Gene description for PSMC5
Gene name	proteasome (prosome, macropain) 26S subunit, ATPase, 5
Gene symbol	PSMC5
Other names/aliases	S8 SUG-1 SUG1 TBP10 TRIP1 p45 p45/SUG
Species	Homo sapiens
Database cross references - PSMC5
ExoCarta	ExoCarta_5705
Entrez Gene	5705
HGNC	9552
MIM	601681
UniProt	P62195
PSMC5 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Mesenchymal stem cells	Unpublished / Not applicable
Neuroblastoma cells	25944692
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Squamous carcinoma cells	20124223
Thymus	23844026
Urine	19056867

Gene ontology annotations for PSMC5

Molecular Function     TBP-class protein binding GO:0017025 IBA     transcription cofactor activity GO:0003712 TAS     proteasome-activating ATPase activity GO:0036402 IBA     ATP binding GO:0005524 IEA     transcription factor binding GO:0008134 IPI     thyrotropin-releasing hormone receptor binding GO:0031531 IPI     protein binding GO:0005515 IPI     ATPase activity GO:0016887 TAS Biological Process     antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS     negative regulation of programmed cell death GO:0043069 NAS     positive regulation of transcription, DNA-templated GO:0045893 NAS     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     gene expression GO:0010467 TAS     G1/S transition of mitotic cell cycle GO:0000082 TAS     positive regulation of canonical Wnt signaling pathway GO:0090263 TAS     cellular nitrogen compound metabolic process GO:0034641 TAS     regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 TAS     apoptotic process GO:0006915 TAS     positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS     negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051436 TAS     programmed cell death GO:0012501 TAS     positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 IBA     positive regulation of proteasomal protein catabolic process GO:1901800 IBA     antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 TAS     mitotic cell cycle GO:0000278 TAS     viral process GO:0016032 TAS     small molecule metabolic process GO:0044281 TAS     innate immune response GO:0045087 TAS     stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS     positive regulation of inclusion body assembly GO:0090261 IEA     ER-associated ubiquitin-dependent protein catabolic process GO:0030433 IBA     DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS     regulation of cellular amino acid metabolic process GO:0006521 TAS     anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 TAS     negative regulation of apoptotic process GO:0043066 TAS     transcription from RNA polymerase II promoter GO:0006366 TAS     antigen processing and presentation of peptide antigen via MHC class I GO:0002474 TAS     regulation of apoptotic process GO:0042981 TAS     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS     protein polyubiquitination GO:0000209 TAS     negative regulation of transcription, DNA-templated GO:0045892 IEA Subcellular Localization     proteasome complex GO:0000502 IDA     proteasome accessory complex GO:0022624 ISS     membrane GO:0016020 IDA     cytoplasm GO:0005737 IDA     nucleus GO:0005634 IDA     blood microparticle GO:0072562 IDA     extracellular exosome GO:0070062 IDA     cytosol GO:0005829 TAS     inclusion body GO:0016234 IEA     cytosolic proteasome complex GO:0031597 IBA     proteasome regulatory particle, base subcomplex GO:0008540 IBA     cytoplasmic vesicle GO:0031410 IDA     nuclear proteasome complex GO:0031595 IBA     nucleoplasm GO:0005654 TAS