Gene description for MAZ
Gene name MYC-associated zinc finger protein (purine-binding transcription factor)
Gene symbol MAZ
Other names/aliases PUR1
Pur-1
SAF-1
SAF-2
SAF-3
ZF87
ZNF801
Zif87
Species Homo sapiens
 Database cross references - MAZ
ExoCarta ExoCarta_4150
Entrez Gene 4150
HGNC 6914
MIM 600999
UniProt P56270  
 MAZ identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for MAZ
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IDA
    metal ion binding GO:0046872 IEA
    sequence-specific DNA binding RNA polymerase II transcription factor activity GO:0000981 IEA
    poly(A) RNA binding GO:0044822 IDA
    chromatin binding GO:0003682 IEA
Biological Process
    termination of RNA polymerase II transcription GO:0006369 IDA
    transcription initiation from RNA polymerase II promoter GO:0006367 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified MAZ in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for MAZ
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DCC  
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
2 CSNK2A1 1457
Biochemical Activity Homo sapiens
3 BPTF 2186
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which MAZ is involved
No pathways found





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