Gene description for TMEM9
Gene name transmembrane protein 9
Gene symbol TMEM9
Other names/aliases TMEM9A
Species Homo sapiens
 Database cross references - TMEM9
ExoCarta ExoCarta_252839
Vesiclepedia VP_252839
Entrez Gene 252839
HGNC 18823
UniProt Q9P0T7  
 TMEM9 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for TMEM9
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    lysosomal lumen acidification GO:0007042 IDA
    protein transport GO:0015031 IEA
    regulation of protein catabolic process GO:0042176 ISS
    endosomal lumen acidification GO:0048388 IDA
    proton-transporting V-type ATPase complex assembly GO:0070070 IDA
    positive regulation of canonical Wnt signaling pathway GO:0090263 IDA
Subcellular Localization
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IDA
    late endosome GO:0005770 IDA
    microtubule cytoskeleton GO:0015630 IDA
    multivesicular body membrane GO:0032585 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    intercellular bridge GO:0045171 IDA
    mitotic spindle GO:0072686 IDA
 Experiment description of studies that identified TMEM9 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TMEM9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Co-fractionation Homo sapiens
2 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
3 C2CD2L 9854
Two-hybrid Homo sapiens
4 HSD17B11 51170
Proximity Label-MS Homo sapiens
5 OXCT1 5019
Co-fractionation Homo sapiens
6 ATR  
Affinity Capture-MS Homo sapiens
7 AGPAT5 55326
Affinity Capture-MS Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 HEATR6  
Affinity Capture-MS Homo sapiens
10 METTL7A 25840
Proximity Label-MS Homo sapiens
11 TSC2 7249
Affinity Capture-MS Homo sapiens
12 TFB2M  
Affinity Capture-MS Homo sapiens
13 NOP9 161424
Affinity Capture-MS Homo sapiens
14 EMP1  
Two-hybrid Homo sapiens
15 CCDC132 55610
Affinity Capture-MS Homo sapiens
16 ATP13A2  
Affinity Capture-MS Homo sapiens
17 TUSC5  
Two-hybrid Homo sapiens
18 JPH1 56704
Affinity Capture-MS Homo sapiens
19 VPS52 6293
Affinity Capture-MS Homo sapiens
20 VMP1 81671
Affinity Capture-MS Homo sapiens
21 BNIP1 662
Affinity Capture-MS Homo sapiens
22 GJD3  
Proximity Label-MS Homo sapiens
23 EYA2  
Affinity Capture-MS Homo sapiens
24 GATB  
Affinity Capture-MS Homo sapiens
25 PTPN1 5770
Proximity Label-MS Homo sapiens
26 SYVN1 84447
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 DERL1 79139
Proximity Label-MS Homo sapiens
28 STX4 6810
Proximity Label-MS Homo sapiens
29 VPS29 51699
Co-fractionation Homo sapiens
30 ABCD1 215
Affinity Capture-MS Homo sapiens
31 APEX1 328
Affinity Capture-RNA Homo sapiens
32 NEK7 140609
Affinity Capture-MS Homo sapiens
33 PPTC7 160760
Affinity Capture-MS Homo sapiens
34 PIGN 23556
Affinity Capture-MS Homo sapiens
35 TM2D3  
Affinity Capture-MS Homo sapiens
36 B3GAT1  
Proximity Label-MS Homo sapiens
37 ANKLE2 23141
Affinity Capture-MS Homo sapiens
38 SLC20A1 6574
Affinity Capture-MS Homo sapiens
39 GP1BB 2812
Affinity Capture-MS Homo sapiens
40 C16orf58 64755
Affinity Capture-MS Homo sapiens
41 SLC30A8  
Two-hybrid Homo sapiens
42 MON2 23041
Affinity Capture-MS Homo sapiens
43 RINT1 60561
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 MDN1 23195
Affinity Capture-MS Homo sapiens
45 SLC25A29  
Affinity Capture-MS Homo sapiens
46 FAM8A1 51439
Affinity Capture-MS Homo sapiens
47 RAB3B 5865
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TRDN 10345
Affinity Capture-MS Homo sapiens
49 CLEC2B  
Affinity Capture-MS Homo sapiens
50 MRPL12 6182
Co-fractionation Homo sapiens
51 SSR1 6745
Proximity Label-MS Homo sapiens
52 CD3E 916
Affinity Capture-MS Homo sapiens
53 PRDX2 7001
Co-fractionation Homo sapiens
54 STEAP3 55240
Affinity Capture-MS Homo sapiens
55 GGA1 26088
Affinity Capture-MS Homo sapiens
56 C2CD2 25966
Affinity Capture-MS Homo sapiens
57 FANCD2  
Affinity Capture-MS Homo sapiens
58 TMEM97 27346
Affinity Capture-MS Homo sapiens
59 STX6 10228
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
60 TMEM140  
Two-hybrid Homo sapiens
61 NDUFAF1  
Affinity Capture-MS Homo sapiens
62 ATP1A3 478
Affinity Capture-MS Homo sapiens
63 VPS53 55275
Affinity Capture-MS Homo sapiens
64 DNM1 1759
Affinity Capture-MS Homo sapiens
65 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
66 ESYT2 57488
Affinity Capture-MS Homo sapiens
67 FZD7 8324
Affinity Capture-MS Homo sapiens
68 STX10 8677
Affinity Capture-MS Homo sapiens
69 FEM1A  
Affinity Capture-MS Homo sapiens
70 ALG5 29880
Affinity Capture-MS Homo sapiens
71 MAD2L2 10459
Affinity Capture-MS Homo sapiens
72 SACM1L 22908
Affinity Capture-MS Homo sapiens
73 PDS5B 23047
Affinity Capture-MS Homo sapiens
74 FASTKD1  
Affinity Capture-MS Homo sapiens
75 VTI1A 143187
Affinity Capture-MS Homo sapiens
76 UCKL1 54963
Affinity Capture-MS Homo sapiens
77 KIAA1715 80856
Proximity Label-MS Homo sapiens
78 ZDHHC17 23390
Affinity Capture-MS Homo sapiens
79 CLCN4 1183
Affinity Capture-MS Homo sapiens
80 EMD 2010
Proximity Label-MS Homo sapiens
81 ADGRL3 23284
Affinity Capture-MS Homo sapiens
82 CLCN3 1182
Affinity Capture-MS Homo sapiens
83 RAD51C  
Affinity Capture-MS Homo sapiens
84 TUBGCP4 27229
Affinity Capture-MS Homo sapiens
85 INTS4  
Affinity Capture-MS Homo sapiens
86 PDXDC1 23042
Affinity Capture-MS Homo sapiens
87 TVP23C  
Affinity Capture-MS Homo sapiens
88 FAM118B  
Affinity Capture-MS Homo sapiens
89 TAMM41  
Affinity Capture-MS Homo sapiens
90 TM9SF2 9375
Affinity Capture-MS Homo sapiens
91 PDS5A 23244
Affinity Capture-MS Homo sapiens
92 SLC25A19  
Affinity Capture-MS Homo sapiens
93 CCDC107  
Affinity Capture-MS Homo sapiens
94 GOPC 57120
Affinity Capture-MS Homo sapiens
95 RPN1 6184
Proximity Label-MS Homo sapiens
96 VMA21  
Co-fractionation Homo sapiens
97 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
98 STX5 6811
Affinity Capture-MS Homo sapiens
99 DNM2 1785
Affinity Capture-MS Homo sapiens
100 RANBP6 26953
Affinity Capture-MS Homo sapiens
101 ELOVL5 60481
Proximity Label-MS Homo sapiens
102 DNM1L 10059
Affinity Capture-MS Homo sapiens
103 SEC61B 10952
Proximity Label-MS Homo sapiens
104 GOLGA5 9950
Affinity Capture-MS Homo sapiens
105 TNFAIP2 7127
Affinity Capture-MS Homo sapiens
106 CLDN10  
Two-hybrid Homo sapiens
107 TMEM60  
Two-hybrid Homo sapiens
108 NINJ2  
Two-hybrid Homo sapiens
109 PKMYT1  
Affinity Capture-MS Homo sapiens
110 RAB29 8934
Affinity Capture-MS Homo sapiens
111 HUS1  
Affinity Capture-MS Homo sapiens
112 CXCR4 7852
Affinity Capture-MS Homo sapiens
113 RPN2 6185
Proximity Label-MS Homo sapiens
114 LRRC59 55379
Proximity Label-MS Homo sapiens
115 DUOXA2  
Affinity Capture-MS Homo sapiens
116 TNFSF8  
Affinity Capture-MS Homo sapiens
117 S100A16 140576
Co-fractionation Homo sapiens
118 GALNT6 11226
Two-hybrid Homo sapiens
119 TMEM9B 56674
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
120 INTS7  
Affinity Capture-MS Homo sapiens
121 BCAP31 10134
Proximity Label-MS Homo sapiens
122 HSD3B7 80270
Proximity Label-MS Homo sapiens
123 DAB2IP 153090
Affinity Capture-MS Homo sapiens
124 CDC6  
Affinity Capture-MS Homo sapiens
125 KLRD1  
Affinity Capture-MS Homo sapiens
126 AAAS 8086
Affinity Capture-MS Homo sapiens
127 GJA3  
Affinity Capture-MS Homo sapiens
128 TTC27 55622
Affinity Capture-MS Homo sapiens
129 LPAR1 1902
Affinity Capture-MS Homo sapiens
130 CYP2C18  
Affinity Capture-MS Homo sapiens
131 CECR5 27440
Affinity Capture-MS Homo sapiens
132 GBF1 8729
Affinity Capture-MS Homo sapiens
133 JAK1 3716
Affinity Capture-MS Homo sapiens
134 OMA1  
Affinity Capture-MS Homo sapiens
135 RAB9A 9367
Proximity Label-MS Homo sapiens
136 KCNN4 3783
Affinity Capture-MS Homo sapiens
137 ACAD9 28976
Affinity Capture-MS Homo sapiens
138 SLC12A6 9990
Affinity Capture-MS Homo sapiens
139 LTN1 26046
Affinity Capture-MS Homo sapiens
140 ATP13A3 79572
Affinity Capture-MS Homo sapiens
141 SEPT11 55752
Co-fractionation Homo sapiens
142 KIDINS220 57498
Affinity Capture-MS Homo sapiens
143 HEATR1 55127
Affinity Capture-MS Homo sapiens
144 OSBPL8 114882
Affinity Capture-MS Homo sapiens
145 GGCX 2677
Affinity Capture-MS Homo sapiens
146 CLCN5 1184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 NUBPL 80224
Affinity Capture-MS Homo sapiens
148 TPCN1 53373
Affinity Capture-MS Homo sapiens
149 FLVCR1 28982
Affinity Capture-MS Homo sapiens
150 PPT1 5538
Co-fractionation Homo sapiens
151 GLS 2744
Affinity Capture-MS Homo sapiens
152 RHOBTB3 22836
Affinity Capture-MS Homo sapiens
153 NUP205 23165
Affinity Capture-MS Homo sapiens
154 XPR1 9213
Affinity Capture-MS Homo sapiens
155 KNTC1 9735
Affinity Capture-MS Homo sapiens
156 HSPA12A 259217
Affinity Capture-MS Homo sapiens
157 UQCC1 55245
Affinity Capture-MS Homo sapiens
158 LDLRAD1  
Affinity Capture-MS Homo sapiens
159 DSTYK 25778
Affinity Capture-MS Homo sapiens
160 RSPH14  
Affinity Capture-MS Homo sapiens
161 EPHA4 2043
Affinity Capture-MS Homo sapiens
162 AURKB 9212
Affinity Capture-MS Homo sapiens
163 CLEC2D  
Affinity Capture-MS Homo sapiens
164 LGALS3 3958
Affinity Capture-MS Homo sapiens
165 RIF1  
Affinity Capture-MS Homo sapiens
166 NEK6 10783
Affinity Capture-MS Homo sapiens
167 CD1A 909
Affinity Capture-MS Homo sapiens
168 TUBB3 10381
Affinity Capture-MS Homo sapiens
169 OXSR1 9943
Affinity Capture-MS Homo sapiens
170 INTS2  
Affinity Capture-MS Homo sapiens
171 GPD1L 23171
Affinity Capture-MS Homo sapiens
172 OPA3 80207
Affinity Capture-MS Homo sapiens
173 UGDH 7358
Affinity Capture-MS Homo sapiens
174 ZDHHC13 54503
Affinity Capture-MS Homo sapiens
175 CLDN1 9076
Two-hybrid Homo sapiens
176 UBE3C 9690
Affinity Capture-MS Homo sapiens
177 GPR50  
Affinity Capture-MS Homo sapiens
178 UFL1 23376
Affinity Capture-MS Homo sapiens
179 GUF1  
Affinity Capture-MS Homo sapiens
180 FASTKD3  
Affinity Capture-MS Homo sapiens
181 OGFOD3 79701
Affinity Capture-MS Homo sapiens
182 LPCAT2 54947
Affinity Capture-MS Homo sapiens
183 XPO5 57510
Affinity Capture-MS Homo sapiens
184 ATP6V0C 527
Two-hybrid Homo sapiens
185 TBRG4 9238
Affinity Capture-MS Homo sapiens
186 SLC25A4 291
Affinity Capture-MS Homo sapiens
187 SEC62 7095
Proximity Label-MS Homo sapiens
188 NDC1 55706
Affinity Capture-MS Homo sapiens
189 SLC27A3 11000
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 SORT1 6272
Affinity Capture-MS Homo sapiens
191 DNM3 26052
Affinity Capture-MS Homo sapiens
192 PGAP2  
Two-hybrid Homo sapiens
193 RAB5C 5878
Proximity Label-MS Homo sapiens
194 TAP1 6890
Affinity Capture-MS Homo sapiens
195 WFS1 7466
Affinity Capture-MS Homo sapiens
196 CKAP4 10970
Proximity Label-MS Homo sapiens
197 SLC1A1 6505
Affinity Capture-MS Homo sapiens
198 CLEC4E  
Affinity Capture-MS Homo sapiens
199 CCRN4L  
Affinity Capture-MS Homo sapiens
200 ECSIT 51295
Affinity Capture-MS Homo sapiens
201 PCDHB3  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TMEM9 is involved
No pathways found





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