Gene description for CUL7
Gene name cullin 7
Gene symbol CUL7
Other names/aliases 3M1
KIAA0076
dJ20C7.5
Species Homo sapiens
 Database cross references - CUL7
ExoCarta ExoCarta_9820
Vesiclepedia VP_9820
Entrez Gene 9820
HGNC 21024
MIM 609577
UniProt Q14999  
 CUL7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CUL7
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin protein ligase binding GO:0031625 IEA
    ubiquitin ligase complex scaffold activity GO:0160072 IDA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IMP
    mitotic cytokinesis GO:0000281 IMP
    vasculogenesis GO:0001570 ISS
    epithelial to mesenchymal transition GO:0001837 IDA
    placenta development GO:0001890 IDA
    proteolysis GO:0006508 NAS
    ubiquitin-dependent protein catabolic process GO:0006511 IEA
    Golgi organization GO:0007030 ISS
    regulation of mitotic nuclear division GO:0007088 IMP
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IEA
    protein ubiquitination GO:0016567 TAS
    positive regulation of dendrite morphogenesis GO:0050775 IGI
    positive regulation of dendrite morphogenesis GO:0050775 ISS
Subcellular Localization
    anaphase-promoting complex GO:0005680 NAS
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    centrosome GO:0005813 IDA
    cytosol GO:0005829 TAS
    Cul7-RING ubiquitin ligase complex GO:0031467 IDA
    perinuclear region of cytoplasm GO:0048471 IDA
    3M complex GO:1990393 IDA
 Experiment description of studies that identified CUL7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CUL7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Affinity Capture-MS Homo sapiens
2 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
3 HIST1H4K 8362
Affinity Capture-MS Homo sapiens
4 KLHL28  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 CXorf67  
Affinity Capture-MS Homo sapiens
6 SLC1A5 6510
Affinity Capture-MS Homo sapiens
7 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TK1 7083
Affinity Capture-MS Homo sapiens
9 C1orf27 54953
Affinity Capture-MS Homo sapiens
10 PRPF8 10594
Affinity Capture-MS Homo sapiens
11 ARPC2 10109
Affinity Capture-MS Homo sapiens
12 TOP2B 7155
Affinity Capture-MS Homo sapiens
13 RAB9A 9367
Affinity Capture-MS Homo sapiens
14 DDX17 10521
Affinity Capture-MS Homo sapiens
15 UBA1 7317
Affinity Capture-MS Homo sapiens
16 RALYL 138046
Affinity Capture-MS Homo sapiens
17 SNRNP40 9410
Affinity Capture-MS Homo sapiens
18 NPEPPS 9520
Affinity Capture-MS Homo sapiens
19 UBC 7316
Affinity Capture-MS Homo sapiens
20 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
21 KPNA2 3838
Affinity Capture-MS Homo sapiens
22 PRPF40A 55660
Affinity Capture-MS Homo sapiens
23 TAF15 8148
Affinity Capture-MS Homo sapiens
24 GCN1L1 10985
Affinity Capture-MS Homo sapiens
25 PRKDC 5591
Affinity Capture-MS Homo sapiens
26 CKB 1152
Affinity Capture-MS Homo sapiens
27 DDX23 9416
Affinity Capture-MS Homo sapiens
28 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
29 SNRNP70 6625
Affinity Capture-MS Homo sapiens
30 PFKL 5211
Affinity Capture-MS Homo sapiens
31 RBM6 10180
Affinity Capture-MS Homo sapiens
32 DARS 1615
Affinity Capture-MS Homo sapiens
33 GFPT1 2673
Affinity Capture-MS Homo sapiens
34 ACTR3 10096
Affinity Capture-MS Homo sapiens
35 SF3B1 23451
Affinity Capture-MS Homo sapiens
36 H2AFV 94239
Affinity Capture-MS Homo sapiens
37 CALD1 800
Affinity Capture-MS Homo sapiens
38 CPSF7 79869
Affinity Capture-MS Homo sapiens
39 ETFA 2108
Affinity Capture-MS Homo sapiens
40 PIK3C3 5289
Affinity Capture-MS Homo sapiens
41 RPS9 6203
Affinity Capture-MS Homo sapiens
42 RPF2 84154
Affinity Capture-MS Homo sapiens
43 PTCD1 26024
Affinity Capture-MS Homo sapiens
44 ANPEP 290
Affinity Capture-MS Homo sapiens
45 SNRPD3 6634
Affinity Capture-MS Homo sapiens
46 CTNNA1 1495
Affinity Capture-MS Homo sapiens
47 NUDT16L1 84309
Affinity Capture-MS Homo sapiens
48 PTPRF 5792
Affinity Capture-MS Homo sapiens
49 TFRC 7037
Affinity Capture-MS Homo sapiens
50 EEF1A1 1915
Affinity Capture-MS Homo sapiens
51 RBM14 10432
Affinity Capture-MS Homo sapiens
52 ACIN1 22985
Affinity Capture-MS Homo sapiens
53 RPS14 6208
Affinity Capture-MS Homo sapiens
54 EMC1 23065
Affinity Capture-MS Homo sapiens
55 RBMX 27316
Affinity Capture-MS Homo sapiens
56 TFB1M  
Affinity Capture-MS Homo sapiens
57 RAN 5901
Affinity Capture-MS Homo sapiens
58 TCOF1 6949
Affinity Capture-MS Homo sapiens
59 PHLDB2 90102
Affinity Capture-MS Homo sapiens
60 TCP1 6950
Affinity Capture-MS Homo sapiens
61 PKM 5315
Affinity Capture-MS Homo sapiens
62 CAPZA1 829
Affinity Capture-MS Homo sapiens
63 MRE11A 4361
Affinity Capture-MS Homo sapiens
64 RAB14 51552
Affinity Capture-MS Homo sapiens
65 MAP1B 4131
Affinity Capture-MS Homo sapiens
66 RRP9 9136
Affinity Capture-MS Homo sapiens
67 CSTF2 1478
Affinity Capture-MS Homo sapiens
68 SRSF3 6428
Affinity Capture-MS Homo sapiens
69 RPL19 6143
Affinity Capture-MS Homo sapiens
70 TUFM 7284
Affinity Capture-MS Homo sapiens
71 DCAF8L1  
Affinity Capture-MS Homo sapiens
72 MKRN4P  
Affinity Capture-MS Homo sapiens
73 FAR1 84188
Affinity Capture-MS Homo sapiens
74 TPM4 7171
Affinity Capture-MS Homo sapiens
75 NSMF  
Affinity Capture-MS Homo sapiens
76 PABPC1 26986
Affinity Capture-MS Homo sapiens
77 NUDC 10726
Affinity Capture-MS Homo sapiens
78 PCDHGA3  
Affinity Capture-MS Homo sapiens
79 ACTN4 81
Affinity Capture-MS Homo sapiens
80 CBX5 23468
Affinity Capture-MS Homo sapiens
81 KRT9 3857
Affinity Capture-MS Homo sapiens
82 ITM2C 81618
Affinity Capture-MS Homo sapiens
83 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
84 F12  
Affinity Capture-MS Homo sapiens
85 P4HB 5034
Affinity Capture-MS Homo sapiens
86 ENO1 2023
Affinity Capture-MS Homo sapiens
87 PTRF 284119
Affinity Capture-MS Homo sapiens
88 HECTD1 25831
Affinity Capture-MS Homo sapiens
89 MRPS15  
Affinity Capture-MS Homo sapiens
90 RRP1B 23076
Affinity Capture-MS Homo sapiens
91 SON 6651
Affinity Capture-MS Homo sapiens
92 DDX39B 7919
Affinity Capture-MS Homo sapiens
93 FLOT2 2319
Affinity Capture-MS Homo sapiens
94 NCL 4691
Affinity Capture-MS Homo sapiens
95 GTPBP4 23560
Affinity Capture-MS Homo sapiens
96 SLC25A5 292
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 KLHL14 57565
Affinity Capture-MS Homo sapiens
98 ZNF326 284695
Affinity Capture-MS Homo sapiens
99 BCLAF1 9774
Affinity Capture-MS Homo sapiens
100 HSPA5 3309
Affinity Capture-MS Homo sapiens
101 RBM39 9584
Affinity Capture-MS Homo sapiens
102 HADHB 3032
Affinity Capture-MS Homo sapiens
103 HADHA 3030
Affinity Capture-MS Homo sapiens
104 DHCR7 1717
Affinity Capture-MS Homo sapiens
105 LMNB1 4001
Affinity Capture-MS Homo sapiens
106 YBX1 4904
Affinity Capture-MS Homo sapiens
107 SIRT7  
Affinity Capture-MS Homo sapiens
108 ANXA1 301
Affinity Capture-MS Homo sapiens
109 PRKAR1A 5573
Affinity Capture-MS Homo sapiens
110 PLK1 5347
Affinity Capture-MS Homo sapiens
111 CCDC8  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 ACTBL2 345651
Affinity Capture-MS Homo sapiens
113 GPD2 2820
Affinity Capture-MS Homo sapiens
114 MTNR1A  
Two-hybrid Homo sapiens
115 EBNA1BP2 10969
Affinity Capture-MS Homo sapiens
116 ATAD3C 219293
Affinity Capture-MS Homo sapiens
117 RPN2 6185
Affinity Capture-MS Homo sapiens
118 AAAS 8086
Affinity Capture-MS Homo sapiens
119 XRN2 22803
Affinity Capture-MS Homo sapiens
120 EEF1B2 1933
Affinity Capture-MS Homo sapiens
121 EIF2S2 8894
Affinity Capture-MS Homo sapiens
122 ZC3H11A  
Affinity Capture-MS Homo sapiens
123 RBBP4 5928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 RRP15  
Affinity Capture-MS Homo sapiens
125 C14orf183  
Affinity Capture-MS Homo sapiens
126 KRT14 3861
Affinity Capture-MS Homo sapiens
127 GLO1 2739
Affinity Capture-MS Homo sapiens
128 PRMT5 10419
Affinity Capture-MS Homo sapiens
129 HIST1H4B 8366
Affinity Capture-MS Homo sapiens
130 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
131 PCBP1 5093
Affinity Capture-MS Homo sapiens
132 SPEN 23013
Affinity Capture-MS Homo sapiens
133 SOHLH1  
Affinity Capture-MS Homo sapiens
134 SF3B6 51639
Affinity Capture-MS Homo sapiens
135 NSUN5P1  
Affinity Capture-MS Homo sapiens
136 PSMC5 5705
Affinity Capture-MS Homo sapiens
137 HIST1H4I 8294
Affinity Capture-MS Homo sapiens
138 APEX2  
Affinity Capture-MS Homo sapiens
139 COX2 4513
Affinity Capture-MS Homo sapiens
140 HEATR1 55127
Affinity Capture-MS Homo sapiens
141 SUPT16H 11198
Affinity Capture-MS Homo sapiens
142 GNL3 26354
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 COMMD1 150684
Reconstituted Complex Homo sapiens
144 GOLGB1 2804
Affinity Capture-MS Homo sapiens
145 U2SURP 23350
Affinity Capture-MS Homo sapiens
146 DDX46 9879
Affinity Capture-MS Homo sapiens
147 ARPC3 10094
Affinity Capture-MS Homo sapiens
148 NUDT21 11051
Affinity Capture-MS Homo sapiens
149 FASN 2194
Affinity Capture-MS Homo sapiens
150 MAGOH 4116
Affinity Capture-MS Homo sapiens
151 TBC1D3  
Affinity Capture-Western Homo sapiens
152 IDH3B 3420
Affinity Capture-MS Homo sapiens
153 RPLP0 6175
Affinity Capture-MS Homo sapiens
154 CHTOP  
Affinity Capture-MS Homo sapiens
155 PLEC 5339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
156 RRS1 23212
Affinity Capture-MS Homo sapiens
157 MACF1 23499
Affinity Capture-MS Homo sapiens
158 RBM25 58517
Affinity Capture-MS Homo sapiens
159 RUVBL2 10856
Affinity Capture-MS Homo sapiens
160 PCMT1 5110
Affinity Capture-MS Homo sapiens
161 SRSF9 8683
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 LRPPRC 10128
Affinity Capture-MS Homo sapiens
163 CDC37 11140
Affinity Capture-MS Homo sapiens
164 COX5A 9377
Affinity Capture-MS Homo sapiens
165 SKP1 6500
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 HIST1H2BN 8341
Affinity Capture-MS Homo sapiens
167 APRT 353
Affinity Capture-MS Homo sapiens
168 DIMT1 27292
Affinity Capture-MS Homo sapiens
169 TBL3 10607
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 PUF60 22827
Affinity Capture-MS Homo sapiens
171 PSMD3 5709
Affinity Capture-MS Homo sapiens
172 TARS 6897
Affinity Capture-MS Homo sapiens
173 MAGIX 79917
Affinity Capture-MS Homo sapiens
174 DYNC1H1 1778
Affinity Capture-MS Homo sapiens
175 ERCC6  
Affinity Capture-MS Homo sapiens
176 HIST2H3D 653604
Affinity Capture-MS Homo sapiens
177 HIST1H4L 8368
Affinity Capture-MS Homo sapiens
178 RUVBL1 8607
Affinity Capture-MS Homo sapiens
179 HIST2H2AA4 723790
Affinity Capture-MS Homo sapiens
180 ALYREF 10189
Affinity Capture-MS Homo sapiens
181 HNRNPL 3191
Affinity Capture-MS Homo sapiens
182 SUPT6H 6830
Affinity Capture-MS Homo sapiens
183 HIST1H4J 8363
Affinity Capture-MS Homo sapiens
184 PRPF4 9128
Affinity Capture-MS Homo sapiens
185 CUL7 9820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 CIZ1  
Affinity Capture-MS Homo sapiens
187 MAP1A 4130
Affinity Capture-MS Homo sapiens
188 ANXA2 302
Affinity Capture-MS Homo sapiens
189 SNRPA1 6627
Affinity Capture-MS Homo sapiens
190 USP40 55230
Affinity Capture-MS Homo sapiens
191 RANGAP1 5905
Affinity Capture-MS Homo sapiens
192 SEC61A1 29927
Affinity Capture-MS Homo sapiens
193 HNRNPH1 3187
Affinity Capture-MS Homo sapiens
194 GSTP1 2950
Affinity Capture-MS Homo sapiens
195 SNRPA 6626
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 LDHA 3939
Affinity Capture-MS Homo sapiens
197 SMC3 9126
Affinity Capture-MS Homo sapiens
198 TOR1A 1861
Affinity Capture-MS Homo sapiens
199 WDR3  
Affinity Capture-MS Homo sapiens
200 GART 2618
Affinity Capture-MS Homo sapiens
201 RBM15B  
Affinity Capture-MS Homo sapiens
202 TARDBP 23435
Affinity Capture-MS Homo sapiens
203 D2HGDH 728294
Affinity Capture-MS Homo sapiens
204 UCHL1 7345
Affinity Capture-MS Homo sapiens
205 NOP56 10528
Affinity Capture-MS Homo sapiens
206 CCDC183  
Affinity Capture-MS Homo sapiens
207 APOA1 335
Affinity Capture-MS Homo sapiens
208 SURF4 6836
Affinity Capture-MS Homo sapiens
209 CHCHD1  
Proximity Label-MS Homo sapiens
210 ZFR 51663
Affinity Capture-MS Homo sapiens
211 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
212 EIF4A1 1973
Affinity Capture-MS Homo sapiens
213 COPA 1314
Affinity Capture-MS Homo sapiens
214 PWP2 5822
Affinity Capture-MS Homo sapiens
215 CADPS  
Affinity Capture-MS Homo sapiens
216 NUP160 23279
Affinity Capture-MS Homo sapiens
217 RPS3 6188
Affinity Capture-MS Homo sapiens
218 LGALS3BP 3959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
219 RPS18 6222
Affinity Capture-MS Homo sapiens
220 PSIP1 11168
Affinity Capture-MS Homo sapiens
221 XRCC1 7515
Affinity Capture-MS Homo sapiens
222 PGK1 5230
Affinity Capture-MS Homo sapiens
223 NOLC1 9221
Affinity Capture-MS Homo sapiens
224 H1FX 8971
Affinity Capture-MS Homo sapiens
225 GOLGA3 2802
Affinity Capture-MS Homo sapiens
226 TLN1 7094
Affinity Capture-MS Homo sapiens
227 RRP12 23223
Affinity Capture-MS Homo sapiens
228 HIST2H3A