Gene description for SUPT5H
Gene name suppressor of Ty 5 homolog (S. cerevisiae)
Gene symbol SUPT5H
Other names/aliases SPT5
SPT5H
Tat-CT1
Species Homo sapiens
 Database cross references - SUPT5H
ExoCarta ExoCarta_6829
Vesiclepedia VP_6829
Entrez Gene 6829
HGNC 11469
MIM 602102
UniProt O00267  
 SUPT5H identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
T lymphocytes 34108659    
 Gene ontology annotations for SUPT5H
Molecular Function
    chromatin binding GO:0003682 IEA
    RNA binding GO:0003723 HDA
    mRNA binding GO:0003729 IBA
    protein binding GO:0005515 IPI
    enzyme binding GO:0019899 IPI
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    negative regulation of transcription by RNA polymerase II GO:0000122 IMP
    transcription elongation by RNA polymerase II GO:0006368 IBA
    transcription elongation by RNA polymerase II GO:0006368 IDA
    transcription elongation by RNA polymerase II GO:0006368 IMP
    positive regulation of macroautophagy GO:0016239 IMP
    negative regulation of DNA-templated transcription, elongation GO:0032785 IDA
    negative regulation of DNA-templated transcription, elongation GO:0032785 IMP
    positive regulation of DNA-templated transcription, elongation GO:0032786 IDA
    regulation of transcription elongation by RNA polymerase II GO:0034243 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    transcription elongation-coupled chromatin remodeling GO:0140673 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    DSIF complex GO:0032044 IBA
    DSIF complex GO:0032044 IDA
    DSIF complex GO:0032044 IPI
 Experiment description of studies that identified SUPT5H in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
12
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
17
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
20
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
22
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
23
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
24
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
25
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
26
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
27
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
28
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
29
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
30
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
31
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
32
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
33
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
34
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
35
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
 Protein-protein interactions for SUPT5H
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FAN1  
Affinity Capture-MS Homo sapiens
2 POLR2B 5431
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 POLR2G 5436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 UBR5 51366
Affinity Capture-MS Homo sapiens
5 ATP6V1B2 526
Co-fractionation Homo sapiens
6 UBE2H 7328
Affinity Capture-MS Homo sapiens
7 SMC3 9126
Affinity Capture-Western Homo sapiens
8 EXOSC7 23016
Two-hybrid Homo sapiens
9 RNGTT 8732
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CCNH  
Reconstituted Complex Homo sapiens
11 MED17  
Affinity Capture-MS Homo sapiens
12 COIL  
Proximity Label-MS Homo sapiens
13 GART 2618
Co-fractionation Homo sapiens
14 SLC35G1  
Affinity Capture-MS Homo sapiens
15 MSH6 2956
Co-fractionation Homo sapiens
16 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
17 PRPF8 10594
Affinity Capture-MS Homo sapiens
18 CPNE7 27132
Affinity Capture-MS Homo sapiens
19 MRTO4 51154
Co-fractionation Homo sapiens
20 RAMP1  
Affinity Capture-MS Homo sapiens
21 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
22 SUB1 10923
Co-fractionation Homo sapiens
23 TEX11  
Two-hybrid Homo sapiens
24 PAICS 10606
Co-fractionation Homo sapiens
25 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
26 INTS2  
Affinity Capture-MS Homo sapiens
27 C9orf78 51759
Affinity Capture-MS Homo sapiens
28 SNRNP40 9410
Affinity Capture-MS Homo sapiens
29 SETX  
Affinity Capture-MS Homo sapiens
30 C7orf76  
Affinity Capture-MS Homo sapiens
31 CSNK2A1 1457
Biochemical Activity Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
32 NENF 29937
Co-fractionation Homo sapiens
33 RANBP3 8498
Co-fractionation Homo sapiens
34 PPP4R2  
Affinity Capture-MS Homo sapiens
35 SCAF4 57466
Affinity Capture-MS Homo sapiens
36 INTS1 26173
Affinity Capture-MS Homo sapiens
37 CAP2 10486
Affinity Capture-MS Homo sapiens
38 AIPL1  
Affinity Capture-MS Homo sapiens
39 PPP1R10  
Affinity Capture-MS Homo sapiens
40 SNRPF 6636
Affinity Capture-MS Homo sapiens
41 SOX2  
Affinity Capture-MS Homo sapiens
42 SEC24C 9632
Co-fractionation Homo sapiens
43 SYNE2 23224
Affinity Capture-MS Homo sapiens
44 ILF2 3608
Co-fractionation Homo sapiens
45 INTS9 55756
Affinity Capture-MS Homo sapiens
46 APEX1 328
Affinity Capture-RNA Homo sapiens
Proximity Label-MS Homo sapiens
47 TCEB3 6924
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
48 INTS8  
Affinity Capture-MS Homo sapiens
49 CPSF2 53981
Co-fractionation Homo sapiens
50 HIST1H2AB 8335
Affinity Capture-MS Homo sapiens
51 WDR76  
Affinity Capture-MS Homo sapiens
52 PGK1 5230
Two-hybrid Homo sapiens
53 CRNKL1 51340
Affinity Capture-MS Homo sapiens
54 GTF2F2 2963
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
55 DDX17 10521
Affinity Capture-MS Homo sapiens
56 NOLC1 9221
Affinity Capture-MS Homo sapiens
57 FHL3 2275
Two-hybrid Homo sapiens
58 INIP  
Affinity Capture-MS Homo sapiens
59 SHMT2 6472
Affinity Capture-RNA Homo sapiens
60 POLR2I 5438
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CDH2 1000
Co-fractionation Homo sapiens
62 PCBD1 5092
Two-hybrid Homo sapiens
63 MAGOHB 55110
Affinity Capture-MS Homo sapiens
64 CPSF7 79869
Two-hybrid Homo sapiens
65 SNRPD1 6632
Affinity Capture-MS Homo sapiens
66 ZNF512B  
Two-hybrid Homo sapiens
67 Btf3  
Two-hybrid Mus musculus
68 INTS12  
Affinity Capture-MS Homo sapiens
69 OBSL1 23363
Affinity Capture-MS Homo sapiens
70 PDE5A 8654
Affinity Capture-MS Homo sapiens
71 HMGA1 3159
Affinity Capture-MS Homo sapiens
72 SNRNP48  
Two-hybrid Homo sapiens
73 SNRPC 6631
Affinity Capture-MS Homo sapiens
74 NELFE 7936
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 Myh9 17886
Affinity Capture-MS Mus musculus
76 SMEK1 55671
Affinity Capture-MS Homo sapiens
77 ATRX 546
Affinity Capture-MS Homo sapiens
78 SLX4  
Affinity Capture-MS Homo sapiens
79 BLM 641
Synthetic Growth Defect Homo sapiens
80 POLR2C 5432
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 ZC3H4 23211
Affinity Capture-MS Homo sapiens
82 LMAN2 10960
Two-hybrid Homo sapiens
83 SSBP3  
Two-hybrid Homo sapiens
84 MECP2 4204
Affinity Capture-MS Homo sapiens
85 CSNK2B 1460
Co-fractionation Homo sapiens
86 ZFYVE9  
Two-hybrid Homo sapiens
87 SLU7  
Affinity Capture-MS Homo sapiens
88 PHF2  
Affinity Capture-MS Homo sapiens
89 SNX4 8723
Two-hybrid Homo sapiens
90 RBM8A 9939
Affinity Capture-MS Homo sapiens
91 KIF14 9928
Affinity Capture-MS Homo sapiens
92 POC1A  
Affinity Capture-MS Homo sapiens
93 SAMHD1 25939
Co-fractionation Homo sapiens
94 POLR2K  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 POLR2J  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 H2AFZ 3015
Affinity Capture-MS Homo sapiens
97 C7orf26  
Affinity Capture-MS Homo sapiens
98 CPNE2 221184
Affinity Capture-MS Homo sapiens
99 Bbs5  
Two-hybrid Mus musculus
100 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
101 CBX3 11335
Proximity Label-MS Homo sapiens
102 RPL9 6133
Two-hybrid Homo sapiens
103 WDR70 55100
Co-fractionation Homo sapiens
104 PLEKHO1 51177
Affinity Capture-MS Homo sapiens
105 NUP50 10762
Proximity Label-MS Homo sapiens
106 C17orf85  
Affinity Capture-MS Homo sapiens
107 YBX2 51087
Two-hybrid Homo sapiens
108 PPT2  
Co-fractionation Homo sapiens
109 PNN 5411
Affinity Capture-MS Homo sapiens
110 MCM10 55388
Affinity Capture-MS Homo sapiens
111 ACIN1 22985
Affinity Capture-MS Homo sapiens
112 GOLGA2 2801
Proximity Label-MS Homo sapiens
113 NELFCD 51497
Affinity Capture-MS Homo sapiens
114 RTF1 23168
Co-fractionation Homo sapiens
115 SNRNP200 23020
Affinity Capture-MS Homo sapiens
116 WDR61 80349
Affinity Capture-MS Homo sapiens
117 PLOD2 5352
Co-fractionation Homo sapiens
118 IWS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 CARM1 10498
Co-fractionation Homo sapiens
120 TUBA1B 10376
Affinity Capture-MS Homo sapiens
121 MNAT1  
Biochemical Activity Homo sapiens
122 SAFB2 9667
Affinity Capture-MS Homo sapiens
123 SWAP70 23075
Co-fractionation Homo sapiens
124 BARD1 580
Affinity Capture-MS Homo sapiens
125 DDX5 1655
Affinity Capture-MS Homo sapiens
126 NTRK1 4914
Affinity Capture-MS Homo sapiens
127 RPL31 6160
Proximity Label-MS Homo sapiens
128 FGF12  
Affinity Capture-MS Homo sapiens
129 INTS7  
Affinity Capture-MS Homo sapiens
130 TOX4  
Affinity Capture-MS Homo sapiens
131 PPP2CA 5515
Affinity Capture-MS Homo sapiens
132 NCL 4691
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
133 RPA4  
Proximity Label-MS Homo sapiens
134 ENO1 2023
Affinity Capture-RNA Homo sapiens
135 GANAB 23193
Co-fractionation Homo sapiens
136 SPDYE4  
Proximity Label-MS Homo sapiens
137 MAML3  
Two-hybrid Homo sapiens
138 CTR9 9646
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
139 PAK7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 DDX39B 7919
Affinity Capture-MS Homo sapiens
141 SUPT6H 6830
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 INTS6 26512
Affinity Capture-MS Homo sapiens
143 INTS10  
Affinity Capture-MS Homo sapiens
144 EIF5B 9669
Co-fractionation Homo sapiens
145 FGFR1OP  
Affinity Capture-MS Homo sapiens
146 CT45A5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 NOP56 10528
Proximity Label-MS Homo sapiens
148 CPNE4 131034
Affinity Capture-MS Homo sapiens
149 CD3EAP  
Proximity Label-MS Homo sapiens
150 ANLN 54443
Affinity Capture-MS Homo sapiens
151 BCLAF1 9774
Affinity Capture-MS Homo sapiens
152 DDX26B  
Affinity Capture-MS Homo sapiens
153 DOK4 55715
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
154 HSPA5 3309
Cross-Linking-MS (XL-MS) Homo sapiens
155 TAF15 8148
Affinity Capture-MS Homo sapiens
156 RNF34  
Affinity Capture-MS Homo sapiens
157 SF1 7536
Co-fractionation Homo sapiens
158 CDK7 1022
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
159 LEO1 123169
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 CDC73  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 POLR2H 5437
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
162 MSH2 4436
Co-fractionation Homo sapiens
163 BAZ1B 9031
Affinity Capture-MS Homo sapiens
164 LMNB1 4001
Affinity Capture-MS Homo sapiens
165 NCBP2 22916
Affinity Capture-MS Homo sapiens
166 SIRT7  
Affinity Capture-MS Homo sapiens
167 PPP2CB 5516
Affinity Capture-MS Homo sapiens
168 SNRPB 6628
Affinity Capture-MS Homo sapiens
169 JADE1  
Affinity Capture-MS Homo sapiens
170 HTATSF1 27336
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
171 POLR2E 5434
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 EIF4A3 9775
Affinity Capture-MS Homo sapiens
173 CDKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 FAM21A 387680
Co-fractionation Homo sapiens
175 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 SYT6  
Affinity Capture-MS Homo sapiens
177 MRPL42  
Affinity Capture-MS Homo sapiens
178 EGFR 1956
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
179 SNRPA 6626
Affinity Capture-MS Homo sapiens
180 FUS 2521
Affinity Capture-MS Homo sapiens
181 POLR2A 5430
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
182 CCDC71  
Affinity Capture-MS Homo sapiens
183 SART1 9092
Affinity Capture-MS Homo sapiens
184 FN1 2335
Affinity Capture-MS Homo sapiens
185 NXF1 10482
Affinity Capture-RNA Homo sapiens
186 ZNF655  
Affinity Capture-MS Homo sapiens
187 MED14  
Affinity Capture-MS Homo sapiens
188 PRMT5 10419
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
189 FARSB 10056
Co-fractionation Homo sapiens
190 POLR2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
191 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
192 RPA3 6119
Proximity Label-MS Homo sapiens
193 SIK1  
Two-hybrid Homo sapiens
194 ATP2A1 487
Proximity Label-MS Homo sapiens
195 ZC3H18  
Affinity Capture-MS Homo sapiens
196 RPRD2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
197 SET 6418
Co-fractionation Homo sapiens
198 CSNK2A2 1459
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
199 TERF2  
Affinity Capture-MS Homo sapiens
200 NCBP1 4686
Affinity Capture-MS Homo sapiens
201 TOP1 7150
Affinity Capture-MS Homo sapiens
202 SCAF11  
Affinity Capture-MS Homo sapiens
203 TNS2 23371
Affinity Capture-MS Homo sapiens
204 THOC1 9984
Affinity Capture-MS Homo sapiens
205 PIGF  
Affinity Capture-MS Homo sapiens
206 Junb  
Affinity Capture-MS Mus musculus
207 HIST1H3H 8357
Affinity Capture-MS Homo sapiens
208 RNF2  
Affinity Capture-MS Homo sapiens
209 CSDE1 7812
Co-fractionation Homo sapiens
210 NELFB 25920
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
211 CPSF3L 54973
Affinity Capture-MS Homo sapiens
212 CEP170P1  
Affinity Capture-MS Homo sapiens
213 NFATC2  
Affinity Capture-MS Homo sapiens
214 FTSJ3 117246
Affinity Capture-MS Homo sapiens
215 SUPT16H 11198
Affinity Capture-MS Homo sapiens
216 PYHIN1  
Affinity Capture-MS Homo sapiens
217 ASUN  
Affinity Capture-MS Homo sapiens
218 U2SURP 23350
Co-fractionation Homo sapiens
219 ZRANB1 54764
Affinity Capture-MS Homo sapiens
220 ZNF496  
Two-hybrid Homo sapiens
221 TAF6 6878
Co-fractionation Homo sapiens
222 MYCBP 26292
Affinity Capture-MS Homo sapiens
223 EIF3F 8665
Affinity Capture-MS Homo sapiens
224 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
225 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
226 PPP4C 5531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
227 PLEKHJ1  
Affinity Capture-MS Homo sapiens
228 POLR2F  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
229 SIRT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
230 PARP1 142
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
231 PAPOLA 10914
Co-fractionation Homo sapiens
232 WDR77 79084
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
233 CPSF6 11052
Affinity Capture-MS Homo sapiens
234 TP53 7157
Affinity Capture-MS Homo sapiens
235 STRIP2  
Affinity Capture-MS Homo sapiens
236 ERH 2079
Affinity Capture-MS Homo sapiens
237 POLR2L 5441
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
238 WBP11  
Co-fractionation Homo sapiens
239 SSRP1 6749
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
240 PIN1 5300
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Far Western Homo sapiens
241 ATL2 64225
Affinity Capture-MS Homo sapiens
242 PHF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
243 RNF214  
Affinity Capture-MS Homo sapiens
244 IKBKG 8517
Two-hybrid Homo sapiens
245 EDEM1  
Affinity Capture-MS Homo sapiens
246 VWA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
247 THRAP3 9967
Affinity Capture-MS Homo sapiens
248 INTS4  
Affinity Capture-MS Homo sapiens
249 HSPB1 3315
Two-hybrid Homo sapiens
250 NELFA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
251 WIPF1 7456
Affinity Capture-MS Homo sapiens
252 WDR82 80335
Affinity Capture-MS Homo sapiens
253 HSP90AA1 3320
Co-fractionation Homo sapiens
254 SUPT4H1  
Co-crystal Structure Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
255 DDX23 9416
Proximity Label-MS Homo sapiens
256 HNRNPK 3190
Co-fractionation Homo sapiens
257 WIF1 11197
Affinity Capture-MS Homo sapiens
258 UBR4 23352
Co-fractionation Homo sapiens
259 DHX40  
Proximity Label-MS Homo sapiens
260 NABP2  
Affinity Capture-MS Homo sapiens
261 Rbm14  
Two-hybrid Mus musculus
262 KHDRBS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
263 ERGIC2 51290
Proximity Label-MS Homo sapiens
264 TERF1 7013
Two-hybrid Homo sapiens
265 MIOS 54468
Affinity Capture-MS Homo sapiens
266 RPS24 6229
Proximity Label-MS Homo sapiens
267 MOV10 4343
Affinity Capture-RNA Homo sapiens
268 Rprd1b  
Affinity Capture-MS Mus musculus
269 EYA4 2070
Affinity Capture-MS Homo sapiens
270 VPS26B 112936
Affinity Capture-MS Homo sapiens
271 EEF1D 1936
Co-fractionation Homo sapiens
272 HNRNPC 3183
Affinity Capture-MS Homo sapiens
273 CDK9 1025
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
274 RNPS1 10921
Affinity Capture-MS Homo sapiens
275 ZBTB3  
Two-hybrid Homo sapiens
276 CIT 11113
Affinity Capture-MS Homo sapiens
277 HNRNPF 3185
Affinity Capture-MS Homo sapiens
278 RPRD1B 58490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
279 STK11 6794
Affinity Capture-MS Homo sapiens
280 XRCC6 2547
Co-fractionation Homo sapiens
281 INTS3 65123
Affinity Capture-MS Homo sapiens
282 CUL7 9820
Affinity Capture-MS Homo sapiens
283 EFTUD2 9343
Affinity Capture-MS Homo sapiens
284 PAF1 54623
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
285 CCNT1  
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
286 PSMA5 5686
Affinity Capture-MS Homo sapiens
287 PHF8  
Affinity Capture-MS Homo sapiens
288 PRMT1 3276
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
289 RANGAP1 5905
Co-fractionation Homo sapiens
290 DDX28  
Affinity Capture-MS Homo sapiens
291 EP300 2033
Affinity Capture-MS Homo sapiens
292 ATP1B3 483
Affinity Capture-MS Homo sapiens
293 PAK4 10298
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SUPT5H is involved
PathwayEvidenceSource
Abortive elongation of HIV-1 transcript in the absence of Tat IEA Reactome
Disease IEA Reactome
Disease TAS Reactome
Formation of HIV elongation complex in the absence of HIV Tat IEA Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat TAS Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat IEA Reactome
Formation of RNA Pol II elongation complex TAS Reactome
Formation of the Early Elongation Complex TAS Reactome
Formation of the HIV-1 Early Elongation Complex IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
HIV elongation arrest and recovery IEA Reactome
HIV Infection IEA Reactome
HIV Infection TAS Reactome
HIV Life Cycle IEA Reactome
HIV Life Cycle TAS Reactome
HIV Transcription Elongation IEA Reactome
HIV Transcription Elongation TAS Reactome
Infectious disease IEA Reactome
Infectious disease TAS Reactome
Late Phase of HIV Life Cycle IEA Reactome
Late Phase of HIV Life Cycle TAS Reactome
Metabolism of RNA TAS Reactome
mRNA Capping TAS Reactome
Pausing and recovery of HIV elongation IEA Reactome
Pausing and recovery of Tat-mediated HIV elongation IEA Reactome
RNA Pol II CTD phosphorylation and interaction with CE TAS Reactome
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection IEA Reactome
RNA Polymerase II Pre-transcription Events TAS Reactome
RNA polymerase II transcribes snRNA genes TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RNA Polymerase II Transcription Elongation TAS Reactome
Tat-mediated elongation of the HIV-1 transcript IEA Reactome
Tat-mediated elongation of the HIV-1 transcript TAS Reactome
Tat-mediated HIV elongation arrest and recovery IEA Reactome
TP53 Regulates Transcription of DNA Repair Genes TAS Reactome
Transcription of the HIV genome IEA Reactome
Transcription of the HIV genome TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Viral Infection Pathways IEA Reactome
Viral Infection Pathways TAS Reactome





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