ExoCarta: Gene summary

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Gene description for SRRM1
Gene name	serine/arginine repetitive matrix 1
Gene symbol	SRRM1
Other names/aliases	160-KD POP101 SRM160
Species	Homo sapiens
Database cross references - SRRM1
ExoCarta	ExoCarta_10250
Vesiclepedia	VP_10250
Entrez Gene	10250
HGNC	16638
MIM	605975
UniProt	Q8IYB3
SRRM1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Chondrocytes	35931686
Chondrocytes	35931686
Retinal pigment epithelial cells	35333565
Retinal pigment epithelial cells	35333565

Gene ontology annotations for SRRM1

Molecular Function
	DNA binding	GO:0003677	IEA
	RNA binding	GO:0003723	HDA
	protein binding	GO:0005515	IPI
Biological Process
	RNA splicing, via transesterification reactions	GO:0000375	TAS
	mRNA splicing, via spliceosome	GO:0000398	IC
	RNA splicing	GO:0008380	TAS
	regulation of mRNA splicing, via spliceosome	GO:0048024	IBA
Subcellular Localization
	nucleus	GO:0005634	TAS
	nucleoplasm	GO:0005654	TAS
	spliceosomal complex	GO:0005681	IBA
	cytosol	GO:0005829	TAS
	nuclear matrix	GO:0016363	IEA
	nuclear speck	GO:0016607	IDA
	catalytic step 2 spliceosome	GO:0071013	IDA

Experiment description of studies that identified SRRM1 in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

497

MISEV standards
✘	Biophysical techniques
✔ CD9\|CD151\|CD63\|CD81\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|RAB5A\|SDCBP\|TFRC\|TSG101\|UCHL1	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

"Varela-EirÃn M, Carpintero-FernÃ¡ndez P, GuitiÃ¡n-CaamaÃ±o A, Varela-VÃ¡zquez A, GarcÃa-Yuste A, SÃ¡nchez-Temprano A, Bravo-LÃ³pez SB, YaÃ±ez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, MayÃ¡n MD."

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

T/C-28a2

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

498

MISEV standards
✔ EM	Biophysical techniques
✔ CD9\|CD151\|CD63\|CD81\|CD82\|FLOT1\|FLOT2\|GAPDH\|LAMP1\|LAMP2\|RAB5A\|SDCBP\|TFRC\|TSG101\|UCHL1	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35931686

Organism

Homo sapiens

Experiment description

Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression

Authors

Journal name

Cell Death Dis

Publication year

2022

Sample

Chondrocytes

Sample name

T/C-28a2

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

834

MISEV standards
✔ EM	Biophysical techniques
✔ LAMP2\|CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

835

MISEV standards
✔ EM	Biophysical techniques
✔ CD63\|FLOT1\|ITGA2B\|ICAM1\|CD9\|CD151\|TFRC\|RAB5A\|GAPDH\|AQP1\|TSG101	Enriched markers
✔ CANX	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

35333565

Organism

Homo sapiens

Experiment description

LAMP2A regulates the loading of proteins into exosomes

Authors

"Ferreira JV, da Rosa Soares A, Ramalho J, MÃ¡ximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, GirÃ£o H, van Niel G, Pereira P"

Journal name

Sci Adv

Publication year

2022

Sample

Retinal pigment epithelial cells

Sample name

ARPE-19

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Protein-protein interactions for SRRM1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

SNRPB2

6629

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

Mtx1

Affinity Capture-MS

Mus musculus

RPSAP58

388524

Affinity Capture-MS

Homo sapiens

GTF2F1

2962

Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens

SMC3

9126

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

HDAC4

Affinity Capture-MS

Homo sapiens

EIF2AK4

440275

Cross-Linking-MS (XL-MS)

Homo sapiens

SNRPE

6635

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

DNAJC8

22826

Proximity Label-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ZNF346

Affinity Capture-MS

Homo sapiens

ARHGAP39

Affinity Capture-MS

Homo sapiens

AKAP13

11214

Affinity Capture-MS

Homo sapiens

PTBP1

5725

Affinity Capture-MS

Homo sapiens

PPIE

10450

Affinity Capture-MS

Homo sapiens

SRPK2

6733

FRET		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

BTF3

689

Affinity Capture-MS

Homo sapiens

RPL13A

23521

Affinity Capture-MS

Homo sapiens

ZC3H14

Affinity Capture-MS

Homo sapiens

ACTC1

Proximity Label-MS

Homo sapiens

ISY1

57461

Affinity Capture-MS

Homo sapiens

DHX8

1659

Proximity Label-MS

Homo sapiens

RPS19

6223

Affinity Capture-MS

Homo sapiens

KIF20A

10112

Affinity Capture-MS

Homo sapiens

BRD2

Affinity Capture-MS

Homo sapiens

RPL14

9045

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CSNK2A1

1457

Biochemical Activity

Homo sapiens

PRPF3

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

CAND1

55832

Affinity Capture-MS

Homo sapiens

PTBP3

9991

Affinity Capture-MS

Homo sapiens

SRSF2

6427

Affinity Capture-MS

Homo sapiens

PRPF40A

55660

Affinity Capture-MS

Homo sapiens

SNRPF

6636

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SNRPD2

6633

Affinity Capture-MS

Homo sapiens

SF3B2

10992

Affinity Capture-MS

Homo sapiens

ILF2

3608

Affinity Capture-MS

Homo sapiens

GSK3A

2931

Affinity Capture-MS

Homo sapiens

APEX1

328

Affinity Capture-RNA

Homo sapiens

TCEB3

6924

Affinity Capture-MS

Homo sapiens

DDX23

9416

Proximity Label-MS

Homo sapiens

TOP2A

7153

Co-fractionation

Homo sapiens

SNRNP70

6625

Co-fractionation

Homo sapiens

RNPS1

10921

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CEP104

Cross-Linking-MS (XL-MS)

Homo sapiens

TGFB1

7040

Affinity Capture-MS

Homo sapiens

KIF23

9493

Affinity Capture-MS

Homo sapiens

NOLC1

9221

Co-fractionation

Homo sapiens

SF3B1

23451

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

PUF60

22827

Affinity Capture-MS

Homo sapiens

NCOA5

Affinity Capture-MS

Homo sapiens

FBXW7

Affinity Capture-MS

Homo sapiens

PRC1

9055

Affinity Capture-MS

Homo sapiens

CALD1

800

Cross-Linking-MS (XL-MS)

Homo sapiens

ANOS1

3730

Affinity Capture-MS

Homo sapiens

SNRPC

6631

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ZMYND11

10771

Affinity Capture-MS

Homo sapiens

YWHAG

7532

Affinity Capture-MS

Homo sapiens

ABI1

10006

Two-hybrid

Homo sapiens

OBSL1

23363

Affinity Capture-MS

Homo sapiens

SF3A2

8175

Affinity Capture-MS

Homo sapiens

BRDT

Affinity Capture-MS

Homo sapiens

SRSF3

6428

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

MACC1

346389

Cross-Linking-MS (XL-MS)

Homo sapiens

RC3H1

149041

Affinity Capture-MS

Homo sapiens

SNRPD3

6634

Affinity Capture-MS

Homo sapiens

ABT1

29777

Affinity Capture-MS

Homo sapiens

ASH2L

9070

Affinity Capture-MS

Homo sapiens

KHDRBS1

10657

Affinity Capture-MS

Homo sapiens

NONO

4841

Affinity Capture-MS

Homo sapiens

MECP2

4204

Affinity Capture-MS

Homo sapiens

MYCN

Affinity Capture-MS

Homo sapiens

RBM42

Affinity Capture-MS

Homo sapiens

SOS1

6654

Affinity Capture-MS

Homo sapiens

CSNK2B

1460

Affinity Capture-MS

Homo sapiens

CCT5

22948

Affinity Capture-MS

Homo sapiens

EIF5B

9669

Co-fractionation

Homo sapiens

RBM14

10432

Co-fractionation

Homo sapiens

RBM8A

9939

Affinity Capture-MS

Homo sapiens

KIF14

9928

Affinity Capture-MS

Homo sapiens

TMTC3

160418

Cross-Linking-MS (XL-MS)

Homo sapiens

HSPA8

3312

Co-fractionation

Homo sapiens

LIN28A

Affinity Capture-MS

Homo sapiens

RBMX

27316

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

EPB41L3

23136

Affinity Capture-MS

Homo sapiens

CLK2

1196

Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens

LMNA

4000

Affinity Capture-MS

Homo sapiens

CNOT3

4849

Affinity Capture-MS

Homo sapiens

HIST1H4A

8359

Affinity Capture-MS

Homo sapiens

DDX21

9188

Affinity Capture-MS

Homo sapiens

PCF11

51585

Affinity Capture-MS

Homo sapiens

TOP2B

7155

Affinity Capture-MS

Homo sapiens

RPL4

6124

Affinity Capture-MS

Homo sapiens

PPIL1

51645

Affinity Capture-MS

Homo sapiens

HMGN2

3151

Cross-Linking-MS (XL-MS)

Homo sapiens

CSTF2

1478

Affinity Capture-MS

Homo sapiens

TRA2A

29896

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

RPL19

6143

Cross-Linking-MS (XL-MS)

Homo sapiens

PNN

5411

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

NEIL1

Affinity Capture-MS

Homo sapiens

ACIN1

22985

Affinity Capture-MS

Homo sapiens

100

SRSF6

6431

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens

101

PURG

Affinity Capture-MS

Homo sapiens

102

CBX3

11335

Affinity Capture-MS

Homo sapiens

103

ZNF22

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

104

RPL18A

6142

Affinity Capture-MS

Homo sapiens

105

ZNF638

27332

Affinity Capture-MS

Homo sapiens

106

DEK

7913

Co-fractionation		Homo sapiens
Affinity Capture-Western		Homo sapiens

107

CHMP4B

128866

Affinity Capture-MS

Homo sapiens

108

RPA2

6118

Proximity Label-MS

Homo sapiens

109

PDS5A

23244

Affinity Capture-MS

Homo sapiens

110

BARD1

580

Affinity Capture-MS

Homo sapiens

111

DDX5

1655

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

112

NTRK1

4914

Affinity Capture-MS

Homo sapiens

113

PLRG1

5356

Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

114

U2AF2

11338

Affinity Capture-MS

Homo sapiens

115

PRPF8

10594

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

116

DNAJA1

3301

Affinity Capture-MS

Homo sapiens

117

RPL36

25873

Affinity Capture-MS

Homo sapiens

118

HIST1H1C

3006

Cross-Linking-MS (XL-MS)

Homo sapiens

119

SMC1A

8243

Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

120

PAXIP1

Affinity Capture-MS

Homo sapiens

121

MAGOH

4116

Affinity Capture-MS

Homo sapiens

122

RPLP0

6175

Affinity Capture-MS

Homo sapiens

123

SRPK3

Affinity Capture-MS

Homo sapiens

124

MAGEB2

4113

Affinity Capture-MS

Homo sapiens

125

DDX39B

7919

Affinity Capture-MS

Homo sapiens

126

FUBP1

8880

Affinity Capture-MS

Homo sapiens

127

CDX1

Affinity Capture-MS

Homo sapiens

128

VPS18

57617

Affinity Capture-MS

Homo sapiens

129

RAD21

5885

Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

130

ST13

6767

Cross-Linking-MS (XL-MS)

Homo sapiens

131

SMARCC2

6601

Affinity Capture-MS

Homo sapiens

132

SRSF4

6429

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens

133

BCLAF1

9774

Affinity Capture-MS

Homo sapiens

134

ANLN

54443

Affinity Capture-MS

Homo sapiens

135

MYH7B

Affinity Capture-MS

Homo sapiens

136

SRSF11

9295

Affinity Capture-MS

Homo sapiens

137

NUMA1

4926

Co-fractionation

Homo sapiens

138

TMPO

7112

Affinity Capture-MS

Homo sapiens

139

RBM39

9584

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

140

CPSF1

29894

Cross-Linking-MS (XL-MS)

Homo sapiens

141

MAP7

9053

Affinity Capture-MS

Homo sapiens

142

UBE2H

7328

Affinity Capture-MS

Homo sapiens

143

C11orf57

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

144

CLK3

Affinity Capture-MS

Homo sapiens

145

CHCHD1

Proximity Label-MS

Homo sapiens

146

RC3H2

Affinity Capture-MS

Homo sapiens

147

ECT2

1894

Affinity Capture-MS

Homo sapiens

148

YBX3

8531

Affinity Capture-MS

Homo sapiens

149

SIRT7

Affinity Capture-MS

Homo sapiens

150

CD2BP2

10421

Affinity Capture-MS

Homo sapiens

151

SAFB

6294

Affinity Capture-MS

Homo sapiens

152

HTATSF1

27336

Co-fractionation

Homo sapiens

153

SRSF1

6426

Affinity Capture-MS

Homo sapiens

154

SRRM4

Two-hybrid

Homo sapiens

155

CUL3

8452

Affinity Capture-MS

Homo sapiens

156

SRSF5

6430

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens

157

EGFR

1956

Affinity Capture-MS

Homo sapiens

158

FUS

2521

Affinity Capture-Western

Homo sapiens

159

UPF3A

Affinity Capture-Western

Homo sapiens

160

ZNF467

Affinity Capture-MS

Homo sapiens

161

WAPAL

Affinity Capture-MS

Homo sapiens

162

ZC3H10

Affinity Capture-MS

Homo sapiens

163

SF3A1

10291

Affinity Capture-MS

Homo sapiens

164

AURKB

9212

Affinity Capture-MS

Homo sapiens

165

RPL28

6158

Affinity Capture-MS

Homo sapiens

166

CRYBB3

Affinity Capture-MS

Homo sapiens

167

PRR3

Affinity Capture-MS

Homo sapiens

168

EEF1A1

1915

Affinity Capture-MS

Homo sapiens

169

PCBP1

5093

Affinity Capture-MS

Homo sapiens

170

TADA2A

Affinity Capture-MS

Homo sapiens

171

PRPF19

27339

Affinity Capture-MS

Homo sapiens

172

MYC

Affinity Capture-MS

Homo sapiens

173

OLIG2

Affinity Capture-MS

Homo sapiens

174

HIST1H2BA

255626

Cross-Linking-MS (XL-MS)

Homo sapiens

175

ZC3H18

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

176

DNAJC9

23234

Proximity Label-MS

Homo sapiens

177

KMT2D

8085

Affinity Capture-MS

Homo sapiens

178

CSNK2A2

1459

Affinity Capture-MS

Homo sapiens

179

TOP1

7150

Affinity Capture-MS

Homo sapiens

180

DDRGK1

65992

Affinity Capture-MS

Homo sapiens

181

SF3B3

23450

Affinity Capture-MS

Homo sapiens

182

SNRNP200

23020

Affinity Capture-MS

Homo sapiens

183

P4HA3

283208

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

184

H2AFB2

Affinity Capture-MS

Homo sapiens

185

CETN2

1069

Cross-Linking-MS (XL-MS)

Homo sapiens

186

HIST1H1T

3010

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

187

BRD3

8019

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

188

SUPT16H

11198

Co-fractionation

Homo sapiens

189

SNRPB

6628

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

190

EIF3H

8667

Affinity Capture-MS

Homo sapiens

191

PAIP1

10605

Affinity Capture-MS

Homo sapiens

192

Smchd1

Affinity Capture-MS

Mus musculus

193

ZRANB1

54764

Affinity Capture-MS

Homo sapiens

194

NES

10763

Affinity Capture-MS

Homo sapiens

195

RPL13

6137

Affinity Capture-MS

Homo sapiens

196

DHX15

1665

Co-fractionation

Homo sapiens

197

GRK5

2869

Affinity Capture-MS

Homo sapiens

198

SNCA

6622

Affinity Capture-MS

Homo sapiens

199

SFPQ

6421

Affinity Capture-MS

Homo sapiens

200

NRP1

8829

Affinity Capture-MS

Homo sapiens

201

PLEKHA4

57664

Affinity Capture-MS

Homo sapiens

202

SPOP

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

203

PAF1

54623

Co-fractionation

Homo sapiens

204

ZCCHC10

Affinity Capture-MS

Homo sapiens

205

PARP1

142

Proximity Label-MS

Homo sapiens

206

PDGFB

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

207

HIST1H2BK

85236

Cross-Linking-MS (XL-MS)

Homo sapiens

208

CNGB1

1258

Affinity Capture-MS

Homo sapiens

209

CPSF6

11052

Affinity Capture-MS

Homo sapiens

210

SYNE2

23224

Cross-Linking-MS (XL-MS)

Homo sapiens

211

RBM25

58517

Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

212

EIF3I

8668

Co-fractionation

Homo sapiens

213

C9orf114

Affinity Capture-MS

Homo sapiens

214

SNRPA1

6627

Affinity Capture-MS

Homo sapiens

215

PIN1

5300

Reconstituted Complex

Homo sapiens

216

SF3B4

10262

Affinity Capture-MS

Homo sapiens

217

HIST2H2AA3

8337

Affinity Capture-MS

Homo sapiens

218

SAP18

10284

Affinity Capture-MS

Homo sapiens

219

DPY30

84661

Affinity Capture-MS

Homo sapiens

220

SNRPA

6626

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens

221

KNOP1

400506

Affinity Capture-MS

Homo sapiens

222

HNRNPM

4670

Affinity Capture-MS

Homo sapiens

223

SMURF1

57154

Affinity Capture-MS

Homo sapiens

224

ZNF48

Affinity Capture-MS

Homo sapiens

225

C4orf17

Cross-Linking-MS (XL-MS)

Homo sapiens

226

ELAVL1

1994

Affinity Capture-RNA

Homo sapiens

227

CHD4

1108

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

228

PLEKHG4B

153478

Affinity Capture-MS

Homo sapiens

229

EIF4A3

9775

Affinity Capture-MS		Homo sapiens
Co-fractionation		Homo sapiens
Affinity Capture-MS		Homo sapiens

230

GTF2I

2969

Affinity Capture-MS

Homo sapiens

231

RANBP2

5903

Co-fractionation

Homo sapiens

232

RPS5

6193

Affinity Capture-MS

Homo sapiens

233

NIFK

84365

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

234

ESR1

Affinity Capture-MS

Homo sapiens

235

UFL1

23376

Affinity Capture-MS

Homo sapiens

236

RBM23

Affinity Capture-MS

Homo sapiens

237

SNRNP40

9410

Affinity Capture-MS

Homo sapiens

238

Srsf1

110809

Affinity Capture-MS

Mus musculus

239

E2F4

Affinity Capture-MS

Homo sapiens

240

OGFR

11054

Affinity Capture-MS

Homo sapiens

241

DHX16

8449

Affinity Capture-MS

Homo sapiens

242

NCL

4691

Affinity Capture-MS

Homo sapiens

243

ALYREF

10189

Affinity Capture-MS

Homo sapiens

244

EFTUD2

9343

Affinity Capture-MS

Homo sapiens

245

STAG2

10735

Affinity Capture-MS

Homo sapiens

246

SRSF7

6432

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

247

PINK1

Affinity Capture-MS

Homo sapiens

248

RPS7

6201

Affinity Capture-MS

Homo sapiens

249

GTF2E1

2960

Co-fractionation

Homo sapiens

250

GRSF1

2926

Proximity Label-MS

Homo sapiens

251

SRRM2

23524

Affinity Capture-Western		Homo sapiens
Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens
Co-fractionation		Homo sapiens

252

LDLR

3949

Negative Genetic

Homo sapiens

253

SNW1

22938

Affinity Capture-MS

Homo sapiens

254

KRAS

3845

Affinity Capture-MS

Homo sapiens

255

SH3KBP1

30011

Affinity Capture-MS

Homo sapiens

256

RBM34

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

257

SSRP1

6749

Affinity Capture-MS

Homo sapiens

258

ARHGEF10L

55160

Affinity Capture-MS

Homo sapiens

259

LUC7L

55692

Affinity Capture-MS

Homo sapiens

260

ASB7

Affinity Capture-MS

Homo sapiens

261

RPL17

6139

Affinity Capture-MS

Homo sapiens

262

CDC5L

988

Affinity Capture-MS		Homo sapiens
Co-purification		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

View the network

Pathways in which SRRM1 is involved

Pathway	Evidence	Source
Gene expression (Transcription)	TAS	Reactome
Metabolism of RNA	TAS	Reactome
mRNA 3'-end processing	TAS	Reactome
mRNA Splicing	TAS	Reactome
mRNA Splicing - Major Pathway	TAS	Reactome
Processing of Capped Intron-Containing Pre-mRNA	TAS	Reactome
RHO GTPase cycle	TAS	Reactome
RHOBTB GTPase Cycle	TAS	Reactome
RHOBTB1 GTPase cycle	TAS	Reactome
RHOBTB2 GTPase cycle	TAS	Reactome
RNA Polymerase II Transcription	TAS	Reactome
RNA Polymerase II Transcription Termination	TAS	Reactome
Signal Transduction	TAS	Reactome
Signaling by Rho GTPases	TAS	Reactome
Signaling by Rho GTPases, Miro GTPases and RHOBTB3	TAS	Reactome
Transport of Mature mRNA derived from an Intron-Containing Transcript	TAS	Reactome
Transport of Mature Transcript to Cytoplasm	TAS	Reactome

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here