Gene description for MDH2
Gene name malate dehydrogenase 2, NAD (mitochondrial)
Gene symbol MDH2
Other names/aliases M-MDH
MDH
MGC:3559
MOR1
Species Homo sapiens
 Database cross references - MDH2
ExoCarta ExoCarta_4191
Vesiclepedia VP_4191
Entrez Gene 4191
HGNC 6971
MIM 154100
UniProt P40926  
 MDH2 identified in exosomes derived from the following tissue/cell type
B cells 20458337    
B cells 20458337    
B cells 20458337    
Bladder cancer cells 20224111    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Melanoma cells 22635005    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Nasopharyngeal carcinoma cells 25857718    
Neuroblastoma cells 25944692    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
Squamous carcinoma cells 20124223    
T lymphocytes 34108659    
Urine 19056867    
 Gene ontology annotations for MDH2
Molecular Function
    RNA binding GO:0003723 HDA
    L-malate dehydrogenase (NAD+) activity GO:0030060 EXP
    L-malate dehydrogenase (NAD+) activity GO:0030060 IBA
    L-malate dehydrogenase (NAD+) activity GO:0030060 IDA
    L-malate dehydrogenase (NAD+) activity GO:0030060 IMP
    identical protein binding GO:0042802 IEA
    L-malate dehydrogenase (NADP+) activity GO:0046554 IEA
Biological Process
    gluconeogenesis GO:0006094 IEA
    tricarboxylic acid cycle GO:0006099 IBA
    tricarboxylic acid cycle GO:0006099 IMP
    tricarboxylic acid cycle GO:0006099 TAS
    malate metabolic process GO:0006108 IDA
    malate metabolic process GO:0006108 IMP
    NADH metabolic process GO:0006734 IEA
    aerobic respiration GO:0009060 IDA
    malate-aspartate shuttle GO:0043490 IMP
    malate-aspartate shuttle GO:0043490 TAS
Subcellular Localization
    nucleus GO:0005634 HDA
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    membrane GO:0016020 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified MDH2 in exosomes
1
Experiment ID 79
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
2
Experiment ID 80
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
3
Experiment ID 81
MISEV standards
✘ Biophysical techniques
✔
CD81|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20458337    
Organism Homo sapiens
Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3
Authors "Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W."
Journal name ICB
Publication year 2010
Sample B cells
Sample name RN (HLA-DR15)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Immunobeads (MHC Class II)
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [FT-ICR]
Western blotting
4
Experiment ID 76
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|GAPDH|HSP90|CD81|CD9|CD63|LAMP1|MHCI
Enriched markers
✔
HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors "Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A."
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
5
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
10
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
11
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
12
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
13
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
14
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
15
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
16
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
17
Experiment ID 282
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
18
Experiment ID 283
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
19
Experiment ID 286
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Sequential centrifugal ultrafiltration - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Sequential centrifugal ultrafiltration
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
20
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
21
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
26
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
29
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
30
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 200
MISEV standards
✔
EM
Biophysical techniques
✔
HSP70|HSP90|TSG101|Alix|GAPDH
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22635005    
Organism Homo sapiens
Experiment description Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Authors "Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, Garcia-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, Martins VR, Skog J, Kaplan RN, Brady MS, Wolchok JD, Chapman PB, Kang Y, Bromberg J, Lyden D."
Journal name Nat Med
Publication year 2012
Sample Melanoma cells
Sample name B16-F10
SK-MEL-202
SK-MEL035
SK-MEL-265
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
33
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
35
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
36
Experiment ID 260
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
37
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
38
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
39
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
40
Experiment ID 219
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name C666-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
41
Experiment ID 220
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP69
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
42
Experiment ID 221
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25857718    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from nasopharyngeal carcinoma cell identifies intercellular transfer of angiogenic proteins
Authors "Chan YK, Zhang H, Liu P, Tsao GS, Li Lung M, Mak NK, Ngok-Shun Wong R, Ying-Kit Yue P"
Journal name Int J Cancer
Publication year 2015
Sample Nasopharyngeal carcinoma cells
Sample name NP460
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.17-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
43
Experiment ID 224
MISEV standards
✔
EM|AFM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81
Enriched markers
✔
GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
44
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
45
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
46
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
47
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
48
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
49
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
50
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
51
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
52
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
53
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
54
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
55
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
56
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
57
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
58
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
59
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MDH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HDAC4  
Affinity Capture-MS Homo sapiens
2 OXCT1 5019
Proximity Label-MS Homo sapiens
3 PKM 5315
Co-fractionation Homo sapiens
4 ACOT9 23597
Proximity Label-MS Homo sapiens
5 ACAA1 30
Co-fractionation Homo sapiens
6 NFATC1 4772
Affinity Capture-MS Homo sapiens
7 ACTC1 70
Affinity Capture-MS Homo sapiens
8 MTG2  
Proximity Label-MS Homo sapiens
9 ISCU 23479
Proximity Label-MS Homo sapiens
10 MRPL24  
Proximity Label-MS Homo sapiens
11 MRPL27 51264
Proximity Label-MS Homo sapiens
12 PARK7 11315
Affinity Capture-MS Homo sapiens
13 SOX2  
Affinity Capture-MS Homo sapiens
14 DECR1 1666
Proximity Label-MS Homo sapiens
15 CCDC90B  
Proximity Label-MS Homo sapiens
16 CKB 1152
Affinity Capture-MS Homo sapiens
17 DDX23 9416
Cross-Linking-MS (XL-MS) Homo sapiens
18 QSOX2 169714
Co-fractionation Homo sapiens
19 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
20 IARS2 55699
Proximity Label-MS Homo sapiens
21 ETFA 2108
Proximity Label-MS Homo sapiens
22 MRPL57  
Proximity Label-MS Homo sapiens
23 POLRMT 5442
Proximity Label-MS Homo sapiens
24 NDUFAB1 4706
Proximity Label-MS Homo sapiens
25 SLC30A9 10463
Proximity Label-MS Homo sapiens
26 BCS1L 617
Proximity Label-MS Homo sapiens
27 PREPL 9581
Proximity Label-MS Homo sapiens
28 VWA8 23078
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
29 MRPL47 57129
Proximity Label-MS Homo sapiens
30 SOD1 6647
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 RBMX 27316
Proximity Label-MS Homo sapiens
32 CHMP4C 92421
Affinity Capture-MS Homo sapiens
33 ACADVL 37
Proximity Label-MS Homo sapiens
34 NT5DC2 64943
Proximity Label-MS Homo sapiens
35 TUFM 7284
Proximity Label-MS Homo sapiens
36 YAP1 10413
Affinity Capture-MS Homo sapiens
37 MYH9 4627
Affinity Capture-MS Homo sapiens
38 MRPS6  
Proximity Label-MS Homo sapiens
39 ACADM 34
Proximity Label-MS Homo sapiens
40 SYNCRIP 10492
Proximity Label-MS Homo sapiens
41 Mapk13  
Affinity Capture-MS Mus musculus
42 DBT 1629
Proximity Label-MS Homo sapiens
43 MTRF1L  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
44 ACN9  
Proximity Label-MS Homo sapiens
45 MRPL41 64975
Proximity Label-MS Homo sapiens
46 MRPL14 64928
Proximity Label-MS Homo sapiens
47 RARS2  
Proximity Label-MS Homo sapiens
48 EARS2  
Proximity Label-MS Homo sapiens
49 HADHA 3030
Proximity Label-MS Homo sapiens
50 BLVRB 645
Affinity Capture-MS Homo sapiens
51 MRPS12  
Proximity Label-MS Homo sapiens
52 MTIF2 4528
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
53 NDUFA13 51079
Proximity Label-MS Homo sapiens
54 SDHA 6389
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
55 CRYAB 1410
Reconstituted Complex Homo sapiens
56 ANXA1 301
Co-fractionation Homo sapiens
57 MRPL16  
Proximity Label-MS Homo sapiens
58 ASS1 445
Affinity Capture-MS Homo sapiens
59 FAHD1 81889
Co-fractionation Homo sapiens
60 GADD45GIP1  
Proximity Label-MS Homo sapiens
61 VARS2  
Proximity Label-MS Homo sapiens
62 FN1 2335
Affinity Capture-MS Homo sapiens
63 HNRNPR 10236
Proximity Label-MS Homo sapiens
64 SOAT1 6646
Affinity Capture-MS Homo sapiens
65 RPA3 6119
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
66 DLST 1743
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
67 AUH 549
Proximity Label-MS Homo sapiens
68 COX2 4513
Proximity Label-MS Homo sapiens
69 DLAT 1737
Proximity Label-MS Homo sapiens
70 MRPL18 29074
Proximity Label-MS Homo sapiens
71 NADK2 133686
Proximity Label-MS Homo sapiens
72 GBAS 2631
Proximity Label-MS Homo sapiens
73 HSPE1 3336
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
74 GLS 2744
Proximity Label-MS Homo sapiens
75 PDK3 5165
Proximity Label-MS Homo sapiens
76 CLPX 10845
Proximity Label-MS Homo sapiens
77 PLEC 5339
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
78 COQ5  
Proximity Label-MS Homo sapiens
79 LARS2 23395
Proximity Label-MS Homo sapiens
80 EMC7 56851
Cross-Linking-MS (XL-MS) Homo sapiens
81 MRPS18C  
Proximity Label-MS Homo sapiens
82 ATP5B 506
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
83 SSBP1 6742
Proximity Label-MS Homo sapiens
84 OAT 4942
Proximity Label-MS Homo sapiens
85 ATAD3A 55210
Proximity Label-MS Homo sapiens
86 CCDC109B 55013
Proximity Label-MS Homo sapiens
87 NIPSNAP1 8508
Proximity Label-MS Homo sapiens
88 NME4 4833
Proximity Label-MS Homo sapiens
89 GAPDH 2597
Co-fractionation Homo sapiens
90 ALYREF 10189
Proximity Label-MS Homo sapiens
91 HNRNPL 3191
Proximity Label-MS Homo sapiens
92 ACOT1 641371
Proximity Label-MS Homo sapiens
93 MAGI3 260425
Cross-Linking-MS (XL-MS) Homo sapiens
94 THNSL1 79896
Proximity Label-MS Homo sapiens
95 MRPS16  
Proximity Label-MS Homo sapiens
96 CUL7 9820
Affinity Capture-MS Homo sapiens
97 MAP1A 4130
Cross-Linking-MS (XL-MS) Homo sapiens
98 MRPL55  
Proximity Label-MS Homo sapiens
99 POLG  
Proximity Label-MS Homo sapiens
100 MRPL28 10573
Proximity Label-MS Homo sapiens
101 NDUFS6  
Proximity Label-MS Homo sapiens
102 DERL1 79139
Affinity Capture-MS Homo sapiens
103 COX5A 9377
Proximity Label-MS Homo sapiens
104 LDHA 3939
Co-fractionation Homo sapiens
105 AFG3L2 10939
Proximity Label-MS Homo sapiens
106 PMPCA 23203
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
107 MRPL48  
Proximity Label-MS Homo sapiens
108 CLIP1 6249
Affinity Capture-MS Homo sapiens
109 ATP5J2-PTCD1  
Proximity Label-MS Homo sapiens
110 GTPBP10  
Proximity Label-MS Homo sapiens
111 RPA2 6118
Proximity Label-MS Homo sapiens
112 ALDH2 217
Proximity Label-MS Homo sapiens
113 CHCHD1  
Proximity Label-MS Homo sapiens
114 PHOSPHO1  
Affinity Capture-MS Homo sapiens
115 MRPL50 54534
Proximity Label-MS Homo sapiens
116 MUT 4594
Proximity Label-MS Homo sapiens
117 MRPL49 740
Proximity Label-MS Homo sapiens
118 ALDH7A1 501
Co-fractionation Homo sapiens
119 NDUFS2 4720
Proximity Label-MS Homo sapiens
120 OGDH 4967
Proximity Label-MS Homo sapiens
121 AK3 50808
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
122 HARS2 23438
Proximity Label-MS Homo sapiens
123 MRPS23 51649
Proximity Label-MS Homo sapiens
124 NDUFA5 4698
Proximity Label-MS Homo sapiens
125 ARMT1 79624
Cross-Linking-MS (XL-MS) Homo sapiens
126 OBSL1 23363
Affinity Capture-MS Homo sapiens
127 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
128 MALSU1  
Proximity Label-MS Homo sapiens
129 ERAL1  
Proximity Label-MS Homo sapiens
130 VCAM1 7412
Affinity Capture-MS Homo sapiens
131 NDUFV3 4731
Proximity Label-MS Homo sapiens
132 MRPS7 51081
Proximity Label-MS Homo sapiens
133 PMPCB 9512
Proximity Label-MS Homo sapiens
134 TACO1  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
135 FASTKD2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
136 PDPR 55066
Proximity Label-MS Homo sapiens
137 FASTKD1  
Proximity Label-MS Homo sapiens
138 PFN1 5216
Affinity Capture-MS Homo sapiens
139 MIF 4282
Affinity Capture-MS Homo sapiens
140 C6orf203  
Proximity Label-MS Homo sapiens
141 TRIM26 7726
Affinity Capture-MS Homo sapiens
142 MRPL45 84311
Proximity Label-MS Homo sapiens
143 ATPAF1  
Proximity Label-MS Homo sapiens
144 MRPL51 51258
Proximity Label-MS Homo sapiens
145 RTN4IP1  
Proximity Label-MS Homo sapiens
146 PDHX 8050
Proximity Label-MS Homo sapiens
147 POLDIP2 26073
Proximity Label-MS Homo sapiens
148 NDUFA2 4695
Proximity Label-MS Homo sapiens
149 MRPL3  
Proximity Label-MS Homo sapiens
150 AARS2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
151 CYLD  
Affinity Capture-MS Homo sapiens
152 ABCB7 22
Proximity Label-MS Homo sapiens
153 GTPBP3  
Proximity Label-MS Homo sapiens
154 NDUFV1 4723
Proximity Label-MS Homo sapiens
155 MRPL44  
Proximity Label-MS Homo sapiens
156 PRDX6 9588
Cross-Linking-MS (XL-MS) Homo sapiens
157 PER2  
Proximity Label-MS Homo sapiens
158 PSMA3 5684
Affinity Capture-MS Homo sapiens
159 IBA57  
Proximity Label-MS Homo sapiens
160 AIFM1 9131
Proximity Label-MS Homo sapiens
161 MRPS35 60488
Proximity Label-MS Homo sapiens
162 MRPS11  
Proximity Label-MS Homo sapiens
163 MTIF3  
Proximity Label-MS Homo sapiens
164 UBE2L3 7332
Co-fractionation Homo sapiens
165 MRPL9 65005
Proximity Label-MS Homo sapiens
166 ATP5F1 515
Proximity Label-MS Homo sapiens
167 HSD17B10 3028
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
168 FUS 2521
Affinity Capture-MS Homo sapiens
169 DHTKD1 55526
Proximity Label-MS Homo sapiens
170 CDK2 1017
Affinity Capture-MS Homo sapiens
171 CEBPZ  
Cross-Linking-MS (XL-MS) Homo sapiens
172 HNRNPAB 3182
Proximity Label-MS Homo sapiens
173 DDRGK1 65992
Affinity Capture-MS Homo sapiens
174 MRPS17 51373
Proximity Label-MS Homo sapiens
175 NDUFV2 4729
Proximity Label-MS Homo sapiens
176 MCUR1 63933
Proximity Label-MS Homo sapiens
177 HUWE1 10075
Affinity Capture-MS Homo sapiens
178 PHGDH 26227
Affinity Capture-MS Homo sapiens
179 PPIF 10105
Proximity Label-MS Homo sapiens
180 CLPP 8192
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
181 CS 1431
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
182 C17orf80 55028
Proximity Label-MS Homo sapiens
183 GOT2 2806
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
184 FDX1 2230
Proximity Label-MS Homo sapiens
185 PARP1 142
Proximity Label-MS Homo sapiens
186 ALDH4A1 8659
Proximity Label-MS Homo sapiens
187 WARS2  
Proximity Label-MS Homo sapiens
188 TRMT61B  
Proximity Label-MS Homo sapiens
189 COX8A  
Proximity Label-MS Homo sapiens
190 SHMT2 6472
Proximity Label-MS Homo sapiens
191 HNRNPK 3190
Proximity Label-MS Homo sapiens
192 ME2 4200
Proximity Label-MS Homo sapiens
193 COQ2  
Affinity Capture-MS Homo sapiens
194 GFM1 85476
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
195 PRDX1 5052
Co-fractionation Homo sapiens
196 YKT6 10652
Co-fractionation Homo sapiens
197 C1QBP 708
Proximity Label-MS Homo sapiens
198 QRSL1  
Proximity Label-MS Homo sapiens
199 PRMT1 3276
Affinity Capture-MS Homo sapiens
200 SUPV3L1 6832
Proximity Label-MS Homo sapiens
201 MRPS9 64965
Proximity Label-MS Homo sapiens
202 COTL1 23406
Co-fractionation Homo sapiens
203 MRPS27 23107
Proximity Label-MS Homo sapiens
204 SLIRP 81892
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
205 DNAJC9 23234
Cross-Linking-MS (XL-MS) Homo sapiens
206 IDH1 3417
Co-fractionation Homo sapiens
207 NDUFS1 4719
Proximity Label-MS Homo sapiens
208 PTMA 5757
Affinity Capture-MS Homo sapiens
209 MRPL30  
Proximity Label-MS Homo sapiens
210 MRPL17  
Proximity Label-MS Homo sapiens
211 ANGEL2 90806
Proximity Label-MS Homo sapiens
212 SUCLG1 8802
Proximity Label-MS Homo sapiens
213 NOA1  
Proximity Label-MS Homo sapiens
214 PYCR1 5831
Proximity Label-MS Homo sapiens
215 GATB  
Proximity Label-MS Homo sapiens
216 CARS2 79587
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
217 LRPPRC 10128
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
218 CAPZB 832
Affinity Capture-MS Homo sapiens
219 NNT 23530
Proximity Label-MS Homo sapiens
220 ACAD9 28976
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
221 HEATR3 55027
Affinity Capture-MS Homo sapiens
222 NDUFS3 4722
Proximity Label-MS Homo sapiens
223 SDHB 6390
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
224 DAZAP1 26528
Co-fractionation Homo sapiens
225 YARS2  
Proximity Label-MS Homo sapiens
226 HINT2 84681
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
227 AASS  
Proximity Label-MS Homo sapiens
228 MRS2  
Proximity Label-MS Homo sapiens
229 ITGA4 3676
Affinity Capture-MS Homo sapiens
230 MRPL39 54148
Proximity Label-MS Homo sapiens
231 NDUFAF1  
Proximity Label-MS Homo sapiens
232 TNS4 84951
Co-fractionation Homo sapiens
233 CALR 811
Affinity Capture-MS Homo sapiens
234 LDHAL6A  
Co-fractionation Homo sapiens
235 TFCP2 7024
Affinity Capture-MS Homo sapiens
236 MRPL4 51073
Proximity Label-MS Homo sapiens
237 MTERF3  
Proximity Label-MS Homo sapiens
238 MDH2 4191
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
239 ALAS1  
Proximity Label-MS Homo sapiens
240 MRPS25 64432
Proximity Label-MS Homo sapiens
241 ATP5A1 498
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
242 THEM4  
Proximity Label-MS Homo sapiens
243 NEB 4703
Cross-Linking-MS (XL-MS) Homo sapiens
244 FASTKD5  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
245 CLNS1A 1207
Co-fractionation Homo sapiens
246 PAM16  
Proximity Label-MS Homo sapiens
247 NDUFAF5  
Proximity Label-MS Homo sapiens
248 TRMT11 60487
Proximity Label-MS Homo sapiens
249 COPS5 10987
Affinity Capture-MS Homo sapiens
250 TPI1 7167
Affinity Capture-MS Homo sapiens
251 U2AF2 11338
Affinity Capture-MS Homo sapiens
252 CCDC8  
Affinity Capture-MS Homo sapiens
253 PPA2 27068
Proximity Label-MS Homo sapiens
254 MRPL11 65003
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
255 RAB10 10890
Co-fractionation Homo sapiens
256 NUDC 10726
Co-fractionation Homo sapiens
257 HNRNPA3 220988
Proximity Label-MS Homo sapiens
258 HDAC5 10014
Affinity Capture-MS Homo sapiens
259 TMEM70  
Proximity Label-MS Homo sapiens
260 DNM1L 10059
Affinity Capture-MS Homo sapiens
261 MRPL2 51069
Proximity Label-MS Homo sapiens
262 HNRNPDL 9987
Proximity Label-MS Homo sapiens
263 ECH1 1891
Proximity Label-MS Homo sapiens
264 NTRK1 4914
Affinity Capture-MS Homo sapiens
265 ACAT1 38
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
266 MRPL40 64976
Proximity Label-MS Homo sapiens
267 TRMT10C 54931
Proximity Label-MS Homo sapiens
268 PNPT1 87178
Proximity Label-MS Homo sapiens
269 MRPL10 124995
Proximity Label-MS Homo sapiens
270 MRPS14  
Proximity Label-MS Homo sapiens
271 DHX30 22907
Proximity Label-MS Homo sapiens
272 METTL21B  
Affinity Capture-MS Homo sapiens
273 HNRNPUL1 11100
Proximity Label-MS Homo sapiens
274 CORO1C 23603
Co-fractionation Homo sapiens
275 CALM1 801
Affinity Capture-MS Homo sapiens
276 MRPS28  
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
277 GATC  
Proximity Label-MS Homo sapiens
278 MRPL19 9801
Proximity Label-MS Homo sapiens
279 HSDL2 84263
Proximity Label-MS Homo sapiens
280 THG1L 54974
Proximity Label-MS Homo sapiens
281 MRPS36 92259
Proximity Label-MS Homo sapiens
282 HSPD1 3329
Proximity Label-MS Homo sapiens
283 MRPL38  
Proximity Label-MS Homo sapiens
284 PUS1 80324
Proximity Label-MS Homo sapiens
285 METTL15  
Proximity Label-MS Homo sapiens
286 MTHFD2 10797
Proximity Label-MS Homo sapiens
287 PHB2 11331
Proximity Label-MS Homo sapiens
288 TSFM 10102
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
289 RBFA  
Proximity Label-MS Homo sapiens
290 ATP5J 522
Proximity Label-MS Homo sapiens
291 NDUFAF2  
Proximity Label-MS Homo sapiens
292 CIT 11113
Affinity Capture-MS Homo sapiens
293 ICT1 3396
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
294 LONP1 9361
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
295 MRPL53  
Proximity Label-MS Homo sapiens
296 ACAA2 10449
Co-fractionation Homo sapiens
297 PDHA1 5160
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
298 NDUFA12 55967
Proximity Label-MS Homo sapiens
299 GRPEL1 80273
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
300 MRPS10 55173
Proximity Label-MS Homo sapiens
301 IDH3A 3419
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
302 PCNA 5111
Affinity Capture-MS Homo sapiens
303 UFL1 23376
Affinity Capture-MS Homo sapiens
304 GUF1  
Proximity Label-MS Homo sapiens
305 NDUFS8 4728
Proximity Label-MS Homo sapiens
306 MRPS18B 28973
Proximity Label-MS Homo sapiens
307 TBRG4 9238
Proximity Label-MS Homo sapiens
308 RNMTL1  
Proximity Label-MS Homo sapiens
309 TRMT5  
Proximity Label-MS Homo sapiens
310 MGME1  
Proximity Label-MS Homo sapiens
311 RPUSD3  
Proximity Label-MS Homo sapiens
312 SERBP1 26135
Affinity Capture-MS Homo sapiens
313 MRPS22 56945
Proximity Label-MS Homo sapiens
314 FLAD1 80308
Proximity Label-MS Homo sapiens
315 PRDX3 10935
Proximity Label-MS Homo sapiens
316 DDX28  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
317 TIMM44 10469
Proximity Label-MS Homo sapiens
318 UBE2H 7328
Affinity Capture-MS Homo sapiens
319 SLFN11 91607
Proximity Label-MS Homo sapiens
320 C7orf55-LUC7L2  
Proximity Label-MS Homo sapiens
321 ATPIF1 93974
Proximity Label-MS Homo sapiens
322 HIST1H1D 3007
Cross-Linking-MS (XL-MS) Homo sapiens
323 TRUB2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
324 MRPL37 51253
Proximity Label-MS Homo sapiens
325 ETFB 2109
Proximity Label-MS Homo sapiens
326 NDUFS7 374291
Proximity Label-MS Homo sapiens
327 BASP1 10409
Affinity Capture-MS Homo sapiens
328 MRPL52  
Proximity Label-MS Homo sapiens
329 RPUSD4 84881
Proximity Label-MS Homo sapiens
330 CFL1 1072
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
331 MTRF1  
Proximity Label-MS Homo sapiens
332 HADH 3033
Proximity Label-MS Homo sapiens
333 KIAA1429 25962
Affinity Capture-MS Homo sapiens
334 ATP5D 513
Proximity Label-MS Homo sapiens
335 MRPL20 55052
Proximity Label-MS Homo sapiens
336 TFAM 7019
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
337 PC 5091
Reconstituted Complex Homo sapiens
338 NDUFA7 4701
Proximity Label-MS Homo sapiens
339 MRPL23 6150
Proximity Label-MS Homo sapiens
340 Htatsf1  
Two-hybrid Mus musculus
341 ANP32B 10541
Cross-Linking-MS (XL-MS) Homo sapiens
342 MRPS5 64969
Proximity Label-MS Homo sapiens
343 C8orf82  
Proximity Label-MS Homo sapiens
344 MRPS24 64951
Proximity Label-MS Homo sapiens
345 MRPL12 6182
Proximity Label-MS Homo sapiens
346 MRPS26 64949
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
347 ATP5O 539
Proximity Label-MS Homo sapiens
348 SERPINH1 871
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
349 EXD2  
Proximity Label-MS Homo sapiens
350 GINS4  
Cross-Linking-MS (XL-MS) Homo sapiens
351 MRPS21  
Proximity Label-MS Homo sapiens
352 ATP5H 10476
Proximity Label-MS Homo sapiens
353 NDUFA6  
Proximity Label-MS Homo sapiens
354 DAP3 7818
Proximity Label-MS Homo sapiens
355 NEDD4 4734
Affinity Capture-MS Homo sapiens
356 STOML2 30968
Proximity Label-MS Homo sapiens
357 MRPS30 10884
Proximity Label-MS Homo sapiens
358 MRPL13  
Proximity Label-MS Homo sapiens
359 PRDX5 25824
Co-fractionation Homo sapiens
360 NDUFS4 4724
Proximity Label-MS Homo sapiens
361 COX15 1355
Proximity Label-MS Homo sapiens
362 IKBIP 121457
Cross-Linking-MS (XL-MS) Homo sapiens
363 PSMD4 5710
Affinity Capture-MS Homo sapiens
364 MRPS34 65993
Proximity Label-MS Homo sapiens
365 ACOT2 10965
Proximity Label-MS Homo sapiens
366 ATF2  
Affinity Capture-MS Homo sapiens
367 PTCD3 55037
Proximity Label-MS Homo sapiens
368 HSCB 150274
Proximity Label-MS Homo sapiens
369 MMAB 326625
Proximity Label-MS Homo sapiens
370 VCP 7415
Affinity Capture-MS Homo sapiens
371 LYRM7  
Proximity Label-MS Homo sapiens
372 FH 2271
Reconstituted Complex Homo sapiens
373 DDX54 79039
Proximity Label-MS Homo sapiens
374 LYRM4 57128
Proximity Label-MS Homo sapiens
375 MRPL22  
Proximity Label-MS Homo sapiens
376 NDUFAF3 25915
Proximity Label-MS Homo sapiens
377 MRPS33  
Proximity Label-MS Homo sapiens
378 CD274 29126
Affinity Capture-MS Homo sapiens
379 COX4I1 1327
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
380 OXA1L  
Proximity Label-MS Homo sapiens
381 PHB 5245
Proximity Label-MS Homo sapiens
382 PDE12 201626
Proximity Label-MS Homo sapiens
383 MRPL21 219927
Proximity Label-MS Homo sapiens
384 MRRF  
Proximity Label-MS Homo sapiens
385 FANCD2  
Affinity Capture-MS Homo sapiens
386 NDUFA9 4704
Proximity Label-MS Homo sapiens
387 LETM1 3954
Proximity Label-MS Homo sapiens
388 GCDH 2639
Proximity Label-MS Homo sapiens
389 ANXA5 308
Affinity Capture-MS Homo sapiens
390 C10orf2 56652
Proximity Label-MS Homo sapiens
391 NFS1 9054
Proximity Label-MS Homo sapiens
392 PDIA3 2923
Affinity Capture-MS Homo sapiens
393 ELAC2 60528
Proximity Label-MS Homo sapiens
394 PYCR2 29920
Proximity Label-MS Homo sapiens
395 ECHS1 1892
Proximity Label-MS Homo sapiens
396 MRPL15 29088
Proximity Label-MS Homo sapiens
397 ECI2 10455
Proximity Label-MS Homo sapiens
398 MRPL1  
Proximity Label-MS Homo sapiens
399 GLRX2  
Co-fractionation Homo sapiens
400 PPME1 51400
Affinity Capture-MS Homo sapiens
401 MTHFD1L 25902
Proximity Label-MS Homo sapiens
402 AK4 205
Proximity Label-MS Homo sapiens
403 MRPL42  
Proximity Label-MS Homo sapiens
404 GLUD1 2746
Proximity Label-MS Homo sapiens
405 PTPMT1 114971
Proximity Label-MS Homo sapiens
406 MRPS2 51116
Proximity Label-MS Homo sapiens
407 PNPLA8 50640
Proximity Label-MS Homo sapiens
408 MRPS31  
Proximity Label-MS Homo sapiens
409 MRPL43 84545
Proximity Label-MS Homo sapiens
410 LYPLAL1 127018
Proximity Label-MS Homo sapiens
411 PDHB 5162
Proximity Label-MS Homo sapiens
412 SUCLA2 8803
Proximity Label-MS Homo sapiens
413 C21orf33  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
414 DRD5  
Cross-Linking-MS (XL-MS) Homo sapiens
415 OGDHL  
Proximity Label-MS Homo sapiens
416 SFXN1 94081
Proximity Label-MS Homo sapiens
417 GARS 2617
Proximity Label-MS Homo sapiens
418 PDK1 5163
Proximity Label-MS Homo sapiens
419 TIMM13 26517
Co-fractionation Homo sapiens
420 MRPL46  
Proximity Label-MS Homo sapiens
421 PINK1  
Affinity Capture-MS Homo sapiens
422 GRSF1 2926
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
423 NDUFAF4 29078
Proximity Label-MS Homo sapiens
424 METTL17  
Proximity Label-MS Homo sapiens
425 WARS 7453
Two-hybrid Homo sapiens
426 MRPS18A  
Proximity Label-MS Homo sapiens
427 UFM1 51569
Co-fractionation Homo sapiens
428 ALDOA 226
Co-fractionation Homo sapiens
429 ECSIT 51295
Proximity Label-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here