Gene description for CHCHD3
Gene name coiled-coil-helix-coiled-coil-helix domain containing 3
Gene symbol CHCHD3
Other names/aliases MINOS3
PPP1R22
Species Homo sapiens
 Database cross references - CHCHD3
ExoCarta ExoCarta_54927
Entrez Gene 54927
HGNC 21906
MIM 613748
UniProt Q9NX63  
 CHCHD3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CHCHD3
Molecular Function
    protein complex scaffold GO:0032947 ISS
    phosphatase binding GO:0019902 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001227 IDA
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    inner mitochondrial membrane organization GO:0007007 IMP
    mitochondrial fusion GO:0008053 IMP
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    mitochondrial inner membrane GO:0005743 ISS
    mitochondrion GO:0005739 ISS
 Experiment description of studies that identified CHCHD3 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CHCHD3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DIPA  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
2 KRTAP4-12  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CHCHD3 is involved
No pathways found





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