Gene description for TMEM9
Gene name transmembrane protein 9
Gene symbol TMEM9
Other names/aliases TMEM9A
Species Homo sapiens
 Database cross references - TMEM9
ExoCarta ExoCarta_252839
Vesiclepedia VP_252839
Entrez Gene 252839
HGNC 18823
UniProt Q9P0T7  
 TMEM9 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TMEM9
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    lysosomal lumen acidification GO:0007042 IDA
    protein transport GO:0015031 IEA
    regulation of protein catabolic process GO:0042176 ISS
    endosomal lumen acidification GO:0048388 IDA
    proton-transporting V-type ATPase complex assembly GO:0070070 IDA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IDA
Subcellular Localization
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IDA
    late endosome GO:0005770 IDA
    microtubule cytoskeleton GO:0015630 IDA
    multivesicular body membrane GO:0032585 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    intercellular bridge GO:0045171 IDA
    mitotic spindle GO:0072686 IDA
 Experiment description of studies that identified TMEM9 in sEVs
1
Experiment ID 211
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TMEM9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Co-fractionation Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 C2CD2L 9854
Two-hybrid Homo sapiens
4 HSD17B11 51170
Proximity Label-MS Homo sapiens
5 OXCT1 5019
Co-fractionation Homo sapiens
6 ATR  
Affinity Capture-MS Homo sapiens
7 AGPAT5 55326
Affinity Capture-MS Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 HEATR6  
Affinity Capture-MS Homo sapiens
10 METTL7A 25840
Proximity Label-MS Homo sapiens
11 TSC2 7249
Affinity Capture-MS Homo sapiens
12 TFB2M  
Affinity Capture-MS Homo sapiens
13 NOP9 161424
Affinity Capture-MS Homo sapiens
14 EMP1  
Two-hybrid Homo sapiens
15 CCDC132 55610
Affinity Capture-MS Homo sapiens
16 ATP13A2  
Affinity Capture-MS Homo sapiens
17 TUSC5  
Two-hybrid Homo sapiens
18 JPH1 56704
Affinity Capture-MS Homo sapiens
19 VPS52 6293
Affinity Capture-MS Homo sapiens
20 VMP1 81671
Affinity Capture-MS Homo sapiens
21 BNIP1 662
Affinity Capture-MS Homo sapiens
22 GJD3  
Proximity Label-MS Homo sapiens
23 EYA2  
Affinity Capture-MS Homo sapiens
24 GATB  
Affinity Capture-MS Homo sapiens
25 PTPN1 5770
Proximity Label-MS Homo sapiens
26 SYVN1 84447
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 DERL1 79139
Proximity Label-MS Homo sapiens
28 STX4 6810
Proximity Label-MS Homo sapiens
29 VPS29 51699
Co-fractionation Homo sapiens
30 ABCD1 215
Affinity Capture-MS Homo sapiens
31 APEX1 328
Affinity Capture-RNA Homo sapiens
32 NEK7 140609
Affinity Capture-MS Homo sapiens
33 PPTC7 160760
Affinity Capture-MS Homo sapiens
34 PIGN 23556
Affinity Capture-MS Homo sapiens
35 TM2D3  
Affinity Capture-MS Homo sapiens
36 B3GAT1  
Proximity Label-MS Homo sapiens
37 ANKLE2 23141
Affinity Capture-MS Homo sapiens
38 SLC20A1 6574
Affinity Capture-MS Homo sapiens
39 GP1BB 2812
Affinity Capture-MS Homo sapiens
40 C16orf58 64755
Affinity Capture-MS Homo sapiens
41 SLC30A8  
Two-hybrid Homo sapiens
42 MON2 23041
Affinity Capture-MS Homo sapiens
43 RINT1 60561
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 MDN1 23195
Affinity Capture-MS Homo sapiens
45 SLC25A29  
Affinity Capture-MS Homo sapiens
46 FAM8A1 51439
Affinity Capture-MS Homo sapiens
47 RAB3B 5865
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TRDN 10345
Affinity Capture-MS Homo sapiens
49 CLEC2B  
Affinity Capture-MS Homo sapiens
50 MRPL12 6182
Co-fractionation Homo sapiens
51 SSR1 6745
Proximity Label-MS Homo sapiens
52 CD3E 916
Affinity Capture-MS Homo sapiens
53 PRDX2 7001
Co-fractionation Homo sapiens
54 STEAP3 55240
Affinity Capture-MS Homo sapiens
55 GGA1 26088
Affinity Capture-MS Homo sapiens
56 C2CD2 25966
Affinity Capture-MS Homo sapiens
57 FANCD2  
Affinity Capture-MS Homo sapiens
58 TMEM97 27346
Affinity Capture-MS Homo sapiens
59 STX6 10228
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
60 TMEM140  
Two-hybrid Homo sapiens
61 NDUFAF1  
Affinity Capture-MS Homo sapiens
62 ATP1A3 478
Affinity Capture-MS Homo sapiens
63 VPS53 55275
Affinity Capture-MS Homo sapiens
64 DNM1 1759
Affinity Capture-MS Homo sapiens
65 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
66 ESYT2 57488
Affinity Capture-MS Homo sapiens
67 FZD7 8324
Affinity Capture-MS Homo sapiens
68 STX10 8677
Affinity Capture-MS Homo sapiens
69 FEM1A  
Affinity Capture-MS Homo sapiens
70 ALG5 29880
Affinity Capture-MS Homo sapiens
71 MAD2L2 10459
Affinity Capture-MS Homo sapiens
72 SACM1L 22908
Affinity Capture-MS Homo sapiens
73 PDS5B 23047
Affinity Capture-MS Homo sapiens
74 FASTKD1  
Affinity Capture-MS Homo sapiens
75 VTI1A 143187
Affinity Capture-MS Homo sapiens
76 UCKL1 54963
Affinity Capture-MS Homo sapiens
77 KIAA1715 80856
Proximity Label-MS Homo sapiens
78 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
79 CLCN4 1183
Affinity Capture-MS Homo sapiens
80 EMD 2010
Proximity Label-MS Homo sapiens
81 ADGRL3 23284
Affinity Capture-MS Homo sapiens
82 CLCN3 1182
Affinity Capture-MS Homo sapiens
83 RAD51C  
Affinity Capture-MS Homo sapiens
84 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
85 INTS4  
Affinity Capture-MS Homo sapiens
86 PDXDC1 23042
Affinity Capture-MS Homo sapiens
87 TVP23C  
Affinity Capture-MS Homo sapiens
88 FAM118B  
Affinity Capture-MS Homo sapiens
89 TAMM41  
Affinity Capture-MS Homo sapiens
90 TM9SF2 9375
Affinity Capture-MS Homo sapiens
91 PDS5A 23244
Affinity Capture-MS Homo sapiens
92 SLC25A19  
Affinity Capture-MS Homo sapiens
93 CCDC107  
Affinity Capture-MS Homo sapiens
94 GOPC 57120
Affinity Capture-MS Homo sapiens
95 RPN1 6184
Proximity Label-MS Homo sapiens
96 VMA21  
Co-fractionation Homo sapiens
97 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
98 STX5 6811
Affinity Capture-MS Homo sapiens
99 DNM2 1785
Affinity Capture-MS Homo sapiens
100 RANBP6 26953
Affinity Capture-MS Homo sapiens
101 ELOVL5 60481
Proximity Label-MS Homo sapiens
102 DNM1L 10059
Affinity Capture-MS Homo sapiens
103 SEC61B 10952
Proximity Label-MS Homo sapiens
104 GOLGA5 9950
Affinity Capture-MS Homo sapiens
105 TNFAIP2 7127
Affinity Capture-MS Homo sapiens
106 CLDN10  
Two-hybrid Homo sapiens
107 TMEM60  
Two-hybrid Homo sapiens
108 NINJ2  
Two-hybrid Homo sapiens
109 PKMYT1  
Affinity Capture-MS Homo sapiens
110 RAB29 8934
Affinity Capture-MS Homo sapiens
111 HUS1  
Affinity Capture-MS Homo sapiens
112 CXCR4 7852
Affinity Capture-MS Homo sapiens
113 RPN2 6185
Proximity Label-MS Homo sapiens
114 LRRC59 55379
Proximity Label-MS Homo sapiens
115 DUOXA2  
Affinity Capture-MS Homo sapiens
116 TNFSF8  
Affinity Capture-MS Homo sapiens
117 S100A16 140576
Co-fractionation Homo sapiens
118 GALNT6 11226
Two-hybrid Homo sapiens
119 TMEM9B 56674
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
120 INTS7  
Affinity Capture-MS Homo sapiens
121 BCAP31 10134
Proximity Label-MS Homo sapiens
122 HSD3B7 80270
Proximity Label-MS Homo sapiens
123 DAB2IP 153090
Affinity Capture-MS Homo sapiens
124 CDC6  
Affinity Capture-MS Homo sapiens
125 KLRD1  
Affinity Capture-MS Homo sapiens
126 AAAS 8086
Affinity Capture-MS Homo sapiens
127 GJA3  
Affinity Capture-MS Homo sapiens
128 TTC27 55622
Affinity Capture-MS Homo sapiens
129 LPAR1 1902
Affinity Capture-MS Homo sapiens
130 CYP2C18  
Affinity Capture-MS Homo sapiens
131 CECR5 27440
Affinity Capture-MS Homo sapiens
132 GBF1 8729
Affinity Capture-MS Homo sapiens
133 JAK1 3716
Affinity Capture-MS Homo sapiens
134 OMA1  
Affinity Capture-MS Homo sapiens
135 RAB9A 9367
Proximity Label-MS Homo sapiens
136 KCNN4 3783
Affinity Capture-MS Homo sapiens
137 ACAD9 28976
Affinity Capture-MS Homo sapiens
138 SLC12A6 9990
Affinity Capture-MS Homo sapiens
139 LTN1 26046
Affinity Capture-MS Homo sapiens
140 ATP13A3 79572
Affinity Capture-MS Homo sapiens
141 SEPT11 55752
Co-fractionation Homo sapiens
142 KIDINS220 57498
Affinity Capture-MS Homo sapiens
143 HEATR1 55127
Affinity Capture-MS Homo sapiens
144 OSBPL8 114882
Affinity Capture-MS Homo sapiens
145 GGCX 2677
Affinity Capture-MS Homo sapiens
146 CLCN5 1184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 NUBPL 80224
Affinity Capture-MS Homo sapiens
148 TPCN1 53373
Affinity Capture-MS Homo sapiens
149 FLVCR1 28982
Affinity Capture-MS Homo sapiens
150 PPT1 5538
Co-fractionation Homo sapiens
151 GLS 2744
Affinity Capture-MS Homo sapiens
152 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
153 NUP205 23165
Affinity Capture-MS Homo sapiens
154 XPR1 9213
Affinity Capture-MS Homo sapiens
155 KNTC1 9735
Affinity Capture-MS Homo sapiens
156 HSPA12A 259217
Affinity Capture-MS Homo sapiens
157 UQCC1 55245
Affinity Capture-MS Homo sapiens
158 LDLRAD1  
Affinity Capture-MS Homo sapiens
159 DSTYK 25778
Affinity Capture-MS Homo sapiens
160 RSPH14  
Affinity Capture-MS Homo sapiens
161 EPHA4 2043
Affinity Capture-MS Homo sapiens
162 AURKB 9212
Affinity Capture-MS Homo sapiens
163 CLEC2D  
Affinity Capture-MS Homo sapiens
164 LGALS3 3958
Affinity Capture-MS Homo sapiens
165 RIF1  
Affinity Capture-MS Homo sapiens
166 NEK6 10783
Affinity Capture-MS Homo sapiens
167 CD1A 909
Affinity Capture-MS Homo sapiens
168 TUBB3 10381
Affinity Capture-MS Homo sapiens
169 OXSR1 9943
Affinity Capture-MS Homo sapiens
170 INTS2  
Affinity Capture-MS Homo sapiens
171 GPD1L 23171
Affinity Capture-MS Homo sapiens
172 OPA3 80207
Affinity Capture-MS Homo sapiens
173 UGDH 7358
Affinity Capture-MS Homo sapiens
174 ZDHHC13 54503
Affinity Capture-MS Homo sapiens
175 CLDN1 9076
Two-hybrid Homo sapiens
176 UBE3C 9690
Affinity Capture-MS Homo sapiens
177 GPR50  
Affinity Capture-MS Homo sapiens
178 UFL1 23376
Affinity Capture-MS Homo sapiens
179 GUF1  
Affinity Capture-MS Homo sapiens
180 FASTKD3  
Affinity Capture-MS Homo sapiens
181 OGFOD3 79701
Affinity Capture-MS Homo sapiens
182 LPCAT2 54947
Affinity Capture-MS Homo sapiens
183 XPO5 57510
Affinity Capture-MS Homo sapiens
184 ATP6V0C 527
Two-hybrid Homo sapiens
185 TBRG4 9238
Affinity Capture-MS Homo sapiens
186 SLC25A4 291
Affinity Capture-MS Homo sapiens
187 SEC62 7095
Proximity Label-MS Homo sapiens
188 NDC1 55706
Affinity Capture-MS Homo sapiens
189 SLC27A3 11000
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 SORT1 6272
Affinity Capture-MS Homo sapiens
191 DNM3 26052
Affinity Capture-MS Homo sapiens
192 PGAP2  
Two-hybrid Homo sapiens
193 RAB5C 5878
Proximity Label-MS Homo sapiens
194 TAP1 6890
Affinity Capture-MS Homo sapiens
195 WFS1 7466
Affinity Capture-MS Homo sapiens
196 CKAP4 10970
Proximity Label-MS Homo sapiens
197 SLC1A1 6505
Affinity Capture-MS Homo sapiens
198 CLEC4E  
Affinity Capture-MS Homo sapiens
199 CCRN4L  
Affinity Capture-MS Homo sapiens
200 ECSIT 51295
Affinity Capture-MS Homo sapiens
201 PCDHB3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM9 is involved
No pathways found





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