Gene description for VDAC2
Gene name voltage-dependent anion channel 2
Gene symbol VDAC2
Other names/aliases POR
Species Homo sapiens
 Database cross references - VDAC2
ExoCarta ExoCarta_7417
Vesiclepedia VP_7417
Entrez Gene 7417
HGNC 12672
MIM 193245
UniProt P45880  
 VDAC2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Pluripotent stem cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
 Gene ontology annotations for VDAC2
Molecular Function
    voltage-gated monoatomic ion channel activity GO:0005244 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    oxysterol binding GO:0008142 ISS
    voltage-gated monoatomic anion channel activity GO:0008308 IBA
    voltage-gated monoatomic anion channel activity GO:0008308 IDA
    porin activity GO:0015288 IEA
    cholesterol binding GO:0015485 IDA
    phospholipid scramblase activity GO:0017128 IDA
    phosphatidylcholine binding GO:0031210 IDA
    ceramide binding GO:0097001 IDA
Biological Process
    monoatomic anion transport GO:0006820 IDA
    binding of sperm to zona pellucida GO:0007339 IMP
    plasma membrane phospholipid scrambling GO:0017121 IEA
    negative regulation of protein polymerization GO:0032272 IEA
    phospholipid translocation GO:0045332 IDA
    mitochondrial outer membrane permeabilization GO:0097345 IMP
    monoatomic anion transmembrane transport GO:0098656 IEA
    mitochondrial transmembrane transport GO:1990542 IDA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IEA
Subcellular Localization
    acrosomal vesicle GO:0001669 IDA
    nucleus GO:0005634 HDA
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IBA
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial outer membrane GO:0005741 TAS
    membrane GO:0016020 IDA
    mitochondrial membrane GO:0031966 IDA
    mitochondrial nucleoid GO:0042645 IDA
    membrane raft GO:0045121 IDA
    pore complex GO:0046930 IEA
    sperm midpiece GO:0097225 ISS
 Experiment description of studies that identified VDAC2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
19
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
21
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
23
Experiment ID 219
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
24
Experiment ID 220
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 221
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
26
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
27
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
29
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
30
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
33
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
34
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
35
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
37
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
38
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
40
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
41
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
42
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
43
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for VDAC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STX12 23673
Co-fractionation Homo sapiens
2 RPSA 3921
Co-fractionation Homo sapiens
3 INSIG1  
Affinity Capture-MS Homo sapiens
4 GPX4 2879
Co-fractionation Homo sapiens
5 DENR 8562
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 UBE2H 7328
Affinity Capture-MS Homo sapiens
7 HNRNPC 3183
Cross-Linking-MS (XL-MS) Homo sapiens
8 Tmed2 56334
Affinity Capture-MS Mus musculus
9 KLF8  
Affinity Capture-MS Homo sapiens
10 UTP14A 10813
Co-fractionation Homo sapiens
11 MTCH1 23787
Co-fractionation Homo sapiens
12 RAB1A 5861
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
13 Mtx2  
Affinity Capture-MS Mus musculus
14 VAPA 9218
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
15 NEK11  
Co-fractionation Homo sapiens
16 PTMA 5757
Co-fractionation Homo sapiens
17 DLST 1743
Affinity Capture-MS Homo sapiens
18 BST2 684
Co-fractionation Homo sapiens
19 EMC2 9694
Co-fractionation Homo sapiens
20 MME 4311
Affinity Capture-MS Homo sapiens
21 CD4 920
Affinity Capture-MS Homo sapiens
22 ADRB2  
Affinity Capture-MS Homo sapiens
PCA Homo sapiens
23 TMEM205 374882
Co-fractionation Homo sapiens
24 PLOD1 5351
Co-fractionation Homo sapiens
25 CISD1 55847
Co-fractionation Homo sapiens
26 RPS19 6223
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
27 TRIM33 51592
Affinity Capture-MS Homo sapiens
28 ZFR 51663
Co-fractionation Homo sapiens
29 HSP90AB1 3326
Co-fractionation Homo sapiens
30 NDUFS7 374291
Co-fractionation Homo sapiens
31 PLEKHA2 59339
Affinity Capture-MS Homo sapiens
32 ACTN1 87
Co-fractionation Homo sapiens
33 NDUFA4 4697
Co-fractionation Homo sapiens
34 ACTB 60
Co-fractionation Homo sapiens
35 DNAH8 1769
Co-fractionation Homo sapiens
36 SEPT2 4735
Co-fractionation Homo sapiens
37 Tmem109  
Affinity Capture-MS Mus musculus
38 APP 351
Reconstituted Complex Homo sapiens
39 KDELR1 10945
Affinity Capture-MS Homo sapiens
40 POTEF 728378
Co-fractionation Homo sapiens
41 LRPPRC 10128
Co-fractionation Homo sapiens
42 KIAA1429 25962
Affinity Capture-MS Homo sapiens
43 MARCH5  
Affinity Capture-MS Homo sapiens
44 NDUFB9 4715
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
45 PLOD3 8985
Co-fractionation Homo sapiens
46 COIL  
Proximity Label-MS Homo sapiens
47 ZBTB2 57621
Affinity Capture-MS Homo sapiens
48 NDUFS3 4722
Co-fractionation Homo sapiens
49 OGDH 4967
Co-fractionation Homo sapiens
50 PLEKHG5 57449
Co-fractionation Homo sapiens
51 DYRK1A 1859
Affinity Capture-MS Homo sapiens
52 KIF23 9493
Affinity Capture-MS Homo sapiens
53 COX7A2L 9167
Co-fractionation Homo sapiens
54 SPRTN  
Affinity Capture-MS Homo sapiens
55 CYB5R1 51706
Co-fractionation Homo sapiens
56 SHMT2 6472
Co-fractionation Homo sapiens
57 ABCC3 8714
Co-fractionation Homo sapiens
58 PRC1 9055
Affinity Capture-MS Homo sapiens
59 IQGAP1 8826
Co-fractionation Homo sapiens
60 STX7 8417
Co-fractionation Homo sapiens
61 COA3 28958
Co-fractionation Homo sapiens
62 MDC1  
Affinity Capture-MS Homo sapiens
63 Fgfr1op  
Affinity Capture-MS Mus musculus
64 PREB 10113
Co-fractionation Homo sapiens
65 DDX1 1653
Cross-Linking-MS (XL-MS) Homo sapiens
66 INSIG2  
Affinity Capture-MS Homo sapiens
67 C1qbp 12261
Affinity Capture-MS Mus musculus
68 DDOST 1650
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
69 ABCE1 6059
Affinity Capture-MS Homo sapiens
70 AASS  
Co-fractionation Homo sapiens
71 RCBTB1  
Co-fractionation Homo sapiens
72 ATP5O 539
Co-fractionation Homo sapiens
73 SLC9A9 285195
Affinity Capture-MS Homo sapiens
74 FANCD2  
Affinity Capture-MS Homo sapiens
75 C20orf24  
Co-fractionation Homo sapiens
76 ITGA4 3676
Affinity Capture-MS Homo sapiens
77 GALNT2 2590
Co-fractionation Homo sapiens
78 NDUFV1 4723
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
79 VCAM1 7412
Affinity Capture-MS Homo sapiens
80 TOMM40 10452
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
81 ATP6V0D1 9114
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
82 CANX 821
Co-fractionation Homo sapiens
83 MECP2 4204
Affinity Capture-MS Homo sapiens
84 ANKRD34C  
Co-fractionation Homo sapiens
85 SSR3 6747
Co-fractionation Homo sapiens
86 FAF2 23197
Affinity Capture-MS Homo sapiens
87 FGFR1 2260
Affinity Capture-MS Homo sapiens
88 UQCRQ 27089
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
89 MMGT1 93380
Affinity Capture-MS Homo sapiens
90 NDUFS5 4725
Co-fractionation Homo sapiens
91 KIF14 9928
Affinity Capture-MS Homo sapiens
92 ATP1A3 478
Co-fractionation Homo sapiens
93 EMC1 23065
Affinity Capture-MS Homo sapiens
94 LMAN1 3998
Co-fractionation Homo sapiens
95 PSME3 10197
Affinity Capture-MS Homo sapiens
96 KLF16  
Affinity Capture-MS Homo sapiens
97 CHMP4C 92421
Affinity Capture-MS Homo sapiens
98 OCIAD2 132299
Co-fractionation Homo sapiens
99 PCNP 57092
Cross-Linking-MS (XL-MS) Homo sapiens
100 MTCH2 23788
Co-fractionation Homo sapiens
101 P4HA1 5033
Co-fractionation Homo sapiens
102 NDUFS4 4724
Co-fractionation Homo sapiens
103 COX15 1355
Affinity Capture-MS Homo sapiens
104 GCGR  
Affinity Capture-MS Homo sapiens
105 ITGAV 3685
Co-fractionation Homo sapiens
106 RFC5 5985
Co-fractionation Homo sapiens
107 TMX1 81542
Co-fractionation Homo sapiens
108 PARK2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 PHB 5245
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
110 JAGN1 84522
Co-fractionation Homo sapiens
111 SFXN3 81855
Co-fractionation Homo sapiens
112 HSP90B1 7184
Co-fractionation Homo sapiens
113 NDUFA8 4702
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
114 CAP1 10487
Co-fractionation Homo sapiens
115 TUBA1A 7846
Co-fractionation Homo sapiens
116 ILVBL 10994
Co-fractionation Homo sapiens
117 ATF2  
Affinity Capture-MS Homo sapiens
118 FAM162A 26355
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
119 ACACA 31
Negative Genetic Homo sapiens
120 MAGT1 84061
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
121 C12orf49  
Negative Genetic Homo sapiens
122 SLC25A20 788
Co-fractionation Homo sapiens
123 RPA2 6118
Proximity Label-MS Homo sapiens
124 PHB2 11331
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
125 VCP 7415
Co-fractionation Homo sapiens
126 NTRK1 4914
Affinity Capture-MS Homo sapiens
127 P4HA2 8974
Co-fractionation Homo sapiens
128 ACADM 34
Co-fractionation Homo sapiens
129 FBXL6  
Affinity Capture-MS Homo sapiens
130 LRP1 4035
Co-fractionation Homo sapiens
131 RAB2A 5862
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
132 MOGS 7841
Co-fractionation Homo sapiens
133 CYC1 1537
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
134 UQCRC1 7384
Co-fractionation Homo sapiens
135 RPN1 6184
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
136 GANAB 23193
Co-fractionation Homo sapiens
137 PML 5371
Co-fractionation Homo sapiens
138 ZNF454  
Co-fractionation Homo sapiens
139 TECR 9524
Co-fractionation Homo sapiens
140 STON2 85439
Co-fractionation Homo sapiens
141 FLOT2 2319
Co-fractionation Homo sapiens
142 SND1 27044
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
143 HDAC5 10014
Affinity Capture-MS Homo sapiens
144 NIPSNAP1 8508
Co-fractionation Homo sapiens
145 ATP5B 506
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
146 RER1 11079
Co-fractionation Homo sapiens
147 SLC25A5 292
Co-fractionation Homo sapiens
148 COX4I1 1327
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
149 ATP1A2 477
Co-fractionation Homo sapiens
150 ANLN 54443
Affinity Capture-MS Homo sapiens
151 NDUFA12 55967
Co-fractionation Homo sapiens
152 ATG16L1 55054
Affinity Capture-MS Homo sapiens
153 HNRNPD 3184
Co-fractionation Homo sapiens
154 Rab5c 19345
Affinity Capture-MS Mus musculus
155 FASN 2194
Negative Genetic Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
156 SGPL1 8879
Co-fractionation Homo sapiens
157 CLN3 1201
Affinity Capture-MS Homo sapiens
158 COX7A2 1347
Co-fractionation Homo sapiens
159 HADHB 3032
Co-fractionation Homo sapiens
160 SUGP1  
Co-fractionation Homo sapiens
161 RPN2 6185
Co-fractionation Homo sapiens
162 METTL14  
Affinity Capture-MS Homo sapiens
163 GNB4 59345
Co-fractionation Homo sapiens
164 ATP5I 521
Co-fractionation Homo sapiens
165 OTUD1 220213
Affinity Capture-MS Homo sapiens
166 KIF20A 10112
Affinity Capture-MS Homo sapiens
167 NDUFA9 4704
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
168 PCCB 5096
Co-fractionation Homo sapiens
169 ECT2 1894
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
170 MTX2 10651
Affinity Capture-MS Homo sapiens
171 CPT1A 1374
Co-fractionation Homo sapiens
172 UQCRC2 7385
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
173 UBE2L3 7332
Co-fractionation Homo sapiens
174 CTNNB1 1499
Co-fractionation Homo sapiens
175 U2AF2 11338
Co-fractionation Homo sapiens
176 GOLT1B 51026
Affinity Capture-MS Homo sapiens
177 Rmdn3  
Affinity Capture-MS Mus musculus
178 BCAP31 10134
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
179 CUL3 8452
Affinity Capture-MS Homo sapiens
180 ATP5F1 515
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
181 FKBP8 23770
Affinity Capture-MS Homo sapiens
182 MYO19  
Affinity Capture-MS Homo sapiens
183 PHKG2 5261
Affinity Capture-MS Homo sapiens
184 FBXO6 26270
Affinity Capture-MS Homo sapiens
185 SEPT11 55752
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
186 ABCC1 4363
Co-fractionation Homo sapiens
187 FN1 2335
Affinity Capture-MS Homo sapiens
188 OCIAD1 54940
Proximity Label-MS Homo sapiens
189 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
190 ZNF782  
Co-fractionation Homo sapiens
191 HADHA 3030
Co-fractionation Homo sapiens
192 CDK2 1017
Affinity Capture-MS Homo sapiens
193 PRKACA 5566
Affinity Capture-MS Homo sapiens
194 MAPK6  
Affinity Capture-MS Homo sapiens
195 ATP5J2 9551
Co-fractionation Homo sapiens
196 SOAT1 6646
Affinity Capture-MS Homo sapiens
197 RPA3 6119
Proximity Label-MS Homo sapiens
198 MYOF 26509
Co-fractionation Homo sapiens
199 COX6C 1345
Co-fractionation Homo sapiens
200 PINK1  
Affinity Capture-MS Homo sapiens
201 ATP1B3 483
Co-fractionation Homo sapiens
202 ATP6V1A 523
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
203 MPV17 4358
Co-fractionation Homo sapiens
204 SERINC3 10955
Affinity Capture-MS Homo sapiens
205 HSPA4 3308
Cross-Linking-MS (XL-MS) Homo sapiens
206 MYCN  
Affinity Capture-MS Homo sapiens
207 SIRT2 22933
Affinity Capture-MS Homo sapiens
208 HDLBP 3069
Co-fractionation Homo sapiens
209 CUL9  
Co-fractionation Homo sapiens
210 DDRGK1 65992
Affinity Capture-MS Homo sapiens
211 VDAC1 7416
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
212 CLTC 1213
Co-fractionation Homo sapiens
213 COX2 4513
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
214 HNRNPU 3192
Co-fractionation Homo sapiens
215 ARL8B 55207
Co-fractionation Homo sapiens
216 NDUFS1 4719
Co-fractionation Homo sapiens
217 C9orf72  
Affinity Capture-MS Homo sapiens
218 NEDD4L 23327
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
219 SCCPDH 51097
Co-fractionation Homo sapiens
220 NDUFS2 4720
Co-fractionation Homo sapiens
221 DNAJC10 54431
Co-fractionation Homo sapiens
222 GBAS 2631
Co-fractionation Homo sapiens
223 ATP6V1H 51606
Co-fractionation Homo sapiens
224 IMMT 10989
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
225 SLC4A1 6521
Co-fractionation Homo sapiens
226 PPT1 5538
Affinity Capture-MS Homo sapiens
227 SNCA 6622
Affinity Capture-Western Homo sapiens
228 DNAJC11 55735
Affinity Capture-MS Homo sapiens
229 PLXNB2 23654
Co-fractionation Homo sapiens
230 SLC25A11 8402
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
231 RRBP1 6238
Co-fractionation Homo sapiens
232 BKRF1  
Affinity Capture-MS
233 ATP5A1 498
Co-fractionation Homo sapiens
234 JUP 3728
Co-fractionation Homo sapiens
235 FOXRED2  
Affinity Capture-MS Homo sapiens
236 CIT 11113
Affinity Capture-MS Homo sapiens
237 MEST 4232
Co-fractionation Homo sapiens
238 CALU 813
Co-fractionation Homo sapiens
239 TMEM63B 55362
Affinity Capture-MS Homo sapiens
240 NDUFA5 4698
Co-fractionation Homo sapiens
241 COX7C 1350
Co-fractionation Homo sapiens
242 EZR 7430
Co-fractionation Homo sapiens
243 SCP2 6342
Co-fractionation Homo sapiens
244 BCKDHA 593
Co-fractionation Homo sapiens
245 UBA52 7311
Co-fractionation Homo sapiens
246 PDHA1 5160
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
247 Pard6b  
Affinity Capture-MS Mus musculus
248 NAP1L1 4673
Co-fractionation Homo sapiens
249 SMURF1 57154
Affinity Capture-MS Homo sapiens
250 Htt  
Affinity Capture-MS Mus musculus
251 ELAVL1 1994
Co-fractionation Homo sapiens
252 COX8A  
Co-fractionation Homo sapiens
253 HSP90AA1 3320
Co-fractionation Homo sapiens
254 THOC6 79228
Co-fractionation Homo sapiens
255 GNB1 2782
Co-fractionation Homo sapiens
256 TSPO 706
Co-fractionation Homo sapiens
257 MKI67  
Affinity Capture-MS Homo sapiens
258 MYL12A 10627
Co-fractionation Homo sapiens
259 SSBP1 6742
Co-fractionation Homo sapiens
260 ATP6V1F 9296
Co-fractionation Homo sapiens
261 TRAP1 10131
Co-fractionation Homo sapiens
262 UFL1 23376
Affinity Capture-MS Homo sapiens
263 BAK1 578
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
264 COQ2  
Affinity Capture-MS Homo sapiens
265 NDUFS8 4728
Co-fractionation Homo sapiens
266 ATP5D 513
Co-fractionation Homo sapiens
267 NCL 4691
Co-fractionation Homo sapiens
268 BCL2L1 598
Affinity Capture-MS Homo sapiens
269 TTYH3 80727
Co-fractionation Homo sapiens
270 SPATA33  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
271 TOMM5  
Co-fractionation Homo sapiens
272 RAB7A 7879
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
273 ATP1A1 476
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
274 CYB5R3 1727
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
275 MCOLN1 57192
Co-fractionation Homo sapiens
276 XRCC6 2547
Proximity Label-MS Homo sapiens
277 CISD2 493856
Co-fractionation Homo sapiens
278 IGF2BP1 10642
Co-fractionation Homo sapiens
279 ATP5C1 509
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
280 RAB5C 5878
Affinity Capture-MS Homo sapiens
281 ADGRE5 976
Affinity Capture-MS Homo sapiens
282 Trappc11  
Affinity Capture-MS Mus musculus
283 ARF5 381
Affinity Capture-MS Homo sapiens
284 VDAC3 7419
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
285 PHF8  
Co-fractionation Homo sapiens
286 TFAM 7019
Co-fractionation Homo sapiens
287 RANGAP1 5905
Cross-Linking-MS (XL-MS) Homo sapiens
288 MGST3 4259
Co-fractionation Homo sapiens
289 SEPT7 989
Co-fractionation Homo sapiens
290 ACAA2 10449
Co-fractionation Homo sapiens
291 GNB2 2783
Co-fractionation Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here