Gene description for DDX23
Gene name DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Gene symbol DDX23
Other names/aliases PRPF28
Species Homo sapiens
 Database cross references - DDX23
ExoCarta ExoCarta_9416
Entrez Gene 9416
HGNC 17347
MIM 612172
UniProt Q9BUQ8  
 DDX23 identified in exosomes derived from the following tissue/cell type
Saliva 19199708    
 Gene ontology annotations for DDX23
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    ATP-dependent RNA helicase activity GO:0004004 TAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP-dependent helicase activity GO:0008026 IDA
Biological Process
    RNA splicing, via transesterification reactions GO:0000375 TAS
    RNA splicing GO:0008380 TAS
    RNA secondary structure unwinding GO:0010501 IBA
    cis assembly of pre-catalytic spliceosome GO:0000354 IC
    mRNA splicing, via spliceosome GO:0000398 TAS
    gene expression GO:0010467 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
    plasma membrane GO:0005886 IDA
    U5 snRNP GO:0005682 IDA
    nucleoplasm GO:0005654 TAS
    catalytic step 2 spliceosome GO:0071013 IDA
    nucleolus GO:0005730 IDA
    mitochondrion GO:0005739 IDA
 Experiment description of studies that identified DDX23 in exosomes
Experiment ID 66
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for DDX23
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD2BP2 10421
Affinity Capture-MS Homo sapiens
2 RNPS1 10921
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DDX23 is involved
mRNA Splicing - Major Pathway TAS Reactome
mRNA Splicing - Minor Pathway TAS Reactome

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