Gene description for ELOVL5
Gene name ELOVL fatty acid elongase 5
Gene symbol ELOVL5
Other names/aliases HELO1
SCA38
dJ483K16.1
Species Homo sapiens
 Database cross references - ELOVL5
ExoCarta ExoCarta_60481
Vesiclepedia VP_60481
Entrez Gene 60481
HGNC 21308
MIM 611805
UniProt Q9NYP7  
 ELOVL5 identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ELOVL5
Molecular Function
    protein binding GO:0005515 IPI
    fatty acid elongase activity GO:0009922 EXP
    fatty acid elongase activity GO:0009922 IBA
    fatty acid elongase activity GO:0009922 IDA
    fatty acid elongase activity GO:0009922 TAS
Biological Process
    unsaturated fatty acid biosynthetic process GO:0006636 IEA
    fatty acid elongation, saturated fatty acid GO:0019367 IBA
    sphingolipid biosynthetic process GO:0030148 IBA
    fatty acid elongation, monounsaturated fatty acid GO:0034625 IBA
    fatty acid elongation, monounsaturated fatty acid GO:0034625 IDA
    fatty acid elongation, polyunsaturated fatty acid GO:0034626 IBA
    fatty acid elongation, polyunsaturated fatty acid GO:0034626 IDA
    long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS
    alpha-linolenic acid metabolic process GO:0036109 TAS
    very long-chain fatty acid biosynthetic process GO:0042761 IBA
    very long-chain fatty acid biosynthetic process GO:0042761 IDA
    linoleic acid metabolic process GO:0043651 TAS
    positive regulation of fatty acid biosynthetic process GO:0045723 IMP
Subcellular Localization
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
    dendrite GO:0030425 IEA
    neuronal cell body GO:0043025 IDA
    dendritic tree GO:0097447 IDA
 Experiment description of studies that identified ELOVL5 in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ELOVL5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 ITGB1 3688
Proximity Label-MS Homo sapiens
3 C2CD2L 9854
Proximity Label-MS Homo sapiens
4 SUCO  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
5 SLC38A1 81539
Proximity Label-MS Homo sapiens
6 PLEKHA3  
Proximity Label-MS Homo sapiens
7 DDHD2 23259
Proximity Label-MS Homo sapiens
8 ARHGAP1 392
Proximity Label-MS Homo sapiens
9 CLCN7 1186
Proximity Label-MS Homo sapiens
10 ANKLE2 23141
Proximity Label-MS Homo sapiens
11 SYAP1 94056
Proximity Label-MS Homo sapiens
12 SLC1A5 6510
Proximity Label-MS Homo sapiens
13 RINT1 60561
Proximity Label-MS Homo sapiens
14 SLC7A5 8140
Proximity Label-MS Homo sapiens
15 TIMM17A  
Affinity Capture-MS Homo sapiens
16 VMP1 81671
Proximity Label-MS Homo sapiens
17 VAPA 9218
Proximity Label-MS Homo sapiens
18 DHRS7 51635
Proximity Label-MS Homo sapiens
19 GJA1 2697
Proximity Label-MS Homo sapiens
20 SRPRB 58477
Proximity Label-MS Homo sapiens
21 COPG2 26958
Proximity Label-MS Homo sapiens
22 ARL6IP5 10550
Proximity Label-MS Homo sapiens
23 ARFGAP2 84364
Proximity Label-MS Homo sapiens
24 RTN1 6252
Proximity Label-MS Homo sapiens
25 JPH1 56704
Proximity Label-MS Homo sapiens
26 VAMP3 9341
Proximity Label-MS Homo sapiens
27 ARFGAP3 26286
Proximity Label-MS Homo sapiens
28 RTN4 57142
Proximity Label-MS Homo sapiens
29 BSCL2  
Affinity Capture-MS Homo sapiens
30 ITCH 83737
Proximity Label-MS Homo sapiens
31 SURF4 6836
Proximity Label-MS Homo sapiens
32 SMPD4 55627
Proximity Label-MS Homo sapiens
33 UBC 7316
Reconstituted Complex Homo sapiens
34 ARCN1 372
Proximity Label-MS Homo sapiens
35 DPEP1 1800
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 VAMP2 6844
Proximity Label-MS Homo sapiens
37 IFNGR1 3459
Proximity Label-MS Homo sapiens
38 LNPEP 4012
Proximity Label-MS Homo sapiens
39 H2AFX 3014
Affinity Capture-MS Homo sapiens
40 PTPN1 5770
Proximity Label-MS Homo sapiens
41 Ktn1  
Affinity Capture-MS Mus musculus
42 COPA 1314
Proximity Label-MS Homo sapiens
43 VPS13A 23230
Proximity Label-MS Homo sapiens
44 HSD17B12 51144
Proximity Label-MS Homo sapiens
45 SLC22A9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 NUP160 23279
Proximity Label-MS Homo sapiens
47 SV2A 9900
Proximity Label-MS Homo sapiens
48 TRPM7 54822
Proximity Label-MS Homo sapiens
49 POR 5447
Proximity Label-MS Homo sapiens
50 PTDSS1 9791
Proximity Label-MS Homo sapiens
51 TEX264 51368
Proximity Label-MS Homo sapiens
52 VANGL2  
Proximity Label-MS Homo sapiens
53 SLC20A1 6574
Proximity Label-MS Homo sapiens
54 JAG1 182
Proximity Label-MS Homo sapiens
55 LRP6 4040
Proximity Label-MS Homo sapiens
56 GOLGB1 2804
Proximity Label-MS Homo sapiens
57 LRP5 4041
Proximity Label-MS Homo sapiens
58 MON2 23041
Proximity Label-MS Homo sapiens
59 OSBPL9 114883
Proximity Label-MS Homo sapiens
60 ELOVL2  
Proximity Label-MS Homo sapiens
61 COPB2 9276
Proximity Label-MS Homo sapiens
62 SRPR 6734
Proximity Label-MS Homo sapiens
63 RHBDD2  
Proximity Label-MS Homo sapiens
64 GINM1 116254
Proximity Label-MS Homo sapiens
65 ARFIP1 27236
Proximity Label-MS Homo sapiens
66 UNC5B 219699
Proximity Label-MS Homo sapiens
67 UFL1 23376
Proximity Label-MS Homo sapiens
68 CPD 1362
Proximity Label-MS Homo sapiens
69 TAPT1 202018
Proximity Label-MS Homo sapiens
70 USE1 55850
Proximity Label-MS Homo sapiens
71 VRK2 7444
Proximity Label-MS Homo sapiens
72 TOR1AIP2 163590
Proximity Label-MS Homo sapiens
73 YIPF3 25844
Proximity Label-MS Homo sapiens
74 FAM169A  
Proximity Label-MS Homo sapiens
75 SSR1 6745
Proximity Label-MS Homo sapiens
76 STX18 53407
Proximity Label-MS Homo sapiens
77 SEMA4C 54910
Proximity Label-MS Homo sapiens
78 TMEM115 11070
Proximity Label-MS Homo sapiens
79 USP33  
Proximity Label-MS Homo sapiens
80 PGRMC2 10424
Proximity Label-MS Homo sapiens
81 CD99 4267
Proximity Label-MS Homo sapiens
82 DNAJC16  
Proximity Label-MS Homo sapiens
83 SYNE3 161176
Proximity Label-MS Homo sapiens
84 CCDC47 57003
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
85 SGMS1  
Proximity Label-MS Homo sapiens
86 GOLGA4  
Proximity Label-MS Homo sapiens
87 LSG1  
Proximity Label-MS Homo sapiens
88 MTDH 92140
Proximity Label-MS Homo sapiens
89 BET1 10282
Proximity Label-MS Homo sapiens
90 SLC30A9 10463
Proximity Label-MS Homo sapiens
91 TMEM33 55161
Proximity Label-MS Homo sapiens
92 ARFGEF2 10564
Proximity Label-MS Homo sapiens
93 ESYT2 57488
Proximity Label-MS Homo sapiens
94 STX10 8677
Proximity Label-MS Homo sapiens
95 FAF2 23197
Proximity Label-MS Homo sapiens
96 SMCR8 140775
Proximity Label-MS Homo sapiens
97 TMEM59 9528
Proximity Label-MS Homo sapiens
98 TFRC 7037
Proximity Label-MS Homo sapiens
99 TMEM87A 25963
Proximity Label-MS Homo sapiens
100 NOTCH2 4853
Proximity Label-MS Homo sapiens
101 CAMLG 819
Proximity Label-MS Homo sapiens
102 DSC3 1825
Proximity Label-MS Homo sapiens
103 NUP155 9631
Proximity Label-MS Homo sapiens
104 KIAA1715 80856
Proximity Label-MS Homo sapiens
105 LRRC59 55379
Proximity Label-MS Homo sapiens
106 SNAP47 116841
Proximity Label-MS Homo sapiens
107 LEMD3  
Proximity Label-MS Homo sapiens
108 EIF2AK3  
Proximity Label-MS Homo sapiens
109 LMNB1 4001
Proximity Label-MS Homo sapiens
110 CHMP7 91782
Proximity Label-MS Homo sapiens
111 SCFD1 23256
Proximity Label-MS Homo sapiens
112 SENP2 59343
Proximity Label-MS Homo sapiens
113 CANT1 124583
Proximity Label-MS Homo sapiens
114 STBD1 8987
Proximity Label-MS Homo sapiens
115 EMD 2010
Proximity Label-MS Homo sapiens
116 FAM114A2  
Proximity Label-MS Homo sapiens
117 SLC39A6 25800
Proximity Label-MS Homo sapiens
118 LRIG2  
Proximity Label-MS Homo sapiens
119 RPL8 6132
Proximity Label-MS Homo sapiens
120 OSBPL8 114882
Proximity Label-MS Homo sapiens
121 TMX1 81542
Proximity Label-MS Homo sapiens
122 TMEM165 55858
Proximity Label-MS Homo sapiens
123 COPG1 22820
Proximity Label-MS Homo sapiens
124 SEC62 7095
Proximity Label-MS Homo sapiens
125 BET1L 51272
Proximity Label-MS Homo sapiens
126 WWOX 51741
Proximity Label-MS Homo sapiens
127 COPB1 1315
Proximity Label-MS Homo sapiens
128 GORAB 92344
Proximity Label-MS Homo sapiens
129 CERS2 29956
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
130 PDXDC1 23042
Proximity Label-MS Homo sapiens
131 STT3B 201595
Proximity Label-MS Homo sapiens
132 GCC2 9648
Proximity Label-MS Homo sapiens
133 CDKAL1  
Proximity Label-MS Homo sapiens
134 CYB5A 1528
Proximity Label-MS Homo sapiens
135 CLCC1 23155
Proximity Label-MS Homo sapiens
136 SPRY4 81848
Proximity Label-MS Homo sapiens
137 VAPB 9217
Proximity Label-MS Homo sapiens
138 SFT2D3  
Proximity Label-MS Homo sapiens
139 TMED8 283578
Proximity Label-MS Homo sapiens
140 SAR1B 51128
Proximity Label-MS Homo sapiens
141 GORASP2 26003
Proximity Label-MS Homo sapiens
142 GPR182  
Affinity Capture-MS Homo sapiens
143 ITM2C 81618
Proximity Label-MS Homo sapiens
144 PRPF38A 84950
Affinity Capture-MS Homo sapiens
145 RRP36 88745
Affinity Capture-MS Homo sapiens
146 JAG2  
Proximity Label-MS Homo sapiens
147 GOPC 57120
Proximity Label-MS Homo sapiens
148 LRBA 987
Proximity Label-MS Homo sapiens
149 LMF2 91289
Proximity Label-MS Homo sapiens
150 PREB 10113
Proximity Label-MS Homo sapiens
151 TMX4 56255
Proximity Label-MS Homo sapiens
152 RPS6 6194
Proximity Label-MS Homo sapiens
153 STX5 6811
Proximity Label-MS Homo sapiens
154 FYN 2534
Proximity Label-MS Homo sapiens
155 TECR 9524
Proximity Label-MS Homo sapiens
156 EIF3H 8667
Proximity Label-MS Homo sapiens
157 LMNB2 84823
Proximity Label-MS Homo sapiens
158 ATP2C1 27032
Proximity Label-MS Homo sapiens
159 FLOT2 2319
Proximity Label-MS Homo sapiens
160 SND1 27044
Proximity Label-MS Homo sapiens
161 ANO10 55129
Proximity Label-MS Homo sapiens
162 COG4 25839
Proximity Label-MS Homo sapiens
163 NDC1 55706
Proximity Label-MS Homo sapiens
164 SEC23IP 11196
Proximity Label-MS Homo sapiens
165 VPS54  
Proximity Label-MS Homo sapiens
166 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
167 ACBD3 64746
Proximity Label-MS Homo sapiens
168 SNAP29 9342
Proximity Label-MS Homo sapiens
169 DOLPP1  
Proximity Label-MS Homo sapiens
170 C5orf15 56951
Proximity Label-MS Homo sapiens
171 REEP5 7905
Proximity Label-MS Homo sapiens
172 TMF1 7110
Proximity Label-MS Homo sapiens
173 SEC63 11231
Proximity Label-MS Homo sapiens
174 VEZT 55591
Proximity Label-MS Homo sapiens
175 PKMYT1  
Proximity Label-MS Homo sapiens
176 RAB6A 5870
Proximity Label-MS Homo sapiens
177 SLC4A7 9497
Proximity Label-MS Homo sapiens
178 MXRA7 439921
Proximity Label-MS Homo sapiens
179 CYB5B 80777
Proximity Label-MS Homo sapiens
180 GOLGA3 2802
Proximity Label-MS Homo sapiens
181 APLNR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 ITPR2 3709
Proximity Label-MS Homo sapiens
183 SLC4A2 6522
Proximity Label-MS Homo sapiens
184 TMX3 54495
Proximity Label-MS Homo sapiens
185 CANX 821
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
186 TP53I11  
Proximity Label-MS Homo sapiens
187 AGPAT1 10554
Proximity Label-MS Homo sapiens
188 ATF6  
Proximity Label-MS Homo sapiens
189 DHCR7 1717
Proximity Label-MS Homo sapiens
190 CDCA3 83461
Proximity Label-MS Homo sapiens
191 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
192 GPR108 56927
Proximity Label-MS Homo sapiens
193 ATP2B1 490
Proximity Label-MS Homo sapiens
194 ADCY9 115
Proximity Label-MS Homo sapiens
195 TBC1D22B  
Proximity Label-MS Homo sapiens
196 LYSMD3  
Proximity Label-MS Homo sapiens
197 HMOX2 3163
Proximity Label-MS Homo sapiens
198 ARFGEF1 10565
Proximity Label-MS Homo sapiens
199 IGF2R 3482
Proximity Label-MS Homo sapiens
200 SLC30A6 55676
Proximity Label-MS Homo sapiens
201 CRELD1 78987
Affinity Capture-MS Homo sapiens
202 BCAP31 10134
Proximity Label-MS Homo sapiens
203 TMEM199  
Proximity Label-MS Homo sapiens
204 ATP6AP2 10159
Proximity Label-MS Homo sapiens
205 NR3C1 2908
Proximity Label-MS Homo sapiens
206 STIM1 6786
Proximity Label-MS Homo sapiens
207 RPL21 6144
Proximity Label-MS Homo sapiens
208 RPL3 6122
Proximity Label-MS Homo sapiens
209 FKBP8 23770
Proximity Label-MS Homo sapiens
210 ARF1 375
Proximity Label-MS Homo sapiens
211 RIC1 57589
Proximity Label-MS Homo sapiens
212 GBF1 8729
Proximity Label-MS Homo sapiens
213 SYNE2 23224
Proximity Label-MS Homo sapiens
214 TMEM194A  
Proximity Label-MS Homo sapiens
215 YIPF5 81555
Affinity Capture-MS Homo sapiens
216 SUN1 23353
Proximity Label-MS Homo sapiens
217 SEC24A 10802
Proximity Label-MS Homo sapiens
218 KIAA1467 57613
Proximity Label-MS Homo sapiens
219 COG1 9382
Proximity Label-MS Homo sapiens
220 TMEM230 29058
Proximity Label-MS Homo sapiens
221 OSBPL11 114885
Proximity Label-MS Homo sapiens
222 ITPR1 3708
Proximity Label-MS Homo sapiens
223 ZW10 9183
Proximity Label-MS Homo sapiens
224 SLC2A1 6513
Proximity Label-MS Homo sapiens
225 ACSL3 2181
Proximity Label-MS Homo sapiens
226 JAK1 3716
Proximity Label-MS Homo sapiens
227 SLC3A2 6520
Proximity Label-MS Homo sapiens
228 TMCO1 54499
Proximity Label-MS Homo sapiens
229 SLC6A15 55117
Proximity Label-MS Homo sapiens
230 SEC16A 9919
Proximity Label-MS Homo sapiens
231 FAM134B 54463
Proximity Label-MS Homo sapiens
232 ROMO1 140823
Affinity Capture-MS Homo sapiens
233 UBIAD1 29914
Proximity Label-MS Homo sapiens
234 MOSPD2 158747
Proximity Label-MS Homo sapiens
235 SLC12A7 10723
Proximity Label-MS Homo sapiens
236 TJAP1 93643
Proximity Label-MS Homo sapiens
237 FNDC3A 22862
Proximity Label-MS Homo sapiens
238 RAB3GAP1 22930
Proximity Label-MS Homo sapiens
239 DDRGK1 65992
Proximity Label-MS Homo sapiens
240 KTN1 3895
Proximity Label-MS Homo sapiens
241 CACNG1  
Affinity Capture-MS Homo sapiens
242 KIAA0319L 79932
Proximity Label-MS Homo sapiens
243 TMEM209 84928
Proximity Label-MS Homo sapiens
244 HLA-A 3105
Proximity Label-MS Homo sapiens
245 LMNA 4000
Proximity Label-MS Homo sapiens
246 SLC35A2  
Proximity Label-MS Homo sapiens
247 Slc6a8 102857
Affinity Capture-MS Mus musculus
248 EMC8 10328
Proximity Label-MS Homo sapiens
249 GRAMD1B  
Proximity Label-MS Homo sapiens
250 SNX5 27131
Proximity Label-MS Homo sapiens
251 SLC12A2 6558
Proximity Label-MS Homo sapiens
252 ACBD5 91452
Proximity Label-MS Homo sapiens
253 UBE2J1 51465
Proximity Label-MS Homo sapiens
254 TSPAN10 83882
Affinity Capture-MS Homo sapiens
255 RAB3GAP2 25782
Proximity Label-MS Homo sapiens
256 LRIG3  
Proximity Label-MS Homo sapiens
257 TMEM9 252839
Proximity Label-MS Homo sapiens
258 MBOAT7 79143
Proximity Label-MS Homo sapiens
259 LBR 3930