Gene description for C1QBP
Gene name complement component 1, q subcomponent binding protein
Gene symbol C1QBP
Other names/aliases GC1QBP
Species Homo sapiens
 Database cross references - C1QBP
ExoCarta ExoCarta_708
Entrez Gene 708
HGNC 1243
MIM 601269
UniProt Q07021  
 C1QBP identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for C1QBP
Molecular Function
    adrenergic receptor binding GO:0031690 ISS
    mRNA binding GO:0003729 ISS
    protein kinase C binding GO:0005080 IEA
    protein binding GO:0005515 IPI
    hyaluronic acid binding GO:0005540 IDA
    mitochondrial ribosome binding GO:0097177 ISS
    transcription corepressor activity GO:0003714 IDA
    complement component C1q binding GO:0001849 IDA
    transcription factor binding GO:0008134 IDA
    kininogen binding GO:0030984 IDA
Biological Process
    negative regulation of interferon-gamma production GO:0032689 IDA
    blood coagulation, intrinsic pathway GO:0007597 TAS
    positive regulation of protein kinase B signaling GO:0051897 IMP
    positive regulation of trophoblast cell migration GO:1901165 IMP
    positive regulation of cell adhesion GO:0045785 IMP
    positive regulation of mitochondrial translation GO:0070131 ISS
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 IMP
    RNA splicing GO:0008380 IEA
    phosphatidylinositol 3-kinase signaling GO:0014065 IMP
    blood coagulation GO:0007596 TAS
    negative regulation of defense response to virus GO:0050687 IMP
    negative regulation of RIG-I signaling pathway GO:0039536 IDA
    negative regulation of mRNA splicing, via spliceosome GO:0048025 IDA
    mRNA processing GO:0006397 IEA
    positive regulation of dendritic cell chemotaxis GO:2000510 IMP
    positive regulation of neutrophil chemotaxis GO:0090023 IDA
    negative regulation of MDA-5 signaling pathway GO:0039534 IDA
    viral process GO:0016032 IEA
    mature ribosome assembly GO:0042256 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    negative regulation of interleukin-12 production GO:0032695 IDA
    apoptotic process GO:0006915 IEA
    complement activation, classical pathway GO:0006958 IEA
    innate immune response GO:0045087 IEA
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of apoptotic process GO:0043065 IMP
    regulation of complement activation GO:0030449 IDA
    immune response GO:0006955 TAS
Subcellular Localization
    extracellular space GO:0005615 IEA
    cytoplasm GO:0005737 ISS
    nucleolus GO:0005730 IEA
    mitochondrion GO:0005739 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
    cell surface GO:0009986 IDA
    mitochondrial matrix GO:0005759 IEA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified C1QBP in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for C1QBP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK1 5594
Invitro Homo sapiens
Invivo Homo sapiens
2 GAB1  
Affinity Capture-Western Homo sapiens
3 SRSF9 8683
Far Western Homo sapiens
4 SRSF1 6426
Reconstituted Complex Homo sapiens
5 FBL 2091
Affinity Capture-MS Homo sapiens
6 PRKCZ 5590
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
7 MAPK3 5595
Invitro Homo sapiens
Invivo Homo sapiens
8 PRRC2A 7916
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 PRKD1 5587
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
10 MMP14 4323
Invitro Homo sapiens
Invivo Homo sapiens
11 PRKCD 5580
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
12 PRKCA 5578
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which C1QBP is involved
Intrinsic Pathway of Fibrin Clot Formation TAS Reactome

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