Gene description for IGF2BP1
Gene name insulin-like growth factor 2 mRNA binding protein 1
Gene symbol IGF2BP1
Other names/aliases CRD-BP
Species Homo sapiens
 Database cross references - IGF2BP1
ExoCarta ExoCarta_10642
Entrez Gene 10642
HGNC 28866
MIM 608288
UniProt Q9NZI8  
 IGF2BP1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for IGF2BP1
Molecular Function
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    translation regulator activity GO:0045182 IDA
    mRNA 5'-UTR binding GO:0048027 IDA
    mRNA binding GO:0003729 IDA
    mRNA 3'-UTR binding GO:0003730 IDA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    CRD-mediated mRNA stabilization GO:0070934 IDA
    gene expression GO:0010467 TAS
    regulation of mRNA stability involved in response to stress GO:0010610 IMP
    negative regulation of translation GO:0017148 IDA
    mRNA transport GO:0051028 IEA
    regulation of cytokine biosynthetic process GO:0042035 IC
Subcellular Localization
    dendritic spine GO:0043197 IEA
    cytoplasm GO:0005737 IDA
    ribonucleoprotein complex GO:0030529 IDA
    lamellipodium GO:0030027 IEA
    nucleus GO:0005634 IEA
    filopodium GO:0030175 IEA
    cytosol GO:0005829 TAS
    perinuclear region of cytoplasm GO:0048471 IEA
    growth cone GO:0030426 IEA
    cytoplasmic stress granule GO:0010494 IDA
    CRD-mediated mRNA stability complex GO:0070937 IDA
    axon GO:0030424 IEA
 Experiment description of studies that identified IGF2BP1 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IGF2BP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SMYD2  
Affinity Capture-MS Homo sapiens
2 ZNF9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 ILK 3611
Affinity Capture-MS Homo sapiens
5 GSK3B 2932
Affinity Capture-MS Homo sapiens
6 PRKRA 8575
Affinity Capture-MS Homo sapiens
7 PUF60 22827
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which IGF2BP1 is involved
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA TAS Reactome

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