Gene description for HMGB1
Gene name	high mobility group box 1
Gene symbol	HMGB1
Other names/aliases	HMG1 HMG3 SBP-1
Species	Homo sapiens
Database cross references - HMGB1
ExoCarta	ExoCarta_3146
Entrez Gene	3146
HGNC	4983
MIM	163905
UniProt	P09429
HMGB1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Colorectal cancer cells	25890246
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Squamous carcinoma cells	20124223

Gene ontology annotations for HMGB1

Molecular Function     single-stranded DNA binding GO:0003697 ISS     cytokine activity GO:0005125 ISS     protein binding GO:0005515 IPI     double-stranded DNA binding GO:0003690 ISS     repressing transcription factor binding GO:0070491 IPI     poly(A) RNA binding GO:0044822 IDA     damaged DNA binding GO:0003684 ISS     sequence-specific DNA binding transcription factor activity GO:0003700 IDA     chemoattractant activity GO:0042056 ISS     RAGE receptor binding GO:0050786 ISS     chromatin binding GO:0003682 IBA     DNA binding, bending GO:0008301 ISS     transcription factor binding GO:0008134 IPI Biological Process     chromatin remodeling GO:0006338 IBA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     DNA topological change GO:0006265 ISS     apoptotic DNA fragmentation GO:0006309 TAS     apoptotic process GO:0006915 TAS     base-excision repair, DNA ligation GO:0006288 IDA     inflammatory response GO:0006954 IDA     cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS     myeloid dendritic cell activation GO:0001773 ISS     inflammatory response to antigenic stimulus GO:0002437 IEP     positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 IDA     regulation of transcription from RNA polymerase II promoter GO:0006357 IDA     programmed cell death GO:0012501 TAS     negative regulation of blood vessel endothelial cell migration GO:0043537 IDA     positive regulation of apoptotic process GO:0043065 IDA     DNA recombination GO:0006310 ISS     positive chemotaxis GO:0050918 ISS     V(D)J recombination GO:0033151 IDA     negative regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0017055 IDA     positive regulation of DNA binding GO:0043388 IDA     dendritic cell chemotaxis GO:0002407 ISS     innate immune response GO:0045087 TAS     DNA ligation involved in DNA repair GO:0051103 ISS     negative regulation of apoptotic cell clearance GO:2000426 IEA     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     neuron projection development GO:0031175 ISS Subcellular Localization     transcriptional repressor complex GO:0017053 IDA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     cell surface GO:0009986 IDA     extracellular space GO:0005615 IDA     condensed chromosome GO:0000793 IDA     extracellular region GO:0005576 TAS