Gene description for SARS2
Gene name seryl-tRNA synthetase 2, mitochondrial
Gene symbol SARS2
Other names/aliases SARS
SARSM
SERS
SYS
SerRS
SerRSmt
mtSerRS
Species Homo sapiens
 Database cross references - SARS2
ExoCarta ExoCarta_54938
Vesiclepedia VP_54938
Entrez Gene 54938
HGNC 17697
MIM 612804
UniProt Q9NP81  
 SARS2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SARS2
Molecular Function
    tRNA binding GO:0000049 IBA
    RNA binding GO:0003723 HDA
    serine-tRNA ligase activity GO:0004828 IBA
    serine-tRNA ligase activity GO:0004828 ISS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 ISS
Biological Process
    seryl-tRNA aminoacylation GO:0006434 ISS
    mitochondrial seryl-tRNA aminoacylation GO:0070158 IBA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 ISS
    mitochondrial matrix GO:0005759 TAS
    cytosol GO:0005829 IBA
 Experiment description of studies that identified SARS2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SARS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATG16L1 55054
Affinity Capture-MS Homo sapiens
2 UBR4 23352
Affinity Capture-MS Homo sapiens
3 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
4 CISD3 284106
Affinity Capture-MS Homo sapiens
5 RIT1 6016
Negative Genetic Homo sapiens
6 HSCB 150274
Proximity Label-MS Homo sapiens
7 UBE2H 7328
Affinity Capture-MS Homo sapiens
8 SBDS 51119
Co-fractionation Homo sapiens
9 GLUD1 2746
Co-fractionation Homo sapiens
10 SPTAN1 6709
Co-fractionation Homo sapiens
11 TSFM 10102
Proximity Label-MS Homo sapiens
12 AUH 549
Proximity Label-MS Homo sapiens
13 UBE2A  
Affinity Capture-MS Homo sapiens
14 ILF3 3609
Co-fractionation Homo sapiens
15 DNAJA3 9093
Proximity Label-MS Homo sapiens
16 FBXL6  
Affinity Capture-MS Homo sapiens
17 KIF14 9928
Affinity Capture-MS Homo sapiens
18 ESR1  
Reconstituted Complex Homo sapiens
19 USP15 9958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ICT1 3396
Affinity Capture-MS Homo sapiens
21 CLPP 8192
Proximity Label-MS Homo sapiens
22 MAPK1 5594
Co-fractionation Homo sapiens
23 CALU 813
Co-fractionation Homo sapiens
24 RPA2 6118
Proximity Label-MS Homo sapiens
25 NF2 4771
Affinity Capture-MS Homo sapiens
26 NFATC1 4772
Affinity Capture-MS Homo sapiens
27 KCMF1 56888
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PDHA1 5160
Proximity Label-MS Homo sapiens
29 FOXA1  
Affinity Capture-MS Homo sapiens
30 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 USP44  
Affinity Capture-MS Homo sapiens
32 WDYHV1  
Two-hybrid Homo sapiens
33 DMWD  
Affinity Capture-MS Homo sapiens
34 NENF 29937
Co-fractionation Homo sapiens
35 BPNT1 10380
Affinity Capture-MS Homo sapiens
36 PARK2  
Affinity Capture-MS Homo sapiens
37 PUF60 22827
Affinity Capture-MS Homo sapiens
38 MTHFD1 4522
Co-fractionation Homo sapiens
39 SPATA20  
Affinity Capture-MS Homo sapiens
40 TARS 6897
Co-fractionation Homo sapiens
41 PPT2  
Co-fractionation Homo sapiens
42 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
43 ILF2 3608
Co-fractionation Homo sapiens
44 TUFM 7284
Co-fractionation Homo sapiens
45 APEX1 328
Affinity Capture-RNA Homo sapiens
46 CCT6A 908
Co-fractionation Homo sapiens
47 PPTC7 160760
Affinity Capture-MS Homo sapiens
48 MTIF2 4528
Proximity Label-MS Homo sapiens
49 E2F4  
Affinity Capture-MS Homo sapiens
50 LRWD1  
Affinity Capture-MS Homo sapiens
51 MCUR1 63933
Proximity Label-MS Homo sapiens
52 UBE2B 7320
Affinity Capture-MS Homo sapiens
53 VWA8 23078
Affinity Capture-MS Homo sapiens
54 PRKCDBP 112464
Co-fractionation Homo sapiens
55 GUF1  
Affinity Capture-MS Homo sapiens
56 NTRK1 4914
Affinity Capture-MS Homo sapiens
57 EGFR 1956
Negative Genetic Homo sapiens
58 IFI16 3428
Affinity Capture-MS Homo sapiens
59 CHCHD2  
Affinity Capture-MS Homo sapiens
60 HARS2 23438
Co-fractionation Homo sapiens
61 CDH2 1000
Co-fractionation Homo sapiens
62 ACAD9 28976
Proximity Label-MS Homo sapiens
63 FBXO17 115290
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 MATR3 9782
Co-fractionation Homo sapiens
65 DDRGK1 65992
Affinity Capture-MS Homo sapiens
66 UFL1 23376
Affinity Capture-MS Homo sapiens
67 C9orf72  
Affinity Capture-MS Homo sapiens
68 KRAS 3845
Negative Genetic Homo sapiens
69 MTRF1L  
Proximity Label-MS Homo sapiens
70 RPA3 6119
Proximity Label-MS Homo sapiens
71 PYHIN1  
Affinity Capture-MS Homo sapiens
72 RAD21 5885
Affinity Capture-Western Homo sapiens
73 EXD2  
Proximity Label-MS Homo sapiens
74 TULP3 7289
Affinity Capture-MS Homo sapiens
75 NDUFS7 374291
Affinity Capture-MS Homo sapiens
76 OGT 8473
Reconstituted Complex Homo sapiens
77 COX4I1 1327
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SARS2 is involved
PathwayEvidenceSource
Metabolism of proteins TAS Reactome
Mitochondrial tRNA aminoacylation TAS Reactome
Translation TAS Reactome
tRNA Aminoacylation TAS Reactome





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