Gene description for DNAJB11
Gene name DnaJ (Hsp40) homolog, subfamily B, member 11
Gene symbol DNAJB11
Other names/aliases ABBP-2
ABBP2
DJ9
Dj-9
EDJ
ERdj3
ERj3
ERj3p
PRO1080
UNQ537
Species Homo sapiens
 Database cross references - DNAJB11
ExoCarta ExoCarta_51726
Entrez Gene 51726
HGNC 14889
MIM 611341
UniProt Q9UBS4  
 DNAJB11 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for DNAJB11
Molecular Function
    unfolded protein binding GO:0051082 IEA
    protein binding GO:0005515 IPI
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    mRNA modification GO:0016556 IEA
    endoplasmic reticulum unfolded protein response GO:0030968 TAS
    IRE1-mediated unfolded protein response GO:0036498 TAS
    protein folding GO:0006457 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 TAS
    nucleus GO:0005634 IEA
    membrane GO:0016020 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
 Experiment description of studies that identified DNAJB11 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DNAJB11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HSPA4 3308
Affinity Capture-Western Homo sapiens
2 BAG6 7917
Two-hybrid Homo sapiens
3 PTN  
Two-hybrid Homo sapiens
4 DOK2 9046
Affinity Capture-MS Homo sapiens
5 APOBEC1  
Reconstituted Complex Homo sapiens
6 UBR1  
Two-hybrid Homo sapiens
7 HSPA1A  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DNAJB11 is involved
PathwayEvidenceSource
XBP1(S) activates chaperone genes TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here