Gene description for PTDSS1
Gene name phosphatidylserine synthase 1
Gene symbol PTDSS1
Other names/aliases LMHD
PSS1
PSSA
Species Homo sapiens
 Database cross references - PTDSS1
ExoCarta ExoCarta_9791
Vesiclepedia VP_9791
Entrez Gene 9791
HGNC 9587
MIM 612792
UniProt P48651  
 PTDSS1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PTDSS1
Molecular Function
    transferase activity GO:0016740 TAS
    L-serine-phosphatidylethanolamine phosphatidyltransferase activity GO:0106245 IDA
    L-serine-phosphatidylethanolamine phosphatidyltransferase activity GO:0106245 IMP
    L-serine-phosphatidylcholine phosphatidyltransferase activity GO:0106258 IDA
    L-serine-phosphatidylcholine phosphatidyltransferase activity GO:0106258 IMP
Biological Process
    phosphatidylserine biosynthetic process GO:0006659 IDA
    phosphatidylserine biosynthetic process GO:0006659 IEA
    phosphatidylserine biosynthetic process GO:0006659 TAS
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 ISS
    endoplasmic reticulum membrane GO:0005789 TAS
    membrane GO:0016020 HDA
    membrane GO:0016020 ISS
 Experiment description of studies that identified PTDSS1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PTDSS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 CAPNS2 84290
Affinity Capture-MS Homo sapiens
3 HMOX1 3162
Affinity Capture-MS Homo sapiens
4 HSD17B11 51170
Proximity Label-MS Homo sapiens
5 Tmed2 56334
Affinity Capture-MS Mus musculus
6 C5AR1  
Affinity Capture-MS Homo sapiens
7 LYG2  
Affinity Capture-MS Homo sapiens
8 FAM26D  
Affinity Capture-MS Homo sapiens
9 SERPINB4 6318
Affinity Capture-MS Homo sapiens
10 MARCKS 4082
Proximity Label-MS Homo sapiens
11 LAMP3  
Proximity Label-MS Homo sapiens
12 ALB 213
Affinity Capture-MS Homo sapiens
13 ANXA8 653145
Affinity Capture-MS Homo sapiens
14 GDPD3 79153
Affinity Capture-MS Homo sapiens
15 ACOX1 51
Affinity Capture-MS Homo sapiens
16 GJD3  
Proximity Label-MS Homo sapiens
17 LAMP2 3920
Proximity Label-MS Homo sapiens
18 DNAJC25 548645
Proximity Label-MS Homo sapiens
19 S100A3  
Affinity Capture-MS Homo sapiens
20 Ktn1  
Affinity Capture-MS Mus musculus
21 NPC2 10577
Affinity Capture-MS Homo sapiens
22 PSMB8 5696
Affinity Capture-MS Homo sapiens
23 S100P 6286
Affinity Capture-MS Homo sapiens
24 APOD 347
Affinity Capture-MS Homo sapiens
25 S100A14 57402
Affinity Capture-MS Homo sapiens
26 HPX 3263
Affinity Capture-MS Homo sapiens
27 FLG2 388698
Affinity Capture-MS Homo sapiens
28 PPL 5493
Affinity Capture-MS Homo sapiens
29 B3GAT1  
Proximity Label-MS Homo sapiens
30 GSDMA 284110
Affinity Capture-MS Homo sapiens
31 ALDH1A1 216
Affinity Capture-MS Homo sapiens
32 CAPN12  
Affinity Capture-MS Homo sapiens
33 CTBS 1486
Affinity Capture-MS Homo sapiens
34 ORM1 5004
Affinity Capture-MS Homo sapiens
35 C3 718
Affinity Capture-MS Homo sapiens
36 PLK4  
Affinity Capture-MS Homo sapiens
37 ACADVL 37
Affinity Capture-MS Homo sapiens
38 ACPP 55
Affinity Capture-MS Homo sapiens
39 SSR1 6745
Proximity Label-MS Homo sapiens
40 GPLD1  
Affinity Capture-MS Homo sapiens
41 KLK10 5655
Affinity Capture-MS Homo sapiens
42 FLG 2312
Affinity Capture-MS Homo sapiens
43 AGR2 10551
Affinity Capture-MS Homo sapiens
44 CPA4 51200
Affinity Capture-MS Homo sapiens
45 ERMP1 79956
Affinity Capture-MS Homo sapiens
46 PSAPL1  
Affinity Capture-MS Homo sapiens
47 ATG9B  
Affinity Capture-MS Homo sapiens
48 MECP2 4204
Affinity Capture-MS Homo sapiens
49 ERBB2 2064
Affinity Capture-MS Homo sapiens
50 PCYOX1 51449
Affinity Capture-MS Homo sapiens
51 Dctn1 13191
Affinity Capture-MS Mus musculus
52 CTSV 1515
Affinity Capture-MS Homo sapiens
53 PXMP2  
Proximity Label-MS Homo sapiens
54 TSHR 7253
Two-hybrid Homo sapiens
55 HEPHL1  
Affinity Capture-MS Homo sapiens
56 ALDH1A3 220
Affinity Capture-MS Homo sapiens
57 LCP1 3936
Affinity Capture-MS Homo sapiens
58 POF1B 79983
Affinity Capture-MS Homo sapiens
59 PLBD1 79887
Affinity Capture-MS Homo sapiens
60 CST6  
Affinity Capture-MS Homo sapiens
61 STOM 2040
Affinity Capture-MS Homo sapiens
62 STAU1 6780
Affinity Capture-MS Homo sapiens
63 ARG1 383
Affinity Capture-MS Homo sapiens
64 IGHG1 3500
Affinity Capture-MS Homo sapiens
65 RPL31 6160
Proximity Label-MS Homo sapiens
66 S100A8 6279
Affinity Capture-MS Homo sapiens
67 CREB3  
Two-hybrid Homo sapiens
68 EVPL 2125
Affinity Capture-MS Homo sapiens
69 RPN1 6184
Proximity Label-MS Homo sapiens
70 CTSB 1508
Affinity Capture-MS Homo sapiens
71 TGM1 7051
Affinity Capture-MS Homo sapiens
72 SEC62 7095
Proximity Label-MS Homo sapiens
73 H2AFY 9555
Affinity Capture-MS Homo sapiens
74 SEC61B 10952
Proximity Label-MS Homo sapiens
75 CREG1 8804
Affinity Capture-MS Homo sapiens
76 VCP 7415
Affinity Capture-MS Homo sapiens
77 CALML3 810
Affinity Capture-MS Homo sapiens
78 LRRC15 131578
Affinity Capture-MS Homo sapiens
79 SEC63 11231
Proximity Label-MS Homo sapiens
80 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
81 CASP14 23581
Affinity Capture-MS Homo sapiens
82 IMPA2 3613
Affinity Capture-MS Homo sapiens
83 Atp2a2 11938
Affinity Capture-MS Mus musculus
84 IVL 3713
Affinity Capture-MS Homo sapiens
85 RPN2 6185
Proximity Label-MS Homo sapiens
86 TYMP 1890
Affinity Capture-MS Homo sapiens
87 LRRC59 55379
Proximity Label-MS Homo sapiens
88 IL1RN 3557
Affinity Capture-MS Homo sapiens
89 S100A16 140576
Affinity Capture-MS Homo sapiens
90 ASAH1 427
Affinity Capture-MS Homo sapiens
91 CRYAB 1410
Affinity Capture-MS Homo sapiens
92 LAMP1 3916
Proximity Label-MS Homo sapiens
93 DUSP14 11072
Affinity Capture-MS Homo sapiens
94 ANXA1 301
Affinity Capture-MS Homo sapiens
95 IGKC 3514
Affinity Capture-MS Homo sapiens
96 EPPK1 83481
Affinity Capture-MS Homo sapiens
97 S100A7 6278
Affinity Capture-MS Homo sapiens
98 CD207  
Affinity Capture-MS Homo sapiens
99 S100A7A 338324
Affinity Capture-MS Homo sapiens
100 DPP7 29952
Affinity Capture-MS Homo sapiens
101 LPCAT3 10162
Affinity Capture-MS Homo sapiens
102 SERPINB5 5268
Affinity Capture-MS Homo sapiens
103 NTHL1  
Affinity Capture-MS Homo sapiens
104 CRAT 1384
Affinity Capture-MS Homo sapiens
105 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
106 DNASE1L2  
Affinity Capture-MS Homo sapiens
107 PADI3 51702
Affinity Capture-MS Homo sapiens
108 RPA3 6119
Proximity Label-MS Homo sapiens
109 H6PD 9563
Affinity Capture-MS Homo sapiens
110 LGALS7B 653499
Affinity Capture-MS Homo sapiens
111 NCLN 56926
Affinity Capture-MS Homo sapiens
112 PLCD1 5333
Affinity Capture-MS Homo sapiens
113 DHFRL1  
Proximity Label-MS Homo sapiens
114 DDRGK1 65992
Affinity Capture-MS Homo sapiens
115 RNF2  
Affinity Capture-MS Homo sapiens
116 SDR9C7  
Affinity Capture-MS Homo sapiens
117 PKP3 11187
Affinity Capture-MS Homo sapiens
118 DSP 1832
Affinity Capture-MS Homo sapiens
119 GSN 2934
Affinity Capture-MS Homo sapiens
120 CLPP 8192
Proximity Label-MS Homo sapiens
121 PLA2G4E  
Affinity Capture-MS Homo sapiens
122 PDLIM7 9260
Affinity Capture-MS Homo sapiens
123 FASN 2194
Positive Genetic Homo sapiens
124 RNASE7 84659
Affinity Capture-MS Homo sapiens
125 PLEC 5339
Affinity Capture-MS Homo sapiens
126 PREP 5550
Affinity Capture-MS Homo sapiens
127 CKAP4 10970
Proximity Label-MS Homo sapiens
128 JUP 3728
Affinity Capture-MS Homo sapiens
129 FBXL6  
Affinity Capture-MS Homo sapiens
130 IGLC6 3542
Affinity Capture-MS Homo sapiens
131 SDR16C5  
Affinity Capture-MS Homo sapiens
132 ALOX15B  
Affinity Capture-MS Homo sapiens
133 IGLL5 100423062
Affinity Capture-MS Homo sapiens
134 LGALS3 3958
Affinity Capture-MS Homo sapiens
135 VSIG8  
Affinity Capture-MS Homo sapiens
136 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
137 IGHG2 3501
Affinity Capture-MS Homo sapiens
138 KLK7 5650
Affinity Capture-MS Homo sapiens
139 DDX58 23586
Affinity Capture-RNA Homo sapiens
140 PKP1 5317
Affinity Capture-MS Homo sapiens
141 ELOVL5 60481
Proximity Label-MS Homo sapiens
142 SERPINB3 6317
Affinity Capture-MS Homo sapiens
143 TF 7018
Affinity Capture-MS Homo sapiens
144 UFL1 23376
Affinity Capture-MS Homo sapiens
145 TGM3 7053
Affinity Capture-MS Homo sapiens
146 CALML5 51806
Affinity Capture-MS Homo sapiens
147 GM2A 2760
Affinity Capture-MS Homo sapiens
148 DSG4 147409
Affinity Capture-MS Homo sapiens
149 SLC6A8 6535
Affinity Capture-MS Homo sapiens
150 NCCRP1 342897
Affinity Capture-MS Homo sapiens
151 NEU2  
Affinity Capture-MS Homo sapiens
152 DNAJC1 64215
Proximity Label-MS Homo sapiens
153 C9orf72  
Affinity Capture-MS Homo sapiens
154 LCN2 3934
Affinity Capture-MS Homo sapiens
155 TRIM29 23650
Affinity Capture-MS Homo sapiens
156 FCGBP 8857
Affinity Capture-MS Homo sapiens
157 Smn1 20595
Affinity Capture-MS Mus musculus
158 AIM1 202
Affinity Capture-MS Homo sapiens
159 CTSH 1512
Affinity Capture-MS Homo sapiens
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