Gene description for PTPRO
Gene name protein tyrosine phosphatase, receptor type, O
Gene symbol PTPRO
Other names/aliases GLEPP1
NPHS6
PTP-OC
PTP-U2
PTPROT
PTPU2
R-PTP-O
Species Homo sapiens
 Database cross references - PTPRO
ExoCarta ExoCarta_5800
Vesiclepedia VP_5800
Entrez Gene 5800
HGNC 9678
MIM 600579
UniProt Q16827  
 PTPRO identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for PTPRO
Molecular Function
    protein tyrosine phosphatase activity GO:0004725 IBA
    protein tyrosine phosphatase activity GO:0004725 IDA
    protein tyrosine phosphatase activity GO:0004725 IMP
    protein tyrosine phosphatase activity GO:0004725 TAS
    non-membrane spanning protein tyrosine phosphatase activity GO:0004726 IEA
    transmembrane receptor protein tyrosine phosphatase activity GO:0005001 NAS
    protein binding GO:0005515 IPI
    phosphatase activity GO:0016791 ISS
    Wnt-protein binding GO:0017147 IBA
    Wnt-protein binding GO:0017147 ISS
    protein tyrosine phosphatase activity, metal-dependent GO:0030946 IEA
    protein homodimerization activity GO:0042803 ISS
    cadherin binding GO:0045296 IBA
    cadherin binding GO:0045296 IPI
    histone H2AXY142 phosphatase activity GO:0140793 IEA
Biological Process
    cell morphogenesis GO:0000902 ISS
    monocyte chemotaxis GO:0002548 IMP
    regulation of glomerular filtration GO:0003093 IBA
    regulation of glomerular filtration GO:0003093 ISS
    negative regulation of glomerular filtration GO:0003105 ISS
    chromatin remodeling GO:0006338 IEA
    protein dephosphorylation GO:0006470 ISS
    protein dephosphorylation GO:0006470 TAS
    axon guidance GO:0007411 IBA
    axon guidance GO:0007411 ISS
    negative regulation of cell-substrate adhesion GO:0010812 ISS
    negative regulation of neuron projection development GO:0010977 ISS
    lamellipodium assembly GO:0030032 ISS
    glomerulus development GO:0032835 IMP
    peptidyl-tyrosine dephosphorylation GO:0035335 IMP
    slit diaphragm assembly GO:0036060 ISS
    slit diaphragm assembly GO:0036060 NAS
    regulation of synapse organization GO:0050807 IEA
    podocyte differentiation GO:0072112 IBA
    podocyte differentiation GO:0072112 ISS
    negative regulation of canonical Wnt signaling pathway GO:0090090 IBA
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISS
    negative regulation of retinal ganglion cell axon guidance GO:0090260 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 NAS
    membrane GO:0016020 TAS
    apical plasma membrane GO:0016324 ISS
    lateral plasma membrane GO:0016328 ISS
    lamellipodium GO:0030027 ISS
    axon GO:0030424 ISS
    growth cone GO:0030426 ISS
    neuron projection GO:0043005 ISS
    dendritic spine GO:0043197 ISS
    extracellular exosome GO:0070062 HDA
    postsynaptic density membrane GO:0098839 IEA
    glutamatergic synapse GO:0098978 IBA
    GABA-ergic synapse GO:0098982 IBA
 Experiment description of studies that identified PTPRO in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 193
MISEV standards
EM
Biophysical techniques
CD63|CD9
Enriched markers
PHB
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 194
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 195
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PTPRO
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGB1 3688
Affinity Capture-MS Homo sapiens
2 CNNM4 26504
Affinity Capture-MS Homo sapiens
3 SEP15 9403
Affinity Capture-MS Homo sapiens
4 SPTA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
5 SRPRB 58477
Affinity Capture-MS Homo sapiens
6 GTF2IRD1  
Affinity Capture-MS Homo sapiens
7 SH3GL1 6455
Two-hybrid Homo sapiens
8 MAN1B1 11253
Affinity Capture-MS Homo sapiens
9 MAD2L1BP  
Affinity Capture-MS Homo sapiens
10 TXNDC12 51060
Affinity Capture-MS Homo sapiens
11 APP 351
Reconstituted Complex Homo sapiens
12 UBE2G2  
Affinity Capture-MS Homo sapiens
13 DPPA4  
Two-hybrid Homo sapiens
14 VIL1 7429
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
15 SEL1L 6400
Affinity Capture-MS Homo sapiens
16 HLA-B 3106
Affinity Capture-MS Homo sapiens
17 TMED2 10959
Affinity Capture-MS Homo sapiens
18 SYK 6850
Affinity Capture-Western Homo sapiens
19 DNAJC16  
Affinity Capture-MS Homo sapiens
20 PTK7 5754
Affinity Capture-MS Homo sapiens
21 NGLY1 55768
Affinity Capture-MS Homo sapiens
22 CALR 811
Affinity Capture-MS Homo sapiens
23 MECP2 4204
Affinity Capture-MS Homo sapiens
24 ARL1 400
Affinity Capture-MS Homo sapiens
25 GPX8 493869
Affinity Capture-MS Homo sapiens
26 FKBP10 60681
Affinity Capture-MS Homo sapiens
27 ATP6AP1 537
Affinity Capture-MS Homo sapiens
28 HLA-G 3135
Affinity Capture-MS Homo sapiens
29 LMAN1 3998
Affinity Capture-MS Homo sapiens
30 GOLIM4 27333
Affinity Capture-MS Homo sapiens
31 UFL1 23376
Two-hybrid Homo sapiens
32 KIT 3815
Affinity Capture-Western Homo sapiens
33 NOMO1 23420
Affinity Capture-MS Homo sapiens
34 SEC61A2 55176
Affinity Capture-MS Homo sapiens
35 DPYSL4 10570
Two-hybrid Homo sapiens
36 SDF2 6388
Affinity Capture-MS Homo sapiens
37 TMX1 81542
Affinity Capture-MS Homo sapiens
38 SH3GL3  
Two-hybrid Homo sapiens
39 SDF2L1 23753
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 VCP 7415
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
41 P4HB 5034
Affinity Capture-MS Homo sapiens
42 TMX4 56255
Affinity Capture-MS Homo sapiens
43 PDIA6 10130
Affinity Capture-MS Homo sapiens
44 DNAJC30  
Affinity Capture-MS Homo sapiens
45 SDF4 51150
Affinity Capture-MS Homo sapiens
46 PTPRO 5800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 DNAJB11 51726
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CLN6  
Affinity Capture-MS Homo sapiens
49 CANX 821
Affinity Capture-MS Homo sapiens
50 DNAJB12 54788
Affinity Capture-MS Homo sapiens
51 UGGT1 56886
Affinity Capture-MS Homo sapiens
52 RAB34 83871
Affinity Capture-MS Homo sapiens
53 C2orf47  
Affinity Capture-MS Homo sapiens
54 RAB29 8934
Affinity Capture-MS Homo sapiens
55 ERLEC1 27248
Affinity Capture-MS Homo sapiens
56 YWHAZ 7534
Two-hybrid Homo sapiens
57 PDIA3 2923
Affinity Capture-MS Homo sapiens
58 TMEM246 84302
Affinity Capture-MS Homo sapiens
59 CORO1C 23603
Affinity Capture-MS Homo sapiens
60 SPCS3 60559
Affinity Capture-MS Homo sapiens
61 ERP44 23071
Affinity Capture-MS Homo sapiens
62 CYP51A1 1595
Affinity Capture-MS Homo sapiens
63 CNIH4  
Affinity Capture-MS Homo sapiens
64 MET 4233
Affinity Capture-MS Homo sapiens
65 DNAJC3 5611
Affinity Capture-MS Homo sapiens
66 HYOU1 10525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 B3GAT3 26229
Affinity Capture-MS Homo sapiens
68 GANAB 23193
Affinity Capture-MS Homo sapiens
69 PLXNB2 23654
Affinity Capture-MS Homo sapiens
70 PPIB 5479
Affinity Capture-MS Homo sapiens
71 HLA-A 3105
Affinity Capture-MS Homo sapiens
72 NUP210L  
Affinity Capture-MS Homo sapiens
73 TFRC 7037
Affinity Capture-MS Homo sapiens
74 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
75 PRKCSH 5589
Affinity Capture-MS Homo sapiens
76 TMED10 10972
Affinity Capture-MS Homo sapiens
77 PGRMC1 10857
Affinity Capture-MS Homo sapiens
78 PDIA4 9601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 LGALS3 3958
Affinity Capture-MS Homo sapiens
80 SIL1 64374
Affinity Capture-MS Homo sapiens
81 OS9 10956
Affinity Capture-MS Homo sapiens
82 DDX58 23586
Affinity Capture-RNA Homo sapiens
83 YTHDF3  
Affinity Capture-MS Homo sapiens
84 AUP1 550
Affinity Capture-MS Homo sapiens
85 HLA-H 3136
Affinity Capture-MS Homo sapiens
86 MAN1A2 10905
Affinity Capture-MS Homo sapiens
87 HLA-C 3107
Affinity Capture-MS Homo sapiens
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