51 GABARAP 11337
Reconstituted Complex Homo sapiens
52 TRIM21 6737
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
53 RPL31 6160
Affinity Capture-MS Homo sapiens
54 MRPS6  
Affinity Capture-MS Homo sapiens
55 GFPT2 9945
Affinity Capture-MS Homo sapiens
56 NOS2  
Affinity Capture-MS Homo sapiens
57 P4HB 5034
Affinity Capture-MS Homo sapiens
58 ENO1 2023
Affinity Capture-MS Homo sapiens
59 CSNK1E 1454
Affinity Capture-MS Homo sapiens
60 TMX2 51075
Affinity Capture-MS Homo sapiens
61 ADAMTS1 9510
Affinity Capture-MS Homo sapiens
62 COQ10B  
Affinity Capture-MS Homo sapiens
63 RPS26P11  
Affinity Capture-MS Homo sapiens
64 SLC25A5 292
Affinity Capture-MS Homo sapiens
65 IGKV1D-13  
Affinity Capture-MS Homo sapiens
66 TXN2 25828
Two-hybrid Homo sapiens
67 KCNIP2  
Affinity Capture-MS Homo sapiens
68 S100A11 6282
Affinity Capture-MS Homo sapiens
69 ULK3 25989
Affinity Capture-MS Homo sapiens
70 HSPA5 3309
Affinity Capture-MS Homo sapiens
71 SV2A 9900
Affinity Capture-MS Homo sapiens
72 NEO1 4756
Affinity Capture-MS Homo sapiens
73 DOCK8 81704
Affinity Capture-MS Homo sapiens
74 IQCB1  
Affinity Capture-MS Homo sapiens
75 NPM3 10360
Affinity Capture-MS Homo sapiens
76 PRKCZ 5590
Affinity Capture-MS Homo sapiens
77 ACTBL2 345651
Affinity Capture-MS Homo sapiens
78 YWHAZ 7534
Affinity Capture-MS Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
79 IGKV1-33  
Affinity Capture-MS Homo sapiens
80 FN1 2335
Affinity Capture-MS Homo sapiens
81 EPSTI1  
Affinity Capture-MS Homo sapiens
82 PRMT5 10419
Affinity Capture-MS Homo sapiens
83 FARSB 10056
Affinity Capture-MS Homo sapiens
84 SOAT1 6646
Affinity Capture-MS Homo sapiens
85 PCBP1 5093
Affinity Capture-MS Homo sapiens
86 DLST 1743
Affinity Capture-MS Homo sapiens
87 PSMC5 5705
Affinity Capture-MS Homo sapiens
88 ILK 3611
Affinity Capture-MS Homo sapiens
89 CDKN1B 1027
Affinity Capture-Western Homo sapiens
90 MEPE  
Affinity Capture-MS Homo sapiens
91 DRC7  
Affinity Capture-MS Homo sapiens
92 CPXM2 119587
Affinity Capture-MS Homo sapiens
93 RPS16 6217
Affinity Capture-MS Homo sapiens
94 U2SURP 23350
Affinity Capture-MS Homo sapiens
95 HSPE1 3336
Affinity Capture-MS Homo sapiens
96 FASN 2194
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
97 ALKBH2  
Affinity Capture-MS Homo sapiens
98 USP25  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
99 AGPAT9  
Affinity Capture-MS Homo sapiens
100 PCMT1 5110
Affinity Capture-MS Homo sapiens
101 ALOX15B  
Two-hybrid Homo sapiens
102 SKP1 6500
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
103 HIST1H2BN 8341
Affinity Capture-MS Homo sapiens
104 TCN2 6948
Affinity Capture-MS Homo sapiens
105 CAPZB 832
Affinity Capture-MS Homo sapiens
106 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
107 TRPM8  
Affinity Capture-MS Homo sapiens
108 RAB11FIP1 80223
Biochemical Activity Homo sapiens
109 ATAD3A 55210
Affinity Capture-MS Homo sapiens
110 TBK1 29110
Affinity Capture-MS Homo sapiens
111 ERCC6  
Affinity Capture-MS Homo sapiens
112 MAP1LC3A 84557
Reconstituted Complex Homo sapiens
113 RPS24 6229
Affinity Capture-MS Homo sapiens
114 GAPDH 2597
Affinity Capture-MS Homo sapiens
115 ARSG 22901
Affinity Capture-MS Homo sapiens
116 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
117 PDE4DIP 9659
Affinity Capture-MS Homo sapiens
118 RPL23A 6147
Affinity Capture-MS Homo sapiens
119 ALDH1A1 216
Affinity Capture-MS Homo sapiens
120 RAB5C 5878
Affinity Capture-MS Homo sapiens
121 ANXA2 302
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
122 RBCK1  
Two-hybrid Homo sapiens
123 ATP10B  
Affinity Capture-MS Homo sapiens
124 HSPA1B 3304
Affinity Capture-MS Homo sapiens
125 IGLV3-10  
Affinity Capture-MS Homo sapiens
126 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
127 LDHA 3939
Affinity Capture-MS Homo sapiens
128 C19orf68  
Affinity Capture-MS Homo sapiens
129 HBB 3043
Affinity Capture-MS Homo sapiens
130 LOXHD1  
Affinity Capture-MS Homo sapiens
131 TRIM3 10612
Two-hybrid Homo sapiens
132 HSPA6 3310
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 ADGRG4 139378
Affinity Capture-MS Homo sapiens
134 AJAP1  
Affinity Capture-MS Homo sapiens
135 ALB 213
Affinity Capture-MS Homo sapiens
136 APC  
Two-hybrid Homo sapiens
137 TRIM33 51592
Affinity Capture-MS Homo sapiens
138 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
139 CWC25 54883
Two-hybrid Homo sapiens
140 GAN 8139
Affinity Capture-MS Homo sapiens
141 RPS3 6188
Affinity Capture-MS Homo sapiens
142 S100A14 57402
Affinity Capture-MS Homo sapiens
143 RPS18 6222
Affinity Capture-MS Homo sapiens
144 BPTF 2186
Affinity Capture-MS Homo sapiens
145 B3GNT2 10678
Affinity Capture-MS Homo sapiens
146 H1FX 8971
Affinity Capture-MS Homo sapiens
147 C3 718
Affinity Capture-MS Homo sapiens
148 C2orf54  
Affinity Capture-MS Homo sapiens
149 GM2A 2760
Affinity Capture-MS Homo sapiens
150 PRDX2 7001
Affinity Capture-MS Homo sapiens
151 MT1M 4499
Affinity Capture-MS Homo sapiens
152 CUL1 8454
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
153 HSD17B4 3295
Affinity Capture-MS Homo sapiens
154 SETD1A 9739
Affinity Capture-MS Homo sapiens
155 CDC5L 988
Affinity Capture-MS Homo sapiens
156 ZNF184  
Affinity Capture-MS Homo sapiens
157 GSK3B 2932
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
158 TRIM8  
Two-hybrid Homo sapiens
159 CCT2 10576
Affinity Capture-MS Homo sapiens
160 GTF2I 2969
Affinity Capture-MS Homo sapiens
161 PFN1 5216
Affinity Capture-MS Homo sapiens
162 SDK2 54549
Affinity Capture-MS Homo sapiens
163 USP15 9958
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
164 HRG 3273
Affinity Capture-MS Homo sapiens
165 DSG1 1828
Affinity Capture-MS Homo sapiens
166 TPR 7175
Affinity Capture-MS Homo sapiens
167 AKNA  
Affinity Capture-MS Homo sapiens
168 RBX1 9978
Co-fractionation Homo sapiens
169 RPL4 6124
Affinity Capture-MS Homo sapiens
170 ZBTB16  
Two-hybrid Homo sapiens
171 CBL 867
Affinity Capture-MS Homo sapiens
172 DHRS2 10202
Affinity Capture-MS Homo sapiens
173 ALDH18A1 5832
Affinity Capture-MS Homo sapiens
174 PON1 5444
Affinity Capture-MS Homo sapiens
175 IGKV1-5 28299
Affinity Capture-MS Homo sapiens
176 ADD2 119
Affinity Capture-MS Homo sapiens
177 MB21D2  
Affinity Capture-MS Homo sapiens
178 TUBA1C 84790
Affinity Capture-MS Homo sapiens
179 HDGFRP3 50810
Co-fractionation Homo sapiens
180 UBE2L3 7332
Reconstituted Complex Homo sapiens
181 S100A8 6279
Affinity Capture-MS Homo sapiens
182 RLIM 51132
Affinity Capture-MS Homo sapiens
183 NCL 4691
Affinity Capture-MS Homo sapiens
184 GRIP2 80852
Affinity Capture-MS Homo sapiens
185 RPLP0 6175
Affinity Capture-MS Homo sapiens
186 SYNE3 161176
Affinity Capture-MS Homo sapiens
187 GMPS 8833
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
188 SKP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
189 CYLD  
Affinity Capture-MS Homo sapiens
190 SEPT6 23157
Affinity Capture-MS Homo sapiens
191 FBXO45 200933
Affinity Capture-MS Homo sapiens
192 CHPF 79586
Affinity Capture-MS Homo sapiens
193 CASP14 23581
Affinity Capture-MS Homo sapiens
194 RPL32 6161
Affinity Capture-MS Homo sapiens
195 TUBB 203068
Affinity Capture-MS Homo sapiens
196 USP4 7375
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Biochemical Activity Homo sapiens
197 SFN 2810
Affinity Capture-MS Homo sapiens
198 SMCHD1 23347
Affinity Capture-MS Homo sapiens
199 AIFM1 9131
Affinity Capture-MS Homo sapiens
200 KDM4D  
Affinity Capture-MS Homo sapiens
201 RPS2 6187
Affinity Capture-MS Homo sapiens
202 PIP 5304
Affinity Capture-MS Homo sapiens
203 RC3H2  
Affinity Capture-MS Homo sapiens
204 IKZF3  
Affinity Capture-MS Homo sapiens
205 AKAP9 10142
Affinity Capture-MS Homo sapiens
206 PRKAR2A 5576
Affinity Capture-MS Homo sapiens
207 TCP11L1 55346
Two-hybrid Homo sapiens
208 PDIA3 2923
Affinity Capture-MS Homo sapiens
209 TUBB4B 10383
Affinity Capture-MS Homo sapiens
210 ABCC10  
Affinity Capture-MS Homo sapiens
211 FUS 2521
Affinity Capture-MS Homo sapiens
212 SERINC5 256987
Affinity Capture-MS Homo sapiens
213 IKZF1  
Affinity Capture-MS Homo sapiens
214 LGALS7 3963
Affinity Capture-MS Homo sapiens
215 TNRC6A 27327
Affinity Capture-MS Homo sapiens
216 YWHAQ 10971
Affinity Capture-MS Homo sapiens
217 CDK2 1017
Affinity Capture-MS Homo sapiens
218 CEP250 11190
Affinity Capture-MS Homo sapiens
219 R3HDM2  
Affinity Capture-MS Homo sapiens
220 MYC  
Affinity Capture-MS Homo sapiens
221 IRF5  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
222 JAK1 3716
Affinity Capture-MS Homo sapiens
223 SLC3A2 6520
Affinity Capture-MS Homo sapiens
224 BLMH 642
Affinity Capture-MS Homo sapiens
225 Junb