Gene description for PPM1B
Gene name
protein phosphatase, Mg2+/Mn2+ dependent, 1B
Gene symbol
PPM1B
Other names/aliases
PP2C-beta PP2C-beta-X PP2CB PP2CBETA PPC2BETAX
Species
Homo sapiens
Database cross references - PPM1B
ExoCarta
ExoCarta_5495
Entrez Gene
5495
HGNC
9276
MIM
603770
UniProt
O75688
PPM1B identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Gene ontology annotations for PPM1B
Experiment description of studies that identified PPM1B in exosomes
1
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
2
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for PPM1B
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
PPP2CA
5515
Co-purification
Homo sapiens
2
GSN
2934
Affinity Capture-MS
Homo sapiens
3
MAP3K7
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
4
KRT18
3875
Affinity Capture-MS
Homo sapiens
5
ANXA1
301
Affinity Capture-MS
Homo sapiens
6
CDK2
1017
Biochemical Activity
Homo sapiens
Co-purification
Homo sapiens
7
IKBKG
8517
Affinity Capture-Western
Homo sapiens
Affinity Capture-MS
Homo sapiens
Affinity Capture-Western
Homo sapiens
8
ANXA2
302
Affinity Capture-MS
Homo sapiens
9
S100A8
6279
Affinity Capture-MS
Homo sapiens
10
VIL1
7429
Affinity Capture-MS
Homo sapiens
11
IKBKB
3551
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
Biochemical Activity
Homo sapiens
12
CHUK
1147
Affinity Capture-Western
Homo sapiens
Affinity Capture-Western
Homo sapiens
13
VCP
7415
Affinity Capture-MS
Homo sapiens
14
PABPC4
8761
Affinity Capture-MS
Homo sapiens
15
CDK6
1021
Affinity Capture-MS
Homo sapiens
Biochemical Activity
Homo sapiens
Co-purification
Homo sapiens
16
RASGRP1
Affinity Capture-MS
Homo sapiens
View the network
image/svg+xml
Pathways in which PPM1B is involved