Gene description for CDK4
Gene name	cyclin-dependent kinase 4
Gene symbol	CDK4
Other names/aliases	CMM3 PSK-J3
Species	Homo sapiens
Database cross references - CDK4
ExoCarta	ExoCarta_1019
Entrez Gene	1019
HGNC	1773
MIM	123829
UniProt	P11802
CDK4 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927

Gene ontology annotations for CDK4

Molecular Function     cyclin-dependent protein serine/threonine kinase activity GO:0004693 IDA     cyclin binding GO:0030332 IPI     ATP binding GO:0005524 IEA     cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 TAS     protein complex binding GO:0032403 IEA     protein binding GO:0005515 IPI Biological Process     positive regulation of apoptotic process GO:0043065 IEA     response to hyperoxia GO:0055093 IEA     circadian rhythm GO:0007623 IEA     regulation of gene expression GO:0010468 IMP     organ regeneration GO:0031100 IEA     chromatin organization GO:0006325 TAS     positive regulation of fibroblast proliferation GO:0048146 IMP     mitotic cell cycle GO:0000278 TAS     G1/S transition of mitotic cell cycle GO:0000082 IMP     cell division GO:0051301 IEA     positive regulation of translation GO:0045727 IEA     positive regulation of cell size GO:0045793 IEA     response to drug GO:0042493 IGI     response to toxic substance GO:0009636 IEA     protein phosphorylation GO:0006468 IDA     signal transduction GO:0007165 IEA     lens development in camera-type eye GO:0002088 IEA     response to testosterone GO:0033574 IEA     positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IDA     response to lead ion GO:0010288 IEA     regulation of protein kinase activity GO:0045859 TAS     positive regulation of cell proliferation GO:0008284 IMP     negative regulation of cell cycle arrest GO:0071157 IDA Subcellular Localization     perinuclear region of cytoplasm GO:0048471 IEA     nuclear membrane GO:0031965 IDA     nucleolus GO:0005730 IDA     chromatin GO:0000785 IDA     cyclin-dependent protein kinase holoenzyme complex GO:0000307 IDA     nucleus GO:0005634 IDA     bicellular tight junction GO:0005923 IEA     transcription factor complex GO:0005667 IEA     nucleoplasm GO:0005654 TAS     cytosol GO:0005829 TAS