Gene description for SF1
Gene name splicing factor 1
Gene symbol SF1
Other names/aliases BBP
Species Homo sapiens
 Database cross references - SF1
ExoCarta ExoCarta_7536
Entrez Gene 7536
HGNC 12950
MIM 601516
UniProt Q15637  
 SF1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SF1
Molecular Function
    transcription corepressor activity GO:0003714 TAS
    zinc ion binding GO:0008270 IEA
    poly(A) RNA binding GO:0044822 IDA
    RNA binding GO:0003723 TAS
    protein binding GO:0005515 IPI
Biological Process
    spliceosomal complex assembly GO:0000245 NAS
    regulation of steroid biosynthetic process GO:0050810 IEA
    Leydig cell differentiation GO:0033327 IEA
    male sex determination GO:0030238 IEA
    negative regulation of smooth muscle cell proliferation GO:0048662 IEA
    transcription, DNA-templated GO:0006351 IEA
    mRNA splicing, via spliceosome GO:0000398 IC
    negative regulation of nucleic acid-templated transcription GO:1903507 TAS
    mRNA 3'-splice site recognition GO:0000389 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    spliceosomal complex GO:0005681 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 NAS
    ribosome GO:0005840 NAS
 Experiment description of studies that identified SF1 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TAF15 8148
Reconstituted Complex Homo sapiens
2 WWP2 11060
Two-hybrid Homo sapiens
3 TCERG1  
Invivo Homo sapiens
Invitro Homo sapiens
4 DDX17 10521
Two-hybrid Homo sapiens
5 EWSR1 2130
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
6 PLSCR1 5359
Two-hybrid Homo sapiens
7 BCL2  
Invitro Homo sapiens
8 TRIM23 373
Two-hybrid Homo sapiens
9 FUS 2521
Reconstituted Complex Homo sapiens
10 RBPMS  
Two-hybrid Homo sapiens
11 PRPF40A 55660
Affinity Capture-MS Homo sapiens
12 U2AF2 11338
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SF1 is involved
No pathways found

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