Gene description for MSH3
Gene name mutS homolog 3
Gene symbol MSH3
Other names/aliases DUP
Species Homo sapiens
 Database cross references - MSH3
ExoCarta ExoCarta_4437
Entrez Gene 4437
HGNC 7326
MIM 600887
UniProt P20585  
 MSH3 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MSH3
Molecular Function
    heteroduplex DNA loop binding GO:0000404 IBA
    mismatched DNA binding GO:0030983 IDA
    centromeric DNA binding GO:0019237 IEA
    single-stranded DNA binding GO:0003697 IDA
    DNA-dependent ATPase activity GO:0008094 IBA
    protein binding GO:0005515 IPI
    double-strand/single-strand DNA junction binding GO:0000406 IBA
    protein homodimerization activity GO:0042803 IDA
    guanine/thymine mispair binding GO:0032137 IDA
    ATP binding GO:0005524 IEA
    dinucleotide repeat insertion binding GO:0032181 IDA
    oxidized purine DNA binding GO:0032357 IDA
    single guanine insertion binding GO:0032142 IDA
    dinucleotide insertion or deletion binding GO:0032139 IDA
    Y-form DNA binding GO:0000403 IBA
    enzyme binding GO:0019899 IPI
Biological Process
    somatic recombination of immunoglobulin gene segments GO:0016447 IBA
    reciprocal meiotic recombination GO:0007131 IBA
    mismatch repair GO:0006298 TAS
    positive regulation of helicase activity GO:0051096 IDA
    meiotic mismatch repair GO:0000710 IBA
    DNA repair GO:0006281 TAS
    maintenance of DNA repeat elements GO:0043570 IMP
    negative regulation of DNA recombination GO:0045910 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    MutSbeta complex GO:0032302 IDA
    membrane GO:0016020 IDA
    nuclear chromosome GO:0000228 IBA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified MSH3 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MSH3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MSH2 4436
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 BRCA1 672
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
3 PCNA 5111
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
4 BARD1 580
Reconstituted Complex Homo sapiens
5 EXO1  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which MSH3 is involved
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) TAS Reactome

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