Gene description for DNAJA3
Gene name DnaJ (Hsp40) homolog, subfamily A, member 3
Gene symbol DNAJA3
Other names/aliases HCA57
TID1
hTID-1
Species Homo sapiens
 Database cross references - DNAJA3
ExoCarta ExoCarta_9093
Vesiclepedia VP_9093
Entrez Gene 9093
HGNC 11808
MIM 608382
UniProt Q96EY1  
 DNAJA3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DNAJA3
Molecular Function
    type II interferon receptor binding GO:0005133 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    protein kinase binding GO:0019901 IBA
    protein kinase binding GO:0019901 IPI
    Hsp70 protein binding GO:0030544 IEA
    GTPase regulator activity GO:0030695 IEA
    protein-containing complex binding GO:0044877 IDA
    metal ion binding GO:0046872 IEA
    NF-kappaB binding GO:0051059 IPI
    unfolded protein binding GO:0051082 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    IkappaB kinase complex binding GO:0106137 IDA
    DNA-binding transcription factor binding GO:0140297 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    mitochondrial DNA replication GO:0006264 IEA
    protein folding GO:0006457 IDA
    protein folding GO:0006457 IEA
    negative regulation of protein kinase activity GO:0006469 IDA
    activation-induced cell death of T cells GO:0006924 IEA
    mitochondrion organization GO:0007005 IBA
    small GTPase-mediated signal transduction GO:0007264 IEA
    neuromuscular junction development GO:0007528 IDA
    negative regulation of cell population proliferation GO:0008285 IDA
    response to heat GO:0009408 IEA
    positive regulation of protein ubiquitination GO:0031398 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
    T cell differentiation in thymus GO:0033077 IEA
    response to type II interferon GO:0034341 IDA
    positive regulation of T cell proliferation GO:0042102 IEA
    positive regulation of apoptotic process GO:0043065 IDA
    negative regulation of apoptotic process GO:0043066 IDA
    negative regulation of programmed cell death GO:0043069 IEA
    negative regulation of canonical NF-kappaB signal transduction GO:0043124 IDA
    protein stabilization GO:0050821 IDA
    negative regulation of type II interferon-mediated signaling pathway GO:0060336 IDA
    skeletal muscle acetylcholine-gated channel clustering GO:0071340 ISS
    cellular senescence GO:0090398 IEA
    negative regulation of cysteine-type endopeptidase activity GO:2000117 IDA
    positive regulation of cysteine-type endopeptidase activity GO:2001056 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IEA
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 IDA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 IMP
    actin filament GO:0005884 IDA
    cytoplasmic side of plasma membrane GO:0009898 ISS
    neuromuscular junction GO:0031594 ISS
    mitochondrial nucleoid GO:0042645 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    postsynaptic membrane GO:0045211 ISS
 Experiment description of studies that identified DNAJA3 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DNAJA3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 SCFD1 23256
Co-fractionation Homo sapiens
3 MRPS27 23107
Proximity Label-MS Homo sapiens
4 AFG3L2 10939
Proximity Label-MS Homo sapiens
5 MRPS35 60488
Proximity Label-MS Homo sapiens
6 RPS18 6222
Co-fractionation Homo sapiens
7 TIMM21  
Proximity Label-MS Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 RAB1A 5861
Co-fractionation Homo sapiens
10 ZBTB22  
Two-hybrid Homo sapiens
11 NDUFS1 4719
Proximity Label-MS Homo sapiens
12 COX15 1355
Proximity Label-MS Homo sapiens
13 PKM 5315
Co-fractionation Homo sapiens
14 OXA1L  
Proximity Label-MS Homo sapiens
15 HPN  
Affinity Capture-MS Homo sapiens
16 PTPMT1 114971
Proximity Label-MS Homo sapiens
17 CRK 1398
Affinity Capture-MS Homo sapiens
18 TRIM66  
Affinity Capture-MS Homo sapiens
19 TRUB2  
Proximity Label-MS Homo sapiens
20 BRCA1 672
Protein-peptide Homo sapiens
21 MTG2  
Proximity Label-MS Homo sapiens
22 HSPA1L 3305
Affinity Capture-MS Homo sapiens
23 PRMT6  
Two-hybrid Homo sapiens
24 C9orf78 51759
Affinity Capture-MS Homo sapiens
25 MRPL37 51253
Proximity Label-MS Homo sapiens
26 ETFB 2109
Proximity Label-MS Homo sapiens
27 UBC 7316
Affinity Capture-MS Homo sapiens
28 NDUFA12 55967
Proximity Label-MS Homo sapiens
29 MRPL50 54534
Proximity Label-MS Homo sapiens
30 VHL  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
31 RPUSD4 84881
Proximity Label-MS Homo sapiens
32 MRPL49 740
Proximity Label-MS Homo sapiens
33 ASXL1  
Affinity Capture-MS Homo sapiens
34 NDUFS2 4720
Proximity Label-MS Homo sapiens
35 MRPS24 64951
Proximity Label-MS Homo sapiens
36 MTPN 136319
Proximity Label-MS Homo sapiens
37 USP36  
Affinity Capture-MS Homo sapiens
38 KIAA1429 25962
Affinity Capture-MS Homo sapiens
39 FAM214B  
Two-hybrid Homo sapiens
40 TCF19  
Two-hybrid Homo sapiens
41 CTDSP2 10106
Affinity Capture-MS Homo sapiens
42 NDUFS3 4722
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
43 B3GNT2 10678
Affinity Capture-MS Homo sapiens
44 TMEM65 157378
Proximity Label-MS Homo sapiens
45 IARS2 55699
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
46 SARS2 54938
Proximity Label-MS Homo sapiens
47 SDHB 6390
Proximity Label-MS Homo sapiens
48 NDUFA7 4701
Proximity Label-MS Homo sapiens
49 POLDIP2 26073
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
50 MRPL23 6150
Proximity Label-MS Homo sapiens
51 MRPS5 64969
Proximity Label-MS Homo sapiens
52 TMEM231 79583
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
53 INPP5J  
Two-hybrid Homo sapiens
54 MRPS23 51649
Proximity Label-MS Homo sapiens
55 NDUFA5 4698
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
56 MRPL12 6182
Proximity Label-MS Homo sapiens
57 POU5F1  
Affinity Capture-MS Homo sapiens
58 ETFA 2108
Proximity Label-MS Homo sapiens
59 CIDEB  
Two-hybrid Homo sapiens
60 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 PPEF1  
Affinity Capture-MS Homo sapiens
62 MRPS26 64949
Proximity Label-MS Homo sapiens
63 RAD51  
Co-localization Homo sapiens
64 COIL  
Two-hybrid Homo sapiens
65 TULP3 7289
Affinity Capture-MS Homo sapiens
66 ERAL1  
Proximity Label-MS Homo sapiens
67 DGCR2 9993
Proximity Label-MS Homo sapiens
68 NDUFV1 4723
Proximity Label-MS Homo sapiens
69 ATG16L1 55054
Affinity Capture-MS Homo sapiens
70 NDUFV3 4731
Proximity Label-MS Homo sapiens
71 ATP5H 10476
Proximity Label-MS Homo sapiens
72 SSBP1 6742
Proximity Label-MS Homo sapiens
73 MECP2 4204
Affinity Capture-MS Homo sapiens
74 PRTN3 5657
Affinity Capture-MS Homo sapiens
75 MYCN  
Affinity Capture-MS Homo sapiens
76 MRPL4 51073
Proximity Label-MS Homo sapiens
77 USP7 7874
Two-hybrid Homo sapiens
78 NDUFA6  
Proximity Label-MS Homo sapiens
79 VWA8 23078
Proximity Label-MS Homo sapiens
80 UQCRQ 27089
Co-fractionation Homo sapiens
81 GFI1B  
Two-hybrid Homo sapiens
82 SCO1  
Proximity Label-MS Homo sapiens
83 HSPA8 3312
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
84 RAB1B 81876
Co-fractionation Homo sapiens
85 PLD3 23646
Proximity Label-MS Homo sapiens
86 STOML2 30968
Proximity Label-MS Homo sapiens
87 HSPA9 3313
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
88 CHMP4C 92421
Affinity Capture-MS Homo sapiens
89 RPS23 6228
Affinity Capture-MS Homo sapiens
90 UFL1 23376
Affinity Capture-MS Homo sapiens
91 IRS4 8471
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
92 NDUFA9 4704
Proximity Label-MS Homo sapiens
93 NOMO1 23420
Affinity Capture-MS Homo sapiens
94 MIB1 57534
Proximity Label-MS Homo sapiens
95 NDUFS4 4724
Proximity Label-MS Homo sapiens
96 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
97 FASTKD5  
Proximity Label-MS Homo sapiens
98 IRAK1  
Affinity Capture-MS Homo sapiens
99 CTDP1 9150
Affinity Capture-MS Homo sapiens
100 MTMR11  
Affinity Capture-MS Homo sapiens
101 MRPS34 65993
Proximity Label-MS Homo sapiens
102 NDUFS8 4728
Proximity Label-MS Homo sapiens
103 ACADVL 37
Proximity Label-MS Homo sapiens
104 Ppp4c 56420
Affinity Capture-MS Mus musculus
105 PAM16  
Proximity Label-MS Homo sapiens
106 ARGLU1  
Affinity Capture-MS Homo sapiens
107 PTCD3 55037
Proximity Label-MS Homo sapiens
108 Jak2 16452
Two-hybrid Mus musculus
109 CARM1 10498
Two-hybrid Homo sapiens
110 ALS2CR11  
Two-hybrid Homo sapiens
111 GCC1 79571
Two-hybrid Homo sapiens
112 CYSRT1 375791
Two-hybrid Homo sapiens
113 MRS2  
Proximity Label-MS Homo sapiens
114 SHROOM3 57619
Proximity Label-MS Homo sapiens
115 MYO15B 80022
Two-hybrid Homo sapiens
116 RPS25 6230
Proximity Label-MS Homo sapiens
117 NOC4L 79050
Two-hybrid Homo sapiens
118 LRPPRC 10128
Proximity Label-MS Homo sapiens
119 THBS3 7059
Affinity Capture-MS Homo sapiens
120 ECHS1 1892
Proximity Label-MS Homo sapiens
121 NOS2  
Affinity Capture-MS Homo sapiens
122 TMEM186  
Proximity Label-MS Homo sapiens
123 Hnrnpf 98758
Affinity Capture-MS Mus musculus
124 PCSK9 255738
Affinity Capture-MS Homo sapiens
125 SPDYE4  
Affinity Capture-MS Homo sapiens
126 TIMM44 10469
Proximity Label-MS Homo sapiens
127 MRPL22  
Proximity Label-MS Homo sapiens
128 PHF12  
Affinity Capture-MS Homo sapiens
129 COA3 28958
Proximity Label-MS Homo sapiens
130 LATS2 26524
Affinity Capture-MS Homo sapiens
131 Ksr1  
Affinity Capture-MS Mus musculus
132 TMCO3 55002
Affinity Capture-MS Homo sapiens
133 SP100 6672
Affinity Capture-MS Homo sapiens
134 COX4I1 1327
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
135 NDUFAF1  
Proximity Label-MS Homo sapiens
136 ATXN1 6310
Two-hybrid Homo sapiens
137 PHB 5245
Proximity Label-MS Homo sapiens
138 ECH1 1891
Proximity Label-MS Homo sapiens
139 MRPL44  
Proximity Label-MS Homo sapiens
140 ACOT1 641371
Proximity Label-MS Homo sapiens
141 RASA1 5921
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
142 TUBB 203068
Affinity Capture-MS Homo sapiens
143 COX5B 1329
Proximity Label-MS Homo sapiens
144 RNF34  
Two-hybrid Homo sapiens
145 MTIF2 4528
Proximity Label-MS Homo sapiens
146 NDUFB10 4716
Proximity Label-MS Homo sapiens
147 AMBRA1  
Affinity Capture-MS Homo sapiens
148 PPM1E  
Affinity Capture-MS Homo sapiens
149 SDHA 6389
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
150 RC3H2  
Affinity Capture-MS Homo sapiens
151 CLPP 8192
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 LETM1 3954
Proximity Label-MS Homo sapiens
153 RTN4IP1  
Proximity Label-MS Homo sapiens
154 MRPS7 51081
Proximity Label-MS Homo sapiens
155 NFKBIA  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
156 MRPS14  
Proximity Label-MS Homo sapiens
157 SLC30A9 10463
Proximity Label-MS Homo sapiens
158 PRSS50  
Affinity Capture-MS Homo sapiens
159 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
161 FKBP8 23770
Proximity Label-MS Homo sapiens
162 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
163 VARS2  
Proximity Label-MS Homo sapiens
164 PYCR2 29920
Proximity Label-MS Homo sapiens
165 GHITM 27069
Proximity Label-MS Homo sapiens
166 RIPK4  
Affinity Capture-MS Homo sapiens
167 FOSL2  
Two-hybrid Homo sapiens
168 MYO1C 4641
Co-fractionation Homo sapiens
169 CTSG 1511
Affinity Capture-MS Homo sapiens
170 PHB2 11331
Proximity Label-MS Homo sapiens
171 PRKACA 5566
Co-fractionation Homo sapiens
172 MAPK6  
Affinity Capture-MS Homo sapiens
173 ATP5O 539
Proximity Label-MS Homo sapiens
174 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 NIN 51199
Proximity Label-MS Homo sapiens
176 ACP1 52
Proximity Label-MS Homo sapiens
177 DLST 1743
Proximity Label-MS Homo sapiens
178 DAP3 7818
Proximity Label-MS Homo sapiens
179 ABCB7 22
Proximity Label-MS Homo sapiens
180 ACAD9 28976
Proximity Label-MS Homo sapiens
181 NDUFAF4 29078
Proximity Label-MS Homo sapiens
182 DDRGK1 65992
Affinity Capture-MS Homo sapiens
183 ABCB10 23456
Proximity Label-MS Homo sapiens
184 ILK 3611
Affinity Capture-MS Homo sapiens
185 CLTC 1213
Co-fractionation Homo sapiens
186 HAX1  
Affinity Capture-MS Homo sapiens
187 SLC25A6 293
Proximity Label-MS Homo sapiens
188 NANOG  
Affinity Capture-MS Homo sapiens
189 NDUFV2 4729
Proximity Label-MS Homo sapiens
190 MCUR1 63933
Proximity Label-MS Homo sapiens
191 NDUFAF3 25915
Proximity Label-MS Homo sapiens
192 FRMD6 122786
Two-hybrid Homo sapiens
193 HUWE1 10075
Affinity Capture-MS Homo sapiens
194 HIF1A 3091
Affinity Capture-MS Homo sapiens
195 STUB1 10273
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
196 IMMT 10989
Proximity Label-MS Homo sapiens
197 IFNGR2  
Affinity Capture-Western Homo sapiens
198 RELA 5970
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
199 CS 1431
Proximity Label-MS Homo sapiens
200 GLS 2744
Proximity Label-MS Homo sapiens
201 MAP2K2 5605
Affinity Capture-MS Homo sapiens
202 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
203 AATK  
Affinity Capture-MS Homo sapiens
204 STK16 8576
Two-hybrid Homo sapiens
205 TSFM 10102
Proximity Label-MS Homo sapiens
206 CLPX 10845
Affinity Capture-MS Homo sapiens
207 PARP1 142
Proximity Label-MS Homo sapiens
208 BKRF1  
Affinity Capture-MS
209 GRB2 2885
Two-hybrid Homo sapiens
210 MRPS22 56945
Proximity Label-MS Homo sapiens
211 FBXL6  
Affinity Capture-MS Homo sapiens
212 NDUFAF2  
Proximity Label-MS Homo sapiens
213 FAM131C  
Two-hybrid Homo sapiens
214 COQ5  
Proximity Label-MS Homo sapiens
215 ICT1 3396
Affinity Capture-MS Homo sapiens
216 DMC1  
Co-localization Homo sapiens
217 GRSF1 2926
Proximity Label-MS Homo sapiens
218 LGALS3BP 3959
Proximity Label-MS Homo sapiens
219 TNFSF14  
Affinity Capture-MS Homo sapiens
220 MEN1 4221
Affinity Capture-MS Homo sapiens
221 MRPL43 84545
Proximity Label-MS Homo sapiens
222 CUL5 8065
Affinity Capture-MS Homo sapiens
223 PDHA1 5160
Proximity Label-MS Homo sapiens
224 SLC25A40  
Proximity Label-MS Homo sapiens
225 MRPL21 219927
Proximity Label-MS Homo sapiens