Gene description for DKC1
Gene name dyskeratosis congenita 1, dyskerin
Gene symbol DKC1
Other names/aliases CBF5
DKC
DKCX
NAP57
NOLA4
XAP101
Species Homo sapiens
 Database cross references - DKC1
ExoCarta ExoCarta_1736
Vesiclepedia VP_1736
Entrez Gene 1736
HGNC 2890
MIM 300126
UniProt O60832  
 DKC1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 25890246    
Colorectal cancer cells 25890246    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
 Gene ontology annotations for DKC1
Molecular Function
    telomerase activity GO:0003720 IDA
    telomerase activity GO:0003720 IDA
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IPI
    protein binding GO:0005515 IPI
    pseudouridine synthase activity GO:0009982 IBA
    pseudouridine synthase activity GO:0009982 IMP
    box H/ACA snoRNA binding GO:0034513 IPI
    telomerase RNA binding GO:0070034 IPI
Biological Process
    enzyme-directed rRNA pseudouridine synthesis GO:0000455 IMP
    box H/ACA sno(s)RNA 3'-end processing GO:0000495 IBA
    rRNA processing GO:0006364 TAS
    RNA processing GO:0006396 TAS
    telomere maintenance via telomerase GO:0007004 IDA
    telomere maintenance via telomerase GO:0007004 IMP
    telomere maintenance via telomerase GO:0007004 NAS
    rRNA pseudouridine synthesis GO:0031118 IBA
    snRNA pseudouridine synthesis GO:0031120 IBA
    positive regulation of telomere maintenance via telomerase GO:0032212 IDA
    positive regulation of telomere maintenance via telomerase GO:0032212 IMP
    scaRNA localization to Cajal body GO:0090666 IMP
    telomerase RNA stabilization GO:0090669 IMP
    protein localization to Cajal body GO:1904867 HMP
    regulation of telomerase RNA localization to Cajal body GO:1904872 IMP
    positive regulation of telomerase RNA localization to Cajal body GO:1904874 IMP
    telomerase holoenzyme complex assembly GO:1905323 IEA
    mRNA pseudouridine synthesis GO:1990481 IBA
Subcellular Localization
    fibrillar center GO:0001650 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    telomerase holoenzyme complex GO:0005697 IDA
    telomerase holoenzyme complex GO:0005697 NAS
    telomerase holoenzyme complex GO:0005697 TAS
    nucleolus GO:0005730 TAS
    cytoplasm GO:0005737 IEA
    box H/ACA snoRNP complex GO:0031429 IBA
    box H/ACA snoRNP complex GO:0031429 IDA
    box H/ACA snoRNP complex GO:0031429 TAS
    box H/ACA scaRNP complex GO:0072589 TAS
    box H/ACA telomerase RNP complex GO:0090661 IDA
    box H/ACA telomerase RNP complex GO:0090661 TAS
 Experiment description of studies that identified DKC1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 282
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
12
Experiment ID 283
MISEV standards
✔
CEM
Biophysical techniques
✔
Alix|TSG101|CD63|CD81|EpCAM
Enriched markers
✘ Negative markers
✔
DLS
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25890246    
Organism Homo sapiens
Experiment description Highly-purified exosomes and shed microvesicles isolated from the human colon cancer cell line LIM1863 by sequential centrifugal ultrafiltration are biochemically and functionally distinct.
Authors "Xu R, Greening DW, Rai A, Ji H, Simpson RJ."
Journal name Methods
Publication year 2015
Sample Colorectal cancer cells
Sample name LIM1863 - Ultracentrifugation - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Centrifugal concentration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
13
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
14
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
15
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
20
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 255
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
26
Experiment ID 256
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
27
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
28
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
29
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
31
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
32
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
35
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
36
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
38
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
39
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for DKC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LSM2 57819
Co-fractionation Homo sapiens
2 RPSA 3921
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
3 SLFN11 91607
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 RPSAP58 388524
Affinity Capture-MS Homo sapiens
6 UBE2H 7328
Affinity Capture-MS Homo sapiens
7 SLIRP 81892
Proximity Label-MS Homo sapiens
8 GTPBP4 23560
Co-fractionation Homo sapiens
9 WDR46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 KNOP1 400506
Affinity Capture-MS Homo sapiens
11 NOP58 51602
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
12 DDX24 57062
Co-fractionation Homo sapiens
13 COIL  
Proximity Label-MS Homo sapiens
14 PAXIP1  
Affinity Capture-MS Homo sapiens
15 ZNF346  
Affinity Capture-MS Homo sapiens
16 ARHGAP39  
Affinity Capture-MS Homo sapiens
17 ANLN 54443
Affinity Capture-MS Homo sapiens
18 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
19 KIAA0020 9933
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
20 PABPC5 140886
Affinity Capture-MS Homo sapiens
21 RBMS2 5939
Affinity Capture-MS Homo sapiens
22 FMR1 2332
Affinity Capture-MS Homo sapiens
23 BTF3 689
Affinity Capture-MS Homo sapiens
24 ZNHIT2 741
Affinity Capture-MS Homo sapiens
25 RPL13A 23521
Affinity Capture-MS Homo sapiens
26 RPL37A 6168
Affinity Capture-MS Homo sapiens
27 Ybx1 22608
Affinity Capture-MS Mus musculus
28 NOP56 10528
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
29 VDAC1 7416
Affinity Capture-MS Homo sapiens
30 GNL3 26354
Co-fractionation Homo sapiens
31 KIF20A 10112
Affinity Capture-MS Homo sapiens
32 HNRNPC 3183
Affinity Capture-MS Homo sapiens
33 RPL14 9045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 CSNK2A1 1457
Biochemical Activity Homo sapiens
35 PNMAL1  
Affinity Capture-MS Homo sapiens
36 CAND1 55832
Affinity Capture-MS Homo sapiens
37 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
38 PARK7 11315
Affinity Capture-MS Homo sapiens
39 RPF2 84154
Co-fractionation Homo sapiens
40 FAU 2197
Affinity Capture-MS Homo sapiens
41 CWF19L2  
Affinity Capture-MS Homo sapiens
42 APEX1 328
Affinity Capture-RNA Homo sapiens
43 RPS9 6203
Affinity Capture-MS Homo sapiens
44 DIMT1 27292
Co-fractionation Homo sapiens
45 DDX23 9416
Proximity Label-MS Homo sapiens
46 GPATCH4 54865
Affinity Capture-MS Homo sapiens
47 RUVBL1 8607
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
48 WDR48 57599
Affinity Capture-MS Homo sapiens
49 ZBTB2 57621
Affinity Capture-MS Homo sapiens
50 PRR11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 MRPS34 65993
Affinity Capture-MS Homo sapiens
52 RASA2 5922
Affinity Capture-MS Homo sapiens
53 LLPH  
Affinity Capture-MS Homo sapiens
54 KIF23 9493
Affinity Capture-MS Homo sapiens
55 NOLC1 9221
Affinity Capture-Western Homo sapiens
56 H2AFB3  
Affinity Capture-MS Homo sapiens
57 NMD3 51068
Co-fractionation Homo sapiens
58 MPHOSPH10 10199
Co-fractionation Homo sapiens
59 FBXW7  
Affinity Capture-MS Homo sapiens
60 PRC1 9055
Affinity Capture-MS Homo sapiens
61 CHD8 57680
Affinity Capture-MS Homo sapiens
62 NPM1 4869
Affinity Capture-MS Homo sapiens
63 RSRC1  
Affinity Capture-MS Homo sapiens
64 SNRPC 6631
Affinity Capture-MS Homo sapiens
65 PARK2  
Affinity Capture-MS Homo sapiens
66 FBL 2091
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
67 H2AFY2 55506
Affinity Capture-MS Homo sapiens
68 SSR1 6745
Two-hybrid Homo sapiens
69 ZNF2  
Affinity Capture-MS Homo sapiens
70 YBX1 4904
Affinity Capture-MS Homo sapiens
71 ABCE1 6059
Affinity Capture-MS Homo sapiens
72 ADARB1 104
Affinity Capture-MS Homo sapiens
73 RPL10 6134
Affinity Capture-MS Homo sapiens
74 PRKRA 8575
Affinity Capture-MS Homo sapiens
75 NR4A1  
Affinity Capture-MS Homo sapiens
76 RC3H1 149041
Affinity Capture-MS Homo sapiens
77 DAXX  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
PCA Homo sapiens
78 EED  
Affinity Capture-MS Homo sapiens
79 GNL2 29889
Co-fractionation Homo sapiens
80 ABT1 29777
Affinity Capture-MS Homo sapiens
81 DDX18 8886
Co-fractionation Homo sapiens
82 RRP8  
Affinity Capture-MS Homo sapiens
83 MPP1 4354
Affinity Capture-MS Homo sapiens
84 SFN 2810
Affinity Capture-MS Homo sapiens
85 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
86 SMG6  
Co-fractionation Homo sapiens
87 NHP2 55651
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
88 MECP2 4204
Affinity Capture-MS Homo sapiens
89 POLR1E  
Proximity Label-MS Homo sapiens
90 MYCN  
Affinity Capture-MS Homo sapiens
91 MAPRE1 22919
Affinity Capture-MS Homo sapiens
92 FGF17  
Affinity Capture-MS Homo sapiens
93 MAK16  
Affinity Capture-MS Homo sapiens
94 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 MTERF3  
Proximity Label-MS Homo sapiens
96 KIF14 9928
Affinity Capture-MS Homo sapiens
97 GAR1 54433
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 PES1 23481
Affinity Capture-MS Homo sapiens
99 LIN28A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 NINL  
Proximity Label-MS Homo sapiens
101 EPB41L3 23136
Affinity Capture-MS Homo sapiens
102 TCOF1 6949
Affinity Capture-Western Homo sapiens
103 DDX31  
Co-fractionation Homo sapiens
104 DLD 1738
Affinity Capture-MS Homo sapiens
105 RPL30 6156
Affinity Capture-MS Homo sapiens
106 ZBTB48  
Affinity Capture-MS Homo sapiens
107 UTP14A 10813
Co-fractionation Homo sapiens
108 COX15 1355
Affinity Capture-MS Homo sapiens
109 DDX21 9188
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 LIN28B  
Affinity Capture-MS Homo sapiens
111 SRP14 6727
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
112 RPL4 6124
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 RBM28 55131
Co-fractionation Homo sapiens
114 ZBTB47  
Affinity Capture-MS Homo sapiens
115 COQ2  
Affinity Capture-MS Homo sapiens
116 SRSF3 6428
Affinity Capture-MS Homo sapiens
117 YBX2 51087
Affinity Capture-MS Homo sapiens
118 STAU1 6780
Affinity Capture-MS Homo sapiens
119 BASP1 10409
Co-fractionation Homo sapiens
120 SRSF6 6431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 PURG  
Affinity Capture-MS Homo sapiens
122 NOP2 4839
Co-fractionation Homo sapiens
123 C12orf49  
Negative Genetic Homo sapiens
124 RPL5 6125
Affinity Capture-MS Homo sapiens
125 ABCF2 10061
Co-fractionation Homo sapiens
126 RPL18A 6142
Affinity Capture-MS Homo sapiens
127 NOC2L 26155
Co-fractionation Homo sapiens
128 CHMP4B 128866
Affinity Capture-MS Homo sapiens
129 GRAMD4 23151
Affinity Capture-MS Homo sapiens
130 UQCRC2 7385
Co-fractionation Homo sapiens
131 RPS4X 6191
Co-fractionation Homo sapiens
132 NTRK1 4914
Affinity Capture-MS Homo sapiens
133 FGF8  
Affinity Capture-MS Homo sapiens
134 RSL1D1 26156
Affinity Capture-MS Homo sapiens
135 IFI16 3428
Affinity Capture-MS Homo sapiens
136 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 BCHE 590
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
139 RPL36 25873
Affinity Capture-MS Homo sapiens
140 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
141 LYAR 55646
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 Nhp2l1 20826
Affinity Capture-MS Mus musculus
143 HECTD1 25831
Affinity Capture-MS Homo sapiens
144 RPLP0 6175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 BRD4 23476
Affinity Capture-MS Homo sapiens
146 RPLP0P6 220717
Co-fractionation Homo sapiens
147 MAGEB2 4113
Affinity Capture-MS Homo sapiens
148 SUB1 10923
Affinity Capture-MS Homo sapiens
149 TERC  
Affinity Capture-Western Homo sapiens
Protein-RNA Homo sapiens
150 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
151 DDX27 55661
Co-fractionation Homo sapiens
152 FGF13  
Affinity Capture-MS Homo sapiens
153 EIF5B 9669
Co-fractionation Homo sapiens
154 GLTSCR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
155 U2SURP 23350
Affinity Capture-MS Homo sapiens
156 MRPL2 51069
Affinity Capture-MS Homo sapiens
157 DDX56  
Co-fractionation Homo sapiens
158 CHCHD1  
Proximity Label-MS Homo sapiens
159 HAAO  
Affinity Capture-MS Homo sapiens
160 CD3EAP  
Proximity Label-MS Homo sapiens
161 ENDOG  
Co-fractionation Homo sapiens
162 CNBP 7555
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 ELAVL2 1993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
164 FGFBP1 9982
Affinity Capture-MS Homo sapiens
165 PAIP2B  
Affinity Capture-MS Homo sapiens
166 HNRNPD 3184
Affinity Capture-MS Homo sapiens
167 RPL23A 6147
Affinity Capture-MS Homo sapiens
168 E4F1  
Affinity Capture-MS Homo sapiens
169 RPS19 6223
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 RPL31 6160
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
171 TERT  
Affinity Capture-Western Homo sapiens
172 FANCD2  
Affinity Capture-MS Homo sapiens
173 NASP 4678
Co-fractionation Homo sapiens
174 KPNA1 3836
Affinity Capture-MS Homo sapiens
175 RPL7A 6130
Affinity Capture-MS Homo sapiens
176 RPS2 6187
Affinity Capture-MS Homo sapiens
177 XPO1 7514
Affinity Capture-MS Homo sapiens
178 LMNB1 4001
Affinity Capture-MS Homo sapiens
179 RC3H2  
Affinity Capture-MS Homo sapiens
180 ECT2 1894
Affinity Capture-MS Homo sapiens
181 DEPDC1B 55789
Affinity Capture-MS Homo sapiens
182 SRSF4 6429
Affinity Capture-MS Homo sapiens
183 NOC4L 79050
Co-fractionation Homo sapiens
184 RPS12 6206
Cross-Linking-MS (XL-MS) Homo sapiens
185 SRSF1 6426
Affinity Capture-MS Homo sapiens
186 BRD2  
Affinity Capture-MS Homo sapiens
187 U2AF2 11338
Affinity Capture-MS Homo sapiens
188 ZNF71  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
189 CUL3 8452
Affinity Capture-MS Homo sapiens
190 RPS6 6194
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 SRSF5 6430
Affinity Capture-MS Homo sapiens
192 RPL3 6122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
193 CREM  
Affinity Capture-MS Homo sapiens
194 LYPLA2 11313
Two-hybrid Homo sapiens
195 HNRNPA1 3178
Proximity Label-MS Homo sapiens
196 RPL35 11224
Affinity Capture-MS Homo sapiens
197 NAF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
198 SUZ12  
Affinity Capture-MS Homo sapiens
199 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
200 ZC3H10  
Affinity Capture-MS Homo sapiens
201 NXF1 10482
Affinity Capture-RNA Homo sapiens
202 GRSF1 2926
Proximity Label-MS Homo sapiens
203 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
204 HIST1H1B 3009
Affinity Capture-MS Homo sapiens
205 MAPK6  
Two-hybrid Homo sapiens
206 SOAT1 6646
Affinity Capture-MS Homo sapiens
207 RBM4B  
Affinity Capture-MS Homo sapiens
208 MYC  
Affinity Capture-MS Homo sapiens
209 RPA3 6119
Proximity Label-MS Homo sapiens
210 RUVBL2 10856
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
211 NOL12 79159
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
212 DLST 1743
Affinity Capture-MS Homo sapiens
213 RNF151  
Affinity Capture-MS Homo sapiens
214 EEF1G 1937
Two-hybrid Homo sapiens
215 NHP2L1 4809
Co-fractionation Homo sapiens
216 HSPA1A 3303
Cross-Linking-MS (XL-MS) Homo sapiens
217 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
218 CUL7 9820
Affinity Capture-MS Homo sapiens
219 RPL18 6141
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
220 DDRGK1 65992
Affinity Capture-MS Homo sapiens
221 RNF2  
Affinity Capture-MS Homo sapiens
222 BMI1  
Affinity Capture-MS Homo sapiens
223 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
224 SHQ1  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
225 ARGLU1  
Affinity Capture-MS Homo sapiens
226 RPL11 6135
Affinity Capture-MS Homo sapiens
227 RPL7 6129
Affinity Capture-MS Homo sapiens
228 CCDC140  
Affinity Capture-MS Homo sapiens
229 RPS10 6204
Affinity Capture-MS Homo sapiens
230 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
231 RPL26 6154
Affinity Capture-MS Homo sapiens
232 ZC3H3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
233 FTSJ3 117246
Co-fractionation Homo sapiens
234 SUPT16H 11198
Affinity Capture-MS Homo sapiens
235 RPL15 6138
Affinity Capture-MS Homo sapiens
236 RBM17 84991
Affinity Capture-MS Homo sapiens
237 RPS16 6217
Affinity Capture-MS Homo sapiens
238 H2AFX 3014
Affinity Capture-MS Homo sapiens
239 RPL19 6143
Affinity Capture-MS Homo sapiens
240 RPL13 6137
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
241 DHX15 1665
Co-fractionation Homo sapiens
242 TAF6 6878
Co-fractionation Homo sapiens
243 EIF3F 8665
Two-hybrid Homo sapiens
244 ARRB2 409
Affinity Capture-MS Homo sapiens
245 FBXW11  
Affinity Capture-MS Homo sapiens
246 WDR36 134430
Co-fractionation Homo sapiens
247 NAAA  
Affinity Capture-MS Homo sapiens
248 TERF2  
Affinity Capture-MS Homo sapiens
249 SIRT6  
Affinity Capture-MS Homo sapiens
250 PARP1 142
Proximity Label-MS Homo sapiens
251 HMGN4  
Affinity Capture-MS Homo sapiens
252 PDGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
253 LARP4B 23185
Affinity Capture-MS Homo sapiens
254 RRS1 23212
Affinity Capture-MS Homo sapiens
255 HSPA8 3312
Cross-Linking-MS (XL-MS) Homo sapiens
256 WWOX 51741
Affinity Capture-MS Homo sapiens
257 MNDA 4332
Affinity Capture-MS Homo sapiens
258 AAMP 14
Affinity Capture-MS Homo sapiens
259 POLR1C 9533
Co-fractionation Homo sapiens
260 USP36  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
261 ZCRB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
262 DGCR8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
263 WRAP53  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
264 SMURF1 57154
Affinity Capture-MS Homo sapiens
265 ZNF48  
Affinity Capture-MS Homo sapiens
266 UTP23  
Affinity Capture-MS Homo sapiens
267 PRMT1 3276
Affinity Capture-MS Homo sapiens
268 C9orf114  
Affinity Capture-MS Homo sapiens
269 ICT1 3396
Proximity Label-MS Homo sapiens
270 CHD4 1108
Affinity Capture-MS Homo sapiens
271 TBL3 10607
Co-fractionation Homo sapiens
272 SHMT2 6472
Affinity Capture-RNA Homo sapiens
273 PRR3  
Affinity Capture-MS Homo sapiens
274 NIFK 84365
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
275 ESR1  
Affinity Capture-MS Homo sapiens
276 KRR1 11103
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
277 RBM4 5936
Affinity Capture-MS Homo sapiens
278 NEIL1  
Affinity Capture-MS Homo sapiens
279 CHMP4C 92421
Affinity Capture-MS Homo sapiens
280 RPS24 6229
Proximity Label-MS Homo sapiens
281 MOV10 4343
Affinity Capture-RNA Homo sapiens
282 REXO4  
Affinity Capture-MS Homo sapiens
283 IL17B 27190
Affinity Capture-MS Homo sapiens
284 SNRNP70 6625
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
285 ARRB1 408
Affinity Capture-MS Homo sapiens
286 GLI4  
Affinity Capture-MS Homo sapiens
287 RPL23AP32 56969
Affinity Capture-MS Homo sapiens
288 RPS8 6202
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
289 RPL8 6132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
290 BCCIP 56647
Co-fractionation Homo sapiens
291 RPL28 6158
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
292 ERG  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
293 PTGES3 10728
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
294 PPAN 56342
Affinity Capture-MS Homo sapiens
295 KRAS 3845
Negative Genetic Homo sapiens
296 C9orf72  
Affinity Capture-MS Homo sapiens
297 DCAF4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
298 SRP9 6726
Affinity Capture-MS Homo sapiens
299 HSD17B10 3028
Affinity Capture-MS Homo sapiens
300 RBM34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
301 SSRP1 6749
Affinity Capture-MS Homo sapiens
302 SRSF7 6432
Affinity Capture-MS Homo sapiens
303 HIST1H1D 3007
Affinity Capture-MS Homo sapiens
304 NOP10 55505
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
305 JMJD6 23210
Affinity Capture-MS Homo sapiens
306 RPL17 6139
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
307 EP300 2033
Affinity Capture-MS Homo sapiens
308 ARIH1 25820
Affinity Capture-MS Homo sapiens
309 TRIM11  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here