Gene description for SNX33
Gene name sorting nexin 33
Gene symbol SNX33
Other names/aliases SH3PX3
SH3PXD3C
SNX30
Species Homo sapiens
 Database cross references - SNX33
ExoCarta ExoCarta_257364
Entrez Gene 257364
HGNC 28468
UniProt Q8WV41  
 SNX33 identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
Neuroblastoma cells 25944692    
 Gene ontology annotations for SNX33
Molecular Function
    identical protein binding GO:0042802 IPI
    phosphatidylinositol binding GO:0035091 IBA
    protein binding GO:0005515 IPI
Biological Process
    cleavage furrow formation GO:0036089 IMP
    protein import GO:0017038 IDA
    mitotic cytokinesis GO:0000281 IMP
    endosomal transport GO:0016197 IMP
    vesicle organization GO:0016050 IBA
    positive regulation of membrane protein ectodomain proteolysis GO:0051044 IDA
    mitotic nuclear division GO:0007067 IEA
    endocytosis GO:0006897 IMP
    intracellular protein transport GO:0006886 IEA
    negative regulation of endocytosis GO:0045806 IDA
    macropinocytosis GO:0044351 IMP
    positive regulation of protein localization to cell surface GO:2000010 IDA
    membrane tubulation GO:0097320 IDA
    endosome organization GO:0007032 IMP
    negative regulation of protein localization to cell surface GO:2000009 IDA
Subcellular Localization
    cytoplasmic membrane-bounded vesicle GO:0016023 IDA
    cytosol GO:0005829 IDA
    endosome GO:0005768 IBA
    membrane GO:0016020 IDA
    extrinsic component of membrane GO:0019898 IDA
    cytoplasmic vesicle membrane GO:0030659 IEA
 Experiment description of studies that identified SNX33 in exosomes
1
Experiment ID 76
ISEV standards
EM
EV Biophysical techniques
TSG101|GAPDH|HSP90
EV Cytosolic markers
CD81|CD9|CD63|LAMP1|MHCI
EV Membrane markers
HSP90B1
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A.
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SNX33
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SNX33 is involved
No pathways found





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