Gene description for PELP1
Gene name proline, glutamate and leucine rich protein 1
Gene symbol PELP1
Other names/aliases MNAR
P160
Species Homo sapiens
 Database cross references - PELP1
ExoCarta ExoCarta_27043
Entrez Gene 27043
HGNC 30134
MIM 609455
UniProt Q8IZL8  
 PELP1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for PELP1
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 IPI
Biological Process
    transcription, DNA-templated GO:0006351 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    cellular response to estrogen stimulus GO:0071391 IDA
Subcellular Localization
    membrane GO:0016020 IDA
    nucleolus GO:0005730 IDA
    nucleoplasm GO:0005654 IDA
    MLL1 complex GO:0071339 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IEA
    transcriptionally active chromatin GO:0035327 IDA
 Experiment description of studies that identified PELP1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PELP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RB1 5925
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 ESR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 TOM1L1 10040
Two-hybrid Homo sapiens
4 SRC 6714
Affinity Capture-Western Homo sapiens
5 AR 367
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
6 ESR2  
Invitro Homo sapiens
7 NR3C1 2908
Invitro Homo sapiens
8 CREBBP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
9 BAG6 7917
Two-hybrid Homo sapiens
10 EP300 2033
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which PELP1 is involved
No pathways found





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