Gene description for AGO2
Gene name argonaute RISC catalytic component 2
Gene symbol AGO2
Other names/aliases EIF2C2
Q10
Species Homo sapiens
 Database cross references - AGO2
ExoCarta ExoCarta_27161
Vesiclepedia VP_27161
Entrez Gene 27161
HGNC 3263
MIM 606229
UniProt Q9UKV8  
 AGO2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colon cancer cells 34887515    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 34887515    
Colorectal cancer cells 34887515    
Pancreatic cancer cells 34887515    
 Gene ontology annotations for AGO2
Molecular Function
    RNA 7-methylguanosine cap binding GO:0000340 IDA
    RNA polymerase II complex binding GO:0000993 IDA
    core promoter sequence-specific DNA binding GO:0001046 IMP
    RNA binding GO:0003723 HDA
    double-stranded RNA binding GO:0003725 IDA
    single-stranded RNA binding GO:0003727 IBA
    single-stranded RNA binding GO:0003727 IDA
    translation initiation factor activity GO:0003743 NAS
    RNA endonuclease activity GO:0004521 IBA
    RNA endonuclease activity GO:0004521 IDA
    RNA endonuclease activity GO:0004521 TAS
    protein binding GO:0005515 IPI
    siRNA binding GO:0035197 IDA
    siRNA binding GO:0035197 IDA
    miRNA binding GO:0035198 IBA
    miRNA binding GO:0035198 IDA
    miRNA binding GO:0035198 IPI
    miRNA binding GO:0035198 TAS
    mRNA 3'-UTR AU-rich region binding GO:0035925 IDA
    metal ion binding GO:0046872 IEA
    endoribonuclease activity, cleaving siRNA-paired mRNA GO:0070551 IDA
    endoribonuclease activity, cleaving miRNA-paired mRNA GO:0090624 IDA
    endoribonuclease activity, cleaving miRNA-paired mRNA GO:0090624 IMP
    mRNA cap binding GO:0098808 IDA
    mRNA cap binding GO:0098808 IPI
Biological Process
    translation GO:0006412 NAS
    translational initiation GO:0006413 IEA
    post-embryonic development GO:0009791 IEA
    RNA secondary structure unwinding GO:0010501 IDA
    RNA secondary structure unwinding GO:0010501 IMP
    miRNA metabolic process GO:0010586 IEA
    siRNA processing GO:0030422 IDA
    regulatory ncRNA-mediated gene silencing GO:0031047 ISS
    pre-miRNA processing GO:0031054 IBA
    pre-miRNA processing GO:0031054 IDA
    P-body assembly GO:0033962 IDA
    regulatory ncRNA-mediated post-transcriptional gene silencing GO:0035194 IBA
    regulatory ncRNA-mediated post-transcriptional gene silencing GO:0035194 TAS
    miRNA processing GO:0035196 IDA
    miRNA-mediated gene silencing by inhibition of translation GO:0035278 IDA
    miRNA-mediated gene silencing by inhibition of translation GO:0035278 IMP
    miRNA-mediated gene silencing by mRNA destabilization GO:0035279 IDA
    miRNA-mediated gene silencing by mRNA destabilization GO:0035279 IMP
    negative regulation of amyloid precursor protein biosynthetic process GO:0042985 ISS
    positive regulation of translation GO:0045727 IDA
    positive regulation of angiogenesis GO:0045766 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    negative regulation of translational initiation GO:0045947 IDA
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213 ISS
    RISC complex assembly GO:0070922 IDA
    regulation of synapse maturation GO:0090128 IDA
    regulation of synapse maturation GO:0090128 IMP
    siRNA-mediated gene silencing by mRNA destabilization GO:0090625 IDA
    siRNA-mediated gene silencing by mRNA destabilization GO:0090625 IMP
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153 ISS
    positive regulation of trophoblast cell migration GO:1901165 IMP
Subcellular Localization
    P-body GO:0000932 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IC
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    RISC complex GO:0016442 IBA
    RISC complex GO:0016442 IDA
    RISC complex GO:0016442 IGI
    RISC complex GO:0016442 IPI
    dendrite GO:0030425 IEA
    cytoplasmic ribonucleoprotein granule GO:0036464 IBA
    cytoplasmic ribonucleoprotein granule GO:0036464 IDA
    extracellular exosome GO:0070062 IDA
    RISC-loading complex GO:0070578 IDA
    RISC-loading complex GO:0070578 IPI
    postsynapse GO:0098794 IDA
    postsynapse GO:0098794 IMP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
 Experiment description of studies that identified AGO2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1212
MISEV standards
✘ Biophysical techniques
✔
SDCBP
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colon cancer cells
Sample name LS174T
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
6
Experiment ID 282
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
7
Experiment ID 283
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
8
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
9
Experiment ID 1207
MISEV standards
✘ Biophysical techniques
✔
SDCBP|CD9|FLOT1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name HCA-7 SC
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
10
Experiment ID 1205
MISEV standards
✘ Biophysical techniques
✔
FLOT1|SDCBP
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
 Protein-protein interactions for AGO2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CNOT7 29883
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 LIG4 3981
Affinity Capture-MS Homo sapiens
3 S100A11 6282
Affinity Capture-RNA Homo sapiens
4 CRBN  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 BIRC6 57448
Affinity Capture-RNA Homo sapiens
Affinity Capture-MS Homo sapiens
6 CASC2  
Affinity Capture-RNA Homo sapiens
7 XIST  
Affinity Capture-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
8 ANKRD40 91369
Affinity Capture-MS Homo sapiens
9 MIR125B2  
Affinity Capture-RNA Homo sapiens
10 SKI 6497
Affinity Capture-RNA Homo sapiens
11 TARDBP 23435
Affinity Capture-MS Homo sapiens
12 CEP170 9859
Affinity Capture-MS Homo sapiens
13 CRK 1398
Affinity Capture-MS Homo sapiens
14 TRIM66  
Affinity Capture-MS Homo sapiens
15 HAND2  
Affinity Capture-RNA Homo sapiens
16 TUBB8 347688
Affinity Capture-MS Homo sapiens
17 PRKACG  
Affinity Capture-MS Homo sapiens
18 KIF20A 10112
Affinity Capture-MS Homo sapiens
19 RNMT 8731
Co-fractionation Homo sapiens
20 CBWD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
21 UBC 7316
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
22 EYA2  
Proximity Label-MS Homo sapiens
23 CAND1 55832
Affinity Capture-MS Homo sapiens
24 HNRNPR 10236
Co-fractionation Homo sapiens
25 PTBP3 9991
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 FCHO2 115548
Affinity Capture-RNA Homo sapiens
27 EIF4E2  
Co-fractionation Homo sapiens
28 SOX2  
Affinity Capture-MS Homo sapiens
29 MSI1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
30 POTEF 728378
Affinity Capture-MS Homo sapiens
31 LILRB1  
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
32 TNRC6C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
33 MLLT11  
Affinity Capture-MS Homo sapiens
34 RPS20 6224
Affinity Capture-RNA Homo sapiens
35 MIR302A  
Affinity Capture-RNA Homo sapiens
36 TNRC6A 27327
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 PELI1 57162
Affinity Capture-RNA Homo sapiens
38 COPS6 10980
Affinity Capture-MS Homo sapiens
39 COPS5 10987
Affinity Capture-MS Homo sapiens
40 AGO3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 MIR3118-1  
Affinity Capture-RNA Homo sapiens
42 SOCS5  
Affinity Capture-RNA Homo sapiens
43 MIR223  
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
44 IPO8 10526
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
45 PRKRA 8575
Co-fractionation Homo sapiens
46 CNOT6  
Affinity Capture-Western Homo sapiens
47 TRMT1 55621
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
48 DDX6 1656
Co-fractionation Homo sapiens
49 CALR 811
Co-fractionation Homo sapiens
50 NELFA  
Affinity Capture-MS Homo sapiens
51 CUL1 8454
Affinity Capture-MS Homo sapiens
52 BTRC 8945
Protein-RNA Homo sapiens
53 MYCN  
Affinity Capture-MS Homo sapiens
54 ESYT2 57488
Affinity Capture-RNA Homo sapiens
55 RPS11 6205
Affinity Capture-RNA Homo sapiens
56 KIF14 9928
Affinity Capture-MS Homo sapiens
57 HSPA8 3312
Co-fractionation Homo sapiens
58 ADSL 158
Co-fractionation Homo sapiens
59 TNF  
Affinity Capture-MS Homo sapiens
60 NINL  
Proximity Label-MS Homo sapiens
61 CPEB1  
Proximity Label-MS Homo sapiens
62 HSP90AB4P 664618
Affinity Capture-MS Homo sapiens
63 DHX58 79132
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
64 MIB1 57534
Proximity Label-MS Homo sapiens
65 SHPRH  
Affinity Capture-RNA Homo sapiens
66 YTHDF1 54915
Affinity Capture-MS Homo sapiens
67 CNOT2  
Affinity Capture-Western Homo sapiens
68 MALAT1 378938
Affinity Capture-RNA Homo sapiens
69 RB1CC1 9821
Affinity Capture-MS Homo sapiens
70 PARK2  
Affinity Capture-MS Homo sapiens
71 TARBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 CNOT8  
Affinity Capture-Western Homo sapiens
73 MIRLET7I  
Protein-RNA Homo sapiens
74 MIR101-2  
Affinity Capture-RNA Homo sapiens
75 CPS1 1373
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 HTT 3064
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
77 PFKP 5214
Two-hybrid Homo sapiens
78 PAG1 55824
Affinity Capture-RNA Homo sapiens
79 DDX20 11218
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
80 UBR5 51366
Affinity Capture-Western Homo sapiens
81 PABPC1 26986
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
82 CNOT1 23019
Affinity Capture-Western Homo sapiens
83 FUBP1 8880
Affinity Capture-RNA Homo sapiens
84 ACTN4 81
Co-fractionation Homo sapiens
85 NTRK1 4914
Affinity Capture-MS Homo sapiens
86 DCAF7 10238
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
87 HOTAIR  
Affinity Capture-RNA Homo sapiens
88 MIR127  
Affinity Capture-RNA Homo sapiens
89 TAB2  
Affinity Capture-RNA Homo sapiens
90 SYNCRIP 10492
Co-fractionation Homo sapiens
91 NCL 4691
Co-fractionation Homo sapiens
92 DICER1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 TRIM11  
Affinity Capture-MS Homo sapiens
94 RPL27A 6157
Affinity Capture-RNA Homo sapiens
95 H19 283120
Affinity Capture-RNA Homo sapiens
96 DHX9 1660
Affinity Capture-Western Homo sapiens
97 MIR216A  
Affinity Capture-RNA Homo sapiens
98 CUL2 8453
Affinity Capture-MS Homo sapiens
99 EIF4EBP1  
Affinity Capture-Western Homo sapiens
100 GMPS 8833
Affinity Capture-MS Homo sapiens
101 TRIM31  
Affinity Capture-MS Homo sapiens
102 ITCH 83737
Protein-RNA Homo sapiens
103 TMEFF2  
Affinity Capture-RNA Homo sapiens
104 TRIM63  
Two-hybrid Homo sapiens
105 IGBP1 3476
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
106 RRM1 6240
Co-fractionation Homo sapiens
107 HNRNPD 3184
Affinity Capture-MS Homo sapiens
108 IQSEC1 9922
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
109 MIRLET7B  
Protein-RNA Homo sapiens
110 RNF219  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
111 NR4A1  
Affinity Capture-MS Homo sapiens
112 SKP2  
Affinity Capture-RNA Homo sapiens
113 KDM4D  
Affinity Capture-MS Homo sapiens
114 MTIF2 4528
Affinity Capture-MS Homo sapiens
115 TBKBP1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
116 RC3H2  
Affinity Capture-MS Homo sapiens
117 TRPM7 54822
Affinity Capture-RNA Homo sapiens
118 PRKAR1A 5573
Affinity Capture-MS Homo sapiens
119 PHIP 55023
Affinity Capture-MS Homo sapiens
120 CUL3 8452
Affinity Capture-MS Homo sapiens
121 KLHL29  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
122 MCCC1 56922
Affinity Capture-MS Homo sapiens
123 EIF4E 1977
Co-fractionation Homo sapiens
124 EPRS 2058
Co-fractionation Homo sapiens
125 SNX27 81609
Affinity Capture-MS Homo sapiens
126 TP73  
Affinity Capture-Western Homo sapiens
127 GPRASP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 MIR21  
Affinity Capture-RNA Homo sapiens
129 MIR612  
Affinity Capture-RNA Homo sapiens
130 P4HB 5034
Affinity Capture-MS Homo sapiens
131 TRIM55  
Two-hybrid Homo sapiens
132 CNOT6L 246175
Affinity Capture-Western Homo sapiens
133 CEP250 11190
Affinity Capture-MS Homo sapiens
134 AGO4  
Affinity Capture-MS Homo sapiens
135 MIR145  
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
136 FOS 2353
Affinity Capture-RNA Homo sapiens
137 HNRNPA1 3178
Co-fractionation Homo sapiens
138 MYC  
Affinity Capture-MS Homo sapiens
139 RPA3 6119
Proximity Label-MS Homo sapiens
140 MIR27B  
Affinity Capture-RNA Homo sapiens
141 MEX3D  
Affinity Capture-Western Homo sapiens
142 TP63  
Affinity Capture-Western Homo sapiens
143 HSPA1A 3303
Co-fractionation Homo sapiens
144 BMI1  
Affinity Capture-MS Homo sapiens
145 CDKN1B 1027
Affinity Capture-RNA Homo sapiens
146 TNRC6B  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-RNA Homo sapiens
Affinity Capture-MS Homo sapiens
147 PASK  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 NDUFS2 4720
Affinity Capture-MS Homo sapiens
149 C6orf48  
Affinity Capture-RNA Homo sapiens
150 GEMIN4 50628
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
151 TRIM71  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
152 STUB1 10273
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
153 HSP90AB1 3326
Co-fractionation Homo sapiens
154 MAPKAPK2 9261
Biochemical Activity Homo sapiens
155 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
156 GIGYF2 26058
Affinity Capture-MS Homo sapiens
157 TMEM64  
Affinity Capture-RNA Homo sapiens
158 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
159 FOLR1 2348
Affinity Capture-RNA Homo sapiens
160 AGO1  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 MIR221  
Affinity Capture-RNA Homo sapiens
162 MIR4688  
Affinity Capture-RNA Homo sapiens
163 MCL1 4170
Affinity Capture-RNA Homo sapiens
164 RBM25 58517
Affinity Capture-RNA Homo sapiens
165 CUL5 8065
Affinity Capture-MS Homo sapiens
166 MIR188  
Affinity Capture-RNA Homo sapiens
167 MIR378A  
Affinity Capture-RNA Homo sapiens
168 MIR24-1  
Protein-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
169 DANCR  
Affinity Capture-RNA Homo sapiens
170 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
Affinity Capture-Western Homo sapiens
171 PJA2  
Affinity Capture-RNA Homo sapiens
172 HSP90AA1 3320
Affinity Capture-MS Homo sapiens
173 MIR1180  
Affinity Capture-RNA Homo sapiens
174 FKBP5 2289
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 PDCD4 27250
Affinity Capture-RNA Homo sapiens
176 SQSTM1 8878
Proximity Label-MS Homo sapiens
177 UFL1 23376
Affinity Capture-MS Homo sapiens
178 MIF 4282
Affinity Capture-MS Homo sapiens
179 TBK1 29110
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
180 RBM4 5936
Affinity Capture-Western Homo sapiens
181 MBNL1 4154
Affinity Capture-RNA Homo sapiens
182 GAPDH 2597
Co-fractionation Homo sapiens
183 KRIT1 889
Affinity Capture-RNA Homo sapiens
184 HNRNPL 3191
Co-fractionation Homo sapiens
185 MIR579  
Affinity Capture-RNA Homo sapiens
186 LRRK2 120892
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
187 TRIP4 9325
Affinity Capture-MS Homo sapiens
188 RAPGEF5  
Affinity Capture-RNA Homo sapiens
189 CEP135  
Proximity Label-MS Homo sapiens
190 LDLR 3949
Positive Genetic Homo sapiens
191 C9orf72  
Affinity Capture-MS Homo sapiens
192 ATOH1  
Affinity Capture-MS Homo sapiens
193 USP47 55031
Affinity Capture-RNA Homo sapiens
Affinity Capture-RNA Homo sapiens
194 LINC00668  
Affinity Capture-RNA Homo sapiens
195 DSCAM 1826
Affinity Capture-RNA Homo sapiens
196 HNRNPA2B1 3181
Co-fractionation Homo sapiens
197 CNDP2 55748
Affinity Capture-MS Homo sapiens
198 MIR19A  
Protein-RNA Homo sapiens
View the network image/svg+xml
 Pathways in which AGO2 is involved
PathwayEvidenceSource
Adherens junctions interactions TAS Reactome
Adherens junctions interactions IEA Reactome
Beta-catenin independent WNT signaling TAS Reactome
Ca2+ pathway TAS Reactome
Cell junction organization TAS Reactome
Cell junction organization IEA Reactome
Cell-Cell communication TAS Reactome
Cell-Cell communication IEA Reactome
Cell-cell junction organization TAS Reactome
Cell-cell junction organization IEA Reactome
Competing endogenous RNAs (ceRNAs) regulate PTEN translation TAS Reactome
Developmental Biology IEA Reactome
Developmental Biology TAS Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
ESR-mediated signaling TAS Reactome
Estrogen-dependent gene expression TAS Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Gene Silencing by RNA TAS Reactome
Generic Transcription Pathway TAS Reactome
Generic Transcription Pathway IEA Reactome
Intracellular signaling by second messengers TAS Reactome
M-decay: degradation of maternal mRNAs by maternally stored factors IEA Reactome
MAPK family signaling cascades TAS Reactome
MAPK6/MAPK4 signaling TAS Reactome
Maternal to zygotic transition (MZT) IEA Reactome
MicroRNA (miRNA) biogenesis TAS Reactome
MITF-M-dependent gene expression TAS Reactome
MITF-M-regulated melanocyte development TAS Reactome
NR1H2 and NR1H3-mediated signaling TAS Reactome
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux TAS Reactome
Nuclear events stimulated by ALK signaling in cancer TAS Reactome
PIP3 activates AKT signaling TAS Reactome
Post-transcriptional silencing by small RNAs TAS Reactome
Pre-NOTCH Expression and Processing TAS Reactome
Pre-NOTCH Transcription and Translation TAS Reactome
PTEN Regulation TAS Reactome
Regulation of CDH11 Expression and Function TAS Reactome
Regulation of CDH11 Expression and Function IEA Reactome
Regulation of CDH11 mRNA translation by microRNAs TAS Reactome
Regulation of CDH11 mRNA translation by microRNAs IEA Reactome
Regulation of Expression and Function of Type II Classical Cadherins TAS Reactome
Regulation of Expression and Function of Type II Classical Cadherins IEA Reactome
Regulation of Homotypic Cell-Cell Adhesion TAS Reactome
Regulation of Homotypic Cell-Cell Adhesion IEA Reactome
Regulation of MECP2 expression and activity IEA Reactome
Regulation of MITF-M-dependent genes involved in apoptosis TAS Reactome
Regulation of NPAS4 gene expression TAS Reactome
Regulation of NPAS4 mRNA translation TAS Reactome
Regulation of PTEN mRNA translation TAS Reactome
Regulation of RUNX1 Expression and Activity TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription IEA Reactome
Signal Transduction TAS Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by NOTCH TAS Reactome
Signaling by Nuclear Receptors TAS Reactome
Signaling by TGFB family members TAS Reactome
Signaling by TGFBR3 TAS Reactome
Signaling by WNT TAS Reactome
Small interfering RNA (siRNA) biogenesis TAS Reactome
TGFBR3 expression TAS Reactome
TP53 Regulates Metabolic Genes TAS Reactome
Transcriptional Regulation by MECP2 IEA Reactome
Transcriptional Regulation by MECP2 TAS Reactome
Transcriptional Regulation by NPAS4 TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome
Transcriptional regulation by small RNAs TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome





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