Gene description for D2HGDH
Gene name D-2-hydroxyglutarate dehydrogenase
Gene symbol D2HGDH
Other names/aliases D2HGD
Species Homo sapiens
 Database cross references - D2HGDH
ExoCarta ExoCarta_728294
Vesiclepedia VP_728294
Entrez Gene 728294
HGNC 28358
MIM 609186
UniProt Q8N465  
 D2HGDH identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for D2HGDH
Molecular Function
    zinc ion binding GO:0008270 IDA
    (R)-2-hydroxyglutarate dehydrogenase activity GO:0051990 EXP
    (R)-2-hydroxyglutarate dehydrogenase activity GO:0051990 IMP
    (R)-2-hydroxyglutarate dehydrogenase activity GO:0051990 ISS
    FAD binding GO:0071949 IEA
Biological Process
    2-oxoglutarate metabolic process GO:0006103 TAS
    malate metabolic process GO:0006108 IDA
    response to manganese ion GO:0010042 ISS
    response to zinc ion GO:0010043 ISS
    protein metabolic process GO:0019538 ISS
    response to cobalt ion GO:0032025 ISS
    response to magnesium ion GO:0032026 ISS
    response to calcium ion GO:0051592 ISS
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 ISS
    mitochondrial matrix GO:0005759 TAS
 Experiment description of studies that identified D2HGDH in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for D2HGDH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 ARMC4  
Affinity Capture-MS Homo sapiens
3 ABCF3 55324
Affinity Capture-MS Homo sapiens
4 VPS41 27072
Affinity Capture-MS Homo sapiens
5 HELZ 9931
Affinity Capture-MS Homo sapiens
6 HCST  
Affinity Capture-MS Homo sapiens
7 CHTF18 63922
Affinity Capture-MS Homo sapiens
8 IFT122 55764
Affinity Capture-MS Homo sapiens
9 FUK 197258
Affinity Capture-MS Homo sapiens
10 TCF7L2  
Affinity Capture-MS Homo sapiens
11 RPS6KA4 8986
Affinity Capture-MS Homo sapiens
12 SAMD1  
Affinity Capture-MS Homo sapiens
13 HOOK2  
Affinity Capture-MS Homo sapiens
14 RIPK1 8737
Affinity Capture-MS Homo sapiens
15 ANKS1A 23294
Affinity Capture-MS Homo sapiens
16 CEP97 79598
Affinity Capture-MS Homo sapiens
17 PEX1 5189
Affinity Capture-MS Homo sapiens
18 PLEKHG4  
Affinity Capture-MS Homo sapiens
19 ETV3  
Affinity Capture-MS Homo sapiens
20 ERF  
Affinity Capture-MS Homo sapiens
21 TBCB 1155
Co-fractionation Homo sapiens
22 RFC3 5983
Affinity Capture-MS Homo sapiens
23 IQSEC1 9922
Affinity Capture-MS Homo sapiens
24 SDHB 6390
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 WDR74 54663
Affinity Capture-MS Homo sapiens
26 TRMT44  
Affinity Capture-MS Homo sapiens
27 TELO2 9894
Affinity Capture-MS Homo sapiens
28 YARS2  
Affinity Capture-MS Homo sapiens
29 TRABD 80305
Affinity Capture-MS Homo sapiens
30 MRPS24 64951
Affinity Capture-MS Homo sapiens
31 KIR2DS3  
Affinity Capture-MS Homo sapiens
32 HAUS6  
Affinity Capture-MS Homo sapiens
33 ZSWIM8 23053
Affinity Capture-MS Homo sapiens
34 ANAPC7 51434
Affinity Capture-MS Homo sapiens
35 TRMT1 55621
Affinity Capture-MS Homo sapiens
36 MAP3K6  
Affinity Capture-MS Homo sapiens
37 VWA5B2  
Affinity Capture-MS Homo sapiens
38 VPS16 64601
Affinity Capture-MS Homo sapiens
39 RNF123 63891
Affinity Capture-MS Homo sapiens
40 ZNF462  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ARHGEF4  
Affinity Capture-MS Homo sapiens
42 PLEKHH3  
Affinity Capture-MS Homo sapiens
43 HSPA8 3312
Affinity Capture-MS Homo sapiens
44 UCKL1 54963
Affinity Capture-MS Homo sapiens
45 POLD1 5424
Affinity Capture-MS Homo sapiens
46 CNOT11 55571
Affinity Capture-MS Homo sapiens
47 CDC23 8697
Affinity Capture-MS Homo sapiens
48 RGSL1  
Co-fractionation Homo sapiens
49 ANKHD1 54882
Affinity Capture-MS Homo sapiens
50 TUBA1A 7846
Affinity Capture-MS Homo sapiens
51 PRKAG1 5571
Affinity Capture-MS Homo sapiens
52 TIGIT  
Affinity Capture-MS Homo sapiens
53 DHRS4L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RAB30 27314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 TUBA1C 84790
Affinity Capture-MS Homo sapiens
56 MNAT1  
Affinity Capture-MS Homo sapiens
57 NUDT16 131870
Affinity Capture-MS Homo sapiens
58 HPS3 84343
Affinity Capture-MS Homo sapiens
59 THBS1 7057
Affinity Capture-MS Homo sapiens
60 TRIM32 22954
Affinity Capture-MS Homo sapiens
61 LRBA 987
Affinity Capture-MS Homo sapiens
62 GIT1 28964
Affinity Capture-MS Homo sapiens
63 TUBB 203068
Affinity Capture-MS Homo sapiens
64 EIF4G2 1982
Affinity Capture-MS Homo sapiens
65 ARAP3 64411
Affinity Capture-MS Homo sapiens
66 CCZ1 51622
Affinity Capture-MS Homo sapiens
67 VCPIP1 80124
Affinity Capture-MS Homo sapiens
68 VPS18 57617
Affinity Capture-MS Homo sapiens
69 TAF6L 10629
Affinity Capture-MS Homo sapiens
70 UBXN6 80700
Affinity Capture-MS Homo sapiens
71 RTEL1 51750
Affinity Capture-MS Homo sapiens
72 WDR11 55717
Affinity Capture-MS Homo sapiens
73 RNF219  
Affinity Capture-MS Homo sapiens
74 MAP7 9053
Affinity Capture-MS Homo sapiens
75 RGL3  
Affinity Capture-MS Homo sapiens
76 PAN3 255967
Affinity Capture-MS Homo sapiens
77 NPRL3  
Affinity Capture-MS Homo sapiens
78 CD79B 974
Affinity Capture-MS Homo sapiens
79 SMG8 55181
Affinity Capture-MS Homo sapiens
80 DOCK7 85440
Affinity Capture-MS Homo sapiens
81 NPTN 27020
Affinity Capture-MS Homo sapiens
82 MADD 8567
Affinity Capture-MS Homo sapiens
83 RICTOR 253260
Affinity Capture-MS Homo sapiens
84 FAHD1 81889
Affinity Capture-MS Homo sapiens
85 TTF2 8458
Affinity Capture-MS Homo sapiens
86 SBF1 6305
Affinity Capture-MS Homo sapiens
87 TBCD 6904
Affinity Capture-MS Homo sapiens
88 AP1G2 8906
Affinity Capture-MS Homo sapiens
89 GATC  
Affinity Capture-MS Homo sapiens
90 HAUS5 23354
Affinity Capture-MS Homo sapiens
91 MTUS1  
Affinity Capture-MS Homo sapiens
92 RGPD5  
Affinity Capture-MS Homo sapiens
93 MEX3D  
Affinity Capture-MS Homo sapiens
94 SHKBP1  
Affinity Capture-MS Homo sapiens
95 ESRP2 80004
Affinity Capture-MS Homo sapiens
96 KIAA1671  
Affinity Capture-MS Homo sapiens
97 HSPD1 3329
Affinity Capture-MS Homo sapiens
98 PNPLA2  
Affinity Capture-MS Homo sapiens
99 PFDN5 5204
Affinity Capture-MS Homo sapiens
100 IFT140 9742
Affinity Capture-MS Homo sapiens
101 HAUS3  
Affinity Capture-MS Homo sapiens
102 HERC1 8925
Affinity Capture-MS Homo sapiens
103 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
104 SLFN5 162394
Affinity Capture-MS Homo sapiens
105 GIGYF2 26058
Affinity Capture-MS Homo sapiens
106 FBXL6  
Affinity Capture-MS Homo sapiens
107 RAD17  
Affinity Capture-MS Homo sapiens
108 THUMPD3 25917
Affinity Capture-MS Homo sapiens
109 VPS13B  
Affinity Capture-MS Homo sapiens
110 PPP1R13L 10848
Affinity Capture-MS Homo sapiens
111 STK38 11329
Affinity Capture-MS Homo sapiens
112 ABHD10 55347
Affinity Capture-MS Homo sapiens
113 MISP 126353
Affinity Capture-MS Homo sapiens
114 IQGAP3 128239
Affinity Capture-MS Homo sapiens
115 IKBKG 8517
Affinity Capture-MS Homo sapiens
116 TUBGCP3 10426
Affinity Capture-MS Homo sapiens
117 DNAAF5 54919
Affinity Capture-MS Homo sapiens
118 OXSR1 9943
Affinity Capture-MS Homo sapiens
119 ANAPC1 64682
Affinity Capture-MS Homo sapiens
120 PTBP3 9991
Affinity Capture-MS Homo sapiens
121 LSS 4047
Affinity Capture-MS Homo sapiens
122 TBC1D2B 23102
Affinity Capture-MS Homo sapiens
123 SLAMF1 6504
Affinity Capture-MS Homo sapiens
124 RAD50 10111
Affinity Capture-MS Homo sapiens
125 VPS33A 65082
Affinity Capture-MS Homo sapiens
126 TBK1 29110
Affinity Capture-MS Homo sapiens
127 SPG11 80208
Affinity Capture-MS Homo sapiens
128 RNF31 55072
Affinity Capture-MS Homo sapiens
129 MYL10 93408
Affinity Capture-MS Homo sapiens
130 WDR59 79726
Affinity Capture-MS Homo sapiens
131 PIK3R2 5296
Affinity Capture-MS Homo sapiens
132 CUL7 9820
Affinity Capture-MS Homo sapiens
133 P2RX2  
Affinity Capture-MS Homo sapiens
134 YBEY  
Affinity Capture-MS Homo sapiens
135 CDK11A 728642
Affinity Capture-MS Homo sapiens
136 DDX28  
Affinity Capture-MS Homo sapiens
137 EDRF1  
Affinity Capture-MS Homo sapiens
138 GPAT2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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