Gene description for DDX24
Gene name DEAD (Asp-Glu-Ala-Asp) box helicase 24
Gene symbol DDX24
Other names/aliases -
Species Homo sapiens
 Database cross references - DDX24
ExoCarta ExoCarta_57062
Entrez Gene 57062
HGNC 13266
MIM 606181
UniProt Q9GZR7  
 DDX24 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DDX24
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    RNA helicase activity GO:0003724 NAS
    ATP-dependent RNA helicase activity GO:0004004 IBA
    ATP binding GO:0005524 IEA
Biological Process
    RNA metabolic process GO:0016070 NAS
    RNA secondary structure unwinding GO:0010501 IBA
Subcellular Localization
    nucleolus GO:0005730 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified DDX24 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DDX24
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PIN1 5300
Two-hybrid Homo sapiens
2 SPTAN1 6709
Two-hybrid Homo sapiens
3 PAFAH1B3 5050
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 TRDMT1  
Two-hybrid Homo sapiens
6 BCS1L  
Two-hybrid Homo sapiens
7 HSPA5 3309
Two-hybrid Homo sapiens
8 HSP90AB1 3326
Two-hybrid Homo sapiens
9 Eif4a2 13682
Two-hybrid Mus musculus
10 VDAC3 7419
Two-hybrid Homo sapiens
11 GIT1 28964
Two-hybrid Homo sapiens
12 MYC  
Affinity Capture-MS Homo sapiens
13 POLA2  
Two-hybrid Homo sapiens
14 EIF3E 3646
Two-hybrid Homo sapiens
15 TPI1 7167
Two-hybrid Homo sapiens
16 FLJ20345  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which DDX24 is involved
No pathways found

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