Gene description for CAMK4
Gene name calcium/calmodulin-dependent protein kinase IV
Gene symbol CAMK4
Other names/aliases CaMK IV
CaMK-GR
IV
caMK
Species Homo sapiens
 Database cross references - CAMK4
ExoCarta ExoCarta_814
Entrez Gene 814
HGNC 1464
MIM 114080
UniProt Q16566  
 CAMK4 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for CAMK4
Molecular Function
    ATP binding GO:0005524 IEA
    calcium-dependent protein serine/threonine kinase activity GO:0009931 IBA
    calmodulin binding GO:0005516 IBA
    calmodulin-dependent protein kinase activity GO:0004683 IDA
Biological Process
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    peptidyl-serine phosphorylation GO:0018105 IBA
    activation of phospholipase C activity GO:0007202 TAS
    nucleocytoplasmic transport GO:0006913 IEA
    signal transduction GO:0007165 TAS
    long-term memory GO:0007616 IGI
    protein autophosphorylation GO:0046777 IBA
    fibroblast growth factor receptor signaling pathway GO:0008543 TAS
    epidermal growth factor receptor signaling pathway GO:0007173 TAS
    intracellular signal transduction GO:0035556 IBA
    regulation of T cell differentiation in thymus GO:0033081 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    myeloid dendritic cell differentiation GO:0043011 IMP
    innate immune response GO:0045087 TAS
    neuron-neuron synaptic transmission GO:0007270 IEA
    synaptic transmission GO:0007268 TAS
    positive regulation of protein export from nucleus GO:0046827 IEA
    inflammatory response GO:0006954 IEA
    protein phosphorylation GO:0006468 TAS
    myeloid dendritic cell cytokine production GO:0002372 IMP
    regulation of osteoclast differentiation GO:0045670 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    extracellular exosome GO:0070062 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IBA
    nucleolus GO:0005730 IDA
 Experiment description of studies that identified CAMK4 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CAMK4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RELA  
Affinity Capture-MS Homo sapiens
2 CAMKK1  
Invitro Homo sapiens
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