Gene description for CPSF7
Gene name cleavage and polyadenylation specific factor 7, 59kDa
Gene symbol CPSF7
Other names/aliases CFIm59
Species Homo sapiens
 Database cross references - CPSF7
ExoCarta ExoCarta_79869
Entrez Gene 79869
HGNC 30098
UniProt Q8N684  
 CPSF7 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for CPSF7
Molecular Function
    protein binding GO:0005515 IPI
    nucleotide binding GO:0000166 IEA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 TAS
    mRNA 3'-end processing GO:0031124 TAS
    transcription from RNA polymerase II promoter GO:0006366 TAS
    gene expression GO:0010467 TAS
    RNA splicing GO:0008380 TAS
    termination of RNA polymerase II transcription GO:0006369 TAS
    protein tetramerization GO:0051262 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    membrane GO:0016020 IDA
    mRNA cleavage factor complex GO:0005849 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified CPSF7 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CPSF7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SORBS3 10174
Two-hybrid Homo sapiens
2 GCC1  
Two-hybrid Homo sapiens
3 NUDT21 11051
Two-hybrid Homo sapiens
4 NCK2 8440
Two-hybrid Homo sapiens
5 EWSR1 2130
Two-hybrid Homo sapiens
6 HRMT1L1  
Two-hybrid Homo sapiens
7 DVL2 1856
Two-hybrid Homo sapiens
View the network image/svg+xml



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