Gene description for TRMT10C
Gene name tRNA methyltransferase 10 homolog C (S. cerevisiae)
Gene symbol TRMT10C
Other names/aliases HNYA
MRPP1
RG9MTD1
Species Homo sapiens
 Database cross references - TRMT10C
ExoCarta ExoCarta_54931
Vesiclepedia VP_54931
Entrez Gene 54931
HGNC 26022
MIM 615423
UniProt Q7L0Y3  
 TRMT10C identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
 Gene ontology annotations for TRMT10C
Molecular Function
    tRNA binding GO:0000049 IBA
    tRNA binding GO:0000049 IDA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    tRNA (guanosine(9)-N1)-methyltransferase activity GO:0052905 IDA
    tRNA (adenine(9)-N1)-methyltransferase activity GO:0160106 IDA
Biological Process
    mitochondrial RNA 5'-end processing GO:0000964 IMP
    mRNA processing GO:0006397 IDA
    positive regulation of mitochondrial translation GO:0070131 IBA
    positive regulation of mitochondrial translation GO:0070131 IMP
    mitochondrial tRNA methylation GO:0070901 IDA
    mitochondrial tRNA processing GO:0090646 IMP
    mitochondrial tRNA 5'-end processing GO:0097745 IBA
    mitochondrial tRNA 5'-end processing GO:0097745 IDA
    mitochondrial tRNA 3'-end processing GO:1990180 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IMP
    mitochondrial matrix GO:0005759 TAS
    mitochondrial ribonuclease P complex GO:0030678 IPI
    mitochondrial ribonuclease P complex GO:0030678 TAS
    mitochondrial nucleoid GO:0042645 IDA
    tRNA methyltransferase complex GO:0043527 IPI
 Experiment description of studies that identified TRMT10C in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TRMT10C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 Mdm2  
Affinity Capture-MS Mus musculus
3 SLIRP 81892
Proximity Label-MS Homo sapiens
4 PMPCA 23203
Proximity Label-MS Homo sapiens
5 Smc1a  
Affinity Capture-MS Mus musculus
6 ANLN 54443
Affinity Capture-MS Homo sapiens
7 RPA2 6118
Proximity Label-MS Homo sapiens
8 TRUB2  
Proximity Label-MS Homo sapiens
9 NOP56 10528
Affinity Capture-MS Homo sapiens
10 MTG2  
Proximity Label-MS Homo sapiens
11 NGRN  
Proximity Label-MS Homo sapiens
12 CHCHD1  
Proximity Label-MS Homo sapiens
13 SSB 6741
Affinity Capture-MS Homo sapiens
14 CAND1 55832
Affinity Capture-MS Homo sapiens
15 RPUSD4 84881
Proximity Label-MS Homo sapiens
16 VWA5A 4013
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DNAJC15  
Proximity Label-MS Homo sapiens
18 MTRF1  
Proximity Label-MS Homo sapiens
19 GFM2 84340
Proximity Label-MS Homo sapiens
20 CCDC90B  
Proximity Label-MS Homo sapiens
21 LRPPRC 10128
Proximity Label-MS Homo sapiens
22 C9orf78 51759
Affinity Capture-MS Homo sapiens
23 TFAM 7019
Proximity Label-MS Homo sapiens
24 KIF23 9493
Affinity Capture-MS Homo sapiens
25 USP39 10713
Affinity Capture-MS Homo sapiens
26 CHCHD2  
Affinity Capture-MS Homo sapiens
27 FBXW7  
Affinity Capture-MS Homo sapiens
28 HINT2 84681
Proximity Label-MS Homo sapiens
29 POU5F1  
Affinity Capture-MS Homo sapiens
30 MRPS26 64949
Proximity Label-MS Homo sapiens
31 EXD2  
Proximity Label-MS Homo sapiens
32 CEP57  
Affinity Capture-MS Homo sapiens
33 MECP2 4204
Affinity Capture-MS Homo sapiens
34 Eif3a 13669
Affinity Capture-MS Mus musculus
35 PMPCB 9512
Proximity Label-MS Homo sapiens
36 TACO1  
Proximity Label-MS Homo sapiens
37 FASTKD2  
Proximity Label-MS Homo sapiens
38 VWA8 23078
Proximity Label-MS Homo sapiens
39 MTERF3  
Proximity Label-MS Homo sapiens
40 KIF14 9928
Affinity Capture-MS Homo sapiens
41 MDH2 4191
Proximity Label-MS Homo sapiens
42 DLD 1738
Affinity Capture-MS Homo sapiens
43 C6orf203  
Proximity Label-MS Homo sapiens
44 Gtf3c4  
Affinity Capture-MS Mus musculus
45 FASTKD5  
Proximity Label-MS Homo sapiens
46 PARK2  
Affinity Capture-MS Homo sapiens
47 MAP1B 4131
Co-fractionation Homo sapiens
48 HADHA 3030
Co-fractionation Homo sapiens
49 TUFM 7284
Proximity Label-MS Homo sapiens
50 HSCB 150274
Proximity Label-MS Homo sapiens
51 NTRK1 4914
Affinity Capture-MS Homo sapiens
52 CCDC109B 55013
Proximity Label-MS Homo sapiens
53 TBRG4 9238
Proximity Label-MS Homo sapiens
54 MTFMT  
Proximity Label-MS Homo sapiens
55 MRPL11 65003
Proximity Label-MS Homo sapiens
56 MTRF1L  
Proximity Label-MS Homo sapiens
57 SDPR 8436
Co-fractionation Homo sapiens
58 H2AFY 9555
Co-fractionation Homo sapiens
59 TMEM70  
Proximity Label-MS Homo sapiens
60 CISD3 284106
Affinity Capture-MS Homo sapiens
61 C15orf48  
Affinity Capture-MS Homo sapiens
62 OGT 8473
Reconstituted Complex Homo sapiens
63 OTC 5009
Proximity Label-MS Homo sapiens
64 MRRF  
Proximity Label-MS Homo sapiens
65 AIFM1 9131
Proximity Label-MS Homo sapiens
66 MRPS12  
Proximity Label-MS Homo sapiens
67 MTIF2 4528
Proximity Label-MS Homo sapiens
68 Cct3 12462
Affinity Capture-MS Mus musculus
69 MTIF3  
Proximity Label-MS Homo sapiens
70 CUL3 8452
Affinity Capture-MS Homo sapiens
71 DUSP26 78986
Affinity Capture-MS Homo sapiens
72 EGFR 1956
Affinity Capture-MS Homo sapiens
73 HSD17B10 3028
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
74 ELAC2 60528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 DHX30 22907
Proximity Label-MS Homo sapiens
76 C12orf65  
Proximity Label-MS Homo sapiens
77 MYCN  
Affinity Capture-MS Homo sapiens
78 MTG1  
Proximity Label-MS Homo sapiens
79 TRNI  
Biochemical Activity Homo sapiens
80 ACAD9 28976
Proximity Label-MS Homo sapiens
81 DDRGK1 65992
Affinity Capture-MS Homo sapiens
82 RHOB 388
Proximity Label-MS Homo sapiens
83 Rpl35 66489
Affinity Capture-MS Mus musculus
84 TRNT1 51095
Affinity Capture-MS Homo sapiens
85 HSPA9 3313
Proximity Label-MS Homo sapiens
86 METTL15  
Proximity Label-MS Homo sapiens
87 AKAP1 8165
Proximity Label-MS Homo sapiens
88 MCUR1 63933
Proximity Label-MS Homo sapiens
89 CLPP 8192
Proximity Label-MS Homo sapiens
90 DNAJC28  
Proximity Label-MS Homo sapiens
91 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
92 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
93 TSFM 10102
Proximity Label-MS Homo sapiens
94 AUH 549
Proximity Label-MS Homo sapiens
95 HDGF 3068
Affinity Capture-MS Homo sapiens
96 DNAJC19 131118
Proximity Label-MS Homo sapiens
97 TP53 7157
Affinity Capture-MS Homo sapiens
98 CEP76  
Affinity Capture-MS Homo sapiens
99 ICT1 3396
Proximity Label-MS Homo sapiens
100 HECTD3 79654
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 LONP1 9361
Proximity Label-MS Homo sapiens
102 TPTE  
Proximity Label-MS Homo sapiens
103 ASB1 51665
Affinity Capture-MS Homo sapiens
104 ZZEF1 23140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 PDHA1 5160
Proximity Label-MS Homo sapiens
106 COX8A  
Proximity Label-MS Homo sapiens
107 C21orf33  
Proximity Label-MS Homo sapiens
108 SSBP1 6742
Proximity Label-MS Homo sapiens
109 PPM1G 5496
Co-fractionation Homo sapiens
110 UFL1 23376
Affinity Capture-MS Homo sapiens
111 FASTKD3  
Proximity Label-MS Homo sapiens
112 GFM1 85476
Proximity Label-MS Homo sapiens
113 AARS2  
Proximity Label-MS Homo sapiens
114 TEFM  
Proximity Label-MS Homo sapiens
115 RPUSD3  
Proximity Label-MS Homo sapiens
116 CIT 11113
Affinity Capture-MS Homo sapiens
117 GRSF1 2926
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
118 C1QBP 708
Proximity Label-MS Homo sapiens
119 SERBP1 26135
Affinity Capture-MS Homo sapiens
120 METTL17  
Proximity Label-MS Homo sapiens
121 ARHGEF10L 55160
Affinity Capture-MS Homo sapiens
122 DDX28  
Proximity Label-MS Homo sapiens
View the network image/svg+xml



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