Gene description for NOC2L
Gene name nucleolar complex associated 2 homolog (S. cerevisiae)
Gene symbol NOC2L
Other names/aliases NET15
NET7
NIR
PPP1R112
Species Homo sapiens
 Database cross references - NOC2L
ExoCarta ExoCarta_26155
Vesiclepedia VP_26155
Entrez Gene 26155
HGNC 24517
MIM 610770
UniProt Q9Y3T9  
 NOC2L identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for NOC2L
Molecular Function
    chromatin binding GO:0003682 IDA
    transcription corepressor activity GO:0003714 IBA
    transcription corepressor activity GO:0003714 IDA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    nucleosome binding GO:0031491 IDA
    histone binding GO:0042393 IBA
    histone binding GO:0042393 IDA
    DNA-binding transcription factor binding GO:0140297 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of B cell apoptotic process GO:0002903 IMP
    apoptotic process GO:0006915 IEA
    cellular response to UV GO:0034644 IDA
    ribosomal large subunit biogenesis GO:0042273 IBA
    transcription initiation-coupled chromatin remodeling GO:0045815 IDA
    negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IDA
    nucleolus GO:0005730 IBA
    nucleolus GO:0005730 IDA
    cytosol GO:0005829 IDA
    Noc1p-Noc2p complex GO:0030690 IBA
    Noc2p-Noc3p complex GO:0030691 IBA
 Experiment description of studies that identified NOC2L in exosomes
1
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NOC2L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 ZBTB38 253461
Affinity Capture-MS Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 RIT1 6016
Negative Genetic Homo sapiens
5 UBE2H 7328
Affinity Capture-MS Homo sapiens
6 RPL26L1 51121
Affinity Capture-MS Homo sapiens
7 HOOK1  
Proximity Label-MS Homo sapiens
8 SPRTN  
Affinity Capture-MS Homo sapiens
9 AATF  
Co-fractionation Homo sapiens
10 ZNF346  
Affinity Capture-MS Homo sapiens
11 MARCKS 4082
Proximity Label-MS Homo sapiens
12 KIAA0020 9933
Co-fractionation Homo sapiens
13 SRPK2 6733
Affinity Capture-MS Homo sapiens
14 HIST2H2BA  
Reconstituted Complex Homo sapiens
15 RPL13A 23521
Affinity Capture-MS Homo sapiens
16 SDAD1  
Co-fractionation Homo sapiens
17 NOP56 10528
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
18 RPL15 6138
Affinity Capture-MS Homo sapiens
19 FGF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 HES6  
Affinity Capture-MS Homo sapiens
21 ATN1  
Two-hybrid Homo sapiens
22 APP 351
Reconstituted Complex Homo sapiens
23 WDR36 134430
Co-fractionation Homo sapiens
24 ILF2 3608
Affinity Capture-MS Homo sapiens
25 APEX1 328
Proximity Label-MS Homo sapiens
26 DDX23 9416
Proximity Label-MS Homo sapiens
27 RPL4 6124
Affinity Capture-MS Homo sapiens
28 RPL10A 4736
Affinity Capture-MS Homo sapiens
29 NSA2  
Co-fractionation Homo sapiens
30 KIF23 9493
Affinity Capture-MS Homo sapiens
31 DDX24 57062
Co-fractionation Homo sapiens
32 CCDC137  
Affinity Capture-MS Homo sapiens
33 RRP12 23223
Co-fractionation Homo sapiens
34 PRC1 9055
Affinity Capture-MS Homo sapiens
35 NPM1 4869
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ANOS1 3730
Affinity Capture-MS Homo sapiens
37 FBL 2091
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
38 POLR1E  
Proximity Label-MS Homo sapiens
39 OBSL1 23363
Affinity Capture-MS Homo sapiens
40 C11orf52 91894
Proximity Label-MS Homo sapiens
41 SRP14 6727
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 RTN1 6252
Affinity Capture-MS Homo sapiens
43 ADARB1 104
Affinity Capture-MS Homo sapiens
44 PRKRA 8575
Affinity Capture-MS Homo sapiens
45 COIL  
Proximity Label-MS Homo sapiens
46 GRWD1 83743
Co-fractionation Homo sapiens
47 ILK 3611
Affinity Capture-MS Homo sapiens
48 DDX18 8886
Co-fractionation Homo sapiens
49 RRP8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 BRF2  
Affinity Capture-MS Homo sapiens
51 KLHL20  
Affinity Capture-MS Homo sapiens
52 MECP2 4204
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 H2AFY2 55506
Affinity Capture-MS Homo sapiens
54 MAK16  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 RPL19 6143
Affinity Capture-MS Homo sapiens
56 DYNLT1 6993
Proximity Label-MS Homo sapiens
57 KIF14 9928
Affinity Capture-MS Homo sapiens
58 LRIF1  
Two-hybrid Homo sapiens
59 PES1 23481
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
60 LIN28A  
Affinity Capture-MS Homo sapiens
61 SRSF6 6431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 CHMP4C 92421
Affinity Capture-MS Homo sapiens
63 RPL27 6155
Co-fractionation Homo sapiens
64 PPP1CA 5499
Reconstituted Complex Homo sapiens
65 DDX31  
Co-fractionation Homo sapiens
66 CPNE2 221184
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
68 DDX21 9188
Affinity Capture-MS Homo sapiens
69 EMD 2010
Proximity Label-MS Homo sapiens
70 PLEKHO1 51177
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 HIST4H4 121504
Reconstituted Complex Homo sapiens
72 RBM4B  
Affinity Capture-MS Homo sapiens
73 RPF2 84154
Co-fractionation Homo sapiens
74 LYN 4067
Proximity Label-MS Homo sapiens
75 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
76 VSIG4  
Affinity Capture-MS Homo sapiens
77 PURG  
Affinity Capture-MS Homo sapiens
78 NOP2 4839
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
79 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
80 RPL18A 6142
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 PBXIP1 57326
Affinity Capture-MS Homo sapiens
82 PDCD11 22984
Affinity Capture-MS Homo sapiens
83 CEBPZ  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
84 NTRK1 4914
Affinity Capture-MS Homo sapiens
85 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 IFI16 3428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 HIST2H2AA3 8337
Reconstituted Complex Homo sapiens
88 RPL36 25873
Affinity Capture-MS Homo sapiens
89 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
90 DDX54 79039
Co-fractionation Homo sapiens
91 RPN1 6184
Proximity Label-MS Homo sapiens
92 LYAR 55646
Affinity Capture-MS Homo sapiens
93 PML 5371
Affinity Capture-MS Homo sapiens
94 RPS6 6194
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 HECTD1 25831
Affinity Capture-MS Homo sapiens
96 RPLP0 6175
Affinity Capture-MS Homo sapiens
97 EED  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 MAGEB2 4113
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 SCN3B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
100 GTPBP4 23560
Co-fractionation Homo sapiens
101 UBXN6 80700
Affinity Capture-MS Homo sapiens
102 CD3EAP  
Proximity Label-MS Homo sapiens
103 ANLN 54443
Affinity Capture-MS Homo sapiens
104 FGFBP1 9982
Affinity Capture-MS Homo sapiens
105 ARHGAP12  
Cross-Linking-MS (XL-MS) Homo sapiens
106 MRPL3  
Affinity Capture-MS Homo sapiens
107 RPL31 6160
Proximity Label-MS Homo sapiens
108 NOC3L 64318
Affinity Capture-MS Homo sapiens
109 RPS24 6229
Proximity Label-MS Homo sapiens
110 MRTO4 51154
Co-fractionation Homo sapiens
111 XPO1 7514
Affinity Capture-MS Homo sapiens
112 PANX1 24145
Proximity Label-MS Homo sapiens
113 CLPP 8192
Proximity Label-MS Homo sapiens
114 SIRT7  
Affinity Capture-MS Homo sapiens
115 RPL35 11224
Affinity Capture-MS Homo sapiens
116 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
117 NPM3 10360
Affinity Capture-MS Homo sapiens
118 USP36  
Affinity Capture-MS Homo sapiens
119 PTEN 5728
Affinity Capture-MS Homo sapiens
120 SRSF5 6430
Affinity Capture-MS Homo sapiens
121 RPL3 6122
Affinity Capture-MS Homo sapiens
122 EBNA1BP2 10969
Co-fractionation Homo sapiens
123 FARP2 9855
Affinity Capture-MS Homo sapiens
124 FOXL1  
Affinity Capture-MS Homo sapiens
125 METTL21B  
Affinity Capture-MS Homo sapiens
126 RPL7L1 285855
Affinity Capture-MS Homo sapiens
127 CYFIP2 26999
Cross-Linking-MS (XL-MS) Homo sapiens
128 HIST3H3 8290
Reconstituted Complex Homo sapiens
129 Ect2  
Affinity Capture-MS Mus musculus
130 ZC3H10  
Affinity Capture-MS Homo sapiens
131 NXF1 10482
Affinity Capture-RNA Homo sapiens
132 AURKB 9212
Affinity Capture-Western Homo sapiens
133 ZNF512  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 FKBP5 2289
Affinity Capture-MS Homo sapiens
135 RBFOX1 54715
Two-hybrid Homo sapiens
136 DGKZ  
Affinity Capture-MS Homo sapiens
137 DKC1 1736
Co-fractionation Homo sapiens
138 RPA3 6119
Proximity Label-MS Homo sapiens
139 JAK1 3716
Affinity Capture-Western Homo sapiens
140 ATP2A1 487
Proximity Label-MS Homo sapiens
141 MAGEB10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 DNAJC9 23234
Proximity Label-MS Homo sapiens
143 RPS14 6208
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 BRD4 23476
Affinity Capture-MS Homo sapiens
145 RPL22 6146
Affinity Capture-MS Homo sapiens
146 SIRT6  
Affinity Capture-MS Homo sapiens
147 RPL18 6141
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
148 DDRGK1 65992
Affinity Capture-MS Homo sapiens
149 RNF2  
Affinity Capture-MS Homo sapiens
150 FOXQ1  
Affinity Capture-MS Homo sapiens
151 Sf3b2  
Two-hybrid Mus musculus
152 H2AFB2  
Affinity Capture-MS Homo sapiens
153 RPL11 6135
Affinity Capture-MS Homo sapiens
154 NOG 9241
Affinity Capture-MS Homo sapiens
155 FSCN1 6624
Affinity Capture-MS Homo sapiens
156 HIST1H1T 3010
Affinity Capture-MS Homo sapiens
157 NOL6 65083
Co-fractionation Homo sapiens
158 DDX52  
Co-fractionation Homo sapiens
159 FTSJ3 117246
Co-fractionation Homo sapiens
160 MDM2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
161 FARP1 10160
Affinity Capture-MS Homo sapiens
162 CCDC8  
Affinity Capture-MS Homo sapiens
163 RPL13 6137
Affinity Capture-MS Homo sapiens
164 DHX15 1665
Co-fractionation Homo sapiens
165 DNAJC28  
Proximity Label-MS Homo sapiens
166 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
167 DNAJB6 10049
Proximity Label-MS Homo sapiens
168 PARP1 142
Proximity Label-MS Homo sapiens
169 PDGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
170 ILF3 3609
Affinity Capture-MS Homo sapiens
171 TP53 7157
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
172 RRS1 23212
Co-fractionation Homo sapiens
173 CCDC102A 92922
Affinity Capture-MS Homo sapiens
174 MNDA 4332
Affinity Capture-MS Homo sapiens
175 ZNF746  
Affinity Capture-MS Homo sapiens
176 FOXB1  
Affinity Capture-MS Homo sapiens
177 GOLGA7 51125
Affinity Capture-MS Homo sapiens
178 ATXN7  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
179 MEN1 4221
Affinity Capture-MS Homo sapiens
180 DGCR8  
Affinity Capture-MS Homo sapiens
181 ZNF48  
Affinity Capture-MS Homo sapiens
182 TPST2 8459
Affinity Capture-MS Homo sapiens
183 TBL3 10607
Co-fractionation Homo sapiens
184 SHMT2 6472
Affinity Capture-RNA Homo sapiens
185 DDX58 23586
Affinity Capture-RNA Homo sapiens
186 NIFK 84365
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
187 DHX40  
Proximity Label-MS Homo sapiens
188 NEIL1  
Affinity Capture-MS Homo sapiens
189 EDA  
Affinity Capture-MS Homo sapiens
190 MAGED1 9500
Affinity Capture-MS Homo sapiens
191 MOV10 4343
Affinity Capture-RNA Homo sapiens
192 FGF13  
Affinity Capture-MS Homo sapiens
193 TECTB  
Affinity Capture-MS Homo sapiens
194 RPL7A 6130
Affinity Capture-MS Homo sapiens
195 RPL23AP32 56969
Affinity Capture-MS Homo sapiens
196 SSSCA1 10534
Affinity Capture-MS Homo sapiens
197 CIT 11113
Affinity Capture-MS Homo sapiens
198 RPL8 6132
Affinity Capture-MS Homo sapiens
199 RPL28 6158
Affinity Capture-MS Homo sapiens
200 GLYR1 84656
Co-fractionation Homo sapiens
201 SERBP1 26135
Affinity Capture-MS Homo sapiens
202 CUL7 9820
Affinity Capture-MS Homo sapiens
203 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
204 HNRNPU 3192
Affinity Capture-MS Homo sapiens
205 RBM34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
206 ZNF467  
Affinity Capture-MS Homo sapiens
207 DDX56  
Co-fractionation Homo sapiens
208 RPL17 6139
Affinity Capture-MS Homo sapiens
209 DERL1 79139
Proximity Label-MS Homo sapiens
210 RPS13 6207
Affinity Capture-MS Homo sapiens
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