Gene description for DDX24
Gene name DEAD (Asp-Glu-Ala-Asp) box helicase 24
Gene symbol DDX24
Other names/aliases -
Species Homo sapiens
 Database cross references - DDX24
ExoCarta ExoCarta_57062
Vesiclepedia VP_57062
Entrez Gene 57062
HGNC 13266
MIM 606181
UniProt Q9GZR7  
 DDX24 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DDX24
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 HDA
    RNA helicase activity GO:0003724 NAS
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP hydrolysis activity GO:0016887 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    RNA metabolic process GO:0016070 NAS
    chromatin looping GO:0140588 IEA
Subcellular Localization
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    membrane GO:0016020 HDA
 Experiment description of studies that identified DDX24 in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DDX24
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPL11 6135
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
2 ZBTB38 253461
Affinity Capture-MS Homo sapiens
3 ZNF668  
Affinity Capture-MS Homo sapiens
4 RPF2 84154
Co-fractionation Homo sapiens
5 KLF6  
Proximity Label-MS Homo sapiens
6 TRDMT1  
Two-hybrid Homo sapiens
7 RPL26L1 51121
Affinity Capture-MS Homo sapiens
8 Mdm2  
Affinity Capture-Western Mus musculus
Affinity Capture-MS Mus musculus
Affinity Capture-Western Mus musculus
9 Eif4a2 13682
Two-hybrid Mus musculus
10 SPRTN  
Affinity Capture-MS Homo sapiens
11 NOP58 51602
Co-fractionation Homo sapiens
12 DNAJC9 23234
Proximity Label-MS Homo sapiens
13 CNBP 7555
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 COIL  
Proximity Label-MS Homo sapiens
15 ZNF346  
Affinity Capture-MS Homo sapiens
16 NPM3 10360
Affinity Capture-MS Homo sapiens
17 KIAA0020 9933
Co-fractionation Homo sapiens
18 SRPK2 6733
Affinity Capture-MS Homo sapiens
19 DDX21 9188
Affinity Capture-MS Homo sapiens
20 LHX2  
Proximity Label-MS Homo sapiens
21 RPL13A 23521
Affinity Capture-MS Homo sapiens
22 RPL37A 6168
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 LIN28B  
Affinity Capture-MS Homo sapiens
24 BRCA1 672
Two-hybrid Homo sapiens
25 RPL23AP32 56969
Affinity Capture-MS Homo sapiens
26 RPL10 6134
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 RPL15 6138
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
28 BRD2  
Affinity Capture-MS Homo sapiens
29 RPL14 9045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CSNK2A1 1457
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
31 PNMAL1  
Affinity Capture-MS Homo sapiens
32 CAND1 55832
Affinity Capture-MS Homo sapiens
33 LOC100132735  
Protein-RNA Homo sapiens
34 INTS6 26512
Co-fractionation Homo sapiens
35 SOX2  
Proximity Label-MS Homo sapiens
36 CENPA  
Proximity Label-MS Homo sapiens
37 USP36  
Affinity Capture-MS Homo sapiens
38 EGFR 1956
Negative Genetic Homo sapiens
39 DDX23 9416
Proximity Label-MS Homo sapiens
40 GPATCH4 54865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 RPS2 6187
Affinity Capture-MS Homo sapiens
42 SART3 9733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 PRR11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 NSA2  
Co-fractionation Homo sapiens
45 RPL28 6158
Affinity Capture-MS Homo sapiens
46 OTUB1 55611
Affinity Capture-MS Homo sapiens
47 USP39 10713
Affinity Capture-MS Homo sapiens
48 H2AFB3  
Affinity Capture-MS Homo sapiens
49 RPA3 6119
Proximity Label-MS Homo sapiens
50 RRP12 23223
Co-fractionation Homo sapiens
51 ZBTB47  
Affinity Capture-MS Homo sapiens
52 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 ANOS1 3730
Affinity Capture-MS Homo sapiens
54 POU5F1  
Affinity Capture-MS Homo sapiens
55 BRPF3  
Affinity Capture-MS Homo sapiens
56 H2AFY2 55506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 FGF17  
Affinity Capture-MS Homo sapiens
58 ZNF2  
Affinity Capture-MS Homo sapiens
59 Set 56086
Affinity Capture-MS Mus musculus
60 ADARB1 104
Affinity Capture-MS Homo sapiens
61 EIF3E 3646
Two-hybrid Homo sapiens
62 PRKRA 8575
Affinity Capture-MS Homo sapiens
63 GRWD1 83743
Co-fractionation Homo sapiens
64 XRN1 54464
Co-fractionation Homo sapiens
65 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 SLC25A46 91137
Proximity Label-MS Homo sapiens
67 ABT1 29777
Affinity Capture-MS Homo sapiens
68 DDX18 8886
Co-fractionation Homo sapiens
69 RRP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 FBL 2091
Co-fractionation Homo sapiens
71 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 TLX3  
Proximity Label-MS Homo sapiens
73 MYCN  
Affinity Capture-MS Homo sapiens
74 WDR12 55759
Co-fractionation Homo sapiens
75 OASL 8638
Affinity Capture-MS Homo sapiens
76 USP7 7874
Affinity Capture-MS Homo sapiens
77 CSNK2B 1460
Affinity Capture-MS Homo sapiens
78 MAK16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 PSMD14 10213
Affinity Capture-MS Homo sapiens
80 RPL19 6143
Affinity Capture-MS Homo sapiens
81 RBPJ 3516
Affinity Capture-MS Homo sapiens
82 KIF14 9928
Affinity Capture-MS Homo sapiens
83 PES1 23481
Co-fractionation Homo sapiens
84 LIN28A  
Affinity Capture-MS Homo sapiens
85 NAP1L2  
Affinity Capture-MS Homo sapiens
86 POLA2  
Two-hybrid Homo sapiens
87 KLF16  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 TBL3 10607
Co-fractionation Homo sapiens
89 KLF5  
Proximity Label-MS Homo sapiens
90 DDX31  
Co-fractionation Homo sapiens
91 RPL30 6156
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 NOP2 4839
Co-fractionation Homo sapiens
93 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
94 CNOT2  
Affinity Capture-MS Homo sapiens
95 FASTKD5  
Proximity Label-MS Homo sapiens
96 EMD 2010
Proximity Label-MS Homo sapiens
97 SRP14 6727
Affinity Capture-MS Homo sapiens
98 RPL4 6124
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
99 RBM28 55131
Affinity Capture-MS Homo sapiens
100 NOL6 65083
Co-fractionation Homo sapiens
101 RBM19 9904
Affinity Capture-MS Homo sapiens
102 CLSTN1 22883
Affinity Capture-MS Homo sapiens
103 HIST1H2AG 8969
Cross-Linking-MS (XL-MS) Homo sapiens
104 ERGIC2 51290
Proximity Label-MS Homo sapiens
105 RBM4B  
Affinity Capture-MS Homo sapiens
106 YBX2 51087
Affinity Capture-MS Homo sapiens
107 RPL5 6125
Co-fractionation Homo sapiens
108 SRSF6 6431
Affinity Capture-MS Homo sapiens
109 PURG  
Affinity Capture-MS Homo sapiens
110 ZBTB48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 UBE2I 7329
Biochemical Activity Homo sapiens
112 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
113 RPL18A 6142
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 LHX1  
Proximity Label-MS Homo sapiens
115 Srp72  
Affinity Capture-MS Mus musculus
116 GIT1 28964
Two-hybrid Homo sapiens
117 RPS25 6230
Co-fractionation Homo sapiens
118 TSPYL2  
Affinity Capture-MS Homo sapiens
119 RPS10 6204
Affinity Capture-MS Homo sapiens
120 NTRK1 4914
Affinity Capture-MS Homo sapiens
121 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 RSL1D1 26156
Affinity Capture-MS Homo sapiens
123 KMT2E  
Affinity Capture-MS Homo sapiens
124 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
125 REXO4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
127 NCL 4691
Affinity Capture-Western Homo sapiens
128 RPL36 25873
Affinity Capture-MS Homo sapiens
129 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
130 RPL27A 6157
Affinity Capture-MS Homo sapiens
131 ZCCHC10  
Affinity Capture-MS Homo sapiens
132 LYAR 55646
Affinity Capture-MS Homo sapiens
133 HECTD1 25831
Affinity Capture-MS Homo sapiens
134 RPLP0 6175
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
135 SRPK3  
Affinity Capture-MS Homo sapiens
136 MAGEB2 4113
Affinity Capture-MS Homo sapiens
137 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
138 KLF12  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 GTPBP4 23560
Co-fractionation Homo sapiens
140 SOX17  
Proximity Label-MS Homo sapiens
141 TSR2  
Co-fractionation Homo sapiens
142 NOP56 10528
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
143 MGMT 4255
Affinity Capture-MS Homo sapiens
144 CD3EAP  
Proximity Label-MS Homo sapiens
145 WDR46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 SCARNA22  
Affinity Capture-RNA Homo sapiens
147 FGFBP1 9982
Affinity Capture-MS Homo sapiens
148 TLX2  
Proximity Label-MS Homo sapiens
149 RPL23A 6147
Affinity Capture-MS Homo sapiens
150 HSPA5 3309
Two-hybrid Homo sapiens
151 ZBTB2 57621
Affinity Capture-MS Homo sapiens
152 HMGN4  
Affinity Capture-MS Homo sapiens
153 RPS19 6223
Affinity Capture-MS Homo sapiens
154 RPL10A 4736
Affinity Capture-MS Homo sapiens
155 RPL31 6160
Proximity Label-MS Homo sapiens
156 RPLP2 6181
Co-fractionation Homo sapiens
157 UBE2H 7328
Affinity Capture-MS Homo sapiens
158 NOC3L 64318
Co-fractionation Homo sapiens
159 TPI1 7167
Two-hybrid Homo sapiens
160 RPL7A 6130
Affinity Capture-MS Homo sapiens
161 MRTO4 51154
Co-fractionation Homo sapiens
162 RPL13 6137
Affinity Capture-MS Homo sapiens
163 C9orf78 51759
Affinity Capture-MS Homo sapiens
164 RC3H2  
Affinity Capture-MS Homo sapiens
165 RBBP6 5930
Co-fractionation Homo sapiens
166 SIRT7  
Affinity Capture-MS Homo sapiens
167 SRSF4 6429
Affinity Capture-MS Homo sapiens
168 IFI16 3428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 SRSF1 6426
Affinity Capture-MS Homo sapiens
170 BRD8 10902
Affinity Capture-MS Homo sapiens
171 IFT57 55081
Affinity Capture-MS Homo sapiens
172 HSP90AB1 3326
Two-hybrid Homo sapiens
173 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 RPS6 6194
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 GLRA2  
Two-hybrid Homo sapiens
176 SRSF5 6430
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
177 RPL3 6122
Affinity Capture-MS Homo sapiens
178 EBNA1BP2 10969
Co-fractionation Homo sapiens
179 THOC5 8563
Affinity Capture-MS Homo sapiens
180 ARF6 382
Proximity Label-MS Homo sapiens
181 RPL35 11224
Affinity Capture-MS Homo sapiens
182 RPL7 6129
Co-fractionation Homo sapiens
183 NIP7 51388
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
184 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
185 OCIAD1 54940
Proximity Label-MS Homo sapiens
186 NXF1 10482
Affinity Capture-RNA Homo sapiens
187 SPTAN1 6709
Two-hybrid Homo sapiens
188 TERF2IP 54386
Two-hybrid Homo sapiens
189 ZNF512  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 SGTB  
Affinity Capture-MS Homo sapiens
191 CEP250 11190
Affinity Capture-MS Homo sapiens
192 MAP2K3 5606
Affinity Capture-MS Homo sapiens
193 CBX6  
Affinity Capture-MS Homo sapiens
194 PCBP1 5093
Affinity Capture-MS Homo sapiens
195 TRIM44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 DKC1 1736
Co-fractionation Homo sapiens
197 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
198 HECW2  
Affinity Capture-MS Homo sapiens
199 ATP2A1 487
Proximity Label-MS Homo sapiens
200 THAP3  
Affinity Capture-MS Homo sapiens
201 ZNF692  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
202 ZMYND8 23613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 NOL12 79159
Affinity Capture-MS Homo sapiens
204 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
205 RPS14 6208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
206 INO80  
Co-fractionation Homo sapiens
207 NHP2L1 4809
Co-fractionation Homo sapiens
208 KLF15  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 RPL22 6146
Affinity Capture-MS Homo sapiens
210 ZNF687  
Affinity Capture-MS Homo sapiens
211 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
212 CORO1A 11151
Affinity Capture-MS Homo sapiens
213 SET 6418
Affinity Capture-MS Homo sapiens
214 RPL18 6141
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
215 DDRGK1 65992
Affinity Capture-MS Homo sapiens
216 RNF2  
Affinity Capture-MS Homo sapiens
217 RHOB 388
Proximity Label-MS Homo sapiens
218 FOXQ1  
Affinity Capture-MS Homo sapiens
219 H2AFB2  
Affinity Capture-MS Homo sapiens
220 NANOG  
Affinity Capture-MS Homo sapiens
221 ZC3H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
222 FTSJ3 117246
Co-fractionation Homo sapiens
223 MDM2  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
224 GNL3 26354
Co-fractionation Homo sapiens
225 DDX55  
Co-fractionation Homo sapiens
226 ITGB3BP  
Two-hybrid Homo sapiens
227 ETV3  
Proximity Label-MS Homo sapiens
228 SDC2 6383
Affinity Capture-MS Homo sapiens
229 Cbx1  
Affinity Capture-MS Mus musculus
230 SURF6  
Affinity Capture-MS Homo sapiens
231 VDAC3 7419
Two-hybrid Homo sapiens
232 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
233 MKRN1 23608
Affinity Capture-MS Homo sapiens
234 ZC3H10  
Affinity Capture-MS Homo sapiens
235 TERF2  
Two-hybrid Homo sapiens
236 AUH 549
Proximity Label-MS Homo sapiens
237 LAMTOR1 55004
Proximity Label-MS Homo sapiens
238 PDZD2  
Affinity Capture-Western Homo sapiens
239 SPANXN2  
Affinity Capture-MS Homo sapiens
240 PAFAH1B3 5050
Two-hybrid Homo sapiens
241 FBXL6  
Affinity Capture-MS Homo sapiens
242 TP53 7157
Affinity Capture-MS Homo sapiens
243 RPL6 6128
Co-fractionation Homo sapiens
244 MKS1 54903
Two-hybrid Homo sapiens
245 POTEJ 653781
Co-fractionation Homo sapiens
246 TSPYL6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
247 SOX15  
Proximity Label-MS Homo sapiens