Gene description for G3BP2
Gene name GTPase activating protein (SH3 domain) binding protein 2
Gene symbol G3BP2
Other names/aliases -
Species Homo sapiens
 Database cross references - G3BP2
ExoCarta ExoCarta_9908
Entrez Gene 9908
HGNC 30291
UniProt Q9UN86  
 G3BP2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for G3BP2
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    receptor signaling complex scaffold activity GO:0030159 NAS
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
Biological Process
    Ras protein signal transduction GO:0007265 NAS
    mRNA transport GO:0051028 IEA
    cytoplasmic sequestering of NF-kappaB GO:0007253 NAS
Subcellular Localization
    cytoplasm GO:0005737 NAS
 Experiment description of studies that identified G3BP2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for G3BP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NFKB1 4790
Invivo Homo sapiens
Invitro Homo sapiens
2 STK24 8428
Affinity Capture-MS Homo sapiens
3 NFKBIA  
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which G3BP2 is involved
No pathways found





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