Gene description for SLC25A13
Gene name solute carrier family 25 (aspartate/glutamate carrier), member 13
Gene symbol SLC25A13
Other names/aliases ARALAR2
CITRIN
CTLN2
Species Homo sapiens
 Database cross references - SLC25A13
ExoCarta ExoCarta_10165
Vesiclepedia VP_10165
Entrez Gene 10165
HGNC 10983
MIM 603859
UniProt Q9UJS0  
 SLC25A13 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for SLC25A13
Molecular Function
    3-sulfino-L-alanine: proton, glutamate antiporter activity GO:0000514 IDA
    aspartate:glutamate, proton antiporter activity GO:0000515 IDA
    L-glutamate transmembrane transporter activity GO:0005313 IBA
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    L-aspartate transmembrane transporter activity GO:0015183 IBA
    identical protein binding GO:0042802 IDA
Biological Process
    gluconeogenesis GO:0006094 IEA
    ATP biosynthetic process GO:0006754 IDA
    mitochondrial transport GO:0006839 NAS
    neutral amino acid transport GO:0015804 IEA
    aspartate transmembrane transport GO:0015810 IBA
    aspartate transmembrane transport GO:0015810 IDA
    L-glutamate transmembrane transport GO:0015813 IBA
    L-glutamate transmembrane transport GO:0015813 IDA
    malate-aspartate shuttle GO:0043490 IBA
    malate-aspartate shuttle GO:0043490 IDA
    malate-aspartate shuttle GO:0043490 IGI
    cellular respiration GO:0045333 IDA
    response to calcium ion GO:0051592 IDA
    L-aspartate transmembrane transport GO:0070778 IEA
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 ISS
    mitochondrial inner membrane GO:0005743 TAS
    plasma membrane GO:0005886 NAS
 Experiment description of studies that identified SLC25A13 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for SLC25A13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 PDHA1 5160
Affinity Capture-MS Homo sapiens
3 HACD3 51495
Co-fractionation Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 HDAC4  
Affinity Capture-MS Homo sapiens
6 POR 5447
Co-fractionation Homo sapiens
7 SPRTN  
Affinity Capture-MS Homo sapiens
8 COIL  
Proximity Label-MS Homo sapiens
9 ALDH3B2  
Affinity Capture-MS Homo sapiens
10 SKI 6497
Affinity Capture-MS Homo sapiens
11 CSNK1A1 1452
Affinity Capture-MS Homo sapiens
12 CRK 1398
Affinity Capture-MS Homo sapiens
13 ADRB2  
Affinity Capture-MS Homo sapiens
14 ALB 213
Affinity Capture-MS Homo sapiens
15 C9orf78 51759
Affinity Capture-MS Homo sapiens
16 UBC 7316
Affinity Capture-MS Homo sapiens
17 ASXL1  
Affinity Capture-MS Homo sapiens
18 CENPA  
Proximity Label-MS Homo sapiens
19 KIAA1429 25962
Affinity Capture-MS Homo sapiens
20 CORO1B 57175
Co-fractionation Homo sapiens
21 B3GNT2 10678
Affinity Capture-MS Homo sapiens
22 HSP90AA1 3320
Cross-Linking-MS (XL-MS) Homo sapiens
23 MCM2 4171
Affinity Capture-MS Homo sapiens
24 PHB2 11331
Proximity Label-MS Homo sapiens
25 FBXW7  
Affinity Capture-MS Homo sapiens
26 PRC1 9055
Affinity Capture-MS Homo sapiens
27 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PPEF1  
Affinity Capture-MS Homo sapiens
29 Ncstn 59287
Affinity Capture-MS Mus musculus
30 COMT 1312
Co-fractionation Homo sapiens
31 VDAC1 7416
Affinity Capture-MS Homo sapiens
32 NDUFV1 4723
Co-fractionation Homo sapiens
33 ATG16L1 55054
Affinity Capture-MS Homo sapiens
34 MECP2 4204
Affinity Capture-MS Homo sapiens
35 Cct4 12464
Affinity Capture-MS Mus musculus
36 HSD17B4 3295
Co-fractionation Homo sapiens
37 MYCN  
Affinity Capture-MS Homo sapiens
38 HK1 3098
Co-fractionation Homo sapiens
39 RNF148  
Affinity Capture-MS Homo sapiens
40 NEIL3  
Affinity Capture-MS Homo sapiens
41 LAMTOR1 55004
Proximity Label-MS Homo sapiens
42 SFXN1 94081
Proximity Label-MS Homo sapiens
43 NUP155 9631
Proximity Label-MS Homo sapiens
44 ALPI  
Affinity Capture-MS Homo sapiens
45 APOO 79135
Proximity Label-MS Homo sapiens
46 BAG5 9529
Affinity Capture-MS Homo sapiens
47 EFNA2  
Affinity Capture-MS Homo sapiens
48 NF2 4771
Affinity Capture-MS Homo sapiens
49 UFL1 23376
Affinity Capture-MS Homo sapiens
50 POLD1 5424
Affinity Capture-MS Homo sapiens
51 ASB8  
Affinity Capture-MS Homo sapiens
52 IRAK1  
Affinity Capture-MS Homo sapiens
53 USP11 8237
Affinity Capture-MS Homo sapiens
54 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 BRE 9577
Affinity Capture-MS Homo sapiens
56 ATF2  
Affinity Capture-MS Homo sapiens
57 SP7  
Affinity Capture-MS Homo sapiens
58 CHMP4B 128866
Affinity Capture-MS Homo sapiens
59 BTF3 689
Affinity Capture-MS Homo sapiens
60 VCP 7415
Co-fractionation Homo sapiens
61 NTRK1 4914
Affinity Capture-MS Homo sapiens
62 IFI16 3428
Affinity Capture-MS Homo sapiens
63 ESR1  
Affinity Capture-MS Homo sapiens
64 HUWE1 10075
Affinity Capture-MS Homo sapiens
65 UQCRC1 7384
Co-fractionation Homo sapiens
66 DHFRL1  
Proximity Label-MS Homo sapiens
67 HECTD1 25831
Affinity Capture-MS Homo sapiens
68 CYLD  
Affinity Capture-MS Homo sapiens
69 COX4I1 1327
Proximity Label-MS Homo sapiens
70 KDF1  
Affinity Capture-MS Homo sapiens
71 SLC25A12 8604
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 AIFM1 9131
Proximity Label-MS Homo sapiens
73 BCKDHB 594
Co-fractionation Homo sapiens
74 AMBRA1  
Affinity Capture-MS Homo sapiens
75 LRRC59 55379
Co-fractionation Homo sapiens
76 RC3H2  
Affinity Capture-MS Homo sapiens
77 SIRT7  
Affinity Capture-MS Homo sapiens
78 LRRC25  
Affinity Capture-MS Homo sapiens
79 CTNNB1 1499
Affinity Capture-MS Homo sapiens
80 MGARP  
Affinity Capture-MS Homo sapiens
81 CUL3 8452
Affinity Capture-MS Homo sapiens
82 SLX1B  
Affinity Capture-MS Homo sapiens
83 EGFR 1956
Affinity Capture-MS Homo sapiens
84 ARF6 382
Proximity Label-MS Homo sapiens
85 FBXO6 26270
Affinity Capture-MS Homo sapiens
86 RAB35 11021
Proximity Label-MS Homo sapiens
87 RIPK4  
Affinity Capture-MS Homo sapiens
88 LARS 51520
Co-fractionation Homo sapiens
89 AURKB 9212
Affinity Capture-MS Homo sapiens
90 FASN 2194
Negative Genetic Homo sapiens
91 PRKACA 5566
Affinity Capture-MS Homo sapiens
92 MAPK6  
Affinity Capture-MS Homo sapiens
93 SOAT1 6646
Affinity Capture-MS Homo sapiens
94 MYC  
Affinity Capture-MS Homo sapiens
95 RPA3 6119
Proximity Label-MS Homo sapiens
96 EMC2 9694
Co-fractionation Homo sapiens
97 ATP6V1A 523
Co-fractionation Homo sapiens
98 DLST 1743
Affinity Capture-MS Homo sapiens
99 DDRGK1 65992
Affinity Capture-MS Homo sapiens
100 RHOB 388
Proximity Label-MS Homo sapiens
101 ILK 3611
Affinity Capture-MS Homo sapiens
102 XRCC3  
Affinity Capture-MS Homo sapiens
103 ISLR 3671
Affinity Capture-MS Homo sapiens
104 SIK2  
Affinity Capture-MS Homo sapiens
105 ARAF 369
Affinity Capture-MS Homo sapiens
106 BRD9 65980
Affinity Capture-MS Homo sapiens
107 CORO1C 23603
Co-fractionation Homo sapiens
108 AKAP1 8165
Proximity Label-MS Homo sapiens
109 SCCPDH 51097
Co-fractionation Homo sapiens
110 CCDC8  
Affinity Capture-MS Homo sapiens
111 EIF3H 8667
Affinity Capture-MS Homo sapiens
112 IMMT 10989
Co-fractionation Homo sapiens
113 KRT18 3875
Proximity Label-MS Homo sapiens
114 PPT1 5538
Affinity Capture-MS Homo sapiens
115 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
116 AATK  
Affinity Capture-MS Homo sapiens
117 Tubg1 103733
Affinity Capture-MS Mus musculus
118 USP50  
Affinity Capture-MS Homo sapiens
119 PARP1 142
Proximity Label-MS Homo sapiens
120 GRB2 2885
Affinity Capture-MS Homo sapiens
121 C11orf52 91894
Proximity Label-MS Homo sapiens
122 FBXL6  
Affinity Capture-MS Homo sapiens
123 TP53 7157
Affinity Capture-MS Homo sapiens
124 ICT1 3396
Affinity Capture-MS Homo sapiens
125 ZEB1  
Affinity Capture-MS Homo sapiens
126 ZNF746  
Affinity Capture-MS Homo sapiens
127 MFI2 4241
Affinity Capture-MS Homo sapiens
128 EMC4 51234
Co-fractionation Homo sapiens
129 NDUFS7 374291
Co-fractionation Homo sapiens
130 ELAVL1 1994
Co-fractionation Homo sapiens
131 SFTPA2  
Affinity Capture-MS Homo sapiens
132 OTUB1 55611
Affinity Capture-MS Homo sapiens
133 ATP2A2 488
Co-fractionation Homo sapiens
134 AGO4  
Affinity Capture-MS Homo sapiens
135 Tuba3a 22144
Affinity Capture-MS Mus musculus
136 BABAM1 29086
Affinity Capture-MS Homo sapiens
137 NNT 23530
Co-fractionation Homo sapiens
138 DDX3X 1654
Affinity Capture-MS Homo sapiens
139 C16orf72 29035
Affinity Capture-MS Homo sapiens
140 MRPL46  
Co-fractionation Homo sapiens
141 SERBP1 26135
Affinity Capture-MS Homo sapiens
142 ANK3  
Proximity Label-MS Homo sapiens
143 C9orf72  
Affinity Capture-MS Homo sapiens
144 NEFM 4741
Proximity Label-MS Homo sapiens
145 IKBKB 3551
Affinity Capture-MS Homo sapiens
146 LIMK2 3985
Affinity Capture-MS Homo sapiens
147 RBCK1  
Affinity Capture-MS Homo sapiens
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