Gene description for RAE1
Gene name ribonucleic acid export 1
Gene symbol RAE1
Other names/aliases MIG14
MRNP41
Mnrp41
dJ481F12.3
dJ800J21.1
Species Homo sapiens
 Database cross references - RAE1
ExoCarta ExoCarta_8480
Entrez Gene 8480
HGNC 9828
MIM 603343
UniProt P78406  
 RAE1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for RAE1
Molecular Function
    RNA binding GO:0003723 TAS
    microtubule binding GO:0008017 ISS
Biological Process
    carbohydrate metabolic process GO:0005975 TAS
    mitotic cell cycle GO:0000278 TAS
    cellular response to organic cyclic compound GO:0071407 IEA
    regulation of cellular response to heat GO:1900034 TAS
    viral transcription GO:0019083 TAS
    protein sumoylation GO:0016925 TAS
    cellular response to heat GO:0034605 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    gene expression GO:0010467 TAS
    cellular protein metabolic process GO:0044267 TAS
    viral process GO:0016032 TAS
    viral life cycle GO:0019058 TAS
    small molecule metabolic process GO:0044281 TAS
    post-translational protein modification GO:0043687 TAS
    transmembrane transport GO:0055085 TAS
    regulation of glucose transport GO:0010827 TAS
    mitotic nuclear envelope disassembly GO:0007077 TAS
    glucose transport GO:0015758 TAS
    hexose transport GO:0008645 TAS
    mRNA export from nucleus GO:0006406 TAS
Subcellular Localization
    nuclear envelope GO:0005635 TAS
    cytoplasm GO:0005737 IEA
    nuclear pore GO:0005643 TAS
    nucleolus GO:0005730 IDA
    cytoskeleton GO:0005856 TAS
    nuclear outer membrane GO:0005640 TAS
    nucleus GO:0005634 IDA
 Experiment description of studies that identified RAE1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RAE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Bub1  
Affinity Capture-Western Mus musculus
2 BUB1  
Affinity Capture-Western Homo sapiens
3 SFN 2810
Affinity Capture-MS Homo sapiens
4 NUP98 4928
Invivo Homo sapiens
Invitro Homo sapiens
5 KLRK1  
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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