Gene description for FAM98A
Gene name family with sequence similarity 98, member A
Gene symbol FAM98A
Other names/aliases -
Species Homo sapiens
 Database cross references - FAM98A
ExoCarta ExoCarta_25940
Vesiclepedia VP_25940
Entrez Gene 25940
HGNC 24520
UniProt Q8NCA5  
 FAM98A identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for FAM98A
Molecular Function
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    protein methyltransferase activity GO:0008276 IMP
Biological Process
    tRNA splicing, via endonucleolytic cleavage and ligation GO:0006388 NAS
    protein methylation GO:0006479 IMP
    positive regulation of cell population proliferation GO:0008284 IMP
    positive regulation of gene expression GO:0010628 IMP
    lysosome localization GO:0032418 ISS
    positive regulation of ruffle assembly GO:1900029 ISS
Subcellular Localization
    nucleus GO:0005634 NAS
    cytoplasm GO:0005737 NAS
    tRNA-splicing ligase complex GO:0072669 IBA
    tRNA-splicing ligase complex GO:0072669 NAS
 Experiment description of studies that identified FAM98A in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FAM98A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 INTS4  
Co-fractionation Homo sapiens
3 SPATS2  
Affinity Capture-MS Homo sapiens
4 ISG15 9636
Affinity Capture-MS Homo sapiens
5 HOXA5  
Affinity Capture-MS Homo sapiens
6 Fus  
Affinity Capture-MS Mus musculus
7 RIN3  
Affinity Capture-MS Homo sapiens
8 RACGAP1 29127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TARDBP 23435
Affinity Capture-MS Homo sapiens
10 BTF3 689
Affinity Capture-MS Homo sapiens
11 ANAPC15  
Affinity Capture-MS Homo sapiens
12 BYSL 705
Affinity Capture-MS Homo sapiens
13 CAND1 55832
Affinity Capture-MS Homo sapiens
14 PPP1R10  
Affinity Capture-MS Homo sapiens
15 SOX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CAPZB 832
Affinity Capture-MS Homo sapiens
17 UXS1 80146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MCM2 4171
Affinity Capture-MS Homo sapiens
19 ATXN2L 11273
Affinity Capture-MS Homo sapiens
20 COPS5 10987
Affinity Capture-MS Homo sapiens
21 GDI1 2664
Affinity Capture-MS Homo sapiens
22 NPM1 4869
Affinity Capture-MS Homo sapiens
23 PSMC2 5701
Cross-Linking-MS (XL-MS) Homo sapiens
24 HERC2 8924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 FAM98B 283742
Cross-Linking-MS (XL-MS) Homo sapiens
26 DNAJC7 7266
Proximity Label-MS Homo sapiens
27 DDX6 1656
Affinity Capture-MS Homo sapiens
28 Eif3a 13669
Affinity Capture-MS Mus musculus
29 CUL1 8454
Affinity Capture-MS Homo sapiens
30 MYCN  
Affinity Capture-MS Homo sapiens
31 CSNK1D 1453
Affinity Capture-MS Homo sapiens
32 N4BP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 KIF14 9928
Affinity Capture-MS Homo sapiens
34 ATXN2 6311
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PFKM 5213
Co-fractionation Homo sapiens
36 SRP9 6726
Affinity Capture-MS Homo sapiens
37 FOXA1  
Affinity Capture-MS Homo sapiens
38 CMAS 55907
Affinity Capture-MS Homo sapiens
39 ZCCHC9  
Two-hybrid Homo sapiens
40 PINX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 PARK2  
Affinity Capture-MS Homo sapiens
42 MSX2  
Affinity Capture-MS Homo sapiens
43 CLNS1A 1207
Affinity Capture-MS Homo sapiens
44 LDHD  
Affinity Capture-MS Homo sapiens
45 PSMC1 5700
Cross-Linking-MS (XL-MS) Homo sapiens
46 RPL5 6125
Affinity Capture-MS Homo sapiens
47 RPA2 6118
Proximity Label-MS Homo sapiens
48 NTRK1 4914
Affinity Capture-MS Homo sapiens
49 TOX4  
Affinity Capture-MS Homo sapiens
50 LUC7L2 51631
Affinity Capture-MS Homo sapiens
51 LYAR 55646
Affinity Capture-MS Homo sapiens
52 DDX1 1653
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 HECTD1 25831
Affinity Capture-MS Homo sapiens
54 CUL2 8453
Affinity Capture-MS Homo sapiens
55 RRP1B 23076
Affinity Capture-MS Homo sapiens
56 COPS7B 64708
Affinity Capture-MS Homo sapiens
57 GTPBP4 23560
Affinity Capture-MS Homo sapiens
58 FBXO31 79791
Affinity Capture-MS Homo sapiens
59 CCNT1  
Affinity Capture-MS Homo sapiens
60 OGT 8473
Reconstituted Complex Homo sapiens
61 NEURL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 SFPQ 6421
Affinity Capture-MS Homo sapiens
63 COPS7A 50813
Affinity Capture-MS Homo sapiens
64 NR4A1  
Affinity Capture-MS Homo sapiens
65 ESPN  
Affinity Capture-MS Homo sapiens
66 KIF20A 10112
Affinity Capture-MS Homo sapiens
67 RC3H2  
Affinity Capture-MS Homo sapiens
68 2700060E02Rik 68045
Two-hybrid Mus musculus
69 CUL3 8452
Affinity Capture-MS Homo sapiens
70 CIT 11113
Cross-Linking-MS (XL-MS) Homo sapiens
71 DCAF13 25879
Affinity Capture-MS Homo sapiens
72 CTTN 2017
Affinity Capture-MS Homo sapiens
73 EGFR 1956
Affinity Capture-MS Homo sapiens
74 YY1 7528
Affinity Capture-MS Homo sapiens
75 FUS 2521
Affinity Capture-MS Homo sapiens
76 NXF1 10482
Affinity Capture-RNA Homo sapiens
77 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
78 NSRP1  
Affinity Capture-MS Homo sapiens
79 MYC  
Affinity Capture-MS Homo sapiens
80 RPA3 6119
Proximity Label-MS Homo sapiens
81 DDRGK1 65992
Affinity Capture-MS Homo sapiens
82 Rpl35 66489
Affinity Capture-MS Mus musculus
83 RPS16 6217
Affinity Capture-MS Homo sapiens
84 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
85 SPOP  
Affinity Capture-MS Homo sapiens
86 RC3H1 149041
Affinity Capture-MS Homo sapiens
87 PARP1 142
Proximity Label-MS Homo sapiens
88 DNAJA2 10294
Proximity Label-MS Homo sapiens
89 NUFIP2 57532
Affinity Capture-MS Homo sapiens
90 CUL5 8065
Affinity Capture-MS Homo sapiens
91 C1orf35  
Affinity Capture-MS Homo sapiens
92 RNF20 56254
Cross-Linking-MS (XL-MS) Homo sapiens
93 TAF2  
Affinity Capture-MS Homo sapiens
94 UFL1 23376
Affinity Capture-MS Homo sapiens
95 ANXA11 311
Cross-Linking-MS (XL-MS) Homo sapiens
96 SNIP1  
Affinity Capture-MS Homo sapiens
97 BTBD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 EIF4B 1975
Affinity Capture-MS Homo sapiens
99 RTCB 51493
Affinity Capture-MS Homo sapiens
100 TRIM31  
Affinity Capture-MS Homo sapiens
101 Rrbp1  
Affinity Capture-MS Mus musculus
102 C14orf166 51637
Cross-Linking-MS (XL-MS) Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
103 C9orf72  
Affinity Capture-MS Homo sapiens
104 PSPC1 55269
Affinity Capture-MS Homo sapiens
105 EMG1 10436
Two-hybrid Homo sapiens
106 PRMT1 3276
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM98A is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here