Gene description for SLC25A12
Gene name solute carrier family 25 (aspartate/glutamate carrier), member 12
Gene symbol SLC25A12
Other names/aliases AGC1
ARALAR
Species Homo sapiens
 Database cross references - SLC25A12
ExoCarta ExoCarta_8604
Vesiclepedia VP_8604
Entrez Gene 8604
HGNC 10982
MIM 603667
UniProt O75746  
 SLC25A12 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for SLC25A12
Molecular Function
    3-sulfino-L-alanine: proton, glutamate antiporter activity GO:0000514 IDA
    aspartate:glutamate, proton antiporter activity GO:0000515 IDA
    L-glutamate transmembrane transporter activity GO:0005313 IBA
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    L-aspartate transmembrane transporter activity GO:0015183 IBA
    identical protein binding GO:0042802 IDA
Biological Process
    neutral amino acid transport GO:0015804 IEA
    aspartate transmembrane transport GO:0015810 IBA
    aspartate transmembrane transport GO:0015810 IDA
    L-glutamate transmembrane transport GO:0015813 IBA
    L-glutamate transmembrane transport GO:0015813 IDA
    malate-aspartate shuttle GO:0043490 IBA
    malate-aspartate shuttle GO:0043490 IDA
    malate-aspartate shuttle GO:0043490 IGI
    response to calcium ion GO:0051592 IDA
    L-aspartate transmembrane transport GO:0070778 IEA
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    membrane GO:0016020 NAS
 Experiment description of studies that identified SLC25A12 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SLC25A12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SHISA8  
Proximity Label-MS Homo sapiens
2 SLC25A13 10165
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
3 FMOD 2331
Affinity Capture-MS Homo sapiens
4 ATPIF1 93974
Proximity Label-MS Homo sapiens
5 SPRTN  
Affinity Capture-MS Homo sapiens
6 RPS3A 6189
Cross-Linking-MS (XL-MS) Homo sapiens
7 VAPA 9218
Affinity Capture-MS Homo sapiens
8 PAEP  
Affinity Capture-MS Homo sapiens
9 SAMM50 25813
Proximity Label-MS Homo sapiens
10 GJA1 2697
Affinity Capture-MS Homo sapiens
11 ARL6IP5 10550
Proximity Label-MS Homo sapiens
12 DHX30 22907
Proximity Label-MS Homo sapiens
13 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
14 NUDCD3 23386
Proximity Label-MS Homo sapiens
15 JUND 3727
Reconstituted Complex Homo sapiens
16 MRPL24  
Proximity Label-MS Homo sapiens
17 SRGAP2 23380
Affinity Capture-MS Homo sapiens
18 HSPB1 3315
Proximity Label-MS Homo sapiens
19 NDUFA4 4697
Affinity Capture-MS Homo sapiens
20 ASXL1  
Affinity Capture-MS Homo sapiens
21 SOX2  
Affinity Capture-MS Homo sapiens
22 SLC25A24 29957
Proximity Label-MS Homo sapiens
23 CARS2 79587
Proximity Label-MS Homo sapiens
24 LRPPRC 10128
Proximity Label-MS Homo sapiens
25 NUDCD2 134492
Proximity Label-MS Homo sapiens
26 CHCHD4  
Proximity Label-MS Homo sapiens
27 NDUFS3 4722
Proximity Label-MS Homo sapiens
28 OGDH 4967
Proximity Label-MS Homo sapiens
29 TM9SF4 9777
Affinity Capture-MS Homo sapiens
30 COX11  
Proximity Label-MS Homo sapiens
31 PMPCA 23203
Proximity Label-MS Homo sapiens
32 TIMMDC1  
Proximity Label-MS Homo sapiens
33 TRABD 80305
Proximity Label-MS Homo sapiens
34 NDUFA11 126328
Proximity Label-MS Homo sapiens
35 PRC1 9055
Affinity Capture-MS Homo sapiens
36 TIMM23 100287932
Proximity Label-MS Homo sapiens
37 NDUFA5 4698
Proximity Label-MS Homo sapiens
38 PUSL1  
Proximity Label-MS Homo sapiens
39 ETFA 2108
Proximity Label-MS Homo sapiens
40 CHCHD3 54927
Proximity Label-MS Homo sapiens
41 RHOA 387
Co-fractionation Homo sapiens
42 SFXN4  
Proximity Label-MS Homo sapiens
43 CLPB 81570
Proximity Label-MS Homo sapiens
44 C20orf24  
Affinity Capture-MS Homo sapiens
45 LACTB 114294
Proximity Label-MS Homo sapiens
46 HTRA2 27429
Proximity Label-MS Homo sapiens
47 NDUFAF1  
Proximity Label-MS Homo sapiens
48 ATG16L1 55054
Affinity Capture-MS Homo sapiens
49 SLC25A25  
Proximity Label-MS Homo sapiens
50 NDUFV3 4731
Proximity Label-MS Homo sapiens
51 MECP2 4204
Affinity Capture-MS Homo sapiens
52 MPC2 25874
Proximity Label-MS Homo sapiens
53 TIMM50 92609
Proximity Label-MS Homo sapiens
54 MRPL4 51073
Proximity Label-MS Homo sapiens
55 NUDT16L1 84309
Proximity Label-MS Homo sapiens
56 HK1 3098
Co-fractionation Homo sapiens
57 NCSTN 23385
Affinity Capture-MS Homo sapiens
58 DVL2 1856
Affinity Capture-MS Homo sapiens
59 ATAD3A 55210
Proximity Label-MS Homo sapiens
60 APOO 79135
Proximity Label-MS Homo sapiens
61 E2F4  
Affinity Capture-MS Homo sapiens
62 Tbck  
Affinity Capture-MS Mus musculus
63 NF2 4771
Affinity Capture-MS Homo sapiens
64 ATAD3B 83858
Proximity Label-MS Homo sapiens
65 MTCH2 23788
Proximity Label-MS Homo sapiens
66 HCCS 3052
Proximity Label-MS Homo sapiens
67 COX15 1355
Proximity Label-MS Homo sapiens
68 NDUFB7 4713
Proximity Label-MS Homo sapiens
69 PELO 53918
Affinity Capture-MS Homo sapiens
70 EXOG 9941
Proximity Label-MS Homo sapiens
71 PARK2  
Affinity Capture-MS Homo sapiens
72 PHB 5245
Proximity Label-MS Homo sapiens
73 PNKP 11284
Affinity Capture-MS Homo sapiens
74 AGK 55750
Proximity Label-MS Homo sapiens
75 ACOT2 10965
Proximity Label-MS Homo sapiens
76 NDUFA8 4702
Proximity Label-MS Homo sapiens
77 SMIM12  
Proximity Label-MS Homo sapiens
78 MICU2 221154
Proximity Label-MS Homo sapiens
79 ATF2  
Affinity Capture-MS Homo sapiens
80 MTX2 10651
Proximity Label-MS Homo sapiens
81 DIABLO 56616
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
82 FAM162A 26355
Proximity Label-MS Homo sapiens
83 TTC19  
Proximity Label-MS Homo sapiens
84 CCDC51 79714
Proximity Label-MS Homo sapiens
85 SYNJ2BP 55333
Co-fractionation Homo sapiens
86 Pafah1b1 18472
Affinity Capture-MS Mus musculus
87 SMAD3 4088
Affinity Capture-MS Homo sapiens
88 C12orf73  
Proximity Label-MS Homo sapiens
89 CYC1 1537
Proximity Label-MS Homo sapiens
90 PCSK9 255738
Affinity Capture-MS Homo sapiens
91 CHCHD6 84303
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
92 TRIAP1  
Proximity Label-MS Homo sapiens
93 MLF2 8079
Proximity Label-MS Homo sapiens
94 MICU1 10367
Proximity Label-MS Homo sapiens
95 SPRYD7 57213
Affinity Capture-MS Homo sapiens
96 CACYBP 27101
Proximity Label-MS Homo sapiens
97 COX4I1 1327
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
98 NDUFV1 4723
Proximity Label-MS Homo sapiens
99 ENDOG  
Proximity Label-MS Homo sapiens
100 IMMT 10989
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
101 TMPO 7112
Affinity Capture-MS Homo sapiens
102 RPL32 6161
Cross-Linking-MS (XL-MS) Homo sapiens
103 TOMM40 10452
Proximity Label-MS Homo sapiens
104 COX5B 1329
Proximity Label-MS Homo sapiens
105 AK2 204
Proximity Label-MS Homo sapiens
106 KIAA1191  
Proximity Label-MS Homo sapiens
107 AIFM1 9131
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
108 CPOX 1371
Proximity Label-MS Homo sapiens
109 NDUFB10 4716
Proximity Label-MS Homo sapiens
110 NDUFA13 51079
Proximity Label-MS Homo sapiens
111 GPD2 2820
Proximity Label-MS Homo sapiens
112 CDCA3 83461
Proximity Label-MS Homo sapiens
113 LRRC25  
Affinity Capture-MS Homo sapiens
114 RDH13  
Proximity Label-MS Homo sapiens
115 COX6A1  
Proximity Label-MS Homo sapiens
116 MRPS14  
Proximity Label-MS Homo sapiens
117 MGARP  
Affinity Capture-MS Homo sapiens
118 ATP5F1 515
Proximity Label-MS Homo sapiens
119 TXNRD1 7296
Co-fractionation Homo sapiens
120 YTHDF1 54915
Affinity Capture-MS Homo sapiens
121 FBXO6 26270
Affinity Capture-MS Homo sapiens
122 COX6B1 1340
Proximity Label-MS Homo sapiens
123 GHITM 27069
Proximity Label-MS Homo sapiens
124 RIPK4  
Affinity Capture-MS Homo sapiens
125 OCIAD1 54940
Proximity Label-MS Homo sapiens
126 TOMM70A 9868
Proximity Label-MS Homo sapiens
127 MLF1  
Proximity Label-MS Homo sapiens
128 GLO1 2739
Proximity Label-MS Homo sapiens
129 PHB2 11331
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
130 PRKACA 5566
Affinity Capture-MS Homo sapiens
131 GNAS 2778
Co-fractionation Homo sapiens
132 YME1L1 10730
Proximity Label-MS Homo sapiens
133 MYC  
Affinity Capture-MS Homo sapiens
134 RPA3 6119
Proximity Label-MS Homo sapiens
135 APOOL 139322
Proximity Label-MS Homo sapiens
136 COX6C 1345
Proximity Label-MS Homo sapiens
137 AKAP5  
Affinity Capture-MS Homo sapiens
138 TIMM8B 26521
Proximity Label-MS Homo sapiens
139 DLST 1743
Proximity Label-MS Homo sapiens
140 EPN1 29924
Affinity Capture-MS Homo sapiens
141 Stard13  
Affinity Capture-MS Mus musculus
142 SCO1  
Proximity Label-MS Homo sapiens
143 ACAD9 28976
Proximity Label-MS Homo sapiens
144 CST9L  
Affinity Capture-MS Homo sapiens
145 TXNDC5 81567
Cross-Linking-MS (XL-MS) Homo sapiens
146 COA7  
Proximity Label-MS Homo sapiens
147 HAX1  
Proximity Label-MS Homo sapiens
148 COX2 4513
Proximity Label-MS Homo sapiens
149 BRD9 65980
Affinity Capture-MS Homo sapiens
150 NDUFS1 4719
Proximity Label-MS Homo sapiens
151 NDUFB11 54539
Proximity Label-MS Homo sapiens
152 MRPL18 29074
Proximity Label-MS Homo sapiens
153 ZRANB1 54764
Affinity Capture-MS Homo sapiens
154 CLPP 8192
Proximity Label-MS Homo sapiens
155 CCDC58 131076
Proximity Label-MS Homo sapiens
156 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
157 AATK  
Affinity Capture-MS Homo sapiens
158 NAAA  
Affinity Capture-MS Homo sapiens
159 TIMM13 26517
Proximity Label-MS Homo sapiens
160 MRPS2 51116
Proximity Label-MS Homo sapiens
161 ICT1 3396
Affinity Capture-MS Homo sapiens
162 PHLDA3 23612
Affinity Capture-MS Homo sapiens
163 TIMM8A 1678
Proximity Label-MS Homo sapiens
164 DNAJA2 10294
Affinity Capture-MS Homo sapiens
165 ZNF746  
Affinity Capture-MS Homo sapiens
166 MRPS31  
Proximity Label-MS Homo sapiens
167 OPA1 4976
Proximity Label-MS Homo sapiens
168 COX5A 9377
Proximity Label-MS Homo sapiens
169 HIGD2A  
Proximity Label-MS Homo sapiens
170 Htt  
Affinity Capture-MS Mus musculus
171 SFTPA2  
Affinity Capture-MS Homo sapiens
172 SHMT2 6472
Proximity Label-MS Homo sapiens
173 SFXN1 94081
Proximity Label-MS Homo sapiens
174 UFL1 23376
Affinity Capture-MS Homo sapiens
175 NNT 23530
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
176 AFG3L2 10939
Proximity Label-MS Homo sapiens
177 Arhgap6  
Affinity Capture-MS Mus musculus
178 LONP1 9361
Proximity Label-MS Homo sapiens
179 DHFR 1719
Proximity Label-MS Homo sapiens
180 PTGES2 80142
Proximity Label-MS Homo sapiens
181 MRPS9 64965
Proximity Label-MS Homo sapiens
182 C19orf52  
Proximity Label-MS Homo sapiens
183 SLC25A51  
Proximity Label-MS Homo sapiens
184 COX7A2 1347
Proximity Label-MS Homo sapiens
185 SERBP1 26135
Affinity Capture-MS Homo sapiens
186 C9orf72  
Affinity Capture-MS Homo sapiens
187 CNIH4  
Proximity Label-MS Homo sapiens
188 MRPS22 56945
Proximity Label-MS Homo sapiens
189 CKMT1B 1159
Proximity Label-MS Homo sapiens
190 Tpx2  
Affinity Capture-MS Mus musculus
191 SCO2  
Proximity Label-MS Homo sapiens
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