Gene description for METTL7A
Gene name methyltransferase like 7A
Gene symbol METTL7A
Other names/aliases AAM-B
Species Homo sapiens
 Database cross references - METTL7A
ExoCarta ExoCarta_25840
Vesiclepedia VP_25840
Entrez Gene 25840
HGNC 24550
UniProt Q9H8H3  
 METTL7A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for METTL7A
Molecular Function
    mRNA m(6)A methyltransferase activity GO:0001734 IMP
    protein binding GO:0005515 IPI
    methyltransferase activity GO:0008168 IBA
    RNA methyltransferase activity GO:0008173 IDA
    thiol S-methyltransferase activity GO:0018708 IDA
Biological Process
    osteoblast differentiation GO:0001649 IMP
    methylation GO:0032259 IEA
    odontogenesis GO:0042476 IMP
    lncRNA processing GO:0180035 IMP
Subcellular Localization
    extracellular region GO:0005576 TAS
    endoplasmic reticulum GO:0005783 IDA
    lipid droplet GO:0005811 IDA
    cytosol GO:0005829 IEA
    membrane GO:0016020 IEA
    tertiary granule lumen GO:1904724 TAS
 Experiment description of studies that identified METTL7A in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for METTL7A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Proximity Label-MS Homo sapiens
2 ITGB1 3688
Proximity Label-MS Homo sapiens
3 ARHGAP1 392
Proximity Label-MS Homo sapiens
4 NPLOC4 55666
Proximity Label-MS Homo sapiens
5 CCNB2  
Proximity Label-MS Homo sapiens
6 SRPRB 58477
Proximity Label-MS Homo sapiens
7 JPH1 56704
Proximity Label-MS Homo sapiens
8 VMP1 81671
Proximity Label-MS Homo sapiens
9 BTN3A3 10384
Proximity Label-MS Homo sapiens
10 ST7  
Proximity Label-MS Homo sapiens
11 OSBPL9 114883
Proximity Label-MS Homo sapiens
12 APBB2  
Proximity Label-MS Homo sapiens
13 SMPD4 55627
Proximity Label-MS Homo sapiens
14 LRBA 987
Proximity Label-MS Homo sapiens
15 ABCD3 5825
Proximity Label-MS Homo sapiens
16 TMEM201 199953
Proximity Label-MS Homo sapiens
17 USP33  
Proximity Label-MS Homo sapiens
18 BET1 10282
Proximity Label-MS Homo sapiens
19 SLC6A15 55117
Proximity Label-MS Homo sapiens
20 TFRC 7037
Proximity Label-MS Homo sapiens
21 TMEM87A 25963
Proximity Label-MS Homo sapiens
22 NOTCH2 4853
Proximity Label-MS Homo sapiens
23 CAMLG 819
Proximity Label-MS Homo sapiens
24 ATP2A2 488
Proximity Label-MS Homo sapiens
25 SENP2 59343
Proximity Label-MS Homo sapiens
26 LRRC57 255252
Proximity Label-MS Homo sapiens
27 TMX1 81542
Proximity Label-MS Homo sapiens
28 GGT7 2686
Proximity Label-MS Homo sapiens
29 VPS51 738
Proximity Label-MS Homo sapiens
30 CCDC168  
Proximity Label-MS Homo sapiens
31 CERS2 29956
Proximity Label-MS Homo sapiens
32 PDXDC1 23042
Proximity Label-MS Homo sapiens
33 UBXN8  
Proximity Label-MS Homo sapiens
34 CLCC1 23155
Proximity Label-MS Homo sapiens
35 SAR1B 51128
Affinity Capture-MS Homo sapiens
36 GORASP2 26003
Proximity Label-MS Homo sapiens
37 SYNE1 23345
Proximity Label-MS Homo sapiens
38 CD63 967
Affinity Capture-MS Homo sapiens
39 SND1 27044
Proximity Label-MS Homo sapiens
40 STAM 8027
Proximity Label-MS Homo sapiens
41 TMF1 7110
Proximity Label-MS Homo sapiens
42 TMPO 7112
Proximity Label-MS Homo sapiens
43 ANO6 196527
Proximity Label-MS Homo sapiens
44 AGPAT1 10554
Proximity Label-MS Homo sapiens
45 LRRC59 55379
Proximity Label-MS Homo sapiens
46 LMNB1 4001
Proximity Label-MS Homo sapiens
47 SCAMP1 9522
Proximity Label-MS Homo sapiens
48 BCAP31 10134
Proximity Label-MS Homo sapiens
49 TMEM199  
Proximity Label-MS Homo sapiens
50 ATP6AP2 10159
Proximity Label-MS Homo sapiens
51 FKBP8 23770
Proximity Label-MS Homo sapiens
52 AAAS 8086
Proximity Label-MS Homo sapiens
53 CYP51A1 1595
Proximity Label-MS Homo sapiens
54 TMEM173  
Proximity Label-MS Homo sapiens
55 ZW10 9183
Proximity Label-MS Homo sapiens
56 RETSAT 54884
Proximity Label-MS Homo sapiens
57 TMED10 10972
Affinity Capture-MS Homo sapiens
58 RPA3 6119
Proximity Label-MS Homo sapiens
59 TMCO1 54499
Proximity Label-MS Homo sapiens
60 RINT1 60561
Proximity Label-MS Homo sapiens
61 LMF2 91289
Proximity Label-MS Homo sapiens
62 FAM169A  
Proximity Label-MS Homo sapiens
63 KIDINS220 57498
Proximity Label-MS Homo sapiens
64 GOLGB1 2804
Proximity Label-MS Homo sapiens
65 SLC4A2 6522
Proximity Label-MS Homo sapiens
66 TMEM57  
Proximity Label-MS Homo sapiens
67 SCYL3 57147
Proximity Label-MS Homo sapiens
68 AGPAT9  
Proximity Label-MS Homo sapiens
69 ZFYVE27 118813
Proximity Label-MS Homo sapiens
70 WWOX 51741
Proximity Label-MS Homo sapiens
71 EMC7 56851
Proximity Label-MS Homo sapiens
72 CLPTM1 1209
Proximity Label-MS Homo sapiens
73 PTPN2 5771
Proximity Label-MS Homo sapiens
74 ITPR3 3710
Proximity Label-MS Homo sapiens
75 TRIP11 9321
Proximity Label-MS Homo sapiens
76 RABL3 285282
Proximity Label-MS Homo sapiens
77 FAM219A 203259
Proximity Label-MS Homo sapiens
78 HM13 81502
Proximity Label-MS Homo sapiens
79 NDC1 55706
Proximity Label-MS Homo sapiens
80 AREL1  
Proximity Label-MS Homo sapiens
81 RAB11A 8766
Proximity Label-MS Homo sapiens
82 ITPR1 3708
Proximity Label-MS Homo sapiens
83 EPHA2 1969
Proximity Label-MS Homo sapiens
84 EI24  
Proximity Label-MS Homo sapiens
85 CISD2 493856
Proximity Label-MS Homo sapiens
86 VANGL1 81839
Proximity Label-MS Homo sapiens
87 PSMC4 5704
Proximity Label-MS Homo sapiens
88 BRI3BP 140707
Proximity Label-MS Homo sapiens
89 C2CD2L 9854
Proximity Label-MS Homo sapiens
90 KIF16B 55614
Proximity Label-MS Homo sapiens
91 DDHD2 23259
Proximity Label-MS Homo sapiens
92 CAMSAP1 157922
Proximity Label-MS Homo sapiens
93 ATL1 51062
Proximity Label-MS Homo sapiens
94 DHRS7 51635
Proximity Label-MS Homo sapiens
95 GJA1 2697
Proximity Label-MS Homo sapiens
96 RPA2 6118
Proximity Label-MS Homo sapiens
97 ARFGAP2 84364
Proximity Label-MS Homo sapiens
98 SPTLC1 10558
Proximity Label-MS Homo sapiens
99 VAMP2 6844
Proximity Label-MS Homo sapiens
100 NUP160 23279
Proximity Label-MS Homo sapiens
101 VANGL2  
Proximity Label-MS Homo sapiens
102 WDR41  
Proximity Label-MS Homo sapiens
103 CYB5B 80777
Proximity Label-MS Homo sapiens
104 ELOVL2  
Proximity Label-MS Homo sapiens
105 FBXO17 115290
Proximity Label-MS Homo sapiens
106 WDR7 23335
Proximity Label-MS Homo sapiens
107 TMEM115 11070
Proximity Label-MS Homo sapiens
108 SUN2 25777
Proximity Label-MS Homo sapiens
109 RAB6B 51560
Proximity Label-MS Homo sapiens
110 EBAG9 9166
Proximity Label-MS Homo sapiens
111 LMAN1 3998
Proximity Label-MS Homo sapiens
112 KIAA1715 80856
Proximity Label-MS Homo sapiens
113 STAM2 10254
Proximity Label-MS Homo sapiens
114 CHMP7 91782
Proximity Label-MS Homo sapiens
115 MIB1 57534
Proximity Label-MS Homo sapiens
116 VPS45 11311
Proximity Label-MS Homo sapiens
117 STOM 2040
Proximity Label-MS Homo sapiens
118 SNAP47 116841
Proximity Label-MS Homo sapiens
119 CDKAL1  
Proximity Label-MS Homo sapiens
120 PBXIP1 57326
Proximity Label-MS Homo sapiens
121 SLC9A1 6548
Proximity Label-MS Homo sapiens
122 TRPM7 54822
Proximity Label-MS Homo sapiens
123 KCNB2  
Proximity Label-MS Homo sapiens
124 JAG2  
Proximity Label-MS Homo sapiens
125 PREB 10113
Proximity Label-MS Homo sapiens
126 STX5 6811
Proximity Label-MS Homo sapiens
127 TMEM131  
Proximity Label-MS Homo sapiens
128 ANO10 55129
Proximity Label-MS Homo sapiens
129 GOLGA5 9950
Proximity Label-MS Homo sapiens
130 MXRA7 439921
Proximity Label-MS Homo sapiens
131 CANX 821
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
132 EMC8 10328
Proximity Label-MS Homo sapiens
133 ADCY9 115
Proximity Label-MS Homo sapiens
134 SLC27A4 10999
Proximity Label-MS Homo sapiens
135 ARFIP1 27236
Proximity Label-MS Homo sapiens
136 FAM91A1 157769
Proximity Label-MS Homo sapiens
137 SLC3A2 6520
Proximity Label-MS Homo sapiens
138 FAM134B 54463
Proximity Label-MS Homo sapiens
139 VRK2 7444
Proximity Label-MS Homo sapiens
140 DDRGK1 65992
Proximity Label-MS Homo sapiens
141 TMEM209 84928
Proximity Label-MS Homo sapiens
142 VIMP 55829
Proximity Label-MS Homo sapiens
143 LEMD3  
Proximity Label-MS Homo sapiens
144 LMNA 4000
Proximity Label-MS Homo sapiens
145 OSBPL8 114882
Proximity Label-MS Homo sapiens
146 GRAMD1B  
Proximity Label-MS Homo sapiens
147 SUN1 23353
Proximity Label-MS Homo sapiens
148 PLXNB2 23654
Proximity Label-MS Homo sapiens
149 SEC24A 10802
Proximity Label-MS Homo sapiens
150 SLC38A2 54407
Proximity Label-MS Homo sapiens
151 TRIM13  
Proximity Label-MS Homo sapiens
152 TMEM9 252839
Proximity Label-MS Homo sapiens
153 PGRMC1 10857
Proximity Label-MS Homo sapiens
154 VPS13B  
Proximity Label-MS Homo sapiens
155 RTN3 10313
Proximity Label-MS Homo sapiens
156 PDCL 5082
Proximity Label-MS Homo sapiens
157 NSDHL 50814
Proximity Label-MS Homo sapiens
158 TOR1AIP1 26092
Proximity Label-MS Homo sapiens
159 MMGT1 93380
Proximity Label-MS Homo sapiens
160 AUP1 550
Proximity Label-MS Homo sapiens
161 PLD3 23646
Proximity Label-MS Homo sapiens
162 SPPL2B 56928
Affinity Capture-MS Homo sapiens
163 ATP1A1 476
Proximity Label-MS Homo sapiens
164 TMEM109 79073
Proximity Label-MS Homo sapiens
165 YKT6 10652
Proximity Label-MS Homo sapiens
166 IGF2R 3482
Proximity Label-MS Homo sapiens
167 CKAP4 10970
Proximity Label-MS Homo sapiens
168 ATP13A1 57130
Proximity Label-MS Homo sapiens
169 NUPL2 11097
Proximity Label-MS Homo sapiens
170 SUCO  
Proximity Label-MS Homo sapiens
171 OCLN 100506658
Proximity Label-MS Homo sapiens
172 MME 4311
Affinity Capture-MS Homo sapiens
173 NBAS 51594
Proximity Label-MS Homo sapiens
174 TOX3  
Proximity Label-MS Homo sapiens
175 ARCN1 372
Proximity Label-MS Homo sapiens
176 SYNE2 23224
Proximity Label-MS Homo sapiens
177 CCDC9  
Affinity Capture-MS Homo sapiens
178 PTPN1 5770
Proximity Label-MS Homo sapiens
179 APBB1  
Proximity Label-MS Homo sapiens
180 RTN4 57142
Proximity Label-MS Homo sapiens
181 TEX264 51368
Proximity Label-MS Homo sapiens
182 SENP1  
Proximity Label-MS Homo sapiens
183 COPB2 9276
Proximity Label-MS Homo sapiens
184 RHBDD2  
Proximity Label-MS Homo sapiens
185 STX8 9482
Proximity Label-MS Homo sapiens
186 DSC2 1824
Proximity Label-MS Homo sapiens
187 LSG1  
Proximity Label-MS Homo sapiens
188 SSR1 6745
Proximity Label-MS Homo sapiens
189 SYNE3 161176
Proximity Label-MS Homo sapiens
190 CCDC47 57003
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
191 BCAP29 55973
Proximity Label-MS Homo sapiens
192 GOLGA4  
Proximity Label-MS Homo sapiens
193 MTDH 92140
Proximity Label-MS Homo sapiens
194 ESYT2 57488
Proximity Label-MS Homo sapiens
195 GBA2  
Proximity Label-MS Homo sapiens
196 DSC3 1825
Proximity Label-MS Homo sapiens
197 PALD1 27143
Proximity Label-MS Homo sapiens
198 EIF2AK3  
Proximity Label-MS Homo sapiens
199 SCFD1 23256
Proximity Label-MS Homo sapiens
200 CPNE8 144402
Proximity Label-MS Homo sapiens
201 REEP4  
Proximity Label-MS Homo sapiens
202 SPDL1  
Proximity Label-MS Homo sapiens
203 BET1L 51272
Proximity Label-MS Homo sapiens
204 GOLGA2 2801
Proximity Label-MS Homo sapiens
205 OSBPL2 9885
Proximity Label-MS Homo sapiens
206 TACC1 6867
Proximity Label-MS Homo sapiens
207 RPN1 6184
Proximity Label-MS Homo sapiens
208 LIFR 3977
Proximity Label-MS Homo sapiens
209 SLC4A7 9497
Proximity Label-MS Homo sapiens
210 NUP155 9631
Proximity Label-MS Homo sapiens
211 SMCR8 140775
Proximity Label-MS Homo sapiens
212 SRPR 6734
Proximity Label-MS Homo sapiens
213 ITPR2 3709
Proximity Label-MS Homo sapiens
214 PTPN9 5780
Proximity Label-MS Homo sapiens
215 ATF6  
Proximity Label-MS Homo sapiens
216 SAR1A 56681
Affinity Capture-MS Homo sapiens
217 TBC1D22B  
Proximity Label-MS Homo sapiens
218 LMNB2 84823
Proximity Label-MS Homo sapiens
219 VAMP3 9341
Proximity Label-MS Homo sapiens
220 NR3C1 2908
Proximity Label-MS Homo sapiens
221 STIM1 6786
Proximity Label-MS Homo sapiens
222 GBF1 8729
Proximity Label-MS Homo sapiens
223 OCIAD1 54940
Proximity Label-MS Homo sapiens
224 OSBPL11 114885
Proximity Label-MS Homo sapiens
225 SEC16A 9919
Proximity Label-MS Homo sapiens
226 RAB3GAP1 22930
Proximity Label-MS Homo sapiens
227 KTN1 3895
Proximity Label-MS Homo sapiens
228 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
229 HLA-A 3105
Proximity Label-MS Homo sapiens
230 FAM114A2  
Proximity Label-MS Homo sapiens
231 ACBD5 91452
Proximity Label-MS Homo sapiens
232 UBE2J1 51465
Proximity Label-MS Homo sapiens
233 LRIG3  
Proximity Label-MS Homo sapiens
234 MBOAT7 79143
Proximity Label-MS Homo sapiens
235 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
236 PVRL2 5819
Proximity Label-MS Homo sapiens
237 ALDH3A2 224
Proximity Label-MS Homo sapiens
238 RAB3GAP2 25782
Proximity Label-MS Homo sapiens
239 JUP 3728
Affinity Capture-MS Homo sapiens
240 SEC23IP 11196
Proximity Label-MS Homo sapiens
241 TOR1AIP2 163590
Proximity Label-MS Homo sapiens
242 TMEM214 54867
Proximity Label-MS Homo sapiens
243 VAMP4 8674
Proximity Label-MS Homo sapiens
244 PDZD8 118987
Proximity Label-MS Homo sapiens
245 UFL1 23376
Proximity Label-MS Homo sapiens
246 SMIM12  
Proximity Label-MS Homo sapiens
247 INF2 64423
Proximity Label-MS Homo sapiens
248 RAB7A 7879
Proximity Label-MS Homo sapiens
249 SERPINB2 5055
Affinity Capture-MS Homo sapiens
250 AGPAT6 137964