Gene description for SELM
Gene name selenoprotein M
Gene symbol SELM
Other names/aliases SEPM
Species Homo sapiens
 Database cross references - SELM
ExoCarta ExoCarta_140606
Vesiclepedia VP_140606
Entrez Gene 140606
MIM 610918
UniProt Q8WWX9  
 SELM identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SELM
Molecular Function
    protein binding GO:0005515 IPI
    oxidoreductase activity GO:0016491 IBA
Biological Process
    response to selenium ion GO:0010269 IEA
    multicellular organism growth GO:0035264 IEA
    corticosterone secretion GO:0035934 IEA
    hormone metabolic process GO:0042445 IEA
    adipose tissue development GO:0060612 IEA
Subcellular Localization
    endoplasmic reticulum lumen GO:0005788 IBA
    Golgi apparatus GO:0005794 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified SELM in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SELM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC11C 90701
Two-hybrid Homo sapiens
2 NIPA1  
Two-hybrid Homo sapiens
3 NAT10 55226
Affinity Capture-MS Homo sapiens
4 HSPE1 3336
Two-hybrid Homo sapiens
5 UFL1 23376
Affinity Capture-MS Homo sapiens
6 ASPN 54829
Affinity Capture-MS Homo sapiens
7 SGTB  
Two-hybrid Homo sapiens
8 TMEM31  
Two-hybrid Homo sapiens
9 KRTAP12-3  
Two-hybrid Homo sapiens
10 MDFI  
Two-hybrid Homo sapiens
11 MTUS2 23281
Two-hybrid Homo sapiens
12 RAB11FIP5 26056
Co-fractionation Homo sapiens
13 NENF 29937
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 RAB32 10981
Co-fractionation Homo sapiens
15 REEP4  
Two-hybrid Homo sapiens
16 KRTAP1-3  
Two-hybrid Homo sapiens
17 KRTAP10-3  
Two-hybrid Homo sapiens
18 UBE2H 7328
Affinity Capture-MS Homo sapiens
19 NOTCH2NL 388677
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SELM is involved
No pathways found





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