Gene description for RBX1
Gene name	ring-box 1, E3 ubiquitin protein ligase
Gene symbol	RBX1
Other names/aliases	BA554C12.1 RNF75 ROC1
Species	Homo sapiens
Database cross references - RBX1
ExoCarta	ExoCarta_9978
Entrez Gene	9978
HGNC	9928
MIM	603814
UniProt	P62877
RBX1 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for RBX1

Molecular Function     ubiquitin-ubiquitin ligase activity GO:0034450 IDA     ubiquitin-protein transferase activity GO:0004842 IDA     ubiquitin protein ligase binding GO:0031625 IDA     protein complex binding GO:0032403 IEA     zinc ion binding GO:0008270 IEA     ubiquitin protein ligase activity GO:0061630 TAS     NEDD8 transferase activity GO:0019788 IDA     ligase activity GO:0016874 IEA     protein binding GO:0005515 IPI     cullin family protein binding GO:0097602 IDA Biological Process     protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA     protein neddylation GO:0045116 IDA     protein monoubiquitination GO:0006513 IDA     regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 TAS     protein ubiquitination GO:0016567 IDA     cellular response to hypoxia GO:0071456 TAS     DNA repair GO:0006281 TAS     Notch signaling pathway GO:0007219 TAS     DNA damage response, detection of DNA damage GO:0042769 TAS     SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISS     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     viral process GO:0016032 TAS     translesion synthesis GO:0019985 TAS     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS Subcellular Localization     Cul4A-RING E3 ubiquitin ligase complex GO:0031464 IDA     Cul4B-RING E3 ubiquitin ligase complex GO:0031465 IDA     Cul7-RING ubiquitin ligase complex GO:0031467 IDA     Cul3-RING ubiquitin ligase complex GO:0031463 IDA     VCB complex GO:0030891 IEA     cullin-RING ubiquitin ligase complex GO:0031461 IDA     nuclear SCF ubiquitin ligase complex GO:0043224 IBA     cytosol GO:0005829 TAS     Cul2-RING ubiquitin ligase complex GO:0031462 IDA     SCF ubiquitin ligase complex GO:0019005 ISS     Cul5-RING ubiquitin ligase complex GO:0031466 IDA     nucleoplasm GO:0005654 TAS