Gene description for NOC4L
Gene name nucleolar complex associated 4 homolog (S. cerevisiae)
Gene symbol NOC4L
Other names/aliases NET49
NOC4
UTP19
Species Homo sapiens
 Database cross references - NOC4L
ExoCarta ExoCarta_79050
Vesiclepedia VP_79050
Entrez Gene 79050
HGNC 28461
MIM 612819
UniProt Q9BVI4  
 NOC4L identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NOC4L
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
Biological Process
    rRNA processing GO:0006364 ISS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 ISS
    Noc4p-Nop14p complex GO:0030692 IBA
    nuclear membrane GO:0031965 IEA
    small-subunit processome GO:0032040 IBA
 Experiment description of studies that identified NOC4L in exosomes
1
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NOC4L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 CDC14B 8555
Proximity Label-MS Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 H1FNT  
Affinity Capture-MS Homo sapiens
5 CEP250 11190
Affinity Capture-MS Homo sapiens
6 NECAB2  
Two-hybrid Homo sapiens
7 EPM2AIP1 9852
Two-hybrid Homo sapiens
8 NOP58 51602
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
9 DNAJC8 22826
Proximity Label-MS Homo sapiens
10 RPS3A 6189
Affinity Capture-MS Homo sapiens
11 ZNF324B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 ARL6IP5 10550
Co-fractionation Homo sapiens
13 LIN28B  
Affinity Capture-MS Homo sapiens
14 RPS19 6223
Affinity Capture-MS Homo sapiens
15 CHCHD1  
Proximity Label-MS Homo sapiens
16 PNMAL1  
Affinity Capture-MS Homo sapiens
17 LMNA 4000
Proximity Label-MS Homo sapiens
18 SOX2  
Affinity Capture-MS Homo sapiens
19 ZNF414  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 USP36  
Affinity Capture-MS Homo sapiens
21 OXER1  
Two-hybrid Homo sapiens
22 GPATCH4 54865
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TSC22D4 81628
Two-hybrid Homo sapiens
25 PRR11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 ZNF148  
Co-fractionation Homo sapiens
27 CTLA4  
Affinity Capture-MS Homo sapiens
28 KLF8  
Affinity Capture-MS Homo sapiens
29 PRC1 9055
Affinity Capture-MS Homo sapiens
30 STX8 9482
Affinity Capture-MS Homo sapiens
31 STX7 8417
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 OBSL1 23363
Affinity Capture-MS Homo sapiens
33 ADARB1 104
Affinity Capture-MS Homo sapiens
34 FAM207A  
Affinity Capture-MS Homo sapiens
35 RPL29 6159
Co-fractionation Homo sapiens
36 RRP8  
Affinity Capture-MS Homo sapiens
37 KLHL20  
Affinity Capture-MS Homo sapiens
38 MECP2 4204
Affinity Capture-MS Homo sapiens
39 SNX27 81609
Affinity Capture-MS Homo sapiens
40 OASL 8638
Affinity Capture-MS Homo sapiens
41 RPS11 6205
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
42 STX12 23673
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 RBM19 9904
Affinity Capture-MS Homo sapiens
44 PES1 23481
Co-fractionation Homo sapiens
45 LIN28A  
Affinity Capture-MS Homo sapiens
46 KIAA1715 80856
Two-hybrid Homo sapiens
47 TOLLIP 54472
Proximity Label-MS Homo sapiens
48 POLD1 5424
Affinity Capture-MS Homo sapiens
49 TSR1 55720
Affinity Capture-MS Homo sapiens
50 PLSCR1 5359
Two-hybrid Homo sapiens
51 RBM4B  
Affinity Capture-MS Homo sapiens
52 YBX2 51087
Affinity Capture-MS Homo sapiens
53 PURG  
Affinity Capture-MS Homo sapiens
54 DAZAP2  
Two-hybrid Homo sapiens
55 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
56 Srp72  
Affinity Capture-MS Mus musculus
57 OGT 8473
Reconstituted Complex Homo sapiens
58 RPL31 6160
Affinity Capture-MS Homo sapiens
59 UBQLN2 29978
Two-hybrid Homo sapiens
60 RPS7 6201
Co-fractionation Homo sapiens
61 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
62 S100B 6285
Affinity Capture-MS Homo sapiens
63 RPS6 6194
Affinity Capture-MS Homo sapiens
64 HECTD1 25831
Affinity Capture-MS Homo sapiens
65 CEBPA  
Protein-peptide Homo sapiens
66 DAXX  
Affinity Capture-MS Homo sapiens
67 RSL1D1 26156
Affinity Capture-MS Homo sapiens
68 ANLN 54443
Affinity Capture-MS Homo sapiens
69 FGFBP1 9982
Affinity Capture-MS Homo sapiens
70 IPO5 3843
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 ABT1 29777
Affinity Capture-MS Homo sapiens
72 BYSL 705
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 RC3H2  
Affinity Capture-MS Homo sapiens
74 ECT2 1894
Affinity Capture-MS Homo sapiens
75 SIRT7  
Affinity Capture-MS Homo sapiens
76 RPL35 11224
Affinity Capture-MS Homo sapiens
77 NPTN 27020
Affinity Capture-MS Homo sapiens
78 CUL3 8452
Affinity Capture-MS Homo sapiens
79 Rrbp1  
Affinity Capture-MS Mus musculus
80 DCAF13 25879
Affinity Capture-MS Homo sapiens
81 BHLHE40  
Two-hybrid Homo sapiens
82 DNAJC17  
Proximity Label-MS Homo sapiens
83 IKZF1  
Two-hybrid Homo sapiens
84 RPL7 6129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
86 NT5C2 22978
Two-hybrid Homo sapiens
87 KRT15 3866
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
88 PRR3  
Affinity Capture-MS Homo sapiens
89 DKC1 1736
Co-fractionation Homo sapiens
90 MYC  
Affinity Capture-MS Homo sapiens
91 RPA3 6119
Proximity Label-MS Homo sapiens
92 SEC31A 22872
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 DNAJC9 23234
Proximity Label-MS Homo sapiens
94 RPS14 6208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 SART3 9733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 DDRGK1 65992
Affinity Capture-MS Homo sapiens
97 USHBP1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
98 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 ZC3H3  
Affinity Capture-MS Homo sapiens
100 DDX52  
Co-fractionation Homo sapiens
101 DUPD1  
Two-hybrid Homo sapiens
102 MALL  
Affinity Capture-MS Homo sapiens
103 RPS16 6217
Affinity Capture-MS Homo sapiens
104 RPL19 6143
Affinity Capture-MS Homo sapiens
105 ZNF574  
Affinity Capture-MS Homo sapiens
106 SURF6  
Affinity Capture-MS Homo sapiens
107 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
108 FASN 2194
Positive Genetic Homo sapiens
109 PDGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 RRS1 23212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 RPL6 6128
Affinity Capture-MS Homo sapiens
112 LINC00839  
Protein-RNA Homo sapiens
113 POLR3C 10623
Co-fractionation Homo sapiens
114 KRTAP19-6  
Two-hybrid Homo sapiens
115 DNAJA3 9093
Two-hybrid Homo sapiens
116 SIRT1  
Affinity Capture-MS Homo sapiens
117 NIFK 84365
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 KLF16  
Affinity Capture-MS Homo sapiens
119 UFL1 23376
Affinity Capture-MS Homo sapiens
120 KRR1 11103
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
121 NCL 4691
Affinity Capture-MS Homo sapiens
122 TECTB  
Affinity Capture-MS Homo sapiens
123 SSSCA1 10534
Two-hybrid Homo sapiens
124 CIT 11113
Affinity Capture-MS Homo sapiens
125 RPL23A 6147
Affinity Capture-MS Homo sapiens
126 KRAS 3845
Negative Genetic Homo sapiens
127 RC3H1 149041
Affinity Capture-MS Homo sapiens
128 ZBTB42  
Two-hybrid Homo sapiens
129 VIM 7431
Two-hybrid Homo sapiens
130 EMG1 10436
Affinity Capture-MS Homo sapiens
131 FBXO38 81545
Proximity Label-MS Homo sapiens
132 PRSS23 11098
Two-hybrid Homo sapiens
133 ZNF467  
Affinity Capture-MS Homo sapiens
134 RPL17 6139
Affinity Capture-MS Homo sapiens
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